How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: ADORA1

    Description: adenosine A1 receptor

    Entrez Gene ID: 134

    SwissProt Acc Number: P30542

    RefSeq: NM_000674

    It was suspected to be CHD related:

    .."Despite this similarity, two genes involved in cardiovascular diseases, ADORA1 and PTGDS, were differentially up-regulated in EAT. These results provide insights about the biology of EAT and its potential implication in CAD."..

    From PMID: 21603615, in Journal PLoS One , 2011


    There were 2 potential papers with ADORA1 and CHD.

    21603615 "The transcriptome of human epicardial, mediastinal and subcutaneous adipose tissues in men with coronary artery disease."PloS oneMore Details
    19691035 Detecting SNP-expression associations: a comparison of mutual information and median test with standard statistical approaches.Statistics in medicineMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 10 unique genes interacted with ADORA1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    DRD1 Affinity Capture-Western10890919 No
    GNAI2 Affinity Capture-Western11369591 No
    ADA Co-localization12150791 CHD related
    P2RY1 Affinity Capture-Western11390975|11390975 CHD related
    GRM1 Affinity Capture-Western11278325|11278325 No
    ATXN1L Two-hybrid16713569 No
    GNAZ in vitro9166747 No
    GNAO1 in vivo10521440 No
    GNAS in vivo10521440 CHD related
    EPB41L2 in vitro;in vivo;yeast 2-hybrid12974671 No

    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00201Caffeine"For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants."N06BC01;N02BE01
    approvedDB00277Theophylline"For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis."R03DA04;R03DA05
    approvedDB00640Adenosine"Used as an initial treatment for the termination of paroxysmal supraventricular tachycardia (PVST), including that associated with accessory bypass tracts, and is a drug of choice for terminating stable, narrow-complex supraventricular tachycardias (SVT). Also used as an adjunct to thallous chloride TI 201 myocardial perfusion scintigraphy (thallium stress test) in patients who are unable to exercise adequately, as well as an adjunct to vagal maneuvers and clinical assessment to establish a specific diagnosis of undefined, stable, narrow-complex SVT."C01EB10
    approvedDB00651DyphyllineFor relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema.R03DA01
    approvedDB00806PentoxifyllineFor the treatment of patients with intermittent lameness or immobility arising from chronic occlusive arterial disease of the limbs.C04AD03
    approvedDB00996GabapentinFor the management of postherpetic neuralgia in adults and as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy.N03AX12
    approvedDB01223Aminophylline"For the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis."R03DA05
    approvedDB01303Oxtriphylline"Used to treat the symptoms of asthma, bronchitis, and emphysema."R03DA02
    approvedDB04932Defibrotide"Defibrotide is used to treat or prevent a failure of normal blood flow (occlusive venous disease, OVD) in the liver of patients who have had bone marrow transplants or received certain drugs such as oral estrogens, mercaptopurine, and many others. "B01AX01