How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: AGT

    Description: "angiotensinogen (serpin peptidase inhibitor, clade A, member 8)"

    Entrez Gene ID: 183

    SwissProt Acc Number: P01019

    RefSeq: NM_000029

    It was suspected to be CHD related:

    .."Abnormalities in genetic components of this system, such as the angiotensin-converting enzyme (ACE) gene, angiotensin II type 1 (AT1) receptor gene and angiotensinogen (AGT) gene, may cause a variety of adverse cardiovascular effects. "..

    From PMID: 14997233, in Journal Cardiovasc J S Afr , 2004


    There were 49 potential papers with AGT and CHD.

    23943853 Human angiotensinogen +11525 C/A polymorphism modulates its gene expression through microRNA binding.Physiological genomicsMore Details
    23610575 Association between T174M polymorphism in the angiotensinogen gene and risk of coronary artery disease: a meta-analysis.Journal of geriatric cardiology : JGCMore Details
    23137822 The M235T single nucleotide polymorphism in the angiotensinogen gene is associated with coronary artery calcium in patients with a family history of coronary artery disease.AtherosclerosisMore Details
    22791700 "AGT gene polymorphisms (M235T, T174M) are associated with coronary heart disease in a Chinese population."Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    23592589 A study on the polymorphisms of the renin-angiotensin system pathway genes for their effect on blood pressure levels in males from Algeria.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    23407050 Genetic variation-optimized treatment benefit of angiotensin-converting enzyme inhibitors in patients with stable coronary artery disease: a 12-year follow-up study.Pharmacogenetics and genomicsMore Details
    22739771 Genetic variation in the renin-angiotensin-aldosterone system is associated with cardiovascular risk factors and early mortality in established coronary heart disease.Journal of human hypertensionMore Details
    23497386 Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population.BMC cardiovascular disordersMore Details
    22842872 Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: a meta-analysis.Molecular medicine reportsMore Details
    22387727 Renin-angiotensin system genes polymorphism in Egyptians with premature coronary artery disease.GeneMore Details
    22388798 Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.Pharmacogenetics and genomicsMore Details
    22194326 Enhanced external counterpulsation improves peripheral artery function and glucose tolerance in subjects with abnormal glucose tolerance."Journal of applied physiology (Bethesda, Md. : 1985)"More Details
    21450564 Prediabetes influences cardiac rehabilitation in coronary artery disease patients.European journal of preventive cardiologyMore Details
    22508051 Renin-angiotensin-aldosterone system gene polymorphisms and coronary artery disease: detection of gene-gene and gene-environment interactions.Cellular physiology and biochemistry : international journal of experimentalMore Details
    21184753 Polygenetic regression model of renin-angiotensin system genes and the risk of coronary artery disease in a large angiographic population.Clinica chimica acta; international journal of clinical chemistryMore Details
    20663844 Angiotensinogen gene polymorphism in acute myocardial infarction patients.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    21657802 Influence of renin-angiotensin system gene polymorphisms on the risk of ST-segment-elevation myocardial infarction and association with coronary artery disease risk factors.Molecular diagnosis & therapyMore Details
    20547537 Endothelial nitric oxide synthase and angiotensinogen gene polymorphism in coronary artery diseases in Egypt.AngiologyMore Details
    20529973 Polymorphisms of renin-angiotensin system and natriuretic peptide receptor A genes in patients of Greek origin with a history of myocardial infarction.AngiologyMore Details
    20223792 Renin-angiotensin-aldosterone system gene polymorphisms in coronary artery bypass graft surgery patients.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    20580725 Genotypic interactions of renin-angiotensin system genes with diabetes type 2 in a Tunisian population.Life sciencesMore Details
    20075747 New evidence for the fetal insulin hypothesis: fetal angiotensinogen M235T polymorphism is associated with birth weight and elevated fetal total glycated hemoglobin at birth.Journal of hypertensionMore Details
    20448352 [Relationship between T704C polymorphism of angiotensinogen gene and cerebral hemorrhage in Han people in Changsha].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University.More Details
    20861628 Association between genetic polymorphisms in the renin-angiotensin system and systolic heart failure revised by a propensity score-based analysis.CardiologyMore Details
    20863224 Regressive course of oxalate deposition in primary hyperoxaluria after kidney transplantation.Renal failureMore Details
    18710472 "Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians."Clinical endocrinologyMore Details
    18653189 "Interaction of gender, hypertension, and the angiotensinogen gene haplotypes on the risk of coronary artery disease in a large angiographic cohort."AtherosclerosisMore Details
    19779330 The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age.Coronary artery diseaseMore Details
    19185300 A propensity score-based case-control study of renin-angiotensin system gene polymorphisms and diastolic heart failure.AtherosclerosisMore Details
    19327134 Genetic polymorphisms of angiotensin-2 type 1 receptor and angiotensinogen and risk of renal dysfunction and coronary heart disease in type 2 diabetes mellitus.BMC nephrologyMore Details
    19089753 "Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction."Scandinavian journal of clinical and laboratory investigationMore Details
    17683517 The Mediterranean paradox for susceptibility factors in coronary heart disease extends to genetics.Annals of human geneticsMore Details
    18637188 "RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population."BMC cardiovascular disordersMore Details
    18575631 The M235T polymorphism in the AGT gene and CHD risk: evidence of a Hardy-Weinberg equilibrium violation and publication bias in a meta-analysis.PloS oneMore Details
    18409009 The M235T polymorphism of the AGT gene modifies the risk of coronary artery disease associated with the presence of hypercholesterolemia.European journal of epidemiologyMore Details
    17118372 Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction.AtherosclerosisMore Details
    17327458 Polymorphisms of the renin-angiotensin system genes predict progression of subclinical coronary atherosclerosis.DiabetesMore Details
    17429448 "Polymorphisms of angiotensinogen and angiotensin-converting enzyme associated with lower extremity arterial disease in the Health, Aging and Body Composition study."Journal of human hypertensionMore Details
    16492203 Association analysis of genes in the renin-angiotensin system with subclinical cardiovascular disease in families with Type 2 diabetes mellitus: the Diabetes Heart Study.Diabetic medicine : a journal of the British Diabetic AssociationMore Details
    15869758 Metabolic syndrome in aboriginal Canadians: prevalence and genetic associations.AtherosclerosisMore Details
    15599691 Association of angiotensinogen haplotypes with angiotensinogen levels but not with blood pressure or coronary artery disease: the Ludwigshafen Risk and Cardiovascular Health Study."Journal of molecular medicine (Berlin, Germany)"More Details
    16088850 Renin-angiotensin system gene polymorphisms and premature coronary heart disease.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    15563875 Association between the eNOS (Glu298Asp) and the RAS genes polymorphisms and premature coronary artery disease in a Turkish population.Clinica chimica acta; international journal of clinical chemistryMore Details
    15699455 Hypertension genes are genetic markers for insulin sensitivity and resistance.HypertensionMore Details
    15226212 Postmenopausal hormone therapy is associated with atherosclerosis progression in women with abnormal glucose tolerance.CirculationMore Details
    12938141 "Coronary heart disease, hypertension, and angiotensinogen gene variants in Indian population."Journal of clinical laboratory analysisMore Details
    12124994 Highly multiplexed genotyping of coronary artery disease-associated SNPs using MALDI-TOF mass spectrometry.Human mutationMore Details
    11317203 Polymorphisms of the renin-angiotensin system in patients with multifocal renal arterial fibromuscular dysplasia.Journal of human hypertensionMore Details
    10731400 "Searching for a better assessment of the individual coronary risk profile. The role of angiotensin-converting enzyme, angiotensin II type 1 receptor and angiotensinogen gene polymorphisms."European heart journalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 18 unique genes interacted with AGT. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    EWSR1 Two-hybrid16189514|16189514 No
    ENPEP in vitro1756856 No
    AGTR1 in vivo15930094 CHD related
    AGT in vitro1756856,11709400 CHD related
    GRB2 Two-hybrid18624398 CHD related
    TP53 Two-hybrid22416758 CHD related
    ITSN2 Two-hybrid22558309 No
    PRCP in vitro28321 No
    CTSG in vitro10899625,11747312 No
    CMA1 in vitro10899625 CHD related
    MAS1 in vitro12829792 No
    KNG1 in vivo11677365 No
    AGTR2 in vivo8185599 CHD related
    ACE2 in vitro10969042,11815627 CHD related
    MEP1A in vitro11278902 No
    PREP in vitro12173 No
    PRG2 in vitro7539791 No
    DNPEP in vivo12895663 No

    Involved FDA drugs

    There was no drug associated with AGT