How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ACE2

    Description: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

    Entrez Gene ID: 59272

    SwissProt Acc Number: Q9BYF1

    RefSeq: NM_021804

    It was suspected to be CHD related:

    .."Studies todate have investigated ACE2 gene associations in hypertension, left ventricular hypertrophy and coronary artery disease, but the results have been inconsistent. "..

    From PMID: 23013041, in Journal Clin Sci (Lond). , 2013


    References

    There were 6 potential papers with ACE2 and CHD.

    PMIDTitleJournalsDetails
    23013041 The ACE2 gene: its potential as a functional candidate for cardiovascular disease."Clinical science (London, England : 1979)"More Details
    23432153 Emerging markers in cardiovascular disease: where does angiotensin-converting enzyme 2 fit in?Clinical and experimental pharmacology & physiologyMore Details
    22179088 Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications.Journal of hypertensionMore Details
    20507236 ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction.Human gene therapyMore Details
    18250366 Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology.HypertensionMore Details
    16822235 Association study of ACE2 (angiotensin I-converting enzyme 2) gene polymorphisms with coronary heart disease and myocardial infarction in a Chinese Han population."Clinical science (London, England : 1979)"More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 4 unique genes interacted with ACE2. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    GHRL in vitro11815627 CHD related
    NTS in vitro11815627 No
    AGT in vitro10969042,11815627 CHD related
    CALM1 Affinity Capture-Western18070603 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00691MoexiprilFor the treatment of hypertension.C09AA13
    approvedDB00722Lisinopril"For the treatment of hypertension and symptomatic congestive heart failure. May be used in conjunction with thrombolytic agents, aspirin and/or β-blockers to improve survival in hemodynamically stable individuals following myocardial infarction. May be used to slow the progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy. "C09AA03