How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ALB

    Description: albumin

    Entrez Gene ID: 213

    SwissProt Acc Number: P02768

    RefSeq: NM_000477

    It was suspected to be CHD related:

    .."The level of ox-LDL and the ratio of ox-LDL/TC, ox-LDL/LDL-C, ox-LDL/HDL-C and ox-LDL/ALB are better biomarkers than TC, TG, HDL-C and LDL-C for discriminating between patients with coronary artery disease and healthy subjects."..

    From PMID: 18688083, in Journal Dis?Markers.? , 2008


    References

    There were 3 potential papers with ALB and CHD.

    PMIDTitleJournalsDetails
    22038366 A meta-analysis of the biomarkers associated with coronary artery lesions secondary to Kawasaki disease in Chinese children.Journal of Huazhong University of Science and Technology. Medical sciences = Hua More Details
    17227443 Advanced-glycation end products (AGEs) derived from glycated albumin suppress early beta1-adrenergic preconditioning.Fundamental & clinical pharmacologyMore Details
    15485694 Transendothelial exchange of low-density lipoprotein is unaffected by the presence of severe atherosclerosis.Cardiovascular researchMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 35 unique genes interacted with ALB. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    LUC7L2 Two-hybrid16169070|16169070 No
    FCGRT Co-purification12566415|12566415 No
    APP Reconstituted Complex21832049 No
    AGA in vivo15174051 No
    F7 in vivo15174051 CHD related
    ST13 in vivo15174051 No
    RYR2 in vivo15174051 CHD related
    KLK3 in vivo15174051 No
    PRB3 Reconstituted Complex4062880 No
    LRP2 Reconstituted Complex8898021|11158855,8898021 No
    AMBP Affinity Capture-Western9183005|9183005 No
    USP37 Affinity Capture-MS19615732 No
    UIMC1 Affinity Capture-MS19615732 No
    DMWD Affinity Capture-MS19615732 No
    PSMD4 Affinity Capture-MS12601813 No
    NR5A2 Two-hybrid15604093|15604093 No
    YWHAG Affinity Capture-MS15324660|15324660 No
    PSMA3 Affinity Capture-MS22079093 No
    TK1 Two-hybrid21900206 No
    IMMT Two-hybrid21900206 No
    PFDN1 Two-hybrid21900206 No
    KIAA0101 Affinity Capture-MS21628590 No
    UBC Affinity Capture-MS21139048|21890473 No
    FBXO25 Affinity Capture-MS20473970 No
    CRYAB Affinity Capture-MS21357544 No
    FBXO6 Affinity Capture-MS22268729 No
    UBD Affinity Capture-MS22797925 No
    APOE in vitro8063017 CHD related
    CRYAA in vitro9618718 No
    ORM1 in vitro3795040 No
    HNF1A in vitro2460858 CHD related
    PON1 in vitro6324579 CHD related
    SRGN in vitro4062880 No
    RBP4 in vitro571335 No
    CUBN in vivo10811843 CHD related


    Involved FDA drugs

    There was no drug associated with ALB