How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ADIPOR2

    Description: adiponectin receptor 2

    Entrez Gene ID: 79602

    SwissProt Acc Number: Q86V24

    RefSeq: NM_024551

    It was suspected to be CHD related:

    ..Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes...

    From PMID: 20178558, in Journal Cardiovasc Diabetol. , 2010


    References

    There were 10 potential papers with ADIPOR2 and CHD.

    PMIDTitleJournalsDetails
    23317789 Adiponectin receptors in energy homeostasis and obesity pathogenesis.Progress in molecular biology and translational scienceMore Details
    22534793 Arterial stiffness is associated with increased monocyte expression of adiponectin receptor mRNA and protein in patients with coronary artery disease.American journal of hypertensionMore Details
    21284833 Adiponectin levels and expression of adiponectin receptors in isolated monocytes from overweight patients with coronary artery disease.Cardiovascular diabetologyMore Details
    19793768 Long- but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery disease.European heart journalMore Details
    21808585 Adipocytokines: The pied pipers.Journal of pharmacology & pharmacotherapeuticsMore Details
    20178558 Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes.Cardiovascular diabetologyMore Details
    18931038 Genome-wide linkage scan for genes influencing plasma triglyceride levels in the Veterans Administration Genetic Epidemiology Study.DiabetesMore Details
    17906114 Statin reverses reduction of adiponectin receptor expression in infarcted heart and in TNF-alpha-treated cardiomyocytes in association with improved glucose uptake.American journal of physiology. Heart and circulatory physiologyMore Details
    16634986 Adiponectin--a key adipokine in the metabolic syndrome."Diabetes, obesity & metabolism"More Details
    15149866 Adiponectin and atherosclerotic disease.Clinica chimica acta; international journal of clinical chemistryMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 2 unique genes interacted with ADIPOR2. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    APPL1 Affinity Capture-Western16622416 CHD related
    ADIPOQ in vivo12802337 CHD related


    Involved FDA drugs

    There was no drug associated with ADIPOR2