How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ADM

    Description: adrenomedullin

    Entrez Gene ID: 133

    SwissProt Acc Number: P35318

    RefSeq: NM_001124

    It was suspected to be CHD related:

    .."Of greatest interest, the adrenomedullin (ADM) gene, known to be associated with coronary artery vasodilation, was up-regulated in the acute phase of KD"..

    From PMID: 15531734, in Journal Pediatr Res , 2005


    References

    There were 13 potential papers with ADM and CHD.

    PMIDTitleJournalsDetails
    23499766 Plasma intermedin levels in patients with acute myocardial infarction.PeptidesMore Details
    23283493 Injection of vessel-derived stem cells prevents dilated cardiomyopathy and promotes angiogenesis and endogenous cardiac stem cell proliferation in mdx/utrn-/- but not aged mdx mouse models for duchenne muscular dystrophy.Stem cells translational medicineMore Details
    24147025 Sex-Specific Effects of NLRP6/AVR and ADM Loci on Susceptibility to Essential Hypertension in a Sardinian Population.PloS oneMore Details
    22733501 Mid-regional pro-adrenomedullin in acute heart failure: a better biomarker or just another biomarker?Current heart failure reportsMore Details
    24175071 Adrenomedullin and cardiovascular diseases.JRSM cardiovascular diseaseMore Details
    21909115 Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.NatureMore Details
    22328879 Adrenomedullin concentrations at two time points following myocardial infarction and prediction of mid-term outcomes.Archives of medical science : AMSMore Details
    19247278 Plasma MR-proADM correlates to BMI and decreases in relation to leptin after gastric bypass surgery."Obesity (Silver Spring, Md.)"More Details
    19691035 Detecting SNP-expression associations: a comparison of mutual information and median test with standard statistical approaches.Statistics in medicineMore Details
    19371828 Depression after coronary artery disease is associated with heart failure.Journal of the American College of CardiologyMore Details
    17042897 Effect of adrenergic blockade on plasma adrenomedullin concentration during static handgrip in patients with heart failure.Clinical physiology and functional imagingMore Details
    15531734 Adrenomedullin is highly expressed in blood monocytes associated with acute Kawasaki disease: a microarray gene expression study.Pediatric researchMore Details
    11219192 Increased plasma adrenomedullin in patients undergoing percutaneous transluminal coronary angioplasty.Swiss medical weeklyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 5 unique genes interacted with ADM. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    ADM in vitro;in vivo9620797 CHD related
    MME in vitro8687431 No
    CFH in vitro11116141 CHD related
    EDN1 in vivo11410113 CHD related
    CALCRL in vitro;in vivo9620797 No


    Involved FDA drugs

    There was no drug associated with ADM