How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ADH1C

    Description: "alcohol dehydrogenase 1C (class I), gamma polypeptide"

    Entrez Gene ID: 126

    SwissProt Acc Number: P00326

    RefSeq: NM_000669

    It was suspected to be CHD related:

    .."Alcohol dehydrogenase 1C (ADH1C or ADH3) genotype reportedly modifies the association between alcohol consumption and coronary heart disease (CHD) risk,"..

    From PMID: 15910847, in Journal Atherosclerosis , 2005


    References

    There were 8 potential papers with ADH1C and CHD.

    PMIDTitleJournalsDetails
    23321361 Is ADH1C genotype relevant for the cardioprotective effect of alcohol?"Alcohol (Fayetteville, N.Y.)"More Details
    23492672 Exploring causal associations between alcohol and coronary heart disease risk factors: findings from a Mendelian randomization study in the Copenhagen General Population Study.European heart journalMore Details
    20700531 The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population.PloS oneMore Details
    17379229 "Alcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men: British Women's Heart and Health Study and Caerphilly cohorts."AtherosclerosisMore Details
    18043297 "Alcohol consumption, alcohol dehydrogenase and risk of coronary heart disease in the MONICA/KORA-Augsburg cohort 1994/1995-2002."European journal of cardiovascular prevention and rehabilitation : officialMore Details
    16051248 "Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status."AtherosclerosisMore Details
    15910847 Genetic variation in alcohol dehydrogenase 1C and the beneficial effect of alcohol intake on coronary heart disease risk in the Second Northwick Park Heart Study.AtherosclerosisMore Details
    14726542 Prospective evaluation of the alcohol dehydrogenase gamma1/gamma2 gene polymorphism and risk of stroke.Stroke; a journal of cerebral circulationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 1 unique genes interacted with ADH1C. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    ADH1C in vitro11274460,1896463,8201622 CHD related


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approved;nutraceuticalDB00157NADH"Some evidence suggests that NADH might be useful in treating Parkinson's disease, chronic fatigue syndrome, Alzheimer's disease and cardiovascular disease."
    approvedDB00898Ethanol"For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical procedures are contraindicated."D01AE06;D08AX08;V03AB16;V03AZ01
    approvedDB01213Fomepizole"Antizol is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis"V03AB34
    experimentalDB01711"2,3,4,5,6-Pentafluorobenzyl Alcohol"
    experimentalDB01907Nicotinamide-Adenine-Dinucleotide
    experimentalDB02131N-1-Methylheptylformamide
    experimentalDB022492-Ethoxyethanol
    experimentalDB02659Cholic AcidA05AA03
    experimentalDB027214-Iodopyrazole
    experimentalDB02757Pyrazole
    experimentalDB02822Para-Bromobenzyl Alcohol
    experimentalDB028713-Butylthiolane 1-Oxide
    experimentalDB030205-Beta-D-Ribofuranosylnicotinamide Adenine Dinucleotide
    experimentalDB03061(R)-N-(1-Methyl-Hexyl)-Formamide
    experimentalDB03226Trifluoroethanol
    experimentalDB03559Cyclohexylformamide
    experimentalDB04071Cpad
    experimentalDB04113N-Formylpiperidine
    experimentalDB04312"2,3-Difluorobenzyl Alcohol"
    experimentalDB04448"2,4-Difluorobenzyl Alcohol 2,4-Difluoro-1-(Hydroxymethyl)Benzene"