How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ADAMTS13

    Description: "ADAM metallopeptidase with thrombospondin type 1 motif, 13"

    Entrez Gene ID: 11093

    SwissProt Acc Number: Q76LX8

    RefSeq: NM_139025

    It was supported literatures to be a novel CHD related gene:

    .."we were able to observe a significant association between ADAMTS13 900V variant and an increased risk of death (OR: 1,92 CI: 1,14-3,23, p=0,015) or death from cardiac cause (OR:2,67, CI: 1,59-4,49, p=0,0009)."..

    From PMID: 19427680, in Journal Thromb Res. , 2010


    References

    There were 9 potential papers with ADAMTS13 and CHD.

    PMIDTitleJournalsDetails
    22450533 Case report: use of thienopyridines in a patient with acquired idiopathic thrombotic thrombocytopenic purpura.Journal of thrombosis and thrombolysisMore Details
    22915644 Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice.BloodMore Details
    20135067 Prognostic value of plasma von Willebrand factor-cleaving protease (ADAMTS13) antigen levels in patients with coronary artery disease.Thrombosis and haemostasisMore Details
    19427680 Association between ADAMTS13 polymorphisms and risk of cardiovascular events in chronic coronary disease.Thrombosis researchMore Details
    22091368 "Porcine and canine von Willebrand factor and von Willebrand disease: hemostasis, thrombosis, and atherosclerosis studies."ThrombosisMore Details
    19439298 Lower levels of ADAMTS13 are associated with cardiovascular disease in young patients.AtherosclerosisMore Details
    18810578 Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation.Heart and vesselsMore Details
    19085767 Von Willebrand factor: another janus-faced hemostasis protein.Seminars in thrombosis and hemostasisMore Details
    18295305 Changes in plasma von Willebrand factor-cleaving protease (ADAMTS13) levels in patients with unstable angina.Thrombosis researchMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 1 unique genes interacted with ADAMTS13. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    VWF in vitro15824096,12775718 CHD related


    Involved FDA drugs

    There was no drug associated with ADAMTS13