How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: AGTR2

    Description: "angiotensin II receptor, type 2"

    Entrez Gene ID: 186

    SwissProt Acc Number: P50052

    RefSeq: NM_000686

    It was suspected to be CHD related:

    ..A genetic polymorphism in the angiotensin II type 2 receptor (AGTR2 +1675G/A) has been associated with left ventricular hypertrophy..

    From PMID: 20467270, in Journal J Hypertens , 2010


    References

    There were 1 potential papers with AGTR2 and CHD.

    PMIDTitleJournalsDetails
    20467270 Role of the angiotensin II type 2 receptor gene (+1675G/A) polymorphism on left ventricular hypertrophy and geometry in treated hypertensive patients.Journal of hypertensionMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 9 unique genes interacted with AGTR2. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    MTUS1 Two-hybrid15123706|15123706 No
    AGTRAP Reconstituted Complex11733189 No
    ERBB3 yeast 2-hybrid10710290 No
    AGT in vivo8185599 CHD related
    ACE in vivo11459796 CHD related
    PIK3CB in vivo11459796 No
    ZBTB16 in vitro;yeast 2-hybrid14657020 No
    GNAI2 in vitro8663053,11055978 No
    GNAI3 in vitro8663053,11055978 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB01349TasosartanTasosartan is infrequently in the treatment of hypertension and heart failure.C09CA05