How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ACE

    Description: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

    Entrez Gene ID: 1636

    SwissProt Acc Number: P12821

    RefSeq: NM_000789

    It was suspected to be CHD related:

    .."The angiotensin-converting enzyme (ACE) inhibitors are a cornerstone drug therapy in the current treatment of patients with hypertension, stable coronary artery disease and heart failure. "..

    From PMID: 23030290, in Journal Expert Rev Cardiovasc Ther , 2012


    References

    There were 560 potential papers with ACE and CHD.

    PMIDTitleJournalsDetails
    24117346 Genetic variation and gender determine bradykinin type 1 receptor responses in human tissue: implications for the ACE-inhibitor-induced effects in patients with coronary artery disease."Clinical science (London, England : 1979)"More Details
    23200269 Initial white blood cell count is an independent risk factor for survival in patients with dilated cardiomyopathy.International journal of cardiologyMore Details
    24282765 Progression of coronary atherosclerosis in African-American patients.Cardiovascular diagnosis and therapyMore Details
    23664168 Identification of inflamed aortic plaque in conventional fluorodeoxyglucose-positron emission tomography myocardial viability studies.The Canadian journal of cardiologyMore Details
    23766358 Traditional heart failure medications and sudden cardiac death prevention: a review.Journal of cardiovascular pharmacology and therapeuticsMore Details
    24138103 Effects of neutral endopeptidase (neprilysin) inhibition on the response to other vasoactive peptides in small human resistance arteries: studies with thiorphan and omapatrilat.Cardiovascular therapeuticsMore Details
    22718794 Use and effects of cardiac rehabilitation in patients with coronary heart disease: results from the EUROASPIRE III survey.European journal of preventive cardiologyMore Details
    23838152 "Particulate air pollution, ambulatory heart rate variability, and cardiac arrhythmia in retirement community residents with coronary artery disease."Environmental health perspectivesMore Details
    24097995 Premature coronary heart disease in SLE: can we prevent progression?LupusMore Details
    24238749 [Ischaemic heart disease.]Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad More Details
    23809376 Epidemiology of cardioprotective pharmacological agent use in stable coronary heart disease.Indian heart journalMore Details
    23508927 "Treatment patterns, risk factor control and functional capacity in patients with cardiovascular and chronic kidney disease in the cardiac rehabilitation setting."European journal of preventive cardiologyMore Details
    22998169 The care for chronic heart failure by general practitioners. Results from a clinical audit in Italy.The European journal of general practiceMore Details
    23219321 Long-term survival following acute heart failure: the Acute Heart Failure Database Main registry (AHEAD Main).European journal of internal medicineMore Details
    23389085 Therapeutic strategies to improve control of hypertension.Journal of hypertensionMore Details
    23328120 Comparative cardioprotective effects and mechanisms of vitamin E and lisinopril against ischemic reperfusion induced cardiac toxicity.Environmental toxicology and pharmacologyMore Details
    23355629 Effects of angiotensin receptor blockade (ARB) on mortality and cardiovascular outcomes in patients with long-term haemodialysis: a randomized controlled trial."Nephrology, dialysis, transplantation : official publication of the European"More Details
    23511946 Effect of obesity on in-hospital treatment for acute coronary syndrome complicated by new-onset heart failure.Coronary artery diseaseMore Details
    23831044 An unusual ST-segment elevation: apical hypertrophic cardiomyopathy shows the ace up its sleeve.Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa deMore Details
    23866091 Dual renin-angiotensin system inhibition for prevention of renal and cardiovascular events: do the latest trials challenge existing evidence?Cardiovascular diabetologyMore Details
    23933903 Not all angiotensin-converting enzyme inhibitors are equal: focus on ramipril and perindopril.Postgraduate medicineMore Details
    23815539 An update on the cardiovascular pleiotropic effects of milk and milk products."Journal of clinical hypertension (Greenwich, Conn.)"More Details
    22968743 Influence of documented history of coronary artery disease on outcomes in patients admitted for worsening heart failure with reduced ejection fraction in the EVEREST trial.European journal of heart failureMore Details
    23013041 The ACE2 gene: its potential as a functional candidate for cardiovascular disease."Clinical science (London, England : 1979)"More Details
    23392788 Renin-angiotensin system genetic polymorphisms: Lack of association with CRP levels in patients with coronary artery disease.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    23237633 Exaggerated myocardial oxLDL amount and LOX-1 receptor over-expression associated with coronary microvessel inflammation in unstable angina.AtherosclerosisMore Details
    24194563 The impact of age and chronic kidney disease on secondary prevention post-primary percutaneous coronary intervention.QJM : monthly journal of the Association of PhysiciansMore Details
    23990195 Regional differences among female patients with heart failure from The Cardiac Insufficiency BIsoprolol Study in ELDerly (CIBIS ELD).Cardiology journalMore Details
    23990179 "Prognostic value of ACE I/D, AT1R A1166C, PAI-I 4G/5G and GPIIIa a1/a2 polymorphisms in myocardial infarction."Cardiology journalMore Details
    23959571 "Effect of early intensive multifactorial therapy compared with routine care on self-reported health status, general well-being, diabetes-specific quality of life and treatment satisfaction in screen-detected type 2 diabetes mellitus patients (ADDITION-Europe): a cluster-randomised trial."DiabetologiaMore Details
    23661020 Gender specificity of a genetic variant of angiotensin-converting enzyme and risk of coronary artery disease.Molecular biology reportsMore Details
    23867841 Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial. Journal of the American Medical Association 2013; 309: 453-460."Vascular medicine (London, England)"More Details
    23432153 Emerging markers in cardiovascular disease: where does angiotensin-converting enzyme 2 fit in?Clinical and experimental pharmacology & physiologyMore Details
    23674060 "Aortic root disease in athletes: aortic root dilation, anomalous coronary artery, bicuspid aortic valve, and Marfan's syndrome.""Sports medicine (Auckland, N.Z.)"More Details
    22421406 Blockade of the renin-angiotensin-aldosterone system (RAAS) for primary prevention of non-valvular atrial fibrillation: a systematic review and meta analysis of randomized controlled trials.International journal of cardiologyMore Details
    23592589 A study on the polymorphisms of the renin-angiotensin system pathway genes for their effect on blood pressure levels in males from Algeria.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    22345692 Multiple risk factor intervention and progression of coronary atherosclerosis in patients with type 2 diabetes mellitus.European journal of preventive cardiologyMore Details
    23407050 Genetic variation-optimized treatment benefit of angiotensin-converting enzyme inhibitors in patients with stable coronary artery disease: a 12-year follow-up study.Pharmacogenetics and genomicsMore Details
    22739771 Genetic variation in the renin-angiotensin-aldosterone system is associated with cardiovascular risk factors and early mortality in established coronary heart disease.Journal of human hypertensionMore Details
    23476666 The ace of spades: reverse takotsubo cardiomyopathy in the context of angiographic embolization of recurrent metastatic serotonin-positive neuroendocrine tumour of the pancreas.Case reports in medicineMore Details
    23405162 "Gender disparities in the presentation, management and outcomes of acute coronary syndrome patients: data from the 2nd Gulf Registry of Acute Coronary Events (Gulf RACE-2)."PloS oneMore Details
    23627503 Bioactive natural constituents from food sources-potential use in hypertension prevention and treatment.Critical reviews in food science and nutritionMore Details
    24044029 "Comparative Effects of Preoperative Angiotensin-converting Enzyme In-hibitor, Statin and Beta-blocker Treatment on Human Internal Mammary Artery Reactivity in Patients with Coronary Artery Disease: A Pilot Study."The open cardiovascular medicine journalMore Details
    22727178 Outcomes of preoperative angiotensin-converting enzyme inhibitor therapy in patients undergoing isolated coronary artery bypass grafting.The American journal of cardiologyMore Details
    22884917 Serum angiotensin-converting enzyme and recurrent vascular events. The SMART-MR study.AtherosclerosisMore Details
    23253410 Polymorphism of ACE gene as the genetic predisposition of coronary artery disease in Eastern India.Indian heart journalMore Details
    22683751 Association of angiotensin-converting enzyme polymorphism with coronary artery disease in Iranian patients with unipolar depression.Clinical biochemistryMore Details
    22609895 Diagnostic utility of a single-epitope sandwich B-type natriuretic peptide assay in stable coronary artery disease: data from the Akershus Cardiac Examination (ACE) 1 Study.Clinical biochemistryMore Details
    22741147 Prediction of acute cardiac events in patients with noncalcified plaques using dual-source CT angiography.Hellenic journal of nuclear medicineMore Details
    22178056 Acute heart failure in patients with diabetes mellitus: clinical characteristics and predictors of in-hospital mortality.International journal of cardiologyMore Details
    22387727 Renin-angiotensin system genes polymorphism in Egyptians with premature coronary artery disease.GeneMore Details
    22547363 [Arterial Hypertension - when are which combination therapies useful?].Therapeutische Umschau. Revue therapeutiqueMore Details
    22495138 Blood pressure and other determinants of new-onset atrial fibrillation in patients at high cardiovascular risk in the Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease studies.Journal of hypertensionMore Details
    22388798 Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.Pharmacogenetics and genomicsMore Details
    22535449 [Characteristics of therapy of acute myocardial infarction in diabetes].HerzMore Details
    22307319 Angiotensin converting enzyme gene polymorphism is associated with severity of coronary artery disease in men with high total cholesterol levels.Journal of applied geneticsMore Details
    22129490 The prevalence of undiagnosed renal failure in a cohort of COPD patients in western Norway.Respiratory medicineMore Details
    21681430 Synergism between paraoxonase Arg 192 and the angiotensin converting enzyme D allele is associated with severity of coronary artery disease.Molecular biology reportsMore Details
    22445708 GFR and cardiovascular outcomes after acute myocardial infarction: results from the Korea Acute Myocardial Infarction Registry.American journal of kidney diseases : the official journal of the National KidneyMore Details
    22345093 Association between polymorphisms of the renin-angiotensin system and coronary artery disease in Chinese patients with type 2 diabetes.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    22695024 [Use of antihypertensive drugs in France and relationship with cardiovascular disease. FLAHS 2009-2010 surveys].Annales de cardiologie et d'angeiologieMore Details
    22277253 Meta-analysis of the association between the insertion/deletion polymorphism in ACE gene and coronary heart disease among the Chinese population.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    22239123 Cardiac troponin T levels and exercise stress testing in patients with suspected coronary artery disease: the Akershus Cardiac Examination (ACE) 1 study."Clinical science (London, England : 1979)"More Details
    22516738 Prevention of aortic valve stenosis: a realistic therapeutic target?Pharmacology & therapeuticsMore Details
    22747612 Comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for hypertension on clinical end points: a cohort study."Journal of clinical hypertension (Greenwich, Conn.)"More Details
    22011630 Should all patients at high cardiovascular risk receive renin-angiotensin system blockers?QJM : monthly journal of the Association of PhysiciansMore Details
    21688035 Individualised therapy of angiotensin converting enzyme (ACE) inhibitors in stable coronary artery disease: overview of the primary results of the PERindopril GENEtic association (PERGENE) study.Netherlands heart journal : monthly journal of the Netherlands Society ofMore Details
    22064603 Angiotensin-converting enzyme DD polymorphism is associated with poor coronary collateral circulation in patients with coronary artery disease.Journal of investigative medicine : the official publication of the AmericanMore Details
    22078966 Relation between previous angiotensin-converting enzyme inhibitor use and in-hospital outcomes in acute coronary syndromes.The American journal of cardiologyMore Details
    21797844 Microvascular responsiveness in obesity: implications for therapeutic intervention.British journal of pharmacologyMore Details
    22179088 Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications.Journal of hypertensionMore Details
    23149358 Risk stratification in chest pain patients undergoing nuclear stress testing: the Erlanger Stress Score.Critical pathways in cardiologyMore Details
    23223771 Diabetic cardiomyopathy: ongoing controversies in 2012.HerzMore Details
    22679279 "Relationship between angiotensin-converting enzyme gene insertion/deletion polymorphism, angiographically defined coronary artery disease and myocardial infarction in patients with type 2 diabetes mellitus."Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    22392878 Synergistic effect of angiotensin II type-1 receptor 1166A/C with angiotensin-converting enzyme polymorphism on risk of acute myocardial infarction in north Indians.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    23430665 Omega-3 in antiarrhythmic therapy : cons position.High blood pressure & cardiovascular prevention : the official journal of theMore Details
    22521308 Meta-analysis of randomized trials of angioedema as an adverse event of renin-angiotensin system inhibitors.The American journal of cardiologyMore Details
    22813678 Federally qualified health centers and private practice performance on ambulatory care measures.American journal of preventive medicineMore Details
    22447241 Management of acute coronary syndrome in South Africa: insights from the ACCESS (Acute Coronary Events - a Multinational Survey of Current Management Strategies) registry.Cardiovascular journal of AfricaMore Details
    22245237 Angiotensin-converting enzyme insertion/deletion polymorphism is a risk factor for thoracic aortic aneurysm in patients with bicuspid or tricuspid aortic valves.The Journal of thoracic and cardiovascular surgeryMore Details
    23030290 Genetic influences of angiotensin-converting enzyme inhibitor response: an opportunity for personalizing therapy?Expert review of cardiovascular therapyMore Details
    22346362 Cardio classics revisited: focus on the role of amlodipine.Integrated blood pressure controlMore Details
    22838970 Gender disparities in diabetes and coronary heart disease medication among patients with type 2 diabetes: results from the DIANA study.Cardiovascular diabetologyMore Details
    22297600 Impact of renin-angiotensin-aldosterone system gene polymorphisms on left ventricular dysfunction in coronary artery disease patients.Disease markersMore Details
    23237296 Prevention of airway hyperresponsiveness induced by left ventricular dysfunction in rats.Respiratory researchMore Details
    22508051 Renin-angiotensin-aldosterone system gene polymorphisms and coronary artery disease: detection of gene-gene and gene-environment interactions.Cellular physiology and biochemistry : international journal of experimentalMore Details
    22701328 Atherosclerotic disease and risk factor modification in Saudi Arabia: a call to action.Vascular health and risk managementMore Details
    22829804 "The metabolic syndrome, oxidative stress, environment, and cardiovascular disease: the great exploration."Experimental diabetes researchMore Details
    23027453 Sex and gender differences in cardiovascular drug therapy.Handbook of experimental pharmacologyMore Details
    21567207 Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease.Molecular and cellular biochemistryMore Details
    21738031 Vascular compliance in blood pressure.Current opinion in nephrology and hypertensionMore Details
    21786436 Cytochrome P450 2C19 polymorphism is associated with reduced clopidogrel response in cerebrovascular disease.Yonsei medical journalMore Details
    21148050 Increased risk of myocardial infarction associated with angiotensin-converting enzyme gene polymorphism is age dependent.Journal of clinical pharmacologyMore Details
    21872920 "Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey."LancetMore Details
    21674191 Leisure sport activity as a trigger for acute coronary events in men without known coronary artery disease : a single-center case study.HerzMore Details
    22093199 "Should all patients be treated with an angiotensin-converting enzyme inhibitor after coronary artery bypass graft surgery? The impact of angiotensin-converting enzyme inhibitors, statins, and beta-blockers after coronary artery bypass graft surgery."American heart journalMore Details
    21376415 Major gaps in diabetes clinical care among Canada's First Nations: results of the CIRCLE study.Diabetes research and clinical practiceMore Details
    21146895 Underuse of ACE inhibitors and angiotensin II receptor blockers among patients with diabetic nephropathy in Taiwan."Health policy (Amsterdam, Netherlands)"More Details
    21184753 Polygenetic regression model of renin-angiotensin system genes and the risk of coronary artery disease in a large angiographic population.Clinica chimica acta; international journal of clinical chemistryMore Details
    21157371 A pharmacogenetic analysis of determinants of hypertension and blood pressure response to angiotensin-converting enzyme inhibitor therapy in patients with vascular disease and healthy individuals.Journal of hypertensionMore Details
    21507365 Opposing effects of beta blockers and angiotensin-converting enzyme inhibitors on development of new-onset diabetes mellitus in patients with stable coronary artery disease.The American journal of cardiologyMore Details
    21383003 Factors influencing underutilization of evidence-based therapies in women.European heart journalMore Details
    21140270 The effects of perindopril on QT duration and dispersion in patients with coronary slow flow.Heart and vesselsMore Details
    21466773 [Angiotensin converting enzyme inhibitor and calcium antagonist combination. Which place in patients with a stable coronary artery disease?].TherapieMore Details
    19592120 Gender and age-dependent differences in the bradykinin-degradation within the pericardial fluid of patients with coronary artery disease.International journal of cardiologyMore Details
    20869129 Duration of evidence-based medical therapy and the hazard for atherothrombotic events following percutaneous coronary intervention.International journal of cardiologyMore Details
    21809159 Treatment of patients with intermediate cardiovascular risk: Are clinical measures enough?Journal of nuclear cardiology : official publication of the American Society ofMore Details
    21450592 "Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease."European journal of cardiovascular prevention and rehabilitation : officialMore Details
    22123369 Angiotensin-converting enzyme inhibition promotes coronary angiogenesis in the failing heart of Dahl salt-sensitive hypertensive rats.Journal of cardiac failureMore Details
    21803725 [Myocardial Infarction Registry--2010. Experience and first results in Hungary].Orvosi hetilapMore Details
    21682553 "Effects of a secondary prevention combination therapy with an aspirin, an ACE inhibitor and a statin on 1-year mortality of patients with acute myocardial infarction treated with a beta-blocker. Support for a polypill approach."Current medical research and opinionMore Details
    21596033 Relationship between angiotensin II receptor expression and cardiovascular risk factors in Mexican patients with coronary occlusive disease.Experimental and molecular pathologyMore Details
    21323501 Modern treatment of patients at risk: still a HOPE for ACE inhibitors?Expert opinion on pharmacotherapyMore Details
    21053005 "Impact of therapy with statins, beta-blockers and angiotensin-converting enzyme inhibitors on plasma myeloperoxidase in patients with coronary artery disease."Clinical research in cardiology : official journal of the German Cardiac SocietyMore Details
    21265582 "Dose-dependent antihypertensive efficacy and tolerability of perindopril in a large, observational, 12-week, general practice-based study.""American journal of cardiovascular drugs : drugs, devices, and other"More Details
    21955693 Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery.Journal of cardiothoracic surgeryMore Details
    21917174 Potential role of differential medication use in explaining excess risk of cardiovascular events and death associated with chronic kidney disease: a cohort study.BMC nephrologyMore Details
    21274458 Improving blood pressure control in patients with diabetes mellitus and high cardiovascular risk.International journal of hypertensionMore Details
    21673834 The vulnerable plaque: the real villain in acute coronary syndromes.The open cardiovascular medicine journalMore Details
    20685681 "Of fads, fashion, surrogate endpoints and dual RAS blockade."European heart journalMore Details
    20565247 The relationship between ACE gene insertion/deletion polymorphism and diabetic retinopathy in Iranian patients with type 2 diabetes.Ophthalmic geneticsMore Details
    19185934 Clinical management and short-term cost - 64-slice MDCT vs. myocardial perfusion scintigraphy.International journal of cardiologyMore Details
    20625318 Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats.Journal of hypertensionMore Details
    20812878 Aliskiren: beyond blood pressure reduction.Expert opinion on investigational drugsMore Details
    20655894 The angiotensin converting enzyme D allele is an independent risk factor for early onset coronary artery disease.Clinical biochemistryMore Details
    20507236 ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction.Human gene therapyMore Details
    20529973 Polymorphisms of renin-angiotensin system and natriuretic peptide receptor A genes in patients of Greek origin with a history of myocardial infarction.AngiologyMore Details
    20228159 Changing patterns of secondary preventive medication among newly diagnosed coronary heart disease patients with diabetes in Finland: a register-based study.Scandinavian journal of public healthMore Details
    20299978 The I allele of the angiotensin converting enzyme I/D polymorphism confers protection against coronary artery disease.Coronary artery diseaseMore Details
    20019701 Vasculoprotective effect of cilostazol in aldosterone-induced hypertensive rats.Hypertension research : official journal of the Japanese Society of HypertensionMore Details
    20349293 [Current status of antihypertensive drug treatment in primary care practice at launch of the new renin inhibitor aliskiren (RASANT)]."Medizinische Klinik (Munich, Germany : 1983)"More Details
    20346746 [Are cardioprotective drugs underused after a myocardial infarction in patients who suffer from chronic kidney disease?].Nephrologie & therapeutiqueMore Details
    20223792 Renin-angiotensin-aldosterone system gene polymorphisms in coronary artery bypass graft surgery patients.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    20079615 Angiotensin converting enzyme DD genotype not associated with increased risk of coronary artery disease in the Iranian population.Pathophysiology : the official journal of the International Society forMore Details
    20580725 Genotypic interactions of renin-angiotensin system genes with diabetes type 2 in a Tunisian population.Life sciencesMore Details
    20504763 Angiotensin-converting enzyme inhibition down-regulates the pro-atherogenic chemokine receptor 9 (CCR9)-chemokine ligand 25 (CCL25) axis.The Journal of biological chemistryMore Details
    20090429 Role of angiotensin-converting enzyme inhibitors in vascular modulation: beyond the hypertensive effects.American journal of therapeuticsMore Details
    19875769 Therapeutic management in patients with renal failure who experience an acute coronary syndrome.Clinical journal of the American Society of Nephrology : CJASNMore Details
    19927011 Reverse remodeling and improved function by antihypertensive treatment in hypertensive patients with coronary artery disease.Journal of hypertensionMore Details
    19923980 Impact of genetic polymorphisms on platelet function and aspirin resistance.Blood coagulation & fibrinolysis : an international journal in haemostasis andMore Details
    19825824 Ethnic differences in the relationship between albuminuria and calcified atherosclerotic plaque: the African American-diabetes heart study.Diabetes careMore Details
    20104940 Disparities in combination drug therapy use in older adults with coronary heart disease: a cross-sectional time-series in a nationally representative US sample.Drugs & agingMore Details
    21286281 Angina in Women without Obstructive Coronary Artery Disease.Current cardiology reviewsMore Details
    19945447 Effect of angiotensin-converting enzyme inhibitor on matrix metalloproteinase-9 activity in patients with Kawasaki disease.Clinica chimica acta; international journal of clinical chemistryMore Details
    20109118 A randomized clinical trial of secondary prevention among women hospitalized with coronary heart disease.Journal of women's health (2002)More Details
    20172880 Evidence-based commissioning: using population impact measures to help primary care trusts estimate the benefit of interventions in diabetes and heart failure.Quality & safety in health careMore Details
    20570682 Tissue ACE inhibition improves microcirculation in remote myocardium after coronary stenosis: MR imaging study in rats.Microvascular researchMore Details
    20676796 Secondary prevention for coronary artery disease: are we following the guidelines?Irish journal of medical scienceMore Details
    21168679 Blood pressure control in orthotopic heart transplant and kidney allograft recipients is far from satisfactory.Transplantation proceedingsMore Details
    20708328 Clinical predictors of survival in patients treated with therapeutic hypothermia following cardiac arrest.ResuscitationMore Details
    20538738 Genetic determinants of treatment benefit of the angiotensin-converting enzyme-inhibitor perindopril in patients with stable coronary artery disease.European heart journalMore Details
    20613629 "How should we manage heart failure developing in patients already treated with angiotensin-converting enzyme inhibitors and beta-blockers for hypertension, diabetes or coronary disease?"Journal of hypertensionMore Details
    20712529 Tailored therapy of ACE inhibitors in stable coronary artery disease: pharmacogenetic profiling of treatment benefit.PharmacogenomicsMore Details
    20577898 Secondary prevention of CAD with ACE inhibitors: a struggle between life and death of the endothelium.Cardiovascular drugs and therapy / sponsored by the International Society ofMore Details
    20629643 "Genetic association study of the GNB3 C825T, the ACE I/D and the eNOS G894T polymorphisms and the risk to develop erectile dysfunction in a German ED population."AndrologiaMore Details
    20364300 Association of ACE and FACTOR VII gene variability with the risk of coronary heart disease in north Indian population.Molecular and cellular biochemistryMore Details
    20536518 Disparity in management of diabetes and coronary heart disease risk factors by sex in DCCT/EDIC.Diabetic medicine : a journal of the British Diabetic AssociationMore Details
    20877692 Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians.Journal of cardiovascular disease researchMore Details
    20394044 Prevalence and prognosis of chronic obstructive pulmonary disease among 8167 Middle Eastern patients with acute coronary syndrome.Clinical cardiologyMore Details
    20334448 Extent of control of cardiovascular risk factors and adherence to recommended therapies in US multiethnic adults with coronary heart disease: from a 2005-2006 national survey."American journal of cardiovascular drugs : drugs, devices, and other"More Details
    21162760 ACE gene insertion/deletion polymorphism has a mild influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI.BMC cardiovascular disordersMore Details
    20806416 Anaphylactoid-like reactions in a patient with HyperLp(a)lipidemia undergoing LDL apheresis with dextran sulfate adsorption and herbal therapy with the spice turmeric.Journal of clinical apheresisMore Details
    20861628 Association between genetic polymorphisms in the renin-angiotensin system and systolic heart failure revised by a propensity score-based analysis.CardiologyMore Details
    21081219 Organic nitrates and nitrate tolerance--state of the art and future developments."Advances in pharmacology (San Diego, Calif.)"More Details
    19641457 Coronary calcium significantly affects quantitative analysis of coronary ultrasound: importance for atherosclerosis progression/regression studies.Coronary artery diseaseMore Details
    19707983 Effect of ACE inhibition on the fibrinolytic system in patients requiring coronary artery bypass grafting.The Thoracic and cardiovascular surgeonMore Details
    19470037 Implantable cardioverter defibrillators: do women fare worse than men? Gender comparison in the INTRINSIC RV trial.Journal of cardiovascular electrophysiologyMore Details
    19596363 Angiotensin-converting enzyme insertion/deletion polymorphism has no effect on the risk of atherosclerotic stroke or hypertension.Journal of the neurological sciencesMore Details
    19857679 Inadequate blood pressure control in most kidney transplant recipients and patients with coronary artery disease with and without complications.Transplantation proceedingsMore Details
    19713976 Impact of ACE and ApoE polymorphisms on myocardial perfusion: correlation with myocardial single photon emission computed tomographic imaging.Journal of human geneticsMore Details
    19878370 Protective effects of angiotensin-converting enzyme inhibitors in high-risk African American men with coronary heart disease."Journal of clinical hypertension (Greenwich, Conn.)"More Details
    19381108 Angiotensin II receptor blockers and myocardial infarction: an updated analysis of randomized clinical trials.Journal of hypertensionMore Details
    18950770 ACE inhibition with perindopril and biomarkers of atherosclerosis and thrombosis: results from the PERTINENT study.AtherosclerosisMore Details
    18816584 Studies on the molecular recognition between bioactive peptides and angiotensin-converting enzyme.Journal of molecular recognition : JMRMore Details
    19114589 Angiotensin-converting enzyme (ACE) inhibitors modulate cellular retinol-binding protein 1 and adiponectin expression in adipocytes via the ACE-dependent signaling cascade.Molecular pharmacologyMore Details
    19532103 Management of left ventricular diastolic heart failure: is it only blood pressure control?Current opinion in cardiologyMore Details
    19060116 The kinin B1 receptor contributes to the cardioprotective effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in mice.Experimental physiologyMore Details
    19190039 How optimal is the medical management of patients prior to major reconstructive vascular surgery? The results of a cross-sectional study.Vascular and endovascular surgeryMore Details
    19520311 "Statins, ACE inhibitors and ARBs in cardiovascular disease."Best practice & research. Clinical endocrinology & metabolismMore Details
    19464412 Influence of coronary angiography on the utilization of therapies in patients with acute heart failure syndromes: findings from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF).American heart journalMore Details
    19390543 Diabetes mellitus accelerates left ventricular diastolic dysfunction through activation of the renin-angiotensin system in hypertensive rats.Hypertension research : official journal of the Japanese Society of HypertensionMore Details
    19352213 "Antihypertensive pharmacogenetic effect of fibrinogen-beta variant -455G>A on cardiovascular disease, end-stage renal disease, and mortality: the GenHAT study."Pharmacogenetics and genomicsMore Details
    19486852 "Peripheral arterial disease: Pathophysiology, risk factors, diagnosis, treatment, and prevention."Journal of vascular nursing : official publication of the Society for Peripheral More Details
    19491619 Prevention of major cardiovascular events with an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker early or late after stroke.Journal of hypertension. Supplement : official journal of the InternationalMore Details
    18445609 Association of angiotensin-converting enzyme gene 2350G>A polymorphism with myocardial infarction in a Chinese population.Clinical and applied thrombosis/hemostasis : official journal of theMore Details
    19503102 "The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats."Acta pharmacologica SinicaMore Details
    19202146 Quantification of low-dose dobutamine stress using speckle tracking echocardiography in coronary artery disease.European journal of echocardiography : the journal of the Working Group onMore Details
    19649581 "Aliskiren, the first approved renin inhibitor: Clinical application and safety in the treatment of hypertension."Advances in therapyMore Details
    19040564 "Cost-effectiveness of treatments reducing coronary heart disease mortality in Ireland, 2000 to 2010."Value in health : the journal of the International Society for Pharmacoeconomics More Details
    18177954 Elderly patients undergoing major vascular surgery: risk factors and medication associated with risk reduction.Archives of gerontology and geriatricsMore Details
    18946466 Promoter polymorphisms in ACE (angiotensin I-converting enzyme) associated with clinical outcomes in hypertension.Clinical pharmacology and therapeuticsMore Details
    18941131 Noninvasive detection of risk for emotion-provoked myocardial ischemia.Psychosomatic medicineMore Details
    18190989 Impact of telmisartan on coronary stenting in patients with acute myocardial infarction compared with enalapril.International journal of cardiologyMore Details
    19214404 Cardiovascular prevention in clinical practice (ESC and German guidelines 2007).HerzMore Details
    19214406 [ESC/EASD joint guidelines on diabetes and cardiovascular diseases].HerzMore Details
    19828644 Use and cost of branded and generic drugs in patients with coronary heart disease--results from a prospective survey of 1008 patients in two London hospitals.QJM : monthly journal of the Association of PhysiciansMore Details
    19669395 Expression of renin-angiotensin system on dendritic cells of patients with coronary artery disease.InflammationMore Details
    19609772 [Abdominal aortic aneurysm].Der InternistMore Details
    19185300 A propensity score-based case-control study of renin-angiotensin system gene polymorphisms and diastolic heart failure.AtherosclerosisMore Details
    19221687 "Risk factor profile, management and prognosis of patients with peripheral arterial disease with or without coronary artery disease: results of the prospective German REACH registry cohort."Clinical research in cardiology : official journal of the German Cardiac SocietyMore Details
    18931896 Secondary prevention of coronary disease with ACE inhibition--does blood pressure reduction with perindopril explain the benefits in EUROPA?Cardiovascular drugs and therapy / sponsored by the International Society ofMore Details
    19198958 Hypertension guideline adherence among nursing home patients.Journal of general internal medicineMore Details
    19082699 The rationale and design of the PERindopril GENEtic association study (PERGENE): a pharmacogenetic analysis of angiotensin-converting enzyme inhibitor therapy in patients with stable coronary artery disease.Cardiovascular drugs and therapy / sponsored by the International Society ofMore Details
    19233497 Short-term oral treatment with the angiotensin II receptor antagonist losartan does not improve coronary vasomotor function in asymptomatic type 2 diabetes patients.Diabetes research and clinical practiceMore Details
    19379059 Angiotensin-converting enzyme inhibition by perindopril in the treatment of cardiovascular disease.Expert review of cardiovascular therapyMore Details
    19185380 Endothelial dysfunction and cardiovascular risk factors.Diabetes research and clinical practiceMore Details
    19275271 Insight into the mode of action of ACE inhibition in coronary artery disease: the ultimate 'EUROPA' story.DrugsMore Details
    21687027 A mimicry of an acute coronary syndrome.BMJ case reportsMore Details
    19199114 Total occlusion of the infarct-related coronary artery correlates with brachial artery flow-mediated dilation in patients with ST-elevation myocardial infarction.Acute cardiac careMore Details
    19588327 First-line drugs for hypertension.The Cochrane database of systematic reviewsMore Details
    19497121 ACE (I/D) polymorphism and response to treatment in coronary artery disease: a comprehensive database and meta-analysis involving study quality evaluation.BMC medical geneticsMore Details
    18832826 The renin-angiotensin-aldosterone system: approaches to guide angiotensin-converting enzyme inhibition in patients with coronary artery disease.CardiologyMore Details
    19719332 Fixed-dose combinations as initial therapy for hypertension: a review of approved agents and a guide to patient selection.DrugsMore Details
    19728749 Role of angiotensin II type 1 receptor antagonists in the treatment of hypertension in patients aged >or=65 years.Drugs & agingMore Details
    19911855 Valsartan: more than a decade of experience.DrugsMore Details
    18806522 Prevalence of use of cardiovascular drugs in 499 patients with suspected coronary artery disease at time of hospitalization for coronary angiography and in 357 patients with obstructive coronary artery disease documented by coronary angiography.American journal of therapeuticsMore Details
    18651118 [Secondary prevention after myocardial infarction].Der InternistMore Details
    18986411 Diagnostic and prognostic value of rapid pacing stress echocardiography for the detection of coronary artery disease: influence of pacing mode and concomitant antiischemic therapy (final results of multicenter study Pol-RAPSE)."Echocardiography (Mount Kisco, N.Y.)"More Details
    18784380 Blood pressure guidelines - where are we now?Drug and therapeutics bulletinMore Details
    17987382 Pathways involved in the transition from hypertension to hypertrophy to heart failure. Treatment strategies.Heart failure reviewsMore Details
    18295912 Low utilisation of cardiovascular risk reducing therapy in patients with acute coronary syndromes and non-obstructive coronary artery disease.International journal of cardiologyMore Details
    18805152 Preoperative Angiotensin-converting enzyme inhibitors and acute kidney injury after coronary artery bypass grafting.The Annals of thoracic surgeryMore Details
    18759378 An assessment of the effect of thiazolidinedione exposure on the risk of myocardial infarction in type 2 diabetic patients.Pharmacoepidemiology and drug safetyMore Details
    18821518 [Coronary heart disease and dyslipdemia - dosing recommendations at beginning and end of treatment].Therapeutische Umschau. Revue therapeutiqueMore Details
    18706898 No association found between the insertion/deletion of a 287-bp alu repeat sequence within intron 16 of the angiotensin-I-converting enzyme (ACE) gene in Mexican patients and binary restenosis after coronary stenting.Clinica chimica acta; international journal of clinical chemistryMore Details
    18208832 Prognostic impact of diabetes mellitus in patients with heart failure and preserved ejection fraction: a prospective five-year study.Heart (British Cardiac Society)More Details
    18839124 [Sex differences in cardiovascular drug targeting].Der InternistMore Details
    18435634 Use of perioperative cardiac medical therapy among patients undergoing coronary artery bypass graft surgery.Journal of cardiac surgeryMore Details
    18504336 Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis.Archives of internal medicineMore Details
    18440333 Gender disparity in cardiac procedures and medication use for acute myocardial infarction.American heart journalMore Details
    18656088 Persistence of combination of evidence-based medical therapy in patients with acute coronary syndromes.Archives of cardiovascular diseasesMore Details
    18347228 Angiotensin-converting enzyme inhibition after experimental myocardial infarct: role of the kinin B1 and B2 receptors.HypertensionMore Details
    18252761 Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats.Cardiovascular researchMore Details
    18520954 Risk factor-induced cardiovascular remodeling and the effects of angiotensin-converting enzyme inhibitors.Journal of cardiovascular pharmacologyMore Details
    18268512 The influence of obesity and consequent insulin resistance on coronary risk factors in medically treated patients with coronary disease.International journal of obesity (2005)More Details
    18454336 RAS blockade with ARB and ACE inhibitors: current perspective on rationale and patient selection.Clinical research in cardiology : official journal of the German Cardiac SocietyMore Details
    18378239 Inflammatory and non-invasive vascular markers: the multimarker approach for risk stratification in coronary artery disease.AtherosclerosisMore Details
    18520711 Pharmacogenetics of ACE inhibition in stable coronary artery disease: steps towards tailored drug therapy.Current opinion in cardiologyMore Details
    18095949 Tissue angiotensin-converting enzyme inhibitors for the prevention of cardiovascular disease in patients with diabetes mellitus without left ventricular systolic dysfunction or clinical evidence of heart failure: a pooled meta-analysis of randomized placebo-controlled clinical trials."Diabetes, obesity & metabolism"More Details
    17683517 The Mediterranean paradox for susceptibility factors in coronary heart disease extends to genetics.Annals of human geneticsMore Details
    18258559 [Evidence-based optimal treatment strategy of patients with angina pectoris].Orvosi hetilapMore Details
    18068386 French medical practice in type 2 diabetes: the need for better control of cardiovascular risk factors.Diabetes & metabolismMore Details
    18182218 New perspective on the tissue kallikrein-kinin system in myocardial infarction: role of angiogenesis and cardiac regeneration.International immunopharmacologyMore Details
    18000186 "Metabolic and clinical outcomes in nondiabetic individuals with the metabolic syndrome assigned to chlorthalidone, amlodipine, or lisinopril as initial treatment for hypertension: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)."Diabetes careMore Details
    18261706 "Prevalence of use of antiplatelet drugs, beta blockers, statins, and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in older patients with coronary artery disease in an academic nursing home."Journal of the American Medical Directors AssociationMore Details
    17848140 Long-term histological and immunohistochemical findings in human venous aorto-coronary bypass grafts."Clinical science (London, England : 1979)"More Details
    18472027 "[Progression of coronary disease: minutes, weeks, decades...]."Annales de cardiologie et d'angeiologieMore Details
    18312907 Angiotensin-converting enzyme inhibitor and/or angiotensin receptor antagonist for the postmyocardial infarction patient.Cardiology clinicsMore Details
    18787507 Pharmacological effects of lipid-lowering drugs recapitulate with a larger amplitude the phenotypic effects of common variants within their target genes.Pharmacogenetics and genomicsMore Details
    19032136 Optimizing the treatment of hypertension and stable coronary artery disease: clinical evidence for fixed-combination perindopril/amlodipine.Current medical research and opinionMore Details
    18563622 Five-year follow-up of drug utilization for secondary prevention in coronary artery disease.Pharmacy world & science : PWSMore Details
    18701532 Secondary prevention of cardiovascular disease in different primary healthcare systems with and without pay-for-performance.Heart (British Cardiac Society)More Details
    18440425 Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data.LancetMore Details
    18180914 Equal access to treatment? Population-based follow-up of drugs dispensed to patients after acute myocardial infarction in Sweden.European journal of clinical pharmacologyMore Details
    18371492 Medication nonadherence is associated with a broad range of adverse outcomes in patients with coronary artery disease.American heart journalMore Details
    18291721 Heart regeneration: what cells to use and how?Current opinion in pharmacologyMore Details
    18449492 Role of combination therapy in the treatment of hypertension: focus on valsartan plus amlodipine.Advances in therapyMore Details
    18298340 The D allele of angiotensin I-converting enzyme gene insertion/deletion polymorphism is associated with the severity of atherosclerosis.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    18239395 High prevalence of risk factors in coronary artery disease in EUROPA gives HOPE for ACE inhibitors after PEACE.CardiologyMore Details
    18637188 "RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population."BMC cardiovascular disordersMore Details
    18810239 Serum urate predicts long-term risk of acute coronary events in women after a transient ischaemic attack and stroke."Cerebrovascular diseases (Basel, Switzerland)"More Details
    18438718 The effect of withdrawal of ACE inhibitors or angiotensin receptor blockers prior to coronary angiography on the incidence of contrast-induced nephropathy.International urology and nephrologyMore Details
    18803845 Development and first assessment of a questionnaire for health care utilization and costs for cardiac patients.BMC health services researchMore Details
    18418003 Gene expression profiles of vascular smooth muscle show differential expression of mitogen-activated protein kinase pathways during captopril therapy of heart failure.Journal of vascular researchMore Details
    18294050 Modification of the coronary artery disease risk associated with the presence of traditional risk factors by insertion/deletion polymorphism of the ACE gene.Genetic testingMore Details
    17270296 Effects of perindopril on long-term clinical outcome of patients with coronary artery disease and preserved left ventricular function.International journal of cardiologyMore Details
    17403027 The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk.Annals of human geneticsMore Details
    17478487 The relationship between the insertion/deletion polymorphism of the ACE gene and hypertension in Iranian patients with type 2 diabetes."Nephrology, dialysis, transplantation : official publication of the European"More Details
    17875946 Tissue ACE inhibitors for secondary prevention of cardiovascular disease in patients with preserved left ventricular function: a pooled meta-analysis of randomized placebo-controlled trials.Journal of cardiovascular pharmacology and therapeuticsMore Details
    17873142 Long-term nicorandil therapy improves cardiac sympathetic nerve activity after reperfusion therapy in patients with first acute myocardial infarction."Journal of nuclear medicine : official publication, Society of Nuclear Medicine"More Details
    17885543 Nifedipine retard prevents hospitalization for angina pectoris better than angiotensin-converting enzyme inhibitors in hypertensive Japanese patients with previous myocardial infarction (JMIC-B substudy).Journal of hypertensionMore Details
    18036453 The cardioprotective effects of the angiotensin-converting enzyme inhibitor perindopril in patients with stable coronary artery disease are not modified by mild to moderate renal insufficiency: insights from the EUROPA trial.Journal of the American College of CardiologyMore Details
    18035919 Insight into ACE inhibition in the prevention of cardiac events in stable coronary artery disease: the EUROPA trial.Expert review of cardiovascular therapyMore Details
    17118372 Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction.AtherosclerosisMore Details
    17505174 Two giant renal aneurysms and renal arteriovenous fistula associated with cardiac insufficiency and a sustained elevation of atrial natriuretic peptide and brain natriuretic peptide.The American journal of the medical sciencesMore Details
    17449875 "Economic analysis of treatments reducing coronary heart disease mortality in England and Wales, 2000-2010."QJM : monthly journal of the Association of PhysiciansMore Details
    17429286 The relationship between angiotensin-converting enzyme (insertion/deletion) gene polymorphism and left ventricular remodeling in acute myocardial infarction.Coronary artery diseaseMore Details
    17519062 Perindopril arginine: benefits of a new salt of the ACE inhibitor perindopril.Current medical research and opinionMore Details
    16720024 How well does the metabolic syndrome defined by five definitions predict incident diabetes and incident coronary heart disease in a Chinese population?AtherosclerosisMore Details
    17339550 Glucose levels predict hospitalization for congestive heart failure in patients at high cardiovascular risk.CirculationMore Details
    17487822 Angiotensin-converting enzyme inhibitors and coronary heart disease prevention.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    17327458 Polymorphisms of the renin-angiotensin system genes predict progression of subclinical coronary atherosclerosis.DiabetesMore Details
    17519441 Managing acute coronary syndrome: evidence-based approaches.American journal of health-system pharmacy : AJHP : official journal of theMore Details
    17160550 Abnormal asymmetric dimethylarginine/nitric oxide balance in patients with documented coronary artery disease: relation to renal function and homocysteine.Journal of thrombosis and thrombolysisMore Details
    17447137 Vasodilators in acute heart failure.Heart failure reviewsMore Details
    17631211 Prognostic value of B-Type natriuretic peptides in patients with stable coronary artery disease: the PEACE Trial.Journal of the American College of CardiologyMore Details
    17488800 Beneficial effects of eplerenone versus hydrochlorothiazide on coronary circulatory function in patients with diabetes mellitus.The Journal of clinical endocrinology and metabolismMore Details
    17688382 "Side effects of using nitrates to treat heart failure and the acute coronary syndromes, unstable angina and acute myocardial infarction."Expert opinion on drug safetyMore Details
    17140552 ACE inhibition with perindopril and endothelial function. Results of a substudy of the EUROPA study: PERTINENT.Cardiovascular researchMore Details
    17302696 Low doses of intracoronary enalaprilat suppress reperfusion-associated ventricular arrhythmias after primary percutaneous coronary interventions for acute myocardial infarction.Pacing and clinical electrophysiology : PACEMore Details
    17174637 Absence of an interaction between the angiotensin-converting enzyme insertion-deletion polymorphism and pravastatin on cardiovascular disease in high-risk hypertensive patients: the Genetics of Hypertension-Associated Treatment (GenHAT) study.American heart journalMore Details
    17285438 Early sign of atherosclerosis in slow coronary flow and relationship with angiotensin-converting enzyme I/D polymorphism.Heart and vesselsMore Details
    16914369 Effects of aspirin and clopidogrel on plasma brain natriuretic peptide in patients with heart failure receiving ACE inhibitors.European journal of heart failureMore Details
    17224772 Use of generic cardiovascular medications by elderly Medicare beneficiaries receiving generalist or cardiologist care.Medical careMore Details
    17270062 Managing and analysing a large health-care system database for predicting in-hospital mortality among acute myocardial infarction patients.Health services management research : an official journal of the Association ofMore Details
    18025537 Influence of albuminuria on cardiovascular risk in patients with stable coronary artery disease.CirculationMore Details
    18061069 Determinants of progression of coronary artery calcification in type 2 diabetes role of glycemic control and inflammatory/vascular calcification markers.Journal of the American College of CardiologyMore Details
    18004652 Differences in the effect of angiotensin-converting enzyme inhibitors on the rate of endothelial cell apoptosis: in vitro and in vivo studies.Cardiovascular drugs and therapy / sponsored by the International Society ofMore Details
    18158708 "Beneficial effects of ramipril on myocardial diastolic function in patients with type 2 diabetes mellitus, normal LV systolic function and without coronary artery disease: a prospective study using tissue Doppler."Diabetes & vascular disease research : official journal of the InternationalMore Details
    17995559 The cost-effectiveness of improving diabetes care in U.S. federally qualified community health centers.Health services researchMore Details
    18231736 Association of polymorphisms in angiotensin-converting enzyme and type 1 angiotensin II receptor genes with coronary heart disease and the severity of coronary artery stenosis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua More Details
    17666197 Angiotensin receptor blockers versus angiotensin-converting enzyme inhibitors: where do we stand now?The American journal of cardiologyMore Details
    17657599 "ACE inhibition and endothelial function: main findings of PERFECT, a sub-study of the EUROPA trial."Cardiovascular drugs and therapy / sponsored by the International Society ofMore Details
    17989852 [Risk factors for postoperative atrial fibrillation after coronary artery bypass grafting. A prospective analysis].Revista medica de ChileMore Details
    17562973 Angiotensin-converting enzyme genotype interacts with systolic blood pressure to determine coronary heart disease risk in healthy middle-aged men.HypertensionMore Details
    17429448 "Polymorphisms of angiotensinogen and angiotensin-converting enzyme associated with lower extremity arterial disease in the Health, Aging and Body Composition study."Journal of human hypertensionMore Details
    17447196 [Heterotaxia syndrome without congenital cardiac defects in dilated cardiomyopathy].Deutsche medizinische Wochenschrift (1946)More Details
    17433950 Pretreatment with intracoronary enalaprilat protects human myocardium during percutaneous coronary angioplasty.Journal of the American College of CardiologyMore Details
    17303589 The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns.European heart journalMore Details
    17345122 Peripheral arterial occlusive disease: magnetic resonance imaging and the role of aggressive medical management.World journal of surgeryMore Details
    17384371 A mimicry of an acute coronary syndrome.Emergency medicine journal : EMJMore Details
    17164481 "Cardiothoracic ratio within the ""normal"" range independently predicts mortality in patients undergoing coronary angiography."Heart (British Cardiac Society)More Details
    17497040 The level of hs-CRP in coronary artery ectasia and its response to statin and angiotensin-converting enzyme inhibitor treatment.Mediators of inflammationMore Details
    17287605 ADA*2 allele of the adenosine deaminase gene may protect against coronary artery disease.CardiologyMore Details
    17921131 Genetic polymorphisms contribute to acute kidney injury after coronary artery bypass grafting.The heart surgery forumMore Details
    17243909 "Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area."Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    17519002 Renin-angiotensin-aldosterone system polymorphisms: a role or a hole in occurrence and long-term prognosis of acute myocardial infarction at young age.BMC medical geneticsMore Details
    17521710 CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: impact of pre-inflammatory stimuli and renin-angiotensin system modulators.Thrombosis researchMore Details
    17852816 Angiotensin-converting enzyme gene polymorphism and coronary reactivity in young men.Scandinavian journal of clinical and laboratory investigationMore Details
    16815432 Captopril prevents myosin light chain phosphatase isoform switching to preserve normal cGMP-mediated vasodilatation.Journal of molecular and cellular cardiologyMore Details
    16905555 Should angiotensin-converting enzyme-inhibitors be used to improve outcome in patients with coronary artery disease and 'preserved' left ventricular function?European heart journalMore Details
    16480770 The importance of circadian rhythms on drug response in hypertension and coronary heart disease--from mice and man.Pharmacology & therapeuticsMore Details
    16945052 Effect of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers on the rate of new-onset diabetes mellitus: a review and pooled analysis.PharmacotherapyMore Details
    17081085 Use of the ACE inhibitor zofenopril in the treatment of ischemic heart disease.Expert review of cardiovascular therapyMore Details
    16764852 Angiotensin-I-converting enzyme (ACE) insertion/deletion polymorphism in Mexican patients with coronary artery disease. Association with the disease but not with lipid levels.Experimental and molecular pathologyMore Details
    17011901 Interventions to improve guideline compliance following coronary artery bypass grafting.SurgeryMore Details
    16968466 Increased cardiac endothelial nitric oxide synthase expression in patients taking angiotensin-converting enzyme inhibitor therapy.European journal of clinical investigationMore Details
    17380191 C-reactive protein and vulnerability to mental stress-induced myocardial ischemia."Molecular medicine (Cambridge, Mass.)"More Details
    17003740 The ACE-DD genotype is associated with endothelial dysfunction in postmenopausal women."Menopause (New York, N.Y.)"More Details
    16928730 Identifying genetic susceptibilities to diabetes-related complications among individuals at low risk of complications: An application of tree-structured survival analysis.American journal of epidemiologyMore Details
    16829641 Improvements in clinical outcomes with the use of angiotensin-converting enzyme inhibitors: cross-fertilization between clinical and basic investigation.American journal of physiology. Heart and circulatory physiologyMore Details
    16609364 "Restenosis after percutaneous coronary intervention is associated with the angiotensin-II type-1 receptor 1166A/C polymorphism but not with polymorphisms of angiotensin-converting enzyme, angiotensin-II receptor, angiotensinogen or heme oxygenase-1."Pharmacogenetics and genomicsMore Details
    16563945 "Risk constellations in patients with the metabolic syndrome: epidemiology, diagnosis, and treatment patterns."The American journal of medicineMore Details
    16770562 "[Metabolic syndrome: ""common soil"" for diabetes and atherosclerosis. Novel approaches to an integrated therapy]."HerzMore Details
    16505174 Vascular remodeling in the internal mammary artery graft and association with in situ endothelin-1 and receptor expression.CirculationMore Details
    16545643 Cellular immunostaining of angiotensin-converting enzyme in human coronary atherosclerotic plaques.Journal of the American College of CardiologyMore Details
    16545650 Cardioprotective medication is associated with improved survival in patients with peripheral arterial disease.Journal of the American College of CardiologyMore Details
    16492203 Association analysis of genes in the renin-angiotensin system with subclinical cardiovascular disease in families with Type 2 diabetes mellitus: the Diabetes Heart Study.Diabetic medicine : a journal of the British Diabetic AssociationMore Details
    17083070 Aldosterone blockade over and above ACE-inhibitors in patients with coronary artery disease but without heart failure.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    16735672 Aspirin use and outcomes in a community-based cohort of 7352 patients discharged after first hospitalization for heart failure.CirculationMore Details
    16781387 "Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease."Journal of the American College of CardiologyMore Details
    16781228 Angiotensin-converting enzyme inhibition in patients with coronary artery disease and preserved left ventricular function Ischemia Management with Accupril post-bypass graft via inhibition of angiotensin-converting enzyme (IMAGINE) compared with the other major trials in coronary artery disease.American heart journalMore Details
    16585129 A cross-sectional study of secondary cardiac care in general practice: impact of personal and practice characteristics.Family practiceMore Details
    16788330 Gender differences in treatment of heart failure and acute myocardial infarction: a question of quality or epidemiology?Cardiology in reviewMore Details
    16801465 Renal function and effectiveness of angiotensin-converting enzyme inhibitor therapy in patients with chronic stable coronary disease in the Prevention of Events with ACE inhibition (PEACE) trial.CirculationMore Details
    16763185 Carotid intima-media thickness and antihypertensive treatment: a meta-analysis of randomized controlled trials.Stroke; a journal of cerebral circulationMore Details
    16337036 The novel role of C-reactive protein in cardiovascular disease: risk marker or pathogen.International journal of cardiologyMore Details
    16401630 Secondary prevention of coronary heart disease in older patients after the national service framework: population based study.BMJ (Clinical research ed.)More Details
    16368315 Long-term adherence with cardiovascular drug regimens.American heart journalMore Details
    16892341 Selective indole-based ECE inhibitors: synthesis and pharmacological evaluation.ChemMedChemMore Details
    16303122 The relationship between ACE insertion/deletion polymorphism and coronary artery disease with or without myocardial infarction.Clinical biochemistryMore Details
    16370923 Perindopril.Expert opinion on pharmacotherapyMore Details
    16306429 Vascular function and mild renal impairment in stable coronary artery disease."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16598512 ACE inhibition in secondary prevention: are the results controversial?Clinical research in cardiology : official journal of the German Cardiac SocietyMore Details
    16466598 The landscape after PEACE: do all ACE inhibitors act in an identical way?Current medical research and opinionMore Details
    17415628 Fighting against sudden death: a single or multidisciplinary approach.Journal of interventional cardiac electrophysiology : an international journal ofMore Details
    16959725 Optimal medical management of peripheral arterial disease.Vascular and endovascular surgeryMore Details
    16905022 Angiotensin-converting-enzyme inhibitors in stable vascular disease without left ventricular systolic dysfunction or heart failure: a combined analysis of three trials.LancetMore Details
    16799879 Inadequate medical treatment of patients with coronary artery disease by primary care physicians in Germany.Clinical research in cardiology : official journal of the German Cardiac SocietyMore Details
    16765625 The angiotensin-I converting enzyme I/D polymorphism is not associated with type 2 diabetes in individuals undergoing coronary angiography. (The Ludwigshafen Risk and Cardiovascular Health Study).Molecular genetics and metabolismMore Details
    16497685 Treatment benefit by perindopril in patients with stable coronary artery disease at different levels of risk.European heart journalMore Details
    16598590 "Differential antiplatelet effects of angiotensin converting enzyme inhibitors: comparison of ex vivo platelet aggregation in cardiovascular patients with ramipril, captopril and enalapril."Clinical research in cardiology : official journal of the German Cardiac SocietyMore Details
    16568131 Drug Insight: angiotensin-converting-enzyme inhibitors and atrial fibrillation--indications and contraindications.Nature clinical practice. Cardiovascular medicineMore Details
    16553505 Do angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers decrease the risk of hospitalization secondary to community-acquired pneumonia? A nested case-control study.PharmacotherapyMore Details
    16722548 A randomized trial to assess the impact of opinion leader endorsed evidence summaries on the use of secondary prevention strategies in patients with coronary artery disease: the ESP-CAD trial protocol [NCT00175240].Implementation science : ISMore Details
    16674817 Revascularization and cardioprotective drug treatment in myocardial infarction patients: how do they impact on patients' survival when delivered as usual care.BMC cardiovascular disordersMore Details
    21977258 Omega-3 polyunsaturated fatty acids: Their potential role in blood pressure prevention and management.Heart internationalMore Details
    16754275 Differential effects of olmesartan and ramipril on inflammatory response after myocardial infarction in rats.Blood pressureMore Details
    16139131 Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for prevention of type 2 diabetes: a meta-analysis of randomized clinical trials.Journal of the American College of CardiologyMore Details
    16168275 Aspirin use in older patients with heart failure and coronary artery disease: national prescription patterns and relationship with outcomes.Journal of the American College of CardiologyMore Details
    23361602 Antihypertensive drugs and coronary artery disease : evidence from controlled trials.High blood pressure & cardiovascular prevention : the official journal of theMore Details
    16115488 The association between angiotensin-converting enzyme gene polymorphism and coronary calcification. The Rotterdam Coronary Calcification Study.AtherosclerosisMore Details
    16125049 Renin-angiotensin system modulation: the weight of evidence.American journal of hypertensionMore Details
    16125052 Evidence for benefits of perindopril in hypertension and its complications.American journal of hypertensionMore Details
    16162605 Are angiotensin converting enzyme inhibitors beneficial in patients with aortic stenosis?Heart (British Cardiac Society)More Details
    16030030 "Renal function, concomitant medication use and outcomes following acute coronary syndromes.""Nephrology, dialysis, transplantation : official publication of the European"More Details
    16202851 "Combination of site of infarct, unrecognized glucose intolerance, and reinfarction after acute myocardial infarction in normotensive subjects is determinant of the development of subsequent systemic hypertension: a pilot study."American journal of hypertensionMore Details
    16298258 Heart disease in diabetic patients.Seminars in nephrologyMore Details
    15882670 Effects of ACE inhibition during fetal development on cardiac microvasculature in adult spontaneously hypertensive rats.International journal of cardiologyMore Details
    15863668 Angiotensin II type I receptor gene polymorphism: anthropometric and metabolic syndrome traits.Journal of medical geneticsMore Details
    15857358 Perindopril: the reasonable choice in patients with coronary artery disease.International journal of clinical practiceMore Details
    15868362 Influence of the angiotensin converting enzyme inhibitor ramipril on high-sensitivity C-reactive protein (hs-CRP) in patients with documented atherosclerosis.Zeitschrift fur KardiologieMore Details
    15694745 The renin angiotensin system as a therapeutic target to prevent diabetes and its complications.Cardiology clinicsMore Details
    15755465 Multiple risk factor intervention in chronic kidney disease: management of cardiac disease in chronic kidney disease patients.The Medical clinics of North AmericaMore Details
    15699449 Adducin polymorphism: detection and impact on hypertension and related disorders.HypertensionMore Details
    16088850 Renin-angiotensin system gene polymorphisms and premature coronary heart disease.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    15715683 Endothelin receptor blockade improves endothelial function in atherosclerotic patients on angiotensin converting enzyme inhibition.Journal of internal medicineMore Details
    15967849 Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study.CirculationMore Details
    15939098 Regional variation in medication following coronary events in Germany.International journal of cardiologyMore Details
    15769809 Patterns of medication use in the RRI-CKD study: focus on medications with cardiovascular effects."Nephrology, dialysis, transplantation : official publication of the European"More Details
    15937208 Patients undergoing coronary revascularisation: a missed opportunity for secondary prevention?Postgraduate medical journalMore Details
    15851624 Quantitative coronary angiogram analysis: nifedipine retard versus angiotensin-converting enzyme inhibitors (JMIC-B side arm study).HypertensionMore Details
    16009792 Statin therapy may be associated with lower mortality in patients with diastolic heart failure: a preliminary report.CirculationMore Details
    15940697 Generalized arterial calcification of infancy: different clinical courses in two affected siblings.American journal of medical genetics. Part AMore Details
    16263350 Intracoronary beta-irradiation prevents excessive in-stent neointimal proliferation in de novo lesions of patients with high plasma ACE levels. The BetAce randomized trial.Cardiovascular revascularization medicine : including molecular interventionsMore Details
    15653013 Cardiac medical therapy in patients after undergoing coronary artery bypass graft surgery: a review of randomized controlled trials.Journal of the American College of CardiologyMore Details
    15635071 Angiotensin converting enzyme gene polymorphism and cardiovascular morbidity and mortality: the Rotterdam Study.Journal of medical geneticsMore Details
    15563875 Association between the eNOS (Glu298Asp) and the RAS genes polymorphisms and premature coronary artery disease in a Turkish population.Clinica chimica acta; international journal of clinical chemistryMore Details
    15572387 Atherosclerotic risk factors and renal function in the elderly: the role of hyperfibrinogenaemia and smoking. Results from the Italian Longitudinal Study on Ageing (ILSA)."Nephrology, dialysis, transplantation : official publication of the European"More Details
    15595935 Endothelial nitric oxide synthase gene interactions and the risk of ischaemic stroke.Acta neurologica ScandinavicaMore Details
    15520830 "The relation between obesity, abdominal fat deposit and the angiotensin-converting enzyme gene I/D polymorphism and its association with coronary heart disease."International journal of obesity (2005)More Details
    15642544 "Clinical trials update from the American Heart Association meeting: ACORN-CSD, primary care trial of chronic disease management, PEACE, CREATE, SHIELD, A-HeFT, GEMINI, vitamin E meta-analysis, ESCAPE, CARP, and SCD-HeFT cost-effectiveness study."European journal of heart failureMore Details
    15701165 Exploring the equity of GP practice prescribing rates for selected coronary heart disease drugs: a multiple regression analysis with proxies of healthcare need.International journal for equity in healthMore Details
    15686787 Valsartan versus ACE inhibition after bare metal stent implantation--results of the VALVACE trial.International journal of cardiologyMore Details
    15645206 Determinants of subclinical diabetic heart disease.DiabetologiaMore Details
    15361893 Trends in antihypertensive and lipid-lowering therapy in subjects with type II diabetes: clinical effectiveness or clinical discretion?Journal of human hypertensionMore Details
    15694957 Management of heart failure in primary care after implementation of the National Service Framework for Coronary Heart Disease: a cross-sectional study.Public healthMore Details
    15792927 "Expression, localisation and function of ACE and chymase in normal and atherosclerotic human coronary arteries."Vascular pharmacologyMore Details
    16274774 ACE-DD genotype is associated with the occurrence of acute coronary syndrome in postmenopausal women.International journal of cardiologyMore Details
    16162637 Secondary prevention of coronary heart disease in older British men: extent of inequalities before and after implementation of the National Service Framework."Journal of public health (Oxford, England)"More Details
    16310574 Underuse of ACE inhibitors and angiotensin II receptor blockers in elderly patients with diabetes.American journal of kidney diseases : the official journal of the National KidneyMore Details
    16326361 Beneficial effects of add-on hydrochlorothiazide in rats with myocardial infarction optimally treated with quinapril.European journal of heart failureMore Details
    16525945 High angiotensin II responsiveness is associated with decreased endothelium-dependent relaxation in human arteries.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    16368049 Predictors of high-cost managed care patients with acute coronary syndrome.Current medical research and opinionMore Details
    16248996 Prevalence of genetic risk factors for coronary artery disease in Corsica island (France).Experimental and molecular pathologyMore Details
    16061127 Pre-procedural ACE-activity does not predict symptomatic in-stent restenosis.International journal of cardiologyMore Details
    16080968 Treatment and short-term outcome in women and men with acute coronary syndromes.International journal of cardiologyMore Details
    16102438 The effect of combined Angiotensin-converting enzyme inhibition and calcium antagonism on allograft coronary vasculopathy validated by intravascular ultrasound.The Journal of heart and lung transplantation : the official publication of theMore Details
    16020596 Comparison of the effect of enalapril and losartan in conjunction with surgical coronary revascularisation versus revascularisation alone on systemic endothelial function.Heart (British Cardiac Society)More Details
    16084282 Management of cardiovascular disease in the renal transplant recipient.Cardiology clinicsMore Details
    15811979 "Outcomes in hypertensive black and nonblack patients treated with chlorthalidone, amlodipine, and lisinopril."JAMA : the journal of the American Medical AssociationMore Details
    15851619 Arterial hemodynamics in patients after Kawasaki disease.CirculationMore Details
    15699455 Hypertension genes are genetic markers for insulin sensitivity and resistance.HypertensionMore Details
    16416058 [Risk adapted therapy in vascular diseases: antihypertensive treatment in peripheral arterial disease].Zeitschrift fur KardiologieMore Details
    15667649 Pretreatment with ACE inhibitors improves acute outcome of electrical cardioversion in patients with persistent atrial fibrillation.BMC cardiovascular disordersMore Details
    16146835 Influence of angiotensin converting enzyme insertion/deletion polymorphism on long-term total graft occlusion after coronary artery bypass surgery.The heart surgery forumMore Details
    15164145 Polymorphism of angiotensin-1 converting enzyme gene and Kawasaki disease.Pediatric cardiologyMore Details
    15330734 "A review of the angiotensin-converting enzyme inhibitor, zofenopril, in the treatment of cardiovascular diseases."Expert opinion on pharmacotherapyMore Details
    15310530 Fiftieth anniversary of aldosterone: from discovery to cardiovascular therapy.International journal of cardiologyMore Details
    15217805 Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of renin-angiotensin system and oxidative stress."Arteriosclerosis, thrombosis, and vascular biology"More Details
    15526240 Reassessing guidelines for heart failure.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    15489090 "The association among renal insufficiency, pharmacotherapy, and outcomes in 6,427 patients with heart failure and coronary artery disease."Journal of the American College of CardiologyMore Details
    15489091 Renal insufficiency as an independent predictor of mortality among women with heart failure.Journal of the American College of CardiologyMore Details
    15295089 Possible synergic effect of angiotensin-I converting enzyme gene insertion/deletion polymorphism and angiotensin-II type-1 receptor 1166A/C gene polymorphism on ischemic heart disease in patients with Kawasaki disease.Pediatric researchMore Details
    15542420 "Aetiology, comorbidity and drug therapy of chronic heart failure in the real world: the EPICA substudy."European journal of heart failureMore Details
    15336811 Under-diagnosis of diabetes mellitus in patients with coronary artery disease.International journal of cardiologyMore Details
    15472596 Patients with abdominal aortic aneurysm: are we missing the opportunity for cardiovascular risk reduction?Journal of vascular surgeryMore Details
    15101817 Association study of the I/D polymorphism and plasma angiotensin-converting enzyme (ACE) as risk factors for stent restenosis."Clinical science (London, England : 1979)"More Details
    15462689 Provision of cardiovascular protection by ACE inhibitors: a review of recent trials.Current medical research and opinionMore Details
    15534311 Evidence of suboptimal management of cardiovascular risk in patients with type 2 diabetes mellitus and symptomatic atherosclerosis.CMAJ : Canadian Medical Association journal = journal de l'Association medicaleMore Details
    15531767 Angiotensin-converting-enzyme inhibition in stable coronary artery disease.The New England journal of medicineMore Details
    15229622 Effect of statins and ACE inhibitors alone and in combination on clinical outcome in patients with coronary heart disease.Journal of human hypertensionMore Details
    15123532 Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease.CirculationMore Details
    15140344 Recalculation of cardiovascular risk score as a surrogate marker of change in clinical care of diabetes patients: the Alphabet POEM project (Practice Of Evidence-based Medicine).Current medical research and opinionMore Details
    15063599 Diabetes care and complications in a remote primary health care setting.Diabetes research and clinical practiceMore Details
    15007027 Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors.HypertensionMore Details
    15019863 Management of the patient with diabetes mellitus and myocardial infarction: clinical trials update.The American journal of medicineMore Details
    14658015 Myocardial perfusion in type 2 diabetes with left ventricular hypertrophy: normalisation by acute angiotensin-converting enzyme inhibition.European journal of nuclear medicine and molecular imagingMore Details
    15131005 Cardiac angiotensin II participates in coronary microvessel inflammation of unstable angina and strengthens the immunomediated component.Circulation researchMore Details
    15193812 Angiotensin-converting enzyme and p22(phox) polymorphisms and the risk of coronary heart disease in a low-risk Spanish population.International journal of cardiologyMore Details
    15193833 Reinforcement as a means for quality improvement in management of coronary syndromes: adherence to evidence-based medicine.International journal of cardiologyMore Details
    15161462 "Antihypertensive medications and differences in muscle mass in older persons: the Health, Aging and Body Composition Study."Journal of the American Geriatrics SocietyMore Details
    15193809 The renin-angiotensin hypothesis for the pathogenesis of cardiac allograft vasculopathy.International journal of cardiologyMore Details
    15262849 Adrenomedullin administration immediately after myocardial infarction ameliorates progression of heart failure in rats.CirculationMore Details
    15261932 Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery disease.Journal of the American College of CardiologyMore Details
    15234641 "Adherence to evidence-based therapies after discharge for acute coronary syndromes: an ongoing prospective, observational study."The American journal of medicineMore Details
    15235774 Risk factor management in diabetic and non-diabetic patients with coronary heart disease. Findings from the EUROASPIRE I AND II surveys.DiabetologiaMore Details
    15215792 "Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease (ONTARGET/TRANSCEND) trials."American heart journalMore Details
    15223114 The role of angiotensin-converting enzyme and apolipoprotein-E gene polymorphisms on lipid compositions in newborn infants with intrauterine growth restriction.Early human developmentMore Details
    14699004 Angiotensin-converting enzyme inhibitors and 3-hydroxy-3-methylglutaryl coenzyme A reductase in cardiac Syndrome X: role of superoxide dismutase activity.CirculationMore Details
    15012913 Does angiotensin-converting enzyme gene polymorphism affect blood pressure? Findings after 6 years of follow-up in healthy subjects.European journal of heart failureMore Details
    14749684 Tissue angiotensin II in the regulation of inflammatory and fibrogenic components of repair in the rat heart.The Journal of laboratory and clinical medicineMore Details
    14740236 Atheromatous disease of the thoracic aorta and systemic embolism. Clinical picture and therapeutic challenge.Zeitschrift fur KardiologieMore Details
    14970110 Impact of combination evidence-based medical therapy on mortality in patients with acute coronary syndromes.CirculationMore Details
    14592942 Novel anti-inflammatory actions of amlodipine in a rat model of arteriosclerosis induced by long-term inhibition of nitric oxide synthesis.American journal of physiology. Heart and circulatory physiologyMore Details
    14699000 Pressure-independent effects of angiotensin II on hypertensive myocardial fibrosis.HypertensionMore Details
    14975550 Drug prescriptions and referral to cardiac rehabilitation after acute coronary events: comparison between men and women in the French PREVENIR Survey.International journal of cardiologyMore Details
    14743136 "Patients undergoing infrainguinal bypass to treat atherosclerotic vascular disease are underprescribed cardioprotective medications: effect on graft patency, limb salvage, and mortality."Journal of vascular surgeryMore Details
    15598916 Association between cardiovascular outcomes and antihypertensive drug treatment in older women.JAMA : the journal of the American Medical AssociationMore Details
    15530425 ACE inhibition lowers angiotensin II-induced chemokine expression by reduction of NF-kappaB activity and AT1 receptor expression.Biochemical and biophysical research communicationsMore Details
    15556053 "Acute administration of diclofenac, but possibly not long term low dose aspirin, causes detrimental renal effects in heart failure patients treated with ACE-inhibitors."European journal of heart failureMore Details
    15262024 The role of coronary endothelial function testing in patients suspected for angina pectoris.International journal of cardiologyMore Details
    15276022 Salutary effects of attenuation of angiotensin II on coronary perivascular fibrosis associated with insulin resistance and obesity.Journal of molecular and cellular cardiologyMore Details
    15082699 A multicenter risk index for atrial fibrillation after cardiac surgery.JAMA : the journal of the American Medical AssociationMore Details
    15066943 "Abciximab-supported infarct artery stent implantation for acute myocardial infarction and long-term survival: a prospective, multicenter, randomized trial comparing infarct artery stenting plus abciximab with stenting alone."CirculationMore Details
    14644762 ACE inhibitors and statins acutely improve endothelial dysfunction of human coronary arterioles.American journal of physiology. Heart and circulatory physiologyMore Details
    15045142 Angiotensin-converting enzyme insertion/deletion polymorphism and risk of restenosis after directional coronary atherectomy followed by stent implantation.Thrombosis and haemostasisMore Details
    15543563 Five polymorphisms in gene candidates for cardiovascular disease in Afro-Brazilian individuals.Journal of clinical laboratory analysisMore Details
    15021993 [Cardiovascular risk stratification in general practice].Zeitschrift fur KardiologieMore Details
    15021998 [Sudden cardiac death (SCD) and guidelines for SCD].Zeitschrift fur KardiologieMore Details
    15021997 [Pharmacological aspects of secondary prevention post-MI].Zeitschrift fur KardiologieMore Details
    14602526 Angiotensin-converting-enzyme gene polymorphism and heart failure: a case-control study."Biomarkers : biochemical indicators of exposure, response, and susceptibility to "More Details
    12970203 Patterns of secondary prevention in older patients undergoing coronary artery bypass grafting during hospitalization for acute myocardial infarction.CirculationMore Details
    12943483 Calcium antagonists in the treatment of hypertension in patients with ischaemic heart disease.Expert opinion on pharmacotherapyMore Details
    14608518 Interaction between cyclooxygenase and the renin-angiotensin-aldosterone system: rationale and clinical relevance.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    12923384 New evidence on the importance of the renin-angiotensin system in the treatment of higher-risk patients with hypertension.Journal of hypertensionMore Details
    14605016 Adjunctive pharmacotherapy before percutaneous coronary intervention in non-ST-elevation acute coronary syndromes: the role of modulating inflammation.CirculationMore Details
    14581396 Human epicardial adipose tissue is a source of inflammatory mediators.CirculationMore Details
    12759325 Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis.JAMA : the journal of the American Medical AssociationMore Details
    12740004 ACE inhibitors versus diuretics: ALLHAT versus ANBP2.Expert opinion on pharmacotherapyMore Details
    12807566 Use of antihypertensive drug therapy in older persons in an academic nursing home.Journal of the American Medical Directors AssociationMore Details
    12692751 Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    12825146 Genetic risk factors for erectile dysfunction and genetic determinants of drug response--on the way to improve drug safety?HerzMore Details
    12826927 Angiotensin-converting enzyme insertion/deletion genotype is associated with the activities of plasma coagulation factor VII and X independent of triglyceride metabolism.Coronary artery diseaseMore Details
    12819995 [Drug therapy of coronary heart disease--are therapeutic guidelines being paid attention to?].Zeitschrift fur KardiologieMore Details
    12649073 Attenuation of heart failure due to coronary stenosis by ACE inhibitor and angiotensin receptor blocker.American journal of physiology. Heart and circulatory physiologyMore Details
    12485815 In vivo measurement of coronary circulation angiotensin-converting enzyme activity in humans.American journal of physiology. Heart and circulatory physiologyMore Details
    12517247 Eprosartan for the treatment of hypertension.Expert opinion on pharmacotherapyMore Details
    12545338 Two good reasons for an angiotensin-II type 1 receptor blockade with losartan after cardiac transplantation: reduction of incidence and severity of transplant vasculopathy.Transplant international : official journal of the European Society for OrganMore Details
    12669270 No association between the angiotensin-converting-enzyme gene insertion/deletion polymorphism and the occurrence of macroangiopathy in patients with diabetes mellitus type 2.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et More Details
    12595854 Antiplatelet effects of angiotensin-converting enzyme inhibitors compared with aspirin and clopidogrel: a pilot study with whole-blood aggregometry.American heart journalMore Details
    12574792 Endothelin-1 and vasopressin plasma levels are not associated with the insertion/deletion polymorphism of the human angiotensin I-converting enzyme gene in patients with coronary artery disease.Journal of human hypertensionMore Details
    14660997 Quality of care for secondary prevention for patients with coronary heart disease: results of the Hastening the Effective Application of Research through Technology (HEART) trial.American heart journalMore Details
    14660994 "Comparison of treatment and outcomes for patients with acute myocardial infarction in Minneapolis/St. Paul, Minnesota, and Goteborg, Sweden."American heart journalMore Details
    14632542 Secondary prevention of coronary heart disease in the elderly.The Annals of pharmacotherapyMore Details
    14704866 Intensive treatment of coronary artery disease in diabetic patients in clinical practice: results of the MITRA study.Acta diabetologicaMore Details
    12971828 Angiotensin Converting Enzyme and Angiotensin II Type 1 Receptor Polymorphisms in Patients with Coronary Aneurysms.Thrombosis journalMore Details
    12890711 Myogenic constriction is increased in mesenteric resistance arteries from rats with chronic heart failure: instantaneous counteraction by acute AT1 receptor blockade.British journal of pharmacologyMore Details
    12872055 Temporal trends in antihypertensive drug prescriptions in Canada before and after introduction of the Canadian Hypertension Education Program.Journal of hypertensionMore Details
    12649357 "Beneficial effects of sampatrilat, a novel vasopeptidase inhibitor, on cardiac remodeling and function of rats with chronic heart failure following left coronary artery ligation."The Journal of pharmacology and experimental therapeuticsMore Details
    12747597 "Left ventricular size, mass and function in relation to angiotensin-converting enzyme gene and angiotensin-II type 1 receptor gene polymorphisms in patients with coronary artery disease."Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    12833177 "Carrier-state of D allele in ACE gene insertion/deletion polymorphism is associated with coronary artery disease, in contrast to the C677-->T transition in the MTHFR gene."Acta biochimica PolonicaMore Details
    12938141 "Coronary heart disease, hypertension, and angiotensinogen gene variants in Indian population."Journal of clinical laboratory analysisMore Details
    12740554 Blood pressure and lipid lowering in the prevention of stroke: a note to neurologists."Cerebrovascular diseases (Basel, Switzerland)"More Details
    12771530 Hypertension and dialysis.Kidney & blood pressure researchMore Details
    12204859 Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome.American journal of respiratory and critical care medicineMore Details
    12563570 Mortality benefit of angiotensin-converting enzyme inhibitors after cardiac events in patients with end-stage renal disease.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    12200638 Angiotensin inhibition and coronary autoregulation in a canine model of LV hypertrophy.Basic research in cardiologyMore Details
    12439635 Molecular mechanisms involved in atherosclerosis.HerzMore Details
    16222631 Acute-phase reactants and coronary heart disease.Seminars in vascular medicineMore Details
    16222626 Blood pressure and coronary heart disease: a review of the evidence.Seminars in vascular medicineMore Details
    12077687 "Influence of ACE inhibition on myocardial damage, the Kallikrein-Kinin system and hemostasis during cardiopulmonary bypass surgery."The Thoracic and cardiovascular surgeonMore Details
    12807644 Use of antihypertensive drug therapy in older persons in an academic nursing home.Journal of the American Medical Directors AssociationMore Details
    12063286 Scar and pulmonary expression and shedding of ACE in rat myocardial infarction.American journal of physiology. Heart and circulatory physiologyMore Details
    11840224 Sibutramine is safe and effective for weight loss in obese patients whose hypertension is well controlled with angiotensin-converting enzyme inhibitors.Journal of human hypertensionMore Details
    11863326 Management of intermittent claudication: the importance of secondary prevention.European journal of vascular and endovascular surgery : the official journal ofMore Details
    11840363 Hemodialysis-associated hypertension: pathophysiology and therapy.American journal of kidney diseases : the official journal of the National KidneyMore Details
    12584668 The pharmacokinetics and pharmacodynamics of angiotensin-receptor blockers in end-stage renal disease.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    12584671 "Effects of the vasopeptidase inhibitor, omapatrilat, in 723 patients with coronary heart disease."Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    16222616 Common genetic polymorphisms and coronary heart disease.Seminars in vascular medicineMore Details
    12077488 Results from the TIP (Tritace in Proteinuria) intensified monitoring project.Kidney & blood pressure researchMore Details
    12476328 Combined action of the ACE D- and the G-protein beta3 T-allele in major depression: a possible link to cardiovascular disease?Molecular psychiatryMore Details
    11893827 Angiotensin-converting enzyme insertion/deletion polymorphism does not influence the restenosis rate after coronary stent implantation.CardiologyMore Details
    11522607 Effects of ACE inhibition and angiotensin II type 1 receptor blockade on cardiac function and G proteins in rats with chronic heart failure.British journal of pharmacologyMore Details
    11317203 Polymorphisms of the renin-angiotensin system in patients with multifocal renal arterial fibromuscular dysplasia.Journal of human hypertensionMore Details
    11241423 The effect of myocardial bridging of the coronary artery on vasoactive agents and atherosclerosis localization.The Journal of pathologyMore Details
    11446026 [Decreased platelet aggregation during angiotensin-converting enzyme inhibitor therapy. Results of a pilot study].Deutsche medizinische Wochenschrift (1946)More Details
    11684837 Effects of enalapril and L-158809 on myocardial beta-adrenergic receptor density in transplanted rat hearts.European surgical research. Europaische chirurgische Forschung. RecherchesMore Details
    11162135 Myocardial ischemia activates the JAK-STAT pathway through angiotensin II signaling in in vivo myocardium of rats.Journal of molecular and cellular cardiologyMore Details
    11753736 [The treatment of arterial hypertension. An inquiry among doctors in general practice].Deutsche medizinische Wochenschrift (1946)More Details
    11728956 Use of ACE inhibitors is associated with prolonged survival of arteriovenous grafts.American journal of kidney diseases : the official journal of the National KidneyMore Details
    11485372 Association between the NOS3 (-786 T/C) and the ACE (I/D) DNA genotypes and early coronary artery disease.Nitric oxide : biology and chemistry / official journal of the Nitric OxideMore Details
    11259143 Lifestyle and risk factor management and use of drug therapies in coronary patients from 15 countries; principal results from EUROASPIRE II Euro Heart Survey Programme.European heart journalMore Details
    11259147 "Specialty-related differences in the epidemiology, clinical profile, management and outcome of patients hospitalized for heart failure; the OSCUR study. Oucome dello Scompenso Cardiaco in relazione all'Utilizzo delle Risore."European heart journalMore Details
    11359065 "Population genetic analysis of the genes APOE, APOB(3'VNTR) and ACE in some black and Amerindian communities from Colombia."Human heredityMore Details
    11249482 Pharmacotherapy following myocardial infarction--a review of current treatment practices.Expert opinion on pharmacotherapyMore Details
    20086658 Avoiding Repeat Cardiac Events: The ABCDESs of Tertiary Prevention.The Physician and sportsmedicineMore Details
    10878743 Computerised systematic secondary prevention in ischaemic heart disease: a study in one practice.Public healthMore Details
    10831200 Cardiovascular responses to anesthetic induction in patients chronically treated with angiotensin-converting enzyme inhibitors.Canadian journal of anaesthesia = Journal canadien d'anesthesieMore Details
    10879452 Genetic variation in the renin-angiotensin system and athletic performance.European journal of applied physiologyMore Details
    10773756 Polymorphism of the angiotensin-converting enzyme gene in end-stage renal failure patients.NephronMore Details
    11249535 The fixed combination of verapamil SR/trandolapril.Expert opinion on pharmacotherapyMore Details
    10630765 Surviving heart failure: Robert L. Frye lecture.Mayo Clinic proceedings. Mayo ClinicMore Details
    10683191 "The effects of Z13752A, a combined ACE/NEP inhibitor, on responses to coronary artery occlusion; a primary protective role for bradykinin."British journal of pharmacologyMore Details
    11153414 [Secondary prevention in coronary patients after inpation rehabilitation].Deutsche medizinische Wochenschrift (1946)More Details
    11967824 Acute effects of ACE inhibition on coronary endothelial dysfunction.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    10731400 "Searching for a better assessment of the individual coronary risk profile. The role of angiotensin-converting enzyme, angiotensin II type 1 receptor and angiotensinogen gene polymorphisms."European heart journalMore Details
    10747309 Angiotensin-converting enzyme polymorphism and the risk of coronary heart disease in the Saudi male population.Archives of pathology & laboratory medicineMore Details
    10765051 Angiotensin-converting enzyme gene deletion polymorphism determines an increase in frequency of migraine attacks in patients suffering from migraine without aura.European neurologyMore Details
    11714406 Why do antioxidants fail to provide clinical benefit?Current controlled trials in cardiovascular medicineMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 4 unique genes interacted with ACE. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    UBC Reconstituted Complex19850743|21890473 No
    BDKRB2 in vivo10748135 CHD related
    COMT in vivo12729939 CHD related
    AGTR2 in vivo11459796 CHD related


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00178Ramipril"For the management of mild to severe hypertension. May be used to reduce cardiovascular mortality following myocardial infarction in hemodynamically stable individuals who develop clinical signs of congestive heart failure within a few days following myocardial infarction. To reduce the rate of death, myocardial infarction and stroke in individuals at high risk of cardiovascular events. May be used to slow the progression of renal disease in individuals with hypertension, diabetes mellitus and microalubinuria or overt nephropathy. "C09AA05
    approvedDB00492Fosinopril"For treating mild to moderate hypertension, use as an adjunct in treating congestive heart failure, and may be used to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy. "C09AA09
    approvedDB00519Trandolapril"For the treatment of mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure (CHF), to improve survival following myocardial infarction (MI) in individuals who are hemodynamically stable and demonstrate symptoms of left ventricular systolic dysfunction or signs of CHF within a few days following acute MI, and to slow progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy. "C09AA10
    approvedDB00542BenazeprilFor the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.C09AA07
    approvedDB00584EnalaprilFor the treatment of essential or renovascular hypertension and symptomatic congestive heart failure. It may be used alone or in combination with thiazide diuretics.C09AA02
    approvedDB00616Candoxatril"For treatment of hypertension, improve exercise capacity in patients with CHF receiving angiotensin converting enzyme inhibition."
    approvedDB00691MoexiprilFor the treatment of hypertension.C09AA13
    approvedDB00722Lisinopril"For the treatment of hypertension and symptomatic congestive heart failure. May be used in conjunction with thrombolytic agents, aspirin and/or β-blockers to improve survival in hemodynamically stable individuals following myocardial infarction. May be used to slow the progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy. "C09AA03
    approvedDB00790Perindopril"For the treatment of mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease. "C09AA04
    approvedDB00881QuinaprilFor the treatment of hypertension and as adjunct therapy in the treatment of congestive heart failure. May also be used to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy. C09AA06
    approvedDB01180RescinnamineFor the treatment of hypertension.C02AA01
    approvedDB01197Captopril"For the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics). May be used to treat congestive heart failure in combination with other drugs (e.g. cardiac glycosides, diuretics, β-adrenergic blockers). May improve survival in patients with left ventricular dysfunction following myocardial infarction. May be used to treat nephropathy, including diabetic nephropathy. "C09AA01
    approvedDB01340CilazaprilCilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure.C09AA08
    approvedDB01348SpiraprilSpirapril is an ACE inhibitor class drug used to treat hypertension.C09AA11
    experimentalDB020321-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid
    experimentalDB037402-(Acetylamino)-2-Deoxy-a-D-Glucopyranose