TADRRweb: a webserver for assessing safety liabilities of drugs through the network of Drug-Target-Adverse Drug Reactions

User Manual For TADRR

Users for the first time using our website can follow the instructions below.

How to do SEA analysis

1st step: upload SMILES of your compound
You should get the SMILES of compound which you are interested. There are two methods to get the smile: one way is to draw the structure of a compound in the JME editor and then click the 'Get SMILES' button, the other way is to copy your smlie into the textbox directly.

2nd : Start computing.
The computing process may take a few minutes, please be patient.





3rd step: check out analysis results

The result shows the targets that evalues is smaller than ten.
 

The network part

There three parts in the network parts, i.e. Drugs, Targets and Side Effects. We will take the Drugs part for example.

Part 1: Drugs
1st step: search your compound


2nd step: Get the related network
You will get two networks that are related with your drug, i.e drug-target network and drug-SE network. You can select the network that you are interested in and than click the 'Reset Network' button.
You can click each node in the network and then the detail information will be displayed in the table below.

You can click each node in the network and then the detail information will be displayed in the table below.