How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ADRB3

    Description: "adrenergic, beta-3-, receptor"

    Entrez Gene ID: 155

    SwissProt Acc Number: P13945

    RefSeq: NM_000025

    It was suspected to be CHD related:

    .."including Ala/Ala of SCYA11 (eotaxin) Ala23Thr, Cys/Cys or Cys/Ser of PON2 (paraoxonase 2) Ser311Cys and Arg/Arg of ADRB3 (beta3-adrenergic receptor) Trp64Arg, were independently associated with incident cardiac end-point,"..

    From PMID: 20536507, in Journal Diabet Med , 2010


    References

    There were 7 potential papers with ADRB3 and CHD.

    PMIDTitleJournalsDetails
    24201118 Significant role of ADRB3 rs4994 towards the development of coronary artery disease.Coronary artery diseaseMore Details
    20536507 "Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients."Diabetic medicine : a journal of the British Diabetic AssociationMore Details
    18088254 T64A polymorphism in beta3-adrenergic receptor gene (ADRB3) and coronary heart disease: a case-cohort study and meta-analysis.Journal of internal medicineMore Details
    17825092 Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography.Cardiovascular diabetologyMore Details
    15917856 Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study.International journal of obesity (2005)More Details
    15193960 Ethnic differences of coronary artery disease-associated SNPs in two Israeli healthy populations using MALDI-TOF mass spectrometry.Life sciencesMore Details
    12124994 Highly multiplexed genotyping of coronary artery disease-associated SNPs using MALDI-TOF mass spectrometry.Human mutationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 4 unique genes interacted with ADRB3. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    SRC Affinity Capture-Western11013230 CHD related
    ADRB2 in vivo15123695 CHD related
    ADRB3 in vivo15123695 CHD related
    GNAS in vivo8011597 CHD related


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00368NorepinephrineMainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.C01CA03
    approvedDB00571PropranololFor the prophylaxis of migraine.C07AA05
    approvedDB01064IsoproterenolFor the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitisC01CA02;D08AX05
    approvedDB01102Arbutamine"Used to elicit acute cardiovascular responses (cardiac stumulant), similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in patients who cannot exercise adequately."C01CA22
    approvedDB01288FenoterolFenoterol is used for the treatment of asthma.R03CC04;G02CA03;R03AC04
    approved;withdrawn;nutraceuticalDB01363Ephedra"Ephedra is widely used by athletes, despite a lack of evidence that it enhances athletic performance. Ephedra has also been used for weight loss."
    approvedDB01407ClenbuterolUsed as a bronchodilator in the treatment of asthma patients. R03CC13;R03AC14
    approvedDB06262Droxidopa"For treatment of neurogenic orthostatic hypotension (NOH) associated with various disorders including Multiple System Atrophy, Familial Amyloid Polyneuropathy, hemodialysis induced hypotension and Parkinson's Disease. Also investigated for use/treatment in neurologic disorders, nephropathy, blood (blood forming organ disorders, unspecified), and dizzy/fainting spells."
    approvedDB08807Bopindolol"For the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation."C07AA17
    approvedDB08808BupranololUsed to manage hypertension and tachycardia. Also used to treat glaucoma.C07AA19