Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)
Website using assistance : Leihong Wu (11019004@zju.edu.cn)
Coronary Heart Disease Research Platform
Description: apolipoprotein A-I
Entrez Gene ID: 335
SwissProt Acc Number: P02647
RefSeq: NM_000039
It was suspected to be CHD related:
.."These observations show that mutations in ABCA1, APOA1, and LCAT are sufficient to explain >40% of familial hypoalphalipoproteinemia in this cohort. Moreover, individuals with mutations and large reductions in HDLc have increased risk of CAD."..
From PMID: 21875686, in Journal Biochim Biophys Acta , 2012There were 46 potential papers with APOA1 and CHD.
| PMID | Title | Journals | Details |
|---|---|---|---|
| 23078847 | Oxidized ApoC1 on MALDI-TOF and glycated-ApoA1 band on gradient gel as potential diagnostic tools for atherosclerotic vascular disease. | Clinica chimica acta; international journal of clinical chemistry | More Details |
| 23678262 | Association of apolipoprotein b/apolipoprotein A1 ratio and coronary artery stenosis and plaques detected by multi-detector computed tomography in healthy population. | Journal of Korean medical science | More Details |
| 24081495 | Genetic Polymorphisms in the APOA1 Gene and their Relationship with Serum HDL Cholesterol Levels. | Lipids | More Details |
| 23758630 | Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population. | Lipids in health and disease | More Details |
| 21316934 | Phytosterols supplementation decreases plasma small and dense LDL levels in metabolic syndrome patients on a westernized type diet. | "Nutrition, metabolism, and cardiovascular diseases : NMCD" | More Details |
| 21875686 | "Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT." | Biochimica et biophysica acta | More Details |
| 22500948 | "Consistency of extended-release niacin/laropiprant effects on Lp(a), ApoB, non-HDL-C, Apo A1, and ApoB/ApoA1 ratio across patient subgroups." | "American journal of cardiovascular drugs : drugs, devices, and other" | More Details |
| 22297598 | Apo lipoprotein A1 gene polymorphisms predict cardio-metabolic risk in South Asian immigrants. | Disease markers | More Details |
| 22359512 | Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. | PLoS genetics | More Details |
| 22345992 | APOA1 gene polymorphisms in the South Asian immigrant population in the United States. | Indian journal of human genetics | More Details |
| 22152282 | Pitavastatin: novel effects on lipid parameters. | Atherosclerosis. Supplements | More Details |
| 21458815 | Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels associated with a significant increase in high-density lipoprotein cholesterol in patients with coronary artery disease. | Atherosclerosis | More Details |
| 23554700 | ApoB/apoA1 is an effective predictor of coronary heart disease risk in overweight and obesity. | Journal of biomedical research | More Details |
| 20708914 | Association of apolipoprotein A5 gene polymorphisms and serum lipid levels. | "Nutrition, metabolism, and cardiovascular diseases : NMCD" | More Details |
| 21410987 | Metabolic syndrome in South Asian immigrants: more than low HDL requiring aggressive management. | Lipids in health and disease | More Details |
| 20616715 | Marked HDL deficiency and premature coronary heart disease. | Current opinion in lipidology | More Details |
| 21152377 | The common apolipoprotein A-1 polymorphism -75A>G is associated with ethnic differences in recurrent coronary events after recovery from an acute myocardial infarction. | Heart international | More Details |
| 18774574 | Polymorphism in the IL6 promoter region is associated with the risk factors and markers of subclinical atherosclerosis in men: The Cardiovascular Risk in Young Finns Study. | Atherosclerosis | More Details |
| 19350521 | [Association of the hepatic lipase gene -250G/A promoter polymorphism with the susceptibility to type 2 diabetes mellitus combining with coronary heart disease]. | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese | More Details |
| 18398670 | Synergistic effect between apolipoprotein E and apolipoprotein A1 gene polymorphisms in the risk for coronary artery disease. | Molecular and cellular biochemistry | More Details |
| 18640459 | "Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study." | Lancet | More Details |
| 17991756 | Characterization of high density lipoprotein particles in familial apolipoprotein A-I deficiency. | Journal of lipid research | More Details |
| 18333887 | The contribution of ApoB and ApoA1 measurements to cardiovascular risk assessment. | "Diabetes, obesity & metabolism" | More Details |
| 18801202 | Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease. | Lipids in health and disease | More Details |
| 18066136 | "Modulation of apolipoprotein A1 and B, adiponectin, ghrelin, and growth hormone concentrations by plant sterols and exercise in previously sedentary humans." | Canadian journal of physiology and pharmacology | More Details |
| 17924833 | Apolipoprotein polymorphisms and familial hypercholesterolemia. | Pharmacogenomics | More Details |
| 17525004 | PON1 activity is inversely related to LDL apoB carbonyl content in patients with coronary artery disease. | The Kaohsiung journal of medical sciences | More Details |
| 16682089 | The applicability of the Asian modified criteria of the metabolic syndrome in the Korean population. | International journal of cardiology | More Details |
| 17113061 | Do mutations causing low HDL-C promote increased carotid intima-media thickness? | Clinica chimica acta; international journal of clinical chemistry | More Details |
| 18079094 | [Risk status of patients with peripheral arterial disease (PAD)]. | Orvosi hetilap | More Details |
| 17588826 | Establishing the benefit of statins in low-to-moderate--risk primary prevention: the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS). | Atherosclerosis. Supplements | More Details |
| 17473052 | Exercise and diet induced weight loss improves measures of oxidative stress and insulin sensitivity in adults with characteristics of the metabolic syndrome. | American journal of physiology. Endocrinology and metabolism | More Details |
| 16487434 | Short-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects. | Clinical endocrinology | More Details |
| 16752182 | Apolipoprotein B: a predictor of inflammatory status in postmenopausal overweight and obese women. | Diabetologia | More Details |
| 16705465 | The contribution of individual and pairwise combinations of SNPs in the APOA1 and APOC3 genes to interindividual HDL-C variability. | "Journal of molecular medicine (Berlin, Germany)" | More Details |
| 16319130 | Polymorphisms in the PON gene cluster are associated with Alzheimer disease. | Human molecular genetics | More Details |
| 16721833 | Natriuretic peptide Val7Met substitution and risk of coronary artery disease in Greek patients with familial hypercholesterolemia. | Journal of clinical laboratory analysis | More Details |
| 16195894 | Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks. | Human genetics | More Details |
| 15657615 | Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD. | European journal of human genetics : EJHG | More Details |
| 15177121 | Triglyceride-rich lipoproteins inhibit cholesterol efflux to apolipoprotein (apo) A1 from human macrophage foam cells. | Atherosclerosis | More Details |
| 14962947 | In-depth haplotype analysis of ABCA1 gene polymorphisms in relation to plasma ApoA1 levels and myocardial infarction. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 12840658 | Genetics of HDL regulation in humans. | Current opinion in lipidology | More Details |
| 12709788 | ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore. | Human genetics | More Details |
| 11902853 | Vitamin C intake and apolipoproteins in a healthy elderly Japanese population. | Preventive medicine | More Details |
| 12023827 | Gene-diet interaction and plasma lipid responses to dietary intervention. | Biochemical Society transactions | More Details |
| 11133209 | Body mass index and metabolic risk factors for coronary heart disease in women. | European heart journal | More Details |
NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.
There were totally 32 unique genes interacted with APOA1. Show PPI network
| Gene name | Interaction type | reference PMID | CHD relation |
|---|---|---|---|
| PDE1A | Two-hybrid | 11991719|11991719 | No |
| ABCA1 | Reconstituted Complex | 12084722|12084722 | CHD related |
| APOA1 | Co-crystal Structure | 9356442|9003180,9200714,9356442 | CHD related |
| LCAT | Reconstituted Complex | 1644835|1587806 | CHD related |
| APOC1 | Two-hybrid | 11991719 | CHD related |
| SAA2 | Two-hybrid | 11991719 | No |
| APOB | Affinity Capture-Western | 19164805|7592581 | CHD related |
| VCP | Affinity Capture-Western | 19164805 | No |
| APP | Reconstituted Complex | 21832049 | No |
| TTR | in vitro | 10627502 | No |
| CETP | in vivo | 9305883 | CHD related |
| PCMT1 | yeast 2-hybrid | 16169070 | No |
| CFHR1 | in vitro | 8663389 | No |
| ATP5B | in vivo | 2687158 | No |
| HPR | in vitro | 10085035 | CHD related |
| MAP7D1 | Two-hybrid | 16169070 | No |
| TNFRSF10C | Two-hybrid | 16169070 | No |
| TOMM20 | Two-hybrid | 16169070 | No |
| APOL1 | Co-purification | 9325276|9325276 | No |
| APOF | Co-purification | 6816269 | No |
| PLTP | Reconstituted Complex | 9469594 | CHD related |
| GPLD1 | Affinity Capture-Western | 11254757|11254757|11254757 | No |
| LBP | Affinity Capture-Western | 8663389 | CHD related |
| CD40LG | Affinity Capture-Western | 10085035 | CHD related |
| APOA1BP | Affinity Capture-Western | 11991719|11991719 | No |
| UCHL5 | Affinity Capture-MS | 21800051 | No |
| MIS12 | Affinity Capture-MS | 20360068 | No |
| CLEC4G | Two-hybrid | 18624398 | No |
| MAPK6 | Two-hybrid | 21900206 | No |
| SCARB1 | Reconstituted Complex | 10764676|1076467 | CHD related |
| ABCA13 | Reconstituted Complex | 11162594 | No |
| PON1 | in vitro | 16128586 | CHD related |
There was no drug associated with APOA1