How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.
The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

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  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

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  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.

    • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ADA

    Description: adenosine deaminase

    Entrez Gene ID: 100

    SwissProt Acc Number: P00813

    RefSeq: NM_000022

    It was suspected to be CHD related:

    .."Our study indicates that leukocyte hydrolytic enzymes, mainly acid phosphatase, lysozyme and ADA were more active in CHD patients and may contribute to inflammation related with CHD."..

    From PMID: 17259686, in Journal Indian J Med Sci , 2007


    References

    There were 34 potential papers with ADA and CHD.

    PMIDTitleJournalsDetails
    22502874 The report of male gender and retinopathy status improves the current consensus guidelines for the screening of myocardial ischemia in asymptomatic type 2 diabetic patients."Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    23734648 The use of ambulatory strategies for the diagnosis and treatment of obstructive sleep apnea in adults.Expert review of respiratory medicineMore Details
    23497457 The effect of vasopressin on the hemodynamics in CABG patients.Journal of cardiothoracic surgeryMore Details
    23762872 "Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus."Journal of diabetes researchMore Details
    22013153 Electrocardiography-defined silent CHD and risk of cardiovascular events among diabetic patients in a Middle Eastern population.European journal of preventive cardiologyMore Details
    21394027 Hemoglobin A1c as a prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction.Coronary artery diseaseMore Details
    21226683 Physical activity in U.S. older adults with diabetes mellitus: prevalence and correlates of meeting physical activity recommendations.Journal of the American Geriatrics SocietyMore Details
    20971657 Quantitative assessment of initial retention of bone marrow mononuclear cells injected into the coronary arteries.The Journal of heart and lung transplantation : the official publication of theMore Details
    21796800 Target blood pressure in diabetes patients with hypertension--what is the accumulated evidence in 2011?Journal of Zhejiang University. Science. BMore Details
    21888652 Prevalence of dysglycemia among coronary artery bypass surgery patients with no previous diabetic history.Journal of cardiothoracic surgeryMore Details
    20207043 The role of plasma adenosine deaminase in chemoattractant-stimulated oxygen radical production in neutrophils.European journal of cell biologyMore Details
    19845893 Plasma concentrations of TNF-alpha and its soluble receptors sTNFR1 and sTNFR2 in patients with coronary artery disease.Tissue antigensMore Details
    18822414 Detection of occult coronary artery disease in asymptomatic individuals with diabetes mellitus using non-invasive cardiac angiography.AtherosclerosisMore Details
    20428226 "Coronary artery disease: a study on the joint role of birth weight, adenosine deaminase, and gender."Cardiology research and practiceMore Details
    18206734 Impact of impaired fasting glucose on cardiovascular disease: the Framingham Heart Study.Journal of the American College of CardiologyMore Details
    19067531 Prevalence of metabolic syndrome among prediabetic Omani adults: a preliminary study.Metabolic syndrome and related disordersMore Details
    18495284 Prevalence of diabetes mellitus and metabolic syndrome in Slovakia.Diabetes research and clinical practiceMore Details
    16905628 Oral glucose tolerance test is needed for appropriate classification of glucose regulation in patients with coronary artery disease: a report from the Euro Heart Survey on Diabetes and the Heart.Heart (British Cardiac Society)More Details
    17646562 Role of statins for the primary prevention of cardiovascular disease in patients with type 2 diabetes mellitus.American journal of health-system pharmacy : AJHP : official journal of theMore Details
    17287605 ADA*2 allele of the adenosine deaminase gene may protect against coronary artery disease.CardiologyMore Details
    16555364 Prevalence of glucose metabolism abnormalities and cardiovascular co-morbidity in the US elderly adult population.Pharmacoepidemiology and drug safetyMore Details
    16778129 Reduced expression of vascular endothelial growth factor paralleled with the increased angiostatin expression resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in human type 2 diabetic arterial vasculature.Circulation researchMore Details
    16369773 Diabetes mellitus and impaired fasting glucose in Alaska Eskimos: the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study.DiabetologiaMore Details
    16600525 Does adenosine deaminase play a key role in coronary artery disease.Medical hypothesesMore Details
    16291001 Screening for coronary artery disease in patients with diabetes: a Bayesian strategy of clinical risk evaluation and exercise echocardiography.American heart journalMore Details
    15842509 Prognostic value of the Framingham cardiovascular risk equation and the UKPDS risk engine for coronary heart disease in newly diagnosed Type 2 diabetes: results from a United Kingdom study.Diabetic medicine : a journal of the British Diabetic AssociationMore Details
    15860044 Factors predicting the development of metabolic syndrome and type II diabetes against a background of hypertension.European journal of clinical investigationMore Details
    16098841 Rationale for new American Diabetes Association Guidelines: are national cholesterol education program goals adequate for the patient with diabetes mellitus?The American journal of cardiologyMore Details
    16113854 [Diffuse atherosclerotic disease unmasked by invasive physiologic assessment of coronary flow].Arquivos brasileiros de cardiologiaMore Details
    15367826 Endoxin antagonist lessens myocardial ischemia reperfusion injury.Cardiovascular drugs and therapy / sponsored by the International Society ofMore Details
    15569143 Changing aspirin use in patients with Type 2 diabetes in the UKPDS.Diabetic medicine : a journal of the British Diabetic AssociationMore Details
    15002883 "Gender, self-care and functional status among older persons with coronary heart disease: a national perspective."Women & healthMore Details
    12668909 The metabolic syndrome: targeting dyslipidaemia to reduce coronary risk.Journal of cardiovascular riskMore Details
    12486415 Management of dyslipidemia in the high-risk patient.American heart journalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 10 unique genes interacted with ADA. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    ADORA1 Co-localization12150791 CHD related
    DRD1 Co-localization12150791 No
    NR3C1 Reconstituted Complex9154805 CHD related
    ADORA2A Affinity Capture-Western11125033 CHD related
    UBC Affinity Capture-MS21906983|22505724 No
    TERF2IP Two-hybrid21044950 No
    TINF2 Two-hybrid21044950 No
    GRB2 in vitro9299436 CHD related
    DPP4 in vitro11772392 CHD related
    ADORA2B in vitro;in vivo11125033 CHD related


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00552PentostatinFor the treatment of hairy cell leukaemia refractory to alpha interferon.L01XX08
    approvedDB00975DipyridamoleFor as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina.B01AC07;C01DX20
    experimentalDB02096FR221647
    experimentalDB02472"6-Hydroxy-7,8-Dihydro Purine Nucleoside"
    experimentalDB02616FR117016
    experimentalDB02830FR236913
    experimentalDB03015"6-Hydroxy-1,6-Dihydro Purine Nucleoside"
    experimentalDB03220FR233623
    experimentalDB03370FR239087
    experimentalDB03572FR230513
    experimentalDB042181-Deaza-Adenosine
    experimentalDB04440Purine Riboside
    experimentalDB07711"(2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol"
    experimentalDB077831-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
    experimentalDB07785"1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE"
    experimentalDB07786"1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE"