How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ANGPTL4

    Description: angiopoietin-like 4

    Entrez Gene ID: 51129

    SwissProt Acc Number: Q9BY76

    RefSeq: NM_001039667

    It was supported literatures to be a novel CHD related gene:

    .."These data showed that ANGPTL4 might constitute a relevant target for therapeutic vasculoprotection aimed at counteracting the effects of VEGF, thus being crucial for preventing no-reflow and conferring secondary cardioprotection during AMI"..

    From PMID: 22086875, in Journal Circulation , 2012


    References

    There were 8 potential papers with ANGPTL4 and CHD.

    PMIDTitleJournalsDetails
    22086875 Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4.CirculationMore Details
    22100250 Expression of fat mobilizing genes in human epicardial adipose tissue.AtherosclerosisMore Details
    20829508 "The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk.""Arteriosclerosis, thrombosis, and vascular biology"More Details
    19851103 Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events.Current opinion in lipidologyMore Details
    20056168 Modulation of plasma TG lipolysis by Angiopoietin-like proteins and GPIHBP1.Biochimica et biophysica actaMore Details
    18940399 Variation in ANGPTL4 and risk of coronary heart disease: the Atherosclerosis Risk in Communities Study.Metabolism: clinical and experimentalMore Details
    18505769 Serial analysis of the vascular endothelial transcriptome under static and shear stress conditions.Physiological genomicsMore Details
    18974381 "ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk.""Arteriosclerosis, thrombosis, and vascular biology"More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 4 unique genes interacted with ANGPTL4. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    ACTB Co-purification22573825 No
    SMARCA4 Affinity Capture-Western22573825|22573825 No
    KAT5 Co-purification22573825 No
    MYC Co-purification22573825 CHD related


    Involved FDA drugs

    There was no drug associated with ANGPTL4