How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: ANG

    Description: "angiogenin, ribonuclease, RNase A family, 5"

    Entrez Gene ID: 283

    SwissProt Acc Number: P03950

    RefSeq: NM_001097577

    It was suspected to be CHD related:

    ..Pharmacological blockade of the ANG II type 1 receptor (AT1R) is a common therapy for treatment of congestive heart failure and hypertension..

    From PMID: 22886417, in Journal Am J Physiol Heart Circ Physiol , 2012


    There were 105 potential papers with ANG and CHD.

    23832698 Angiotensin II-mediated posttranslational modification of nNOS in the PVN of rats with CHF: role for PIN.American journal of physiology. Heart and circulatory physiologyMore Details
    23792185 Swimming training prevents fat deposition and decreases angiotensin II-induced coronary vasoconstriction in ovariectomized rats.PeptidesMore Details
    24164503 Recent progress in the treatment of cardiovascular disease using olmesartan."Clinical and experimental hypertension (New York, N.Y. : 1993)"More Details
    23257024 Inhibition of brain angiotensin III attenuates sympathetic hyperactivity and cardiac dysfunction in rats post-myocardial infarction.Cardiovascular researchMore Details
    23849603 Effects of traditional Chinese medicine Xin-Ji-Er-Kang formula on 2K1C hypertensive rats: role of oxidative stress and endothelial dysfunction.BMC complementary and alternative medicineMore Details
    23013041 The ACE2 gene: its potential as a functional candidate for cardiovascular disease."Clinical science (London, England : 1979)"More Details
    23392788 Renin-angiotensin system genetic polymorphisms: Lack of association with CRP levels in patients with coronary artery disease.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    23432153 Emerging markers in cardiovascular disease: where does angiotensin-converting enzyme 2 fit in?Clinical and experimental pharmacology & physiologyMore Details
    24167376 Association between angiotensin II type 1 receptor polymorphism and sudden cardiac death in myocardial infarction.Disease markersMore Details
    22832534 Impact of maternal dexamethasone on coronary PGE(2) production and prostaglandin-dependent coronary reactivity."American journal of physiology. Regulatory, integrative and comparative"More Details
    22886417 beta-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.American journal of physiology. Heart and circulatory physiologyMore Details
    22982778 Preconditioning protects the heart in a prolonged uremic condition.American journal of physiology. Heart and circulatory physiologyMore Details
    22389386 Heart angiotensin II-induced cardiomyocyte hypertrophy suppresses coronary angiogenesis and progresses diabetic cardiomyopathy.American journal of physiology. Heart and circulatory physiologyMore Details
    22301421 Utility of exercise stress echocardiography in pediatric cardiac transplant recipients: a single-center experience.The Journal of heart and lung transplantation : the official publication of theMore Details
    21938018 LOX-1 abrogation reduces cardiac hypertrophy and collagen accumulation following chronic ischemia in the mouse.Gene therapyMore Details
    21167013 Impairment of cardiac function and remodeling induced by myocardial infarction in rats are attenuated by the nonpeptide angiotensin-(1-7) analog AVE 0991.Cardiovascular therapeuticsMore Details
    22870080 Serial plasma levels of angiogenic factors in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.Korean circulation journalMore Details
    21622819 Both AT(1) and AT(2) receptors mediate proliferation and migration of porcine vascular smooth muscle cells.American journal of physiology. Heart and circulatory physiologyMore Details
    21825227 Angiotensin II impairs endothelial progenitor cell number and function in vitro and in vivo: implications for vascular regeneration.HypertensionMore Details
    21831995 Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure: role for CAPON and Ang II.Cardiovascular researchMore Details
    21546606 Insulin-like growth factor-1 receptor identifies a pool of human cardiac stem cells with superior therapeutic potential for myocardial regeneration.Circulation researchMore Details
    21596033 Relationship between angiotensin II receptor expression and cardiovascular risk factors in Mexican patients with coronary occlusive disease.Experimental and molecular pathologyMore Details
    21991351 Inhibition of cardiac sympathetic afferent reflex and sympathetic activity by baroreceptor and vagal afferent inputs in chronic heart failure.PloS oneMore Details
    21747998 Endothelin but Not Angiotensin II May Mediate Hypertension-Induced Coronary Vascular Calcification in Chronic Kidney Disease.International journal of nephrologyMore Details
    20625318 Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats.Journal of hypertensionMore Details
    20811386 Levosimendan improves cardiac function and survival in rats with angiotensin II-induced hypertensive heart failure.Hypertension research : official journal of the Japanese Society of HypertensionMore Details
    20507236 ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction.Human gene therapyMore Details
    19861349 The angiotensin II type 2 receptor in cardiovascular disease.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    20016374 Depressed expression of angiogenic growth factors in the subacute phase of myocardial ischemia: a mechanism behind the remodeling plateau?Coronary artery diseaseMore Details
    19959766 Influence of exercise and perivascular adipose tissue on coronary artery vasomotor function in a familial hypercholesterolemic porcine atherosclerosis model."Journal of applied physiology (Bethesda, Md. : 1985)"More Details
    19796634 High glucose enhances angiotensin-II-mediated peroxisome proliferation-activated receptor-gamma inactivation in human coronary artery endothelial cells.Experimental and molecular pathologyMore Details
    20026759 Effects of angiotensin metabolites in the coronary vascular bed of the spontaneously hypertensive rat: loss of angiotensin II type 2 receptor-mediated vasodilation.HypertensionMore Details
    20417517 The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels.AtherosclerosisMore Details
    19745165 A role of matrix metalloproteinase-8 in atherosclerosis.Circulation researchMore Details
    19710393 Enhanced angiotensin-mediated excitation of renal sympathetic nerve activity within the paraventricular nucleus of anesthetized rats with heart failure."American journal of physiology. Regulatory, integrative and comparative"More Details
    19268412 Angiopoietin 2 and cardiovascular disease in dialysis and kidney transplantation.American journal of kidney diseases : the official journal of the National KidneyMore Details
    19187100 Circulating biomarkers of angiogenesis as indicators of left ventricular systolic dysfunction amongst patients with coronary artery disease.Journal of internal medicineMore Details
    19193929 Red wine polyphenols prevent acceleration of neovascularization by angiotensin II in the ischemic rat hindlimb.The Journal of pharmacology and experimental therapeuticsMore Details
    19491620 Benefits of the RAS blockade: clinical evidence before the ONTARGET study.Journal of hypertension. Supplement : official journal of the InternationalMore Details
    19196803 Androgen-androgen receptor system protects against angiotensin II-induced vascular remodeling.EndocrinologyMore Details
    19944371 Hemodynamic alterations in the coronary circulation of cardiomyopathic hamsters: age and Ang II-dependent mechanisms.Journal of cardiac failureMore Details
    19669395 Expression of renin-angiotensin system on dendritic cells of patients with coronary artery disease.InflammationMore Details
    18660453 "Aldosterone induces interleukin-18 through endothelin-1, angiotensin II, Rho/Rho-kinase, and PPARs in cardiomyocytes."American journal of physiology. Heart and circulatory physiologyMore Details
    18214672 "Hypertension, RAS, and gender: what is the role of aminopeptidases?"Heart failure reviewsMore Details
    18829600 The relationship between job stress and urinary cytokines in healthy nurses: a cross-sectional study.Biological research for nursingMore Details
    18768402 Mitogen-activated protein kinases mediate upregulation of hypothalamic angiotensin II type 1 receptors in heart failure rats.HypertensionMore Details
    18344376 "Estrogen, nitric oxide, and hypertension differentially modulate agonist-induced contractile responses in female transgenic (mRen2)27 hypertensive rats."American journal of physiology. Heart and circulatory physiologyMore Details
    18310517 Integrative control of coronary resistance vessel tone by endothelin and angiotensin II is altered in swine with a recent myocardial infarction.American journal of physiology. Heart and circulatory physiologyMore Details
    18368382 New insights on signaling cascades induced by cross-talk between angiotensin II and aldosterone."Journal of molecular medicine (Berlin, Germany)"More Details
    18487441 Inhibition of brain proinflammatory cytokine synthesis reduces hypothalamic excitation in rats with ischemia-induced heart failure.American journal of physiology. Heart and circulatory physiologyMore Details
    17962624 The mechanistic basis for the disparate effects of angiotensin II on coronary collateral growth."Arteriosclerosis, thrombosis, and vascular biology"More Details
    18281816 Rosuvastatin attenuates angiotensin II-induced neointimal formation after stent implantation in the rat.Coronary artery diseaseMore Details
    19082800 Effect of Shengmai injection on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus.Chinese journal of integrative medicineMore Details
    18573259 Differential mechanisms of angiotensin II and PDGF-BB on migration and proliferation of coronary artery smooth muscle cells.Journal of molecular and cellular cardiologyMore Details
    18363614 A prospective study of dobutamine stress echocardiography for the assessment of cardiac allograft vasculopathy in pediatric heart transplant recipients.Pediatric transplantationMore Details
    18356741 Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone.Pediatric researchMore Details
    18054068 Is soluble CD40 ligand a mediator of angiogenesis in patients with coronary artery disease?Thrombosis researchMore Details
    18354258 Angiotensin II induces the vascular expression of VEGF and MMP-2 in vivo: preventive effect of red wine polyphenols.Journal of vascular researchMore Details
    17069818 Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation.AtherosclerosisMore Details
    17624368 Angiotensin II and IGF-1 regulate connexin43 expression via ERK and p38 signaling pathways in vascular smooth muscle cells of coronary artery bypass conduits.The Journal of surgical researchMore Details
    17513949 Angiotensin II type 1 receptor expression in polymorphonuclear leukocytes from high-risk subjects: changes after treatment with simvastatin.Journal of cardiovascular pharmacologyMore Details
    17142340 ANG II type 1 receptor antagonist irbesartan inhibits coronary angiogenesis stimulated by chronic intermittent hypoxia in neonatal rats.American journal of physiology. Heart and circulatory physiologyMore Details
    17329548 Interaction of endothelial nitric oxide and angiotensin in the circulation.Pharmacological reviewsMore Details
    17906107 Carboxypeptidase B and other kininases of the rat coronary and mesenteric arterial bed perfusates.American journal of physiology. Heart and circulatory physiologyMore Details
    17525364 Increased inhibition of inward rectifier K+ channels by angiotensin II in small-diameter coronary artery of isoproterenol-induced hypertrophied model."Arteriosclerosis, thrombosis, and vascular biology"More Details
    17234726 Angiotensin II induces endothelial xanthine oxidase activation: role for endothelial dysfunction in patients with coronary disease."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16679391 Essential role of PKC-zeta in normal and angiotensin II-accelerated neointimal growth after vascular injury.American journal of physiology. Heart and circulatory physiologyMore Details
    16442501 Angiotensin II inhibits inward rectifier K+ channels in rabbit coronary arterial smooth muscle cells through protein kinase Calpha.Biochemical and biophysical research communicationsMore Details
    17083070 Aldosterone blockade over and above ACE-inhibitors in patients with coronary artery disease but without heart failure.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    16955274 rAAV-mediated angiogenin gene transfer induces angiogenesis and modifies left ventricular remodeling in rats with myocardial infarction."Journal of molecular medicine (Berlin, Germany)"More Details
    15961529 Newborn lamb coronary artery reactivity is programmed by early gestation dexamethasone before the onset of systemic hypertension."American journal of physiology. Regulatory, integrative and comparative"More Details
    16271939 Telmisartan inhibits expression of a receptor for advanced glycation end products (RAGE) in angiotensin-II-exposed endothelial cells and decreases serum levels of soluble RAGE in patients with essential hypertension.Microvascular researchMore Details
    15670768 Angiotensin II induces MMP-2 in a p47phox-dependent manner.Biochemical and biophysical research communicationsMore Details
    15817699 Angiotensin II increases human monocyte matrix metalloproteinase-1 through the AT2 receptor and prostaglandin E2: implications for atherosclerotic plaque rupture.Journal of leukocyte biologyMore Details
    16895685 [Atherosclerosis and the kidney].Nephrologie & therapeutiqueMore Details
    15217789 Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity."American journal of physiology. Regulatory, integrative and comparative"More Details
    15699275 Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease.CirculationMore Details
    16525945 High angiotensin II responsiveness is associated with decreased endothelium-dependent relaxation in human arteries.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    16109806 Intronic ANG II type 2 receptor gene polymorphism 1675 G/A modulates receptor protein expression but not mRNA splicing."American journal of physiology. Regulatory, integrative and comparative"More Details
    16099221 AT1 receptor in paraventricular nucleus mediates the enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure.Autonomic neuroscience : basic & clinicalMore Details
    15915003 Blood pressure-independent ETA and AT1 receptor blocker effects on the coronaries of rats harboring human renin and angiotensinogen genes.Kidney & blood pressure researchMore Details
    15302795 "Plasma angiopoietin-1, angiopoietin-2, angiopoietin receptor tie-2, and vascular endothelial growth factor levels in acute coronary syndromes."CirculationMore Details
    15380443 In vivo administration of D-arginine: effects on blood pressure and vascular function in angiotensin II-induced hypertensive rats.AtherosclerosisMore Details
    15371269 AT1 receptor mRNA antisense normalizes enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure.American journal of physiology. Heart and circulatory physiologyMore Details
    15475555 ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure."Journal of applied physiology (Bethesda, Md. : 1985)"More Details
    15120813 Angiotensin II receptors from peritransplantation through first-year post-transplantation and the risk of transplant coronary artery disease.Journal of the American College of CardiologyMore Details
    15007092 Senescent impairment in synergistic cytokine pathways that provide rapid cardioprotection in the rat heart.The Journal of experimental medicineMore Details
    15033249 Cardiac angiotensin II receptors as predictors of transplant coronary artery disease following heart transplantation.European heart journalMore Details
    15131005 Cardiac angiotensin II participates in coronary microvessel inflammation of unstable angina and strengthens the immunomediated component.Circulation researchMore Details
    14749684 Tissue angiotensin II in the regulation of inflammatory and fibrogenic components of repair in the rat heart.The Journal of laboratory and clinical medicineMore Details
    14699000 Pressure-independent effects of angiotensin II on hypertensive myocardial fibrosis.HypertensionMore Details
    15276022 Salutary effects of attenuation of angiotensin II on coronary perivascular fibrosis associated with insulin resistance and obesity.Journal of molecular and cellular cardiologyMore Details
    15031262 Extracellular matrix glycoprotein biglycan enhances vascular smooth muscle cell proliferation and migration.Circulation researchMore Details
    14608518 Interaction between cyclooxygenase and the renin-angiotensin-aldosterone system: rationale and clinical relevance.Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    14551246 Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling.Circulation researchMore Details
    14581407 Aldosterone and not plasminogen activator inhibitor-1 is a critical mediator of early angiotensin II/NG-nitro-L-arginine methyl ester-induced myocardial injury.CirculationMore Details
    12670882 Endothelial cell activation by endotoxin involves superoxide/NO-mediated nitration of prostacyclin synthase and thromboxane receptor stimulation.FASEB journal : official publication of the Federation of American Societies for More Details
    12806586 "Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease."Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    12539168 Angiogenesis of the heart.Microscopy research and techniqueMore Details
    12711879 Reperfusion-induced arrhythmias are suppressed by inhibition of the angiotensin II type 1 receptor.CardiologyMore Details
    12234789 Role of ANG II in coronary capillary angiogenesis at the insulin-resistant stage of a NIDDM rat model.American journal of physiology. Heart and circulatory physiologyMore Details
    11317203 Polymorphisms of the renin-angiotensin system in patients with multifocal renal arterial fibromuscular dysplasia.Journal of human hypertensionMore Details
    10879452 Genetic variation in the renin-angiotensin system and athletic performance.European journal of applied physiologyMore Details
    10880382 Angiotensin II (AT(1)) receptor blockade reduces vascular tissue factor in angiotensin II-induced cardiac vasculopathy.The American journal of pathologyMore Details
    10916078 Angiotensin II-induced growth of vascular smooth muscle cells requires an Src-dependent activation of the epidermal growth factor receptor.Kidney internationalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 9 unique genes interacted with ANG. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    TP53 Affinity Capture-Western22266868 CHD related
    ACTN2 in vitro;in vivo;yeast 2-hybrid15737636 No
    ACTC1 in vitro;in vivo;yeast 2-hybrid8127865 CHD related
    ATP6AP1 Two-hybrid16169070 No
    PTEN Two-hybrid16169070 CHD related
    TDGF1 Two-hybrid16169070 No
    RNH1 Co-crystal Structure9311977|2742853,9311977,2276743 No
    MDM2 Affinity Capture-Western22266868 CHD related
    TNFSF8 in vitro11751393 No

    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    experimentalDB02212Pyrophosphate 2-
    experimentalDB03088Pyroglutamic Acid
    experimentalDB04272Citric AcidA09AB04