How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ALDH2

    Description: aldehyde dehydrogenase 2 family (mitochondrial)

    Entrez Gene ID: 217

    SwissProt Acc Number: P05091

    RefSeq: NM_000690

    It was suspected to be CHD related:

    .."Our results suggest that ALDH2 mutation is a genetic risk marker for ACS, which is explained in part by alcohol consumption, inflammation and number of circulating EPCs."..

    From PMID: 21958412, in Journal J Cell Mol Med.? , 2011


    References

    There were 13 potential papers with ALDH2 and CHD.

    PMIDTitleJournalsDetails
    23685282 Association of genetic polymorphisms in ADH and ALDH2 with risk of coronary artery disease and myocardial infarction: a meta-analysis.GeneMore Details
    23697560 ALDH2 rs671 Polymorphism and coronary heart disease risk among Asian populations: a meta-analysis and meta-regression.DNA and cell biologyMore Details
    23468836 Isoflurane preconditioning confers cardioprotection by activation of ALDH2.PloS oneMore Details
    21971053 Genome-wide association study of coronary artery disease in the Japanese.European journal of human genetics : EJHGMore Details
    21958412 Role of aldehyde dehydrogenase 2 Glu504lys polymorphism in acute coronary syndrome.Journal of cellular and molecular medicineMore Details
    19876063 ALDH2 genetic polymorphism and the risk of type II diabetes mellitus in CAD patients.Hypertension research : official journal of the Japanese Society of HypertensionMore Details
    20417517 The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels.AtherosclerosisMore Details
    20700531 The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population.PloS oneMore Details
    18574453 "The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles."British journal of pharmacologyMore Details
    18037339 Genetic polymorphisms and micronucleus formation: a review of the literature.Mutation researchMore Details
    18442986 Vascular tolerance to nitroglycerin in ascorbate deficiency.Cardiovascular researchMore Details
    16440063 Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin.The Journal of clinical investigationMore Details
    16226933 The oxidative stress concept of nitrate tolerance and the antioxidant properties of hydralazine.The American journal of cardiologyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 15 unique genes interacted with ALDH2. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    UNC119 Two-hybrid16169070|16169070 No
    C2orf18 Two-hybrid16169070|16169070 No
    IGSF21 Two-hybrid16169070|16169070 No
    CRMP1 Two-hybrid16169070|16169070 No
    C14orf1 Two-hybrid16169070|16169070 No
    HSPE1 Two-hybrid12387818 No
    HSPD1 Two-hybrid12387818 CHD related
    APP Reconstituted Complex21832049 No
    ALDH2 in vitro10631996,12795606,9195888 CHD related
    FAM45B yeast 2-hybrid16169070 No
    EIF6 Two-hybrid16169070 No
    UBA5 Affinity Capture-MS20562859 No
    ICT1 Affinity Capture-MS20186120 No
    UBC Affinity Capture-MS21139048|21906983 No
    CUL3 Affinity Capture-MS21145461 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approved;nutraceuticalDB00157NADH"Some evidence suggests that NADH might be useful in treating Parkinson's disease, chronic fatigue syndrome, Alzheimer's disease and cardiovascular disease."
    approvedDB00536GuanidineFor the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.A07AB03
    approvedDB00822DisulfiramFor the treatment and management of chronic alcoholismN07BB01;P03AA04
    experimentalDB01907Nicotinamide-Adenine-Dinucleotide
    experimentalDB02115Daidzin
    experimentalDB04381Crotonaldehyde