How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ADRB1

    Description: "adrenergic, beta-1-, receptor"

    Entrez Gene ID: 153

    SwissProt Acc Number: P08588

    RefSeq: NM_000684

    It was suspected to be CHD related:

    ..Numerous studies have demonstrated that beta(1)- and beta(2)-adrenergic receptor gene (ADRB1 and ADRB2) variants influence cardiovascular risk and beta-blocker responses in hypertension and heart failure...

    From PMID: 18615004, in Journal Clin Pharmacol Ther. , 2008


    References

    There were 8 potential papers with ADRB1 and CHD.

    PMIDTitleJournalsDetails
    24201118 Significant role of ADRB3 rs4994 towards the development of coronary artery disease.Coronary artery diseaseMore Details
    23303523 Loci influencing blood pressure identified using a cardiovascular gene-centric array.Human molecular geneticsMore Details
    22949529 G protein receptor kinase 4 polymorphisms: beta-blocker pharmacogenetics and treatment-related outcomes in hypertension.HypertensionMore Details
    21880673 Protein interaction-based genome-wide analysis of incident coronary heart disease.Circulation. Cardiovascular geneticsMore Details
    18615004 beta-adrenergic receptor gene polymorphisms and beta-blocker treatment outcomes in hypertension.Clinical pharmacology and therapeuticsMore Details
    18413560 Association of beta1-adrenergic receptor genetic polymorphism with mental stress-induced myocardial ischemia in patients with coronary artery disease.Archives of internal medicineMore Details
    17211240 "C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci."Journal of hypertensionMore Details
    15917856 Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study.International journal of obesity (2005)More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 15 unique genes interacted with ADRB1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    GIPC1 Two-hybrid12724327|12724327 No
    ARRB1 Reconstituted Complex10862778|10862778 No
    GRB2 in vitro9843378 CHD related
    SH3GL2 in vitro;in vivo;yeast 2-hybrid10535961 No
    SH3GL3 yeast 2-hybrid10535961 No
    DLG1 in vitro16316992 No
    GOPC in vitro16316992 No
    DLG4 Affinity Capture-Western10995758|10995758|10995758|11526121|10995758,16316992 No
    MAGI2 Affinity Capture-Western11526121|11526121 No
    DLGAP2 in vitro11700307 No
    ADRA2A in vivo12529373 No
    GPRASP1 in vitro15452121 No
    MAGI3 in vitro;in vivo;in vivo16316992 No
    NOS1 in vivo12184796 CHD related
    GPRASP2 in vitro15086532 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00187Esmolol"For the rapid control of ventricular rate in patients with atrial fibrillation or atrial flutter in perioperative, postoperative, or other emergent circumstances where short term control of ventricular rate with a short-acting agent is desirable. Also used in noncompensatory sinus tachycardia where the rapid heart rate requires specific intervention."C07AB09
    approvedDB00195BetaxololFor the management of hypertension.C07AB05;S01ED02
    approvedDB00221Isoetharine"For the treatment of asthma, wheezing, and chronic asthmatic bronchitis."R03AC07;R03CC06
    approvedDB00264Metoprolol"For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches."C07AB02;C07AB52
    approvedDB00335AtenololFor the management of hypertention and long-term management of patients with angina pectorisC07AB03;C07AB11
    approvedDB00368NorepinephrineMainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.C01CA03
    approvedDB00373Timolol"In its oral form it is used to treat high blood pressure and prevent heart attacks, and occasionally to prevent migraine headaches. In its opthalmic form it is used to treat open-angle and occasionally secondary glaucoma."C07AA06;S01ED01
    approved;withdrawnDB00397Phenylpropanolamine"For the treatment of nasal congestion, control of urinary incontinence, priapism and obesity."R01BA01
    approvedDB00489SotalolFor the maintenance of normal sinus rhythm [delay in time to recurrence of atrial fibrillation/atrial flutter (AFIB/AFL)] in patients with symptomatic AFIB/AFL who are currently in sinus rhythm. Also for the treatment of documented life-threatening ventricular arrhythmias.C07AA07;C07AA57
    approvedDB00521CarteololFor the treatment of intraocular hypertension and chronic open-angle glaucomaC07AA15;S01ED05
    approvedDB00571PropranololFor the prophylaxis of migraine.C07AA05
    approvedDB00598Labetalol"For the management of hypertension (alone or in combination with other classes of antihypertensive agents), as well as chronic stable angina pectoris and sympathetic overactivity syndrome associated with severe tetanus. Labetalol is used parenterally for immediate reduction in blood pressure in severe hypertension or in hypertensive crises when considered an emergency, for the control of blood pressure in patients with pheochromocytoma and pregnant women with preeclampsia, and to produce controlled hypotension during anesthesia to reduce bleeding resulting from surgical procedures."C07AG01
    approvedDB00612Bisoprolol"For management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI). "C07AB07
    approvedDB00668EpinephrineUsed to treat anaphylaxis and sepsis. Also one of the body's main adrenergic neurotransmitters.A01AD01;B02BC09;C01CA03;C01CA24;R01AA14;R03AA01;S01EA01
    approvedDB00841DobutamineFor inotropic support in the short- term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical proceduresC01CA07
    approvedDB00852Pseudoephedrine"For the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism."R01BA02
    approvedDB00866Alprenolol"For the treatment of hypertension, angina, and arrhythmia"C07AA01
    approvedDB00960Pindolol"For the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation."C07AA03;C07AA14;C07AA17
    approvedDB01001Salbutamol"For symptomatic relief and prevention of bronchospasm due to bronchial asthma, chronic bronchitis, and other chronic bronchopulmonary disorders such as COPD. "R03CC02;R03AC02
    approvedDB01064IsoproterenolFor the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitisC01CA02;D08AX05
    approvedDB01102Arbutamine"Used to elicit acute cardiovascular responses (cardiac stumulant), similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in patients who cannot exercise adequately."C01CA22
    approvedDB01118Amiodarone"Intravenously, for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. Orally, for the treatment of life-threatening recurrent ventricular arrhythmias such as recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia."C01BD01
    approvedDB01136CarvedilolFor the treatment of mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.C07AG02
    approvedDB01151Desipramine"For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management. "N06AA01
    approvedDB01193AcebutololFor the management of hypertension and ventricular premature beats in adults.C07AB04
    approvedDB01203Nadolol"Used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension."C07AA12
    approvedDB01210LevobunololFor lowering intraocular pressure (IOP) and may be used in patients with chronic open-angle glaucoma or ocular hypertension.S01ED03
    approvedDB01214MetipranololIndicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open angle glaucoma.S01ED04
    approvedDB01288FenoterolFenoterol is used for the treatment of asthma.R03CC04;G02CA03;R03AC04
    approvedDB01291PirbuterolFor the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible bronchospasm including asthma.R03AC08;R03CC07
    approvedDB01295BevantololFor the treatment of angina pectoris and hypertension.C07AB06
    approvedDB01297PractololUsed in the emergency treatment of cardiac arrhythmias.C07AB01
    approvedDB01359PenbutololUsed in the treatment of high blood pressure.C07AA23
    approved;withdrawn;nutraceuticalDB01363Ephedra"Ephedra is widely used by athletes, despite a lack of evidence that it enhances athletic performance. Ephedra has also been used for weight loss."
    approvedDB01407ClenbuterolUsed as a bronchodilator in the treatment of asthma patients. R03CC13;R03AC14
    approvedDB01580Oxprenolol"Used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety."C07AA02
    approvedDB04861NebivololFor the treatment of essential hypertension.C07AB12
    approvedDB06262Droxidopa"For treatment of neurogenic orthostatic hypotension (NOH) associated with various disorders including Multiple System Atrophy, Familial Amyloid Polyneuropathy, hemodialysis induced hypotension and Parkinson's Disease. Also investigated for use/treatment in neurologic disorders, nephropathy, blood (blood forming organ disorders, unspecified), and dizzy/fainting spells."
    experimentalDB083474-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile
    experimentalDB08558"2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL"
    approvedDB08807Bopindolol"For the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation."C07AA17
    approvedDB08808BupranololUsed to manage hypertension and tachycardia. Also used to treat glaucoma.C07AA19