How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ANGPT1

    Description: angiopoietin 1

    Entrez Gene ID: 284

    SwissProt Acc Number: Q15389

    RefSeq: NM_001146

    It was suspected to be CHD related:

    ..we identified ANGPT1 and VEGFA as susceptibility loci for KD..

    From PMID: 21905000, in Journal Arthritis Rheum. , 2012


    References

    There were 3 potential papers with ANGPT1 and CHD.

    PMIDTitleJournalsDetails
    21905000 Disruption of vascular homeostasis in patients with Kawasaki disease: involvement of vascular endothelial growth factor and angiopoietins.Arthritis and rheumatismMore Details
    20157321 Identification of cardiovascular genes in omentum from morbidly obese patients with type 2 diabetes.International journal of obesity (2005)More Details
    18035072 Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease.American heart journalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 4 unique genes interacted with ANGPT1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    ITGA5 in vitro15781448 CHD related
    ANGPT1 in vivo10514510,15769741,15381091 CHD related
    TEK Reconstituted Complex12427764|12427764|8980223|9723709|9204896 CHD related
    ANGPT2 in vitro;in vivo9204896 CHD related


    Involved FDA drugs

    There was no drug associated with ANGPT1