Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)
Website using assistance : Leihong Wu (11019004@zju.edu.cn)
Coronary Heart Disease Research Platform
Description: "angiotensinogen (serpin peptidase inhibitor, clade A, member 8)"
Entrez Gene ID: 183
SwissProt Acc Number: P01019
RefSeq: NM_000029
It was suspected to be CHD related:
.."Abnormalities in genetic components of this system, such as the angiotensin-converting enzyme (ACE) gene, angiotensin II type 1 (AT1) receptor gene and angiotensinogen (AGT) gene, may cause a variety of adverse cardiovascular effects. "..
From PMID: 14997233, in Journal Cardiovasc J S Afr , 2004There were 49 potential papers with AGT and CHD.
| PMID | Title | Journals | Details |
|---|---|---|---|
| 23943853 | Human angiotensinogen +11525 C/A polymorphism modulates its gene expression through microRNA binding. | Physiological genomics | More Details |
| 23610575 | Association between T174M polymorphism in the angiotensinogen gene and risk of coronary artery disease: a meta-analysis. | Journal of geriatric cardiology : JGC | More Details |
| 23137822 | The M235T single nucleotide polymorphism in the angiotensinogen gene is associated with coronary artery calcium in patients with a family history of coronary artery disease. | Atherosclerosis | More Details |
| 22791700 | "AGT gene polymorphisms (M235T, T174M) are associated with coronary heart disease in a Chinese population." | Journal of the renin-angiotensin-aldosterone system : JRAAS | More Details |
| 23592589 | A study on the polymorphisms of the renin-angiotensin system pathway genes for their effect on blood pressure levels in males from Algeria. | Journal of the renin-angiotensin-aldosterone system : JRAAS | More Details |
| 23407050 | Genetic variation-optimized treatment benefit of angiotensin-converting enzyme inhibitors in patients with stable coronary artery disease: a 12-year follow-up study. | Pharmacogenetics and genomics | More Details |
| 22739771 | Genetic variation in the renin-angiotensin-aldosterone system is associated with cardiovascular risk factors and early mortality in established coronary heart disease. | Journal of human hypertension | More Details |
| 23497386 | Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population. | BMC cardiovascular disorders | More Details |
| 22842872 | Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: a meta-analysis. | Molecular medicine reports | More Details |
| 22387727 | Renin-angiotensin system genes polymorphism in Egyptians with premature coronary artery disease. | Gene | More Details |
| 22388798 | Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study. | Pharmacogenetics and genomics | More Details |
| 22194326 | Enhanced external counterpulsation improves peripheral artery function and glucose tolerance in subjects with abnormal glucose tolerance. | "Journal of applied physiology (Bethesda, Md. : 1985)" | More Details |
| 21450564 | Prediabetes influences cardiac rehabilitation in coronary artery disease patients. | European journal of preventive cardiology | More Details |
| 22508051 | Renin-angiotensin-aldosterone system gene polymorphisms and coronary artery disease: detection of gene-gene and gene-environment interactions. | Cellular physiology and biochemistry : international journal of experimental | More Details |
| 21184753 | Polygenetic regression model of renin-angiotensin system genes and the risk of coronary artery disease in a large angiographic population. | Clinica chimica acta; international journal of clinical chemistry | More Details |
| 20663844 | Angiotensinogen gene polymorphism in acute myocardial infarction patients. | Journal of the renin-angiotensin-aldosterone system : JRAAS | More Details |
| 21657802 | Influence of renin-angiotensin system gene polymorphisms on the risk of ST-segment-elevation myocardial infarction and association with coronary artery disease risk factors. | Molecular diagnosis & therapy | More Details |
| 20547537 | Endothelial nitric oxide synthase and angiotensinogen gene polymorphism in coronary artery diseases in Egypt. | Angiology | More Details |
| 20529973 | Polymorphisms of renin-angiotensin system and natriuretic peptide receptor A genes in patients of Greek origin with a history of myocardial infarction. | Angiology | More Details |
| 20223792 | Renin-angiotensin-aldosterone system gene polymorphisms in coronary artery bypass graft surgery patients. | Journal of the renin-angiotensin-aldosterone system : JRAAS | More Details |
| 20580725 | Genotypic interactions of renin-angiotensin system genes with diabetes type 2 in a Tunisian population. | Life sciences | More Details |
| 20075747 | New evidence for the fetal insulin hypothesis: fetal angiotensinogen M235T polymorphism is associated with birth weight and elevated fetal total glycated hemoglobin at birth. | Journal of hypertension | More Details |
| 20448352 | [Relationship between T704C polymorphism of angiotensinogen gene and cerebral hemorrhage in Han people in Changsha]. | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. | More Details |
| 20861628 | Association between genetic polymorphisms in the renin-angiotensin system and systolic heart failure revised by a propensity score-based analysis. | Cardiology | More Details |
| 20863224 | Regressive course of oxalate deposition in primary hyperoxaluria after kidney transplantation. | Renal failure | More Details |
| 18710472 | "Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians." | Clinical endocrinology | More Details |
| 18653189 | "Interaction of gender, hypertension, and the angiotensinogen gene haplotypes on the risk of coronary artery disease in a large angiographic cohort." | Atherosclerosis | More Details |
| 19779330 | The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age. | Coronary artery disease | More Details |
| 19185300 | A propensity score-based case-control study of renin-angiotensin system gene polymorphisms and diastolic heart failure. | Atherosclerosis | More Details |
| 19327134 | Genetic polymorphisms of angiotensin-2 type 1 receptor and angiotensinogen and risk of renal dysfunction and coronary heart disease in type 2 diabetes mellitus. | BMC nephrology | More Details |
| 19089753 | "Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction." | Scandinavian journal of clinical and laboratory investigation | More Details |
| 17683517 | The Mediterranean paradox for susceptibility factors in coronary heart disease extends to genetics. | Annals of human genetics | More Details |
| 18637188 | "RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population." | BMC cardiovascular disorders | More Details |
| 18575631 | The M235T polymorphism in the AGT gene and CHD risk: evidence of a Hardy-Weinberg equilibrium violation and publication bias in a meta-analysis. | PloS one | More Details |
| 18409009 | The M235T polymorphism of the AGT gene modifies the risk of coronary artery disease associated with the presence of hypercholesterolemia. | European journal of epidemiology | More Details |
| 17118372 | Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction. | Atherosclerosis | More Details |
| 17327458 | Polymorphisms of the renin-angiotensin system genes predict progression of subclinical coronary atherosclerosis. | Diabetes | More Details |
| 17429448 | "Polymorphisms of angiotensinogen and angiotensin-converting enzyme associated with lower extremity arterial disease in the Health, Aging and Body Composition study." | Journal of human hypertension | More Details |
| 16492203 | Association analysis of genes in the renin-angiotensin system with subclinical cardiovascular disease in families with Type 2 diabetes mellitus: the Diabetes Heart Study. | Diabetic medicine : a journal of the British Diabetic Association | More Details |
| 15869758 | Metabolic syndrome in aboriginal Canadians: prevalence and genetic associations. | Atherosclerosis | More Details |
| 15599691 | Association of angiotensinogen haplotypes with angiotensinogen levels but not with blood pressure or coronary artery disease: the Ludwigshafen Risk and Cardiovascular Health Study. | "Journal of molecular medicine (Berlin, Germany)" | More Details |
| 16088850 | Renin-angiotensin system gene polymorphisms and premature coronary heart disease. | Journal of the renin-angiotensin-aldosterone system : JRAAS | More Details |
| 15563875 | Association between the eNOS (Glu298Asp) and the RAS genes polymorphisms and premature coronary artery disease in a Turkish population. | Clinica chimica acta; international journal of clinical chemistry | More Details |
| 15699455 | Hypertension genes are genetic markers for insulin sensitivity and resistance. | Hypertension | More Details |
| 15226212 | Postmenopausal hormone therapy is associated with atherosclerosis progression in women with abnormal glucose tolerance. | Circulation | More Details |
| 12938141 | "Coronary heart disease, hypertension, and angiotensinogen gene variants in Indian population." | Journal of clinical laboratory analysis | More Details |
| 12124994 | Highly multiplexed genotyping of coronary artery disease-associated SNPs using MALDI-TOF mass spectrometry. | Human mutation | More Details |
| 11317203 | Polymorphisms of the renin-angiotensin system in patients with multifocal renal arterial fibromuscular dysplasia. | Journal of human hypertension | More Details |
| 10731400 | "Searching for a better assessment of the individual coronary risk profile. The role of angiotensin-converting enzyme, angiotensin II type 1 receptor and angiotensinogen gene polymorphisms." | European heart journal | More Details |
NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.
There were totally 18 unique genes interacted with AGT. Show PPI network
| Gene name | Interaction type | reference PMID | CHD relation |
|---|---|---|---|
| EWSR1 | Two-hybrid | 16189514|16189514 | No |
| ENPEP | in vitro | 1756856 | No |
| AGTR1 | in vivo | 15930094 | CHD related |
| AGT | in vitro | 1756856,11709400 | CHD related |
| GRB2 | Two-hybrid | 18624398 | CHD related |
| TP53 | Two-hybrid | 22416758 | CHD related |
| ITSN2 | Two-hybrid | 22558309 | No |
| PRCP | in vitro | 28321 | No |
| CTSG | in vitro | 10899625,11747312 | No |
| CMA1 | in vitro | 10899625 | CHD related |
| MAS1 | in vitro | 12829792 | No |
| KNG1 | in vivo | 11677365 | No |
| AGTR2 | in vivo | 8185599 | CHD related |
| ACE2 | in vitro | 10969042,11815627 | CHD related |
| MEP1A | in vitro | 11278902 | No |
| PREP | in vitro | 12173 | No |
| PRG2 | in vitro | 7539791 | No |
| DNPEP | in vivo | 12895663 | No |
There was no drug associated with AGT