How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ADIPOQ

    Description: "adiponectin, C1Q and collagen domain containing"

    Entrez Gene ID: 9370

    SwissProt Acc Number: Q15848

    RefSeq: NM_004797

    It was suspected to be CHD related:

    ..There is an association between ADIPOQ gene polymorphisms and CAD risk...

    From PMID: 22386722, in Journal Thromb Res , 2012


    References

    There were 18 potential papers with ADIPOQ and CHD.

    PMIDTitleJournalsDetails
    23764562 Association of adiponectin (AdipoQ) and sulphonylurea receptor (ABCC8) gene polymorphisms with Type 2 Diabetes in North Indian population of Punjab.GeneMore Details
    22515931 Association of the PPARG Pro12Ala polymorphism with type 2 diabetes and incident coronary heart disease in a Hong Kong Chinese population.Diabetes research and clinical practiceMore Details
    22748670 "Association of the adiponectin gene rs1501299 G>T variant, serum adiponectin levels, and the risk of coronary artery disease in a Chinese population."Diabetes research and clinical practiceMore Details
    22459242 "Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects."Journal of diabetes and its complicationsMore Details
    22386722 Association of ADIPOQ gene polymorphisms and coronary artery disease risk: a meta-analysis based on 12 465 subjects.Thrombosis researchMore Details
    21744264 Association of +45(T/G) and +276(G/T) polymorphisms in the adiponectin gene with coronary artery disease in a population of Iranian patients with type 2 diabetes.Molecular biology reportsMore Details
    22639977 Association between polymorphisms in the adiponectin gene and cardiovascular disease: a meta-analysis.BMC medical geneticsMore Details
    21130994 Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction.AtherosclerosisMore Details
    20930713 Associations of SNPs in ADIPOQ and subclinical cardiovascular disease in the multi-ethnic study of atherosclerosis (MESA)."Obesity (Silver Spring, Md.)"More Details
    19960000 Adiponectin multimers and ADIPOQ T45G in coronary artery disease in Caribbean type 2 diabetic subjects of African descent."Obesity (Silver Spring, Md.)"More Details
    20835900 Genetics of diabetes complications.Current diabetes reportsMore Details
    20395949 Variants in the adiponectin gene and serum adiponectin: the Coronary Artery Development in Young Adults (CARDIA) Study."Obesity (Silver Spring, Md.)"More Details
    20528971 Low plasma adiponectin concentration is associated with myocardial infarction in young individuals.Journal of internal medicineMore Details
    21036322 Genetics of adipose tissue biology.Progress in molecular biology and translational scienceMore Details
    20011104 A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.PLoS geneticsMore Details
    18328815 The influence of the adiponectin gene on adiponectin concentrations and parameters of metabolic syndrome in non-diabetic Korean women.Clinica chimica acta; international journal of clinical chemistryMore Details
    17222292 Common adiponectin gene variants show different effects on risk of cardiovascular disease and type 2 diabetes in European subjects.Annals of human geneticsMore Details
    17065357 Analysis of 14 candidate genes for diabetic nephropathy on chromosome 3q in European populations: strongest evidence for association with a variant in the promoter region of the adiponectin gene.DiabetesMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 3 unique genes interacted with ADIPOQ. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    UBC Affinity Capture-Western22085560 No
    CDH13 in vivo15210937 CHD related
    ADIPOR2 in vivo12802337 CHD related


    Involved FDA drugs

    There was no drug associated with ADIPOQ