How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ABCA1

    Description: "ATP-binding cassette, sub-family A (ABC1), member 1"

    Entrez Gene ID: 19

    SwissProt Acc Number: O95477

    RefSeq: NM_005502

    It was suspected to be CHD related:

    ..These results suggest that defective ABCA1 function in cholesterol-loaded macrophages is one potential contributor to the impaired RCT process and the increased coronary heart disease risk in subjects with familial low HDL..

    From PMID: 17372331, in Journal J Lipid Res , 2007


    References

    There were 103 potential papers with ABCA1 and CHD.

    PMIDTitleJournalsDetails
    23825977 "The Effects of Rope Training on Lymphocyte ABCA1 Expression, Plasma ApoA-I and HDL-c in Boy Adolescents."International journal of endocrinology and metabolismMore Details
    24084154 Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults.Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiologyMore Details
    23868939 Novel formulation of a reconstituted high-density lipoprotein (CSL112) dramatically enhances ABCA1-dependent cholesterol efflux."Arteriosclerosis, thrombosis, and vascular biology"More Details
    23505323 Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.Journal of medical geneticsMore Details
    23415429 Cholesterol efflux mediators in homozygous familial hypercholesterolemia patients on low-density lipoprotein apheresis.Journal of clinical lipidologyMore Details
    23666884 Diagnosis and management of familial dyslipoproteinemias.Current cardiology reportsMore Details
    23739627 Monocyte gene expression and coronary artery disease.Current opinion in clinical nutrition and metabolic careMore Details
    24212262 Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes.Coronary artery diseaseMore Details
    24009820 Blood cellular mutant LXR-alpha protein stability governs initiation of coronary heart disease.World journal of cardiologyMore Details
    23800855 Differential regulation of ABCA1 and macrophage cholesterol efflux by elaidic and oleic acids.LipidsMore Details
    23555974 Genetic variants from lipid-related pathways and risk for incident myocardial infarction.PloS oneMore Details
    22402736 Diet-induced weight loss in overweight or obese women and changes in high-density lipoprotein levels and function."Obesity (Silver Spring, Md.)"More Details
    22419126 ABCA1 gene promoter DNA methylation is associated with HDL particle profile and coronary artery disease in familial hypercholesterolemia.Epigenetics : official journal of the DNA Methylation SocietyMore Details
    21840418 The HDL proteome in acute coronary syndromes shifts to an inflammatory profile.Biochimica et biophysica actaMore Details
    21875686 "Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT."Biochimica et biophysica actaMore Details
    22498810 Using bioinformatics and systems genetics to dissect HDL-cholesterol genetics in an MRL/MpJ x SM/J intercross.Journal of lipid researchMore Details
    22528521 Genetics of cholesterol efflux.Current atherosclerosis reportsMore Details
    21643759 Quantitative assessment of the effect of ABCA1 R219K polymorphism on the risk of coronary heart disease.Molecular biology reportsMore Details
    22311493 [Association between -14 bp and ZNF polymorphisms of ABCA1 gene promoter and high density lipoprotein cholesterol level and cardiovascular disease].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = ChineseMore Details
    23053993 "ATP-binding cassette transporter A1 R219K polymorphism and coronary artery disease in Chinese population: a meta-analysis of 5,388 participants."Molecular biology reportsMore Details
    22517613 Prebeta-1 HDL and coronary heart disease.Current opinion in lipidologyMore Details
    23152888 The ABCA1 gene R230C variant is associated with decreased risk of premature coronary artery disease: the genetics of atherosclerotic disease (GEA) study.PloS oneMore Details
    22769014 Platelet activating factor levels and metabolism in Tangier disease: a case study.Lipids in health and diseaseMore Details
    23430904 A Non-classical Presentation of Tangier Disease with Three ABCA1 Mutations.JIMD reportsMore Details
    22363809 Monocyte gene expression signature of patients with early onset coronary artery disease.PloS oneMore Details
    22952570 "Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol."PloS oneMore Details
    21501700 Impact of HDL oxidation by the myeloperoxidase system on sterol efflux by the ABCA1 pathway.Journal of proteomicsMore Details
    21840005 ABCA1 impacts athero-thrombotic risk and 10-year survival in a contemporary secondary prevention setting.AtherosclerosisMore Details
    21802082 The aminoterminal 1-185 domain of human apolipoprotein E suffices for the de novo biogenesis of apoE-containing HDL-like particles in apoA-I deficient mice.AtherosclerosisMore Details
    21300560 Genetic variation of the ATP-binding cassette transporter A1 and susceptibility to coronary heart disease.Molecular genetics and metabolismMore Details
    21574779 High-density lipoprotein metabolism in human apolipoprotein B(100) transgenic/brown adipose tissue deficient mice: a model of obesity-induced hyperinsulinemia."Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition "More Details
    20595220 A frequent variant in the ABCA1 gene is associated with increased coronary heart disease risk and a better response to statin treatment in familial hypercholesterolemia patients.European heart journalMore Details
    21310416 Associations of the ATP-binding cassette transporter A1 R219K polymorphism with HDL-C level and coronary artery disease risk: a meta-analysis.AtherosclerosisMore Details
    22035022 "Effect Of G2706A and G1051A polymorphisms of the ABCA1 gene on the lipid, oxidative stress and homocystein levels in Turkish patients with polycystic ovary syndrome."Lipids in health and diseaseMore Details
    21247457 Genetic variant of V825I in the ATP-binding cassette transporter A1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations.Lipids in health and diseaseMore Details
    21347282 "Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project."PLoS geneticsMore Details
    21858147 Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease.PloS oneMore Details
    21130966 Associations between common polymorphisms of adenosine triphosphate-binding cassette transporter A1 and coronary artery disease in a Tunisian population.Archives of cardiovascular diseasesMore Details
    20075335 Coffee consumption enhances high-density lipoprotein-mediated cholesterol efflux in macrophages.Circulation researchMore Details
    20434407 Update on genetics of postprandial lipemia.Atherosclerosis. SupplementsMore Details
    20374257 Rate-limiting factors of cholesterol efflux in reverse cholesterol transport: acceptors and donors.Clinical and experimental pharmacology & physiologyMore Details
    20064972 Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol export.Journal of lipid researchMore Details
    19965776 The 5A apolipoprotein A-I mimetic peptide displays antiinflammatory and antioxidant properties in vivo and in vitro."Arteriosclerosis, thrombosis, and vascular biology"More Details
    20855565 Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.Journal of lipid researchMore Details
    20138281 "ABC transporters, atherosclerosis and inflammation."AtherosclerosisMore Details
    20303467 The role of ATP-binding-cassette-transporter-A1 (ABCA1) gene polymorphism on coronary artery disease risk.Translational research : the journal of laboratory and clinical medicineMore Details
    19553242 Identification of a novel human cellular HDL biosynthesis defect.European heart journalMore Details
    19673941 Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease.Clinical and experimental pharmacology & physiologyMore Details
    19528336 ATP-binding cassette transporter A1 expression and apolipoprotein A-I binding are impaired in intima-type arterial smooth muscle cells.CirculationMore Details
    19539140 "Promoting mechanisms of vascular health: circulating progenitor cells, angiogenesis, and reverse cholesterol transport."Journal of the American College of CardiologyMore Details
    19304576 Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages."Arteriosclerosis, thrombosis, and vascular biology"More Details
    19059534 Relationships between common polymorphisms of adenosine triphosphate-binding cassette transporter A1 and high-density lipoprotein cholesterol and coronary heart disease in a population with type 2 diabetes mellitus.Metabolism: clinical and experimentalMore Details
    19644050 Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis.Circulation researchMore Details
    19133158 Multiple splice defects in ABCA1 cause low HDL-C in a family with hypoalphalipoproteinemia and premature coronary disease.BMC medical geneticsMore Details
    18802933 Cellular cholesterol efflux to serum is impaired in diabetic nephropathy.Diabetes/metabolism research and reviewsMore Details
    18993152 Comparison of treatment of severe high-density lipoprotein cholesterol deficiency in men with daily atorvastatin (20 mg) versus fenofibrate (200 mg) versus extended-release niacin (2 g).The American journal of cardiologyMore Details
    18996286 Common variants in the ATP-binding cassette transporter 1 gene with decreased HDL-cholesterol levels and coronary artery disease.Archives of medical researchMore Details
    18067591 CD36 mRNA expression is increased in CD14+ monocytes of patients with coronary heart disease.Clinical and experimental pharmacology & physiologyMore Details
    18199144 Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels.Clinical geneticsMore Details
    18193043 Newly identified loci that influence lipid concentrations and risk of coronary artery disease.Nature geneticsMore Details
    18716026 HDL: bridging past and present with a look at the future.FASEB journal : official publication of the Federation of American Societies for More Details
    21291740 "Clinical presentation, laboratory values, and coronary heart disease risk in marked high-density lipoprotein-deficiency states."Journal of clinical lipidologyMore Details
    18420105 Antiarrhythmogenic effect of reconstituted high-density lipoprotein against ischemia/reperfusion in rats.Journal of the American College of CardiologyMore Details
    18162663 Effects of emulsified policosanols with different chain lengths on cholesterol metabolism in heterozygous LDL receptor-deficient mice.Journal of lipid researchMore Details
    17368464 "Common genetic variation in the ATP-binding cassette transporter A1, plasma lipids, and risk of coronary heart disease."AtherosclerosisMore Details
    17412755 Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients.Human molecular geneticsMore Details
    17372331 "Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDL."Journal of lipid researchMore Details
    17521614 Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver.Biochemical and biophysical research communicationsMore Details
    17458880 Monocyte cholesterol homeostasis correlates with the presence of detergent resistant membrane microdomains.Cytometry. Part A : the journal of the International Society for AnalyticalMore Details
    17164237 A unique protease-sensitive high density lipoprotein particle containing the apolipoprotein A-I(Milano) dimer effectively promotes ATP-binding Cassette A1-mediated cell cholesterol efflux.The Journal of biological chemistryMore Details
    17113061 Do mutations causing low HDL-C promote increased carotid intima-media thickness?Clinica chimica acta; international journal of clinical chemistryMore Details
    17922810 Oxidized low-density lipoprotein-induced expression of ABCA1 in blood monocytes precedes coronary atherosclerosis and is associated with plaque complexity in hypercholesterolemic pigs.Journal of thrombosis and haemostasis : JTHMore Details
    16879828 Associations between two common polymorphisms in the ABCA1 gene and subclinical atherosclerosis: Multi-Ethnic Study of Atherosclerosis (MESA).AtherosclerosisMore Details
    17268197 ATP-binding cassette transporter A1 gene I823M polymorphism affects plasma high-density lipoprotein cholesterol level and modifies the effect of low high-density lipoprotein cholesterol on the risk of coronary artery disease.CardiologyMore Details
    17076584 Human immunodeficiency virus impairs reverse cholesterol transport from macrophages.PLoS biologyMore Details
    16415294 A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity.Journal of lipid researchMore Details
    16313984 ABCA1 polymorphisms and prognosis after myocardial infarction in young patients.International journal of cardiologyMore Details
    16508036 Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice.Journal of lipid researchMore Details
    16225879 Promoter haplotype of a new ABCA1 mutant influences expression of familial hypoalphalipoproteinemia.AtherosclerosisMore Details
    16763159 Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16497665 Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-I.The Journal of biological chemistryMore Details
    16446539 Decreased frequencies of ABCA1 polymorphisms R219K and V771M in Hungarian patients with cerebrovascular and cardiovascular diseases."Cerebrovascular diseases (Basel, Switzerland)"More Details
    16704350 Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis.Annual review of nutritionMore Details
    16009332 "ABCA1, ApoA-I and type II DM."Biochemical and biophysical research communicationsMore Details
    16230498 Ability of serum to decrease cellular acylCoA:cholesterol acyl transferase activity predicts cardiovascular outcomes.CirculationMore Details
    15528481 Genotypic effect of the -565C>T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16086925 Candidate gene susceptibility variants predict intermediate end points but not angiographic coronary artery disease.American heart journalMore Details
    15657615 Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD.European journal of human genetics : EJHGMore Details
    15158913 Two novel missense mutations in ABCA1 result in altered trafficking and cause severe autosomal recessive HDL deficiency.Biochimica et biophysica actaMore Details
    15135251 Genetic polymorphisms affecting the phenotypic expression of familial hypercholesterolemia.AtherosclerosisMore Details
    14726473 Association of coronary heart disease with pre-beta-HDL concentrations in Japanese men.Clinical chemistryMore Details
    15177121 Triglyceride-rich lipoproteins inhibit cholesterol efflux to apolipoprotein (apo) A1 from human macrophage foam cells.AtherosclerosisMore Details
    15019541 Familial HDL deficiency due to ABCA1 gene mutations with or without other genetic lipoprotein disorders.AtherosclerosisMore Details
    14962947 In-depth haplotype analysis of ABCA1 gene polymorphisms in relation to plasma ApoA1 levels and myocardial infarction."Arteriosclerosis, thrombosis, and vascular biology"More Details
    14576201 Novel polypyrimidine variation (IVS46: del T -39...-46) in ABCA1 causes exon skipping and contributes to HDL cholesterol deficiency in a family with premature coronary disease.Circulation researchMore Details
    12840658 Genetics of HDL regulation in humans.Current opinion in lipidologyMore Details
    12709788 ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore.Human geneticsMore Details
    12763760 Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene."Arteriosclerosis, thrombosis, and vascular biology"More Details
    12700893 The association of the R219K polymorphism in the ATP-binding cassette transporter 1 ( ABCA1) gene with coronary heart disease and hyperlipidaemia."Journal of molecular medicine (Berlin, Germany)"More Details
    12439635 Molecular mechanisms involved in atherosclerosis.HerzMore Details
    12111371 Clinical variant of Tangier disease in Japan: mutation of the ABCA1 gene in hypoalphalipoproteinemia with corneal lipidosis.Journal of human geneticsMore Details
    11227043 Novel approaches to treating cardiovascular disease: lessons from Tangier disease.Expert opinion on investigational drugsMore Details
    11086027 Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes.The Journal of clinical investigationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 48 unique genes interacted with ABCA1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    FADD Two-hybrid12235128|12235128 No
    CREBBP Affinity Capture-Western11864601 No
    XPC Reconstituted Complex12505994|12505994 No
    SNTB2 Two-hybrid12054535|12054535 No
    UGP1 Two-hybrid12054535 No
    SDHB Two-hybrid12054535|12054535 No
    AOX1 Two-hybrid12054535|12054535 No
    PRPF8 Two-hybrid12054535 No
    UBC Affinity Capture-Western21520210|19268428|21817095 No
    HGS Affinity Capture-Western21520210 No
    COPS5 Affinity Capture-Western19268428 No
    STX12 Affinity Capture-Western15469992 No
    FLOT1 Affinity Capture-Western15469992 No
    CDC42 Affinity Capture-Western16443932 CHD related
    TRIM27 yeast 2-hybrid12054535 No
    SLC25A34 yeast 2-hybrid12054535 No
    UGP2 yeast 2-hybrid12054535 No
    MPDZ in vitro16192269 No
    SNTB1 in vitro;in vivo16192270,16192292 No
    DLG3 in vitro16192271 No
    ARHGEF11 in vitro16192272 No
    SNTA1 in vitro14722086,16192274 No
    ARHGEF12 in vitro16192274 No
    LIN7C in vitro16192275 No
    DLG2 in vitro16192276 No
    LIN7B in vitro16192277 No
    LIN7A in vitro16192278,14722086 No
    SHANK1 in vitro16192279 No
    DLG5 in vitro16192281 No
    PDZK1 in vitro16192282 CHD related
    LIMK1 in vitro16192283 No
    GOPC in vitro16192284 No
    LMO7 in vitro16192285 No
    PDLIM4 in vitro16192286 No
    TIAM1 in vitro16192287 No
    RAPGEF6 in vitro16192288 No
    RIMS2 in vitro16192289 No
    MPP6 in vitro16192290 No
    PDLIM3 in vitro16192291 No
    APOA1 Reconstituted Complex12084722|12084722 CHD related
    COPS2 Affinity Capture-Western19268428 No
    CSNK2A2 Biochemical Activity15218032 No
    LNX1 Biochemical Activity22889411 No
    ATXN10 Two-hybrid16498633 No
    PRKACA in vivo12196520 CHD related
    CSNK2A1 in vitro15218032 CHD related
    PLTP in vitro14559902 CHD related
    SPTLC1 in vivo18484747 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approved;nutraceuticalDB00171Adenosine triphosphate"For nutritional supplementation, also for treating dietary shortage or imbalance"
    approvedDB01016GlyburideIndicated as an adjunct to diet to lower the blood glucose in patients with NIDDM whose hyperglycemia cannot be satisfactorily controlled by diet alone.A10BB01
    approvedDB01599ProbucolUsed to lower LDL and HDL cholesterol.C10AX02