How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ABCG8

    Description: "ATP-binding cassette, sub-family G (WHITE), member 8"

    Entrez Gene ID: 64241

    SwissProt Acc Number: Q9H221

    RefSeq: NM_022437

    It was suspected to be CHD related:

    .."In conclusion, ABCG8 54YY-genotype may be a potential protecting factor against ischemic stroke in young men and may influence plasma CHOL levels."..

    From PMID: 20854103, in Journal Genet Test Mol Biomarkers , 2010


    References

    There were 13 potential papers with ABCG8 and CHD.

    PMIDTitleJournalsDetails
    23926302 Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia.BloodMore Details
    23025809 Essential role of transient receptor potential vanilloid type 1 in evodiamine-mediated protection against atherosclerosis."Acta physiologica (Oxford, England)"More Details
    23843831 ABCG8 Gene Responses to 8 Weeks Treadmill Running With or Without Pistachia atlantica (Baneh) Extraction in Female Rats.International journal of endocrinology and metabolismMore Details
    21576934 A phytosterolemia patient presenting exclusively with macrothrombocytopenia and stomatocytic hemolysis.Acta haematologicaMore Details
    20854103 Frequencies of four ATP-binding cassette transporter G8 polymorphisms in patients with ischemic vascular diseases.Genetic testing and molecular biomarkersMore Details
    20529992 Genetic regulation of serum phytosterol levels and risk of coronary artery disease.Circulation. Cardiovascular geneticsMore Details
    20592455 Effect of genetic variant (rs11887534) in ABCG8 gene in coronary artery disease and response to atorvastatin therapy.Disease markersMore Details
    19217458 The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease.Metabolism: clinical and experimentalMore Details
    18977479 "ABCG8 gene polymorphisms, plasma cholesterol concentrations, and risk of cardiovascular disease in familial hypercholesterolemia."AtherosclerosisMore Details
    17483372 Update on dyslipidemia.The Journal of clinical endocrinology and metabolismMore Details
    16472606 Liver transplantation in a patient with sitosterolemia and cirrhosis.GastroenterologyMore Details
    15599566 Sitosterolemia--a rare disease. Are elevated plant sterols an additional risk factor?Zeitschrift fur KardiologieMore Details
    15030301 Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders.Expert review of cardiovascular therapyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 1 unique genes interacted with ABCG8. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    ABCG5 Affinity Capture-Western12208867 CHD related


    Involved FDA drugs

    There was no drug associated with ABCG8