How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ACAT1

    Description: acetyl-Coenzyme A acetyltransferase 1

    Entrez Gene ID: 38

    SwissProt Acc Number: P24752

    RefSeq: NM_000019

    It was suspected to be CHD related:

    ..This study provided the first evidence that heregulin-beta(1) inhibits atherogenesis and suppresses macrophage foam cell formation via SR-A and ACAT1 downregulation and ABCA1 upregulation...

    From PMID: 19644050, in Journal Circ Res , 2009


    References

    There were 3 potential papers with ACAT1 and CHD.

    PMIDTitleJournalsDetails
    21925457 The roles of salusins in atherosclerosis and related cardiovascular diseases.Journal of the American Society of Hypertension : JASHMore Details
    19644050 Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis.Circulation researchMore Details
    15831806 ACAT2 is a target for treatment of coronary heart disease associated with hypercholesterolemia."Arteriosclerosis, thrombosis, and vascular biology"More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 32 unique genes interacted with ACAT1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    ACAA2 Co-fractionation22939629 No
    TOPBP1 Co-fractionation22939629 No
    UQCRFS1P1 Co-fractionation22939629 No
    TMEM65 Co-fractionation22939629 No
    TIMM44 Co-fractionation22939629 No
    TOMM7 Co-fractionation22939629 No
    UBL4A Co-fractionation22939629 No
    TTF2 Co-fractionation22939629 No
    CSE1L Co-fractionation22939629 No
    UBAP2L Co-fractionation22939629 No
    EIF1B Affinity Capture-MS17353931 No
    HDAC5 Affinity Capture-MS21081666 No
    UBC Affinity Capture-MS21139048|21890473|21906983 No
    RAD21 Affinity Capture-Western22145905 No
    SUMO1 Affinity Capture-MS21110914 No
    SIRT7 Affinity Capture-MS22586326 No
    CUL3 Affinity Capture-MS21145461 No
    CUL1 Affinity Capture-MS21145461 No
    COPS5 Affinity Capture-MS21145461 No
    PEX7 Two-hybrid22057399 No
    FBXO6 Affinity Capture-MS22268729 No
    ACO2 Co-fractionation22939629 No
    FLOT1 Co-fractionation22939629 No
    GCN1L1 Co-fractionation22939629 No
    MARS Co-fractionation22939629 No
    SSBP1 Co-fractionation22939629 No
    FOXM1 Co-fractionation22939629 No
    UQCRB Co-fractionation22939629 No
    SDHA Co-fractionation22939629 CHD related
    SAFB Co-fractionation22939629 No
    SDHB Co-fractionation22939629 No
    TUBB1 Co-fractionation22939629 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00795SulfasalazineFor the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.A07EC01