How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ALOX15

    Description: arachidonate 15-lipoxygenase

    Entrez Gene ID: 246

    SwissProt Acc Number: P16050

    RefSeq: NM_001140

    It was suspected to be CHD related:

    ..we demonstrate increased ALOX15 in human ischemic heart biopsies..

    From PMID: 22750246, in Journal Biochem Biophys Res Commun , 2012


    References

    There were 11 potential papers with ALOX15 and CHD.

    PMIDTitleJournalsDetails
    23906684 Genetic associations with coronary heart disease: meta-analyses of 12 candidate genetic variants.GeneMore Details
    22750246 High expression of arachidonate 15-lipoxygenase and proinflammatory markers in human ischemic heart tissue.Biochemical and biophysical research communicationsMore Details
    21558275 Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease.The Journal of biological chemistryMore Details
    20676957 Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population.Heart and vesselsMore Details
    20592751 Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.Mediators of inflammationMore Details
    19046748 "Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke."AtherosclerosisMore Details
    19131063 No association of two functional polymorphisms in human ALOX15 with myocardial infarction.AtherosclerosisMore Details
    19948975 Integrative predictive model of coronary artery calcification in atherosclerosis.CirculationMore Details
    17959182 A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.AtherosclerosisMore Details
    17439326 The c.-292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    16497176 Regulation of neuronal type genes in congestive heart failure rats."Acta physiologica (Oxford, England)"More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There was NO PPI interaction information about ALOX15



    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    experimentalDB08492(2E)-3-(2-OCT-1-YN-1-YLPHENYL)ACRYLIC ACID