How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.
The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

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  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

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  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.

    • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)




    "Incidence, clinical characteristics, and 4-year follow-up of patients with isolated myocardial bridge: a retrospective, single-center, epidemiologic, coronary arteriographic follow-up study in southern Turkey."
  • Author:"Cicek, Davran;Kalay, Nihat;Muderrisoglu, Haldun"

  • Published Year:2011

  • Journal:Cardiovascular revascularization medicine : including molecular interventions

  • Abstract:"INTRODUCTION: Myocardial bridge is a rare coronary anomaly that is generally considered to be benign. The true incidence and long-term prognosis are still under debate. Therefore, we investigated the prevalence and prognosis of patients with isolated myocardial bridge in our center. METHOD: This study is a retrospective, angiographic follow-up which includes 14,250 patients. Median follow-up was 4 years. The typical angiographic finding of myocardial bridging (MB) is systolic narrowing of an epicardial artery. Exclusion criterion was myocardial bridge with coronary artery disease (CAD). The primary end point was major cardiac events (death, myocardial infarction, and revascularization). RESULTS: Myocardial bridge was observed in 118 (0.83%) patients without CAD. The median age was 56.2. There were 30 (25.5%) male and 88 (74.5%) female patients. The arterial segment that was most frequently involved was the left anterior descending artery, as evident in 91 patients (77.2%). Most of the myocardial bridge produces a systolic narrowing between 30% and 50%. There was no major adverse cardiac event nor a need for any revascularization in the follow-up period with medical treatment. CONCLUSION: Isolated myocardial bridge is a benign and rare coronary anomaly. However, further studies are needed to detect long-term prognosis."

  • 10.1016/j.carrev.2010.01.006

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