How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: AKT1

    Description: v-akt murine thymoma viral oncogene homolog 1

    Entrez Gene ID: 207

    SwissProt Acc Number: P31749

    RefSeq: NM_001014431

    It was suspected to be CHD related:

    ..The AKT1-expressing lentiviral vector resulted in stable over-expression of AKT1 in MSCs...

    From PMID: 20819633, in Journal Chin Med J (Engl) , 2010


    References

    There were 7 potential papers with AKT1 and CHD.

    PMIDTitleJournalsDetails
    22940215 Suppression of post-angioplasty restenosis with an Akt1 siRNA-embedded coronary stent in a rabbit model.BiomaterialsMore Details
    21986482 "Caffeic acid phenethyl ester inhibits proliferation and migration, and induces apoptosis in platelet-derived growth factor-BB-stimulated human coronary smooth muscle cells."Journal of vascular researchMore Details
    22347652 Insulin receptor substrate-1 expression is increased in circulating leukocytes of patients with acute coronary syndrome.ISRN cardiologyMore Details
    20112301 Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats.Molecular nutrition & food researchMore Details
    19762778 Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis."Arteriosclerosis, thrombosis, and vascular biology"More Details
    18054314 Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease.Cell metabolismMore Details
    16487854 Cardioprotective effects of granulocyte colony-stimulating factor in swine with chronic myocardial ischemia.Journal of the American College of CardiologyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 232 unique genes interacted with AKT1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    AR Reconstituted Complex11404460|11404460|11404460,11156376,16210317 CHD related
    PAK1 Reconstituted Complex14749719|12138087 CHD related
    ARHGAP29 Two-hybrid14749388 No
    AKTIP Affinity Capture-Western14749367|14749367 No
    TRIB3 Reconstituted Complex12791994 CHD related
    IRAK1 Affinity Capture-Western11976320|11976320 CHD related
    IMPDH2 Two-hybrid10930578|10930578|10930578 No
    BRAF Affinity Capture-Western10869359|10869359|10869359,11410590 No
    HSPB1 Affinity Capture-Western11042204 No
    MAPKAPK2 Affinity Capture-Western11042204 No
    MAPK14 Affinity Capture-Western11042204 CHD related
    CHN2 Reconstituted Complex11278894 No
    KTN1 Two-hybrid11162552 No
    RAF1 Biochemical Activity10576742|10576742,19058874 CHD related
    BAD Reconstituted Complex11500364|11994280|15998799|15998799|9381178 CHD related
    MTOR Reconstituted Complex10910062|14970221|11438723,10910062 CHD related
    GSK3B Reconstituted Complex16009706|19995607|16123141|15470047|20856200|14645548|11035810,8524413 CHD related
    TERT Affinity Capture-Western15843522|10224060 CHD related
    Akt2 Phenotypic Enhancement15545269 No
    CARHSP1 Reconstituted Complex15910284 No
    PAK6 Reconstituted Complex11773441 No
    CDKN1B Biochemical Activity12042314|12244301 CHD related
    NR4A1 Affinity Capture-Western11274386|11274386|11274386 CHD related
    MAP2K4 Affinity Capture-Western11707464|11707464|15998799|11707464 No
    TCL1B Affinity Capture-Western10983986 No
    HSP90AB1 Affinity Capture-Western10995457 CHD related
    CHUK Affinity Capture-Western10485710|10485710|10485711|17962807|10485710 CHD related
    MAPK8IP1 Affinity Capture-Western12194869|15998799 No
    PKN2 Two-hybrid10926925 No
    MAP3K8 Affinity Capture-Western12138205|12138205|12138205 No
    YWHAZ Affinity Capture-Western11956222|11956222|11956222|16027165|11956222 No
    ARFIP2 Two-hybrid9312003 No
    NPM1 Reconstituted Complex18931307|18931307 No
    STUB1 Affinity Capture-Western18292230 No
    UBC Affinity Capture-Western18292230|12750378|11923280|20059950|21045808|20336670|22410793 No
    MARK2 Affinity Capture-Western18292230 No
    NF2 Affinity Capture-Western17891137|17891137 No
    PIAS1 Two-hybrid17533377 No
    PIAS2 Two-hybrid17533377 No
    NCOR2 Biochemical Activity16613989 No
    ACTA1 Affinity Capture-Western16568092 CHD related
    SMARCC1 Affinity Capture-Western16568092|16568092 No
    SMARCC2 Affinity Capture-Western16568092 No
    FOXO1 Biochemical Activity16076959|10358014 CHD related
    HSPA4 Affinity Capture-Western12750378 No
    NOTCH1 Biochemical Activity18440314 CHD related
    IKBKB Affinity Capture-Western15856005|10485711 CHD related
    EP300 Affinity Capture-Western18182168|11116148 CHD related
    SETDB1 Two-hybrid17577629|17577629|17577629 No
    CREBBP Reconstituted Complex19995607|19995607 No
    GSK3A Biochemical Activity19995607|11509608|17505062|14645548|11035810,11884598,8524413 No
    DNMT1 Biochemical Activity21151116|21151116 No
    ERBB3 Affinity Capture-Western21930127 No
    TRIM13 Affinity Capture-Western21333377 No
    TTC3 Affinity Capture-Western20059950 No
    ESR1 Biochemical Activity11139588|11139588 CHD related
    NCOA4 Two-hybrid18624398 No
    APOH Two-hybrid18624398 CHD related
    ASXL1 Two-hybrid18624398 No
    BPGM Two-hybrid18624398 No
    COMMD1 Two-hybrid18624398 No
    DNAJB1 Two-hybrid18624398 No
    PPL Two-hybrid18624398 No
    PI4K2B Two-hybrid18624398 No
    ZHX1 Two-hybrid21900206 No
    EEF1G Two-hybrid21900206 No
    DCTN1 Two-hybrid21900206 No
    PPP2CA Affinity Capture-Western18191226|18191226 CHD related
    ARRB2 Affinity Capture-Western18191226 No
    WNK4 Biochemical Activity20525693 No
    USP4 Reconstituted Complex22706160|22706160 No
    TOPBP1 Biochemical Activity17006541 No
    RNF11 Biochemical Activity16123141 No
    RNF115 Biochemical Activity16123141 No
    SH3RF1 Biochemical Activity17535800 No
    IBTK Affinity Capture-Western18596081 No
    VCP Affinity Capture-Western16551632|16551632|16027165|16027165|16027165 No
    ACO1 Affinity Capture-MS16027165 No
    NSF Affinity Capture-MS16027165 No
    HSPA8 Affinity Capture-MS16027165 CHD related
    CAMK2A Affinity Capture-MS16027165 CHD related
    ENO2 Affinity Capture-MS16027165 No
    CKB Affinity Capture-MS16027165 No
    GNB1 Affinity Capture-MS16027165 No
    CLTC Affinity Capture-MS16027165 No
    HK1 Affinity Capture-MS16027165 No
    ATP1A1 Affinity Capture-MS16027165 No
    TUBB Affinity Capture-MS16027165|20856200 No
    YWHAG Affinity Capture-MS16027165 No
    YWHAE Affinity Capture-MS16027165 No
    ENO1 Affinity Capture-MS16027165 CHD related
    GAPDH Affinity Capture-MS16027165 No
    HSPA5 Affinity Capture-MS16027165 No
    PEBP1 Affinity Capture-MS16027165 CHD related
    UCHL1 Affinity Capture-MS16027165 No
    MDH1 Affinity Capture-MS16027165 No
    LDHA Affinity Capture-MS16027165 CHD related
    HBB Affinity Capture-MS16027165 No
    PPIA Affinity Capture-MS16027165 CHD related
    ALDOA Affinity Capture-MS16027165 No
    EIF4A1 Affinity Capture-MS16027165 No
    PSMB4 Affinity Capture-MS16027165 No
    GDA Affinity Capture-MS16027165 No
    ATP6V0A2 Affinity Capture-MS16027165 No
    ARHGEF7 Affinity Capture-Western15306850 No
    ARHGEF6 Affinity Capture-Western15306850 No
    STK4 Biochemical Activity19940129|19940129 No
    VIM Affinity Capture-MS20856200|20856200|20856200 CHD related
    DDX5 Affinity Capture-MS20856200|20856200 No
    HSPA9 Affinity Capture-MS20856200|20856200 No
    TPM4 Affinity Capture-MS20856200 No
    TPM2 Affinity Capture-MS20856200 No
    ACTB Affinity Capture-MS20856200 No
    TRHDE Affinity Capture-MS20856200 No
    PFKFB1 Biochemical Activity15896703 No
    APP Reconstituted Complex21832049 No
    CDKN1A in vitro;in vivo11756412 CHD related
    APLP2 in vivo10490823 No
    AKT1 in vitro7891724,9395488 CHD related
    GATA2 in vivo15837948 CHD related
    HMOX1 in vitro;in vivo15581622 CHD related
    MDM4 in vitro16163388 CHD related
    CCDC88A in vitro;in vivo16139227 No
    SH2B2 in vitro;in vivo16141217 No
    PIK3R1 in vitro10527852 CHD related
    MST1R in vitro12919677 No
    STAT1 in vivo15284024 CHD related
    PRKDC in vitro15262962 No
    ESR2 in vivo15001646 CHD related
    HIST2H2BE in vivo9973250 No
    PDK2 in vitro10438924 No
    APPL1 in vitro;in vivo12621049 CHD related
    RAB3D in vitro11903042 No
    WNK1 in vitro;in vivo14611643 CHD related
    CREB1 in vitro9829964 No
    NCF1 in vitro12734380 CHD related
    DLC1 in vivo;yeast 2-hybrid16338927 No
    YBX1 in vitro;in vivo16354698 CHD related
    GATA1 in vitro;in vivo16107690 No
    PHB2 in vivo;yeast 2-hybrid15173318 No
    PPARGC1B in vitro17554339 No
    HTT in vitro;in vivo12062094 No
    PFKFB2 in vitro12853467 No
    ITGB3 in vitro10896934 CHD related
    PTPN1 in vitro;in vivo11579209 CHD related
    FOXO4 in vitro;in vivo11313479,10217147,11689711,16272144 No
    ATXN1 in vitro;in vivo12757707,12741986 No
    S1PR1 in vitro;in vivo11583630 No
    PDE3B in vitro;in vivo10454575 No
    RAC1 in vitro;in vivo10617634 CHD related
    EIF4EBP1 in vitro11777913 No
    CASP9 in vitro9812896 CHD related
    MAP3K5 in vitro;in vivo11154276 CHD related
    FOXO3 in vitro;in vivo10102273 CHD related
    PEA15 in vitro;in vivo12808093 No
    METTL1 in vitro15861136 No
    YAP1 in vitro;in vivo12535517 No
    AKT1S1 in vitro;in vivo12524439,14973226 No
    AHNAK in vitro11535620 No
    PLXNA1 Two-hybrid15187088|15187088|15187088 No
    BRCA1 Reconstituted Complex10542266|19074868|19074868 CHD related
    FANCA Two-hybrid14499622|11855836 No
    HSP90AA1 Affinity Capture-Western12586360|21767636 CHD related
    TCL1A Affinity Capture-Western11707444|12009899|12009899|10983986,12009899 No
    MTCP1 Affinity Capture-Western11707444|11707444 No
    KRT10 Affinity Capture-Western11585925 No
    SMAD2 Affinity Capture-Western16362038 CHD related
    SMAD3 Affinity Capture-Western16362038 CHD related
    SMAD4 Affinity Capture-Western16362038 No
    SMAD7 Affinity Capture-Western16362038 No
    RPS6KB1 Co-purification15149849|11438723 CHD related
    TSC1 Affinity Capture-Western15342917|12167664 No
    TSC2 Affinity Capture-Western12167664|15342917 No
    MAPKAP1 Affinity Capture-Western16962653|21177249 No
    ARHGAP32 Biochemical Activity12446789 No
    PRKCQ Reconstituted Complex11410591|11410591|11410591 No
    THEM4 Affinity Capture-Western11598301|11598301 No
    MAP3K11 Affinity Capture-Western12458207|12458207 No
    PRKCZ Affinity Capture-Western10085094|10085094,11723139,14560023 No
    GAB2 Affinity Capture-Western11782427 No
    PDPK1 Affinity Capture-Western11825911|11825911,11438723,10698680,12149249,11445557,14500673,11278835,9368760,10226025 CHD related
    ILK Affinity Capture-Western11825911|9736715|11313365|9736715,12176337,12149249,11445557,11546794,14500673,11278835 CHD related
    IRS1 Affinity Capture-Western10497255 CHD related
    PLXNB1 Affinity Capture-Western19805522 No
    USP8 Affinity Capture-Western17210635 No
    HDAC3 Affinity Capture-Western20026773 CHD related
    IKBKG Reconstituted Complex20098747|20837477 No
    MXD1 Affinity Capture-Western19526459|19526459 No
    SMARCB1 Affinity Capture-Western16568092|16568092 No
    MDM2 Affinity Capture-Western12145204|21930127 CHD related
    EZH2 Affinity Capture-Western16224021 No
    PPA1 Affinity Capture-Western16186112 No
    XIAP Affinity Capture-Western14645242 CHD related
    CDC37 Affinity Capture-Western12176997 No
    SKP2 Affinity Capture-Western19270694|19270694|21358672|19270695 No
    PA2G4 Affinity Capture-Western21930127 No
    NEDD4 Biochemical Activity19953087 No
    CTBP1 Affinity Capture-Western20361981 No
    CALM1 Reconstituted Complex15840729|15840729 No
    PHLPP1 Affinity Capture-Western20605778 No
    FKBP5 Affinity Capture-Western20605778 No
    PPP3CA Affinity Capture-Western20605778 CHD related
    PTEN Affinity Capture-Western20605778 CHD related
    IQGAP1 Affinity Capture-Western22328503 No
    CHEK1 Affinity Capture-Western17962807 No
    TERF2IP Two-hybrid21044950 No
    PPP1CC Affinity Capture-Western17274640 No
    MUL1 Reconstituted Complex22410793|22410793 No
    RICTOR Biochemical Activity16603397|15718470|18566587|21177249 No
    PPP2R4 Biochemical Activity17505062|14645548 No
    ARHGEF2 Affinity Capture-Western21513698 No
    LRRK2 Biochemical Activity21658387|21658387 No
    SKI Affinity Capture-Western19875456 No
    PPP1CA Biochemical Activity14645548 No
    SNCA Affinity Capture-Western21474915|21474915 No
    PINK1 Affinity Capture-Western21177249 No
    NOS3 Affinity Capture-Western11425855 CHD related
    RHEBL1 in vivo16098514 No
    SORBS2 in vitro;in vivo;yeast 2-hybrid15784622 No
    VEGFA in vivo17318185 CHD related
    MS4A2 in vivo19356729 No
    BCL10 in vitro16280327 No
    AKT2 in vitro;in vivo12176337,12149249,11445557,11546794,14500673,9736715,11278835 CHD related
    SRC in vitro;in vivo11445557 CHD related
    CASP3 in vitro;in vivo12124386 CHD related
    GRB10 in vivo11809791 No
    TNFSF11 in vitro;in vivo10635328 CHD related
    TCL6 in vivo11710897 No
    PRG2 in vitro;in vivo10698680,12149249,11445557,14500673,11278835,12176337,11546794,9736715 No
    CAMKK1 in vitro10833263 No
    UXS1 in vitro;yeast 2-hybrid11877387 No
    PPM1A in vitro15016818 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approved;nutraceuticalDB00171Adenosine triphosphate"For nutritional supplementation, also for treating dietary shortage or imbalance"
    approvedDB01169Arsenic trioxide"For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression"L01XX27
    experimentalDB01863"Inositol 1,3,4,5-Tetrakisphosphate"
    experimentalDB07584"N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine"
    experimentalDB07585"5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine"