How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ALOX5

    Description: arachidonate 5-lipoxygenase

    Entrez Gene ID: 240

    SwissProt Acc Number: P09917

    RefSeq: NM_000698

    It was suspected to be CHD related:

    ..The Sp1 addition/deletion polymorphism in promoter region of the 5-lipoxygenase gene (ALOX5) has been associated with increased risk of carotid atherosclerosis and myocardial infarction...

    From PMID: 23067353, in Journal Clin Transl Sci , 2012


    References

    There were 6 potential papers with ALOX5 and CHD.

    PMIDTitleJournalsDetails
    23067353 Association of Sp1 tandem repeat polymorphism of ALOX5 with coronary artery disease in Indian subjects.Clinical and translational scienceMore Details
    21293878 Genetic contribution of the leukotriene pathway to coronary artery disease.Human geneticsMore Details
    20592751 Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.Mediators of inflammationMore Details
    19130089 Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.Human geneticsMore Details
    18369664 Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease.Human geneticsMore Details
    18398223 Candidate genes of the 5-lipoxygenase pathway in acute coronary syndrome: a pilot study.Biological research for nursingMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 8 unique genes interacted with ALOX5. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    COTL1 Two-hybrid11297527 No
    TGFBRAP1 Two-hybrid10051563 No
    COTL1P1 Two-hybrid10051563 No
    APP Reconstituted Complex21832049 No
    ACTB in vitro7929073 No
    GRB2 Reconstituted Complex8585605|7929073 CHD related
    ALOX5AP in vivo9445303 CHD related
    MAPKAPK2 in vitro10779545,11844797 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approved;nutraceuticalDB00163Vitamin E"Vitamin E, known for its antioxidant activities, is protective against cardiovascular disease and some forms of cancer and has also demonstrated immune-enhancing effects. It may be of limited benefit in some with asthma and rheumatoid arthritis. It may be helpful in some neurological diseases including Alzheimer's, some eye disorders including cataracts, and diabetes and premenstrual syndrome. It may also help protect skin from ultraviolet irradiation although claims that it reverses skin aging, enhances male fertility and exercise performance are poorly supported. It may help relieve some muscle cramps."A11HA03
    approvedDB00179MasoprocolUsed for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated).L01XX10
    approvedDB00233Aminosalicylic AcidFor the treatment of tuberculosisJ04AA01
    approvedDB00244MesalazineFor the treatment of active ulcerative proctitis.A07EC02
    approvedDB00471MontelukastFor the treatment of asthmaR03DC03
    approvedDB00586DiclofenacFor the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.M01AB05;M02AA15;S01BC03;D11AX18
    approvedDB00711Diethylcarbamazine"Used for the treatment of individual patients with certain filarial diseases including tropical pulmonary eosinophilia, loiasis, and lymphatic filariasis caused by infection with <i>Wuchereria bancrofti</i>, <i>Brugia malayi</i>, or <i>Brugia timori</i>."P02CB02
    approvedDB00744ZileutonFor the prophylaxis and chronic treatment of asthma in adults and children 12 years of age and older.
    approvedDB00795SulfasalazineFor the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.A07EC01
    approvedDB00939Meclofenamic acid"For the relief of mild to moderate pain, for the treatment of primary dysmenorrhea and for the treatment of idiopathic heavy menstrual blood loss. Also for relief of the signs and symptoms of acute and chronic rheumatoid arthritis and osteoarthritis."M01AG04;M02AA18
    approvedDB01014BalsalazideFor the treatment of mildly to moderately active ulcerative colitis.A07EC04
    approvedDB01017Minocycline"For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by <i>Streptococcus pneumoniae</i> and for the treatment of asymptomatic carriers of <i>Neisseria meningitidis</i>."A01AB23;J01AA08
    approvedDB01097LeflunomideFor the management of the signs and symptoms of active rheumatoid arthritis (RA) to improve physical function and to slow the progression of structural damage associated with the disease. Has also been used for the prevention of acute and chronic rejection in recipients of solid organ trasnplants and is designated by the FDA as an orphan drug for this use.L04AA13
    nutraceuticalDB01892Hyperforin
    experimentalDB03014Heme