How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ACAT2

    Description: acetyl-Coenzyme A acetyltransferase 2

    Entrez Gene ID: 39

    SwissProt Acc Number: Q9BWD1

    RefSeq: NM_005891

    It was suspected to be CHD related:

    .."Plasma levels of ACAT2-CE have strong potential to predict a patient's likelihood of having CAD when considered in a clinical model but not when used alone. In turn, a clinical model containing ACAT2-CE could reduce the need for cardiac imaging after the exclusion of MI."..

    From PMID: 22687182, in Journal Acad Emerg Med , 2012


    References

    There were 6 potential papers with ACAT2 and CHD.

    PMIDTitleJournalsDetails
    22687182 Cholesteryl esters associated with acyl-CoA:cholesterol acyltransferase predict coronary artery disease in patients with symptoms of acute coronary syndrome.Academic emergency medicine : official journal of the Society for AcademicMore Details
    19467657 "ACAT2 and human hepatic cholesterol metabolism: identification of important gender-related differences in normolipidemic, non-obese Chinese patients."AtherosclerosisMore Details
    17277381 "Monounsaturated fatty acyl-coenzyme A is predictive of atherosclerosis in human apoB-100 transgenic, LDLr-/- mice."Journal of lipid researchMore Details
    15831806 ACAT2 is a target for treatment of coronary heart disease associated with hypercholesterolemia."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16195894 Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks.Human geneticsMore Details
    14557872 Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients.Human geneticsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 10 unique genes interacted with ACAT2. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    VASP Co-fractionation22939629 CHD related
    TTC39C Co-fractionation22939629 No
    ACAT2 in vitro15733928 CHD related
    UBC Affinity Capture-MS21139048|21890473|22053931 No
    TERF1 Two-hybrid21044950 No
    SSU72 Co-fractionation22939629 No
    PSAT1 Co-fractionation22939629 No
    DAK Co-fractionation22939629 No
    CSNK2A1 in vitro16331323 CHD related
    CDX2 in vivo12518221 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    experimentalDB01915S-Hydroxycysteine
    experimentalDB01992Coenzyme A