How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: ALOX5AP

    Description: arachidonate 5-lipoxygenase-activating protein

    Entrez Gene ID: 241

    SwissProt Acc Number: P20292

    RefSeq: NM_001629

    It was suspected to be CHD related:

    ..This meta-analysis investigated the relationship between variants of arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and CHD.the HapB haplotype and rs1722842 polymorphism in ALOX5AP gene were associated with CHD..

    From PMID: 21199733, in Journal Arch Med Res.? , 2010


    There were 17 potential papers with ALOX5AP and CHD.

    22726381 Association of ALOX5AP haplotypes with susceptibility to coronary artery disease in a Chinese Han population.European journal of internal medicineMore Details
    21130994 Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction.AtherosclerosisMore Details
    22460243 ALOX5AP gene variants show differential association with coronary artery disease in different populations.Journal of community geneticsMore Details
    21199733 Variants of arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of coronary heart disease: A meta-analysis.Archives of medical researchMore Details
    20592751 Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.Mediators of inflammationMore Details
    19361804 5-Lipoxygenase activating protein (ALOX5AP) gene variants associate with the presence of xanthomas in familial hypercholesterolemia.AtherosclerosisMore Details
    19130089 Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.Human geneticsMore Details
    19046748 "Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke."AtherosclerosisMore Details
    19596330 Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American population.AtherosclerosisMore Details
    18775537 Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia.AtherosclerosisMore Details
    18374923 ALOX5AP variants are associated with in-stent restenosis after percutaneous coronary intervention.AtherosclerosisMore Details
    18318662 Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population."Clinical science (London, England : 1979)"More Details
    18369664 Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease.Human geneticsMore Details
    18398223 Candidate genes of the 5-lipoxygenase pathway in acute coronary syndrome: a pilot study.Biological research for nursingMore Details
    17505527 ALOX5AP gene variants and risk of coronary artery disease: an angiography-based study.European journal of human genetics : EJHGMore Details
    17176247 Leukotriene B4 production in healthy subjects carrying variants of the arachidonate 5-lipoxygenase-activating protein gene associated with a risk of myocardial infarction."Clinical science (London, England : 1979)"More Details
    16987874 Genetic susceptibility to myocardial infarction and coronary artery disease.Human molecular geneticsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 1 unique genes interacted with ALOX5AP. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    ALOX5 in vivo9445303 CHD related

    Involved FDA drugs

    There was no drug associated with ALOX5AP