How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: APOA1

    Description: apolipoprotein A-I

    Entrez Gene ID: 335

    SwissProt Acc Number: P02647

    RefSeq: NM_000039

    It was suspected to be CHD related:

    .."These observations show that mutations in ABCA1, APOA1, and LCAT are sufficient to explain >40% of familial hypoalphalipoproteinemia in this cohort. Moreover, individuals with mutations and large reductions in HDLc have increased risk of CAD."..

    From PMID: 21875686, in Journal Biochim Biophys Acta , 2012


    There were 46 potential papers with APOA1 and CHD.

    23078847 Oxidized ApoC1 on MALDI-TOF and glycated-ApoA1 band on gradient gel as potential diagnostic tools for atherosclerotic vascular disease.Clinica chimica acta; international journal of clinical chemistryMore Details
    23678262 Association of apolipoprotein b/apolipoprotein A1 ratio and coronary artery stenosis and plaques detected by multi-detector computed tomography in healthy population.Journal of Korean medical scienceMore Details
    24081495 Genetic Polymorphisms in the APOA1 Gene and their Relationship with Serum HDL Cholesterol Levels.LipidsMore Details
    23758630 Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population.Lipids in health and diseaseMore Details
    21316934 Phytosterols supplementation decreases plasma small and dense LDL levels in metabolic syndrome patients on a westernized type diet."Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    21875686 "Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT."Biochimica et biophysica actaMore Details
    22500948 "Consistency of extended-release niacin/laropiprant effects on Lp(a), ApoB, non-HDL-C, Apo A1, and ApoB/ApoA1 ratio across patient subgroups.""American journal of cardiovascular drugs : drugs, devices, and other"More Details
    22297598 Apo lipoprotein A1 gene polymorphisms predict cardio-metabolic risk in South Asian immigrants.Disease markersMore Details
    22359512 Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.PLoS geneticsMore Details
    22345992 APOA1 gene polymorphisms in the South Asian immigrant population in the United States.Indian journal of human geneticsMore Details
    22152282 Pitavastatin: novel effects on lipid parameters.Atherosclerosis. SupplementsMore Details
    21458815 Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels associated with a significant increase in high-density lipoprotein cholesterol in patients with coronary artery disease.AtherosclerosisMore Details
    23554700 ApoB/apoA1 is an effective predictor of coronary heart disease risk in overweight and obesity.Journal of biomedical researchMore Details
    20708914 Association of apolipoprotein A5 gene polymorphisms and serum lipid levels."Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    21410987 Metabolic syndrome in South Asian immigrants: more than low HDL requiring aggressive management.Lipids in health and diseaseMore Details
    20616715 Marked HDL deficiency and premature coronary heart disease.Current opinion in lipidologyMore Details
    21152377 The common apolipoprotein A-1 polymorphism -75A>G is associated with ethnic differences in recurrent coronary events after recovery from an acute myocardial infarction.Heart internationalMore Details
    18774574 Polymorphism in the IL6 promoter region is associated with the risk factors and markers of subclinical atherosclerosis in men: The Cardiovascular Risk in Young Finns Study.AtherosclerosisMore Details
    19350521 [Association of the hepatic lipase gene -250G/A promoter polymorphism with the susceptibility to type 2 diabetes mellitus combining with coronary heart disease].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = ChineseMore Details
    18398670 Synergistic effect between apolipoprotein E and apolipoprotein A1 gene polymorphisms in the risk for coronary artery disease.Molecular and cellular biochemistryMore Details
    18640459 "Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study."LancetMore Details
    17991756 Characterization of high density lipoprotein particles in familial apolipoprotein A-I deficiency.Journal of lipid researchMore Details
    18333887 The contribution of ApoB and ApoA1 measurements to cardiovascular risk assessment."Diabetes, obesity & metabolism"More Details
    18801202 Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease.Lipids in health and diseaseMore Details
    18066136 "Modulation of apolipoprotein A1 and B, adiponectin, ghrelin, and growth hormone concentrations by plant sterols and exercise in previously sedentary humans."Canadian journal of physiology and pharmacologyMore Details
    17924833 Apolipoprotein polymorphisms and familial hypercholesterolemia.PharmacogenomicsMore Details
    17525004 PON1 activity is inversely related to LDL apoB carbonyl content in patients with coronary artery disease.The Kaohsiung journal of medical sciencesMore Details
    16682089 The applicability of the Asian modified criteria of the metabolic syndrome in the Korean population.International journal of cardiologyMore Details
    17113061 Do mutations causing low HDL-C promote increased carotid intima-media thickness?Clinica chimica acta; international journal of clinical chemistryMore Details
    18079094 [Risk status of patients with peripheral arterial disease (PAD)].Orvosi hetilapMore Details
    17588826 Establishing the benefit of statins in low-to-moderate--risk primary prevention: the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS).Atherosclerosis. SupplementsMore Details
    17473052 Exercise and diet induced weight loss improves measures of oxidative stress and insulin sensitivity in adults with characteristics of the metabolic syndrome.American journal of physiology. Endocrinology and metabolismMore Details
    16487434 Short-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects.Clinical endocrinologyMore Details
    16752182 Apolipoprotein B: a predictor of inflammatory status in postmenopausal overweight and obese women.DiabetologiaMore Details
    16705465 The contribution of individual and pairwise combinations of SNPs in the APOA1 and APOC3 genes to interindividual HDL-C variability."Journal of molecular medicine (Berlin, Germany)"More Details
    16319130 Polymorphisms in the PON gene cluster are associated with Alzheimer disease.Human molecular geneticsMore Details
    16721833 Natriuretic peptide Val7Met substitution and risk of coronary artery disease in Greek patients with familial hypercholesterolemia.Journal of clinical laboratory analysisMore Details
    16195894 Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks.Human geneticsMore Details
    15657615 Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD.European journal of human genetics : EJHGMore Details
    15177121 Triglyceride-rich lipoproteins inhibit cholesterol efflux to apolipoprotein (apo) A1 from human macrophage foam cells.AtherosclerosisMore Details
    14962947 In-depth haplotype analysis of ABCA1 gene polymorphisms in relation to plasma ApoA1 levels and myocardial infarction."Arteriosclerosis, thrombosis, and vascular biology"More Details
    12840658 Genetics of HDL regulation in humans.Current opinion in lipidologyMore Details
    12709788 ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore.Human geneticsMore Details
    11902853 Vitamin C intake and apolipoproteins in a healthy elderly Japanese population.Preventive medicineMore Details
    12023827 Gene-diet interaction and plasma lipid responses to dietary intervention.Biochemical Society transactionsMore Details
    11133209 Body mass index and metabolic risk factors for coronary heart disease in women.European heart journalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 32 unique genes interacted with APOA1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    PDE1A Two-hybrid11991719|11991719 No
    ABCA1 Reconstituted Complex12084722|12084722 CHD related
    APOA1 Co-crystal Structure9356442|9003180,9200714,9356442 CHD related
    LCAT Reconstituted Complex1644835|1587806 CHD related
    APOC1 Two-hybrid11991719 CHD related
    SAA2 Two-hybrid11991719 No
    APOB Affinity Capture-Western19164805|7592581 CHD related
    VCP Affinity Capture-Western19164805 No
    APP Reconstituted Complex21832049 No
    TTR in vitro10627502 No
    CETP in vivo9305883 CHD related
    PCMT1 yeast 2-hybrid16169070 No
    CFHR1 in vitro8663389 No
    ATP5B in vivo2687158 No
    HPR in vitro10085035 CHD related
    MAP7D1 Two-hybrid16169070 No
    TNFRSF10C Two-hybrid16169070 No
    TOMM20 Two-hybrid16169070 No
    APOL1 Co-purification9325276|9325276 No
    APOF Co-purification6816269 No
    PLTP Reconstituted Complex9469594 CHD related
    GPLD1 Affinity Capture-Western11254757|11254757|11254757 No
    LBP Affinity Capture-Western8663389 CHD related
    CD40LG Affinity Capture-Western10085035 CHD related
    APOA1BP Affinity Capture-Western11991719|11991719 No
    UCHL5 Affinity Capture-MS21800051 No
    MIS12 Affinity Capture-MS20360068 No
    CLEC4G Two-hybrid18624398 No
    MAPK6 Two-hybrid21900206 No
    SCARB1 Reconstituted Complex10764676|1076467 CHD related
    ABCA13 Reconstituted Complex11162594 No
    PON1 in vitro16128586 CHD related

    Involved FDA drugs

    There was no drug associated with APOA1