How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: APOA5

    Description: apolipoprotein A-V

    Entrez Gene ID: 116519

    SwissProt Acc Number: Q6Q788

    RefSeq: NM_001166598

    It was suspected to be CHD related:

    ..Our findings in these unique samples reinforce the roles of APOA5 and USF1 variants on cardiovascular phenotypes and suggest that both genes contribute to lipid levels and aortic atherosclerosis individually and possibly through epistatic effects...

    From PMID: 19910639, in Journal Arterioscler Thromb Vasc Biol , 2010


    References

    There were 48 potential papers with APOA5 and CHD.

    PMIDTitleJournalsDetails
    23970179 Apolipoprotein A5 gene variants and the risk of coronary heart disease: a casecontrol study and metaanalysis.Molecular medicine reportsMore Details
    23919616 Association of APOA5 -1131T>C polymorphism and serum lipid levels in patients with type 2 diabetes.DNA and cell biologyMore Details
    23505323 Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.Journal of medical geneticsMore Details
    22914599 Mutation screening of the APOA5 gene in subjects with coronary artery disease.Journal of investigative medicine : the official publication of the AmericanMore Details
    23050023 Association of genetic variants influencing lipid levels with coronary artery disease in Japanese individuals.PloS oneMore Details
    21143013 APOA5 -1131T/C polymorphism is associated with coronary artery disease in a Chinese population: a meta-analysis.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    21438666 Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients having coronary artery disease with and without type 2 diabetes.Genetic testing and molecular biomarkersMore Details
    21130994 Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction.AtherosclerosisMore Details
    21287515 [Association of apolipoprotein A5 gene polymorphism with coronary heart disease in Uygur population of Xinjiang].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = ChineseMore Details
    20708914 Association of apolipoprotein A5 gene polymorphisms and serum lipid levels."Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    21889769 Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia.AtherosclerosisMore Details
    20304614 "The influence of the S19W SNP of the APOA5 gene on triglyceride levels in southern Brazil: interactions with the APOE gene, sex and menopause status.""Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    21252261 Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study.Journal of lipid researchMore Details
    21548985 "Relationship of APOA5, PPARgamma and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood."Lipids in health and diseaseMore Details
    21858147 Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease.PloS oneMore Details
    22460246 "Influence of genetic variants in the apolipoprotein A5 and C3 gene on lipids, lipoproteins, and its association with coronary artery disease in Indians."Journal of community geneticsMore Details
    20802161 Interactions between the APOA5 -1131T>C and the FEN1 10154G>T polymorphisms on omega6 polyunsaturated fatty acids in serum phospholipids and coronary artery disease.Journal of lipid researchMore Details
    20452521 Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.LancetMore Details
    19732897 Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese.AtherosclerosisMore Details
    19910639 Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis."Arteriosclerosis, thrombosis, and vascular biology"More Details
    19185864 Association of apolipoprotein A5 concentration with serum insulin and triglyceride levels and coronary artery disease in Korean men.AtherosclerosisMore Details
    19159622 "The apolipoprotein A5 -1131T>C promoter polymorphism in Koreans: association with plasma APOA5 and serum triglyceride concentrations, LDL particle size and coronary artery disease."Clinica chimica acta; international journal of clinical chemistryMore Details
    19878569 Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.BMC medical geneticsMore Details
    18607181 Clinical significance of apolipoprotein A5.Current opinion in lipidologyMore Details
    18415697 Apoprotein A-V: an important regulator of triglyceride metabolism.Journal of inherited metabolic diseaseMore Details
    18801202 Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease.Lipids in health and diseaseMore Details
    17356049 Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population.The Journal of clinical endocrinology and metabolismMore Details
    16682041 "The -1131 T>C and S19W APOA5 gene polymorphisms are associated with high levels of triglycerides and apolipoprotein C-III, but not with coronary artery disease: an angiographic study."AtherosclerosisMore Details
    16054149 Genetic variations of apolipoprotein A5 gene is associated with the risk of coronary artery disease among Chinese in Taiwan.AtherosclerosisMore Details
    16680034 Genetics of familial combined hyperlipidemia.Current opinion in lipidologyMore Details
    16321685 Impact of APOA5/A4/C3 genetic polymorphisms on lipid variables and cardiovascular disease risk in French men.International journal of cardiologyMore Details
    16258166 Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks.Journal of lipid researchMore Details
    16046221 A genetic variant c.553G > T in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and altered triglyceride levels in a Chinese population.AtherosclerosisMore Details
    16125709 SNPs at the APOA5 gene account for the strong association with hypertriglyceridaemia at the APOA5/A4/C3/A1 locus on chromosome 11q23 in the Northern Irish population.AtherosclerosisMore Details
    17032446 "Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans."BMC medical geneticsMore Details
    15877284 Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese.Metabolism: clinical and experimentalMore Details
    15604515 "APOA5 polymorphisms influence plasma triglycerides in young, healthy African Americans and whites of the CARDIA Study."Journal of lipid researchMore Details
    15941710 Thyroid hormone regulates the hypotriglyceridemic gene APOA5.The Journal of biological chemistryMore Details
    16176166 Apolipoprotein A5 and triglyceridemia. Focus on the effects of the common variants.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    16006256 Apolipoprotein A5 gene polymorphism -1131T-->C: association with plasma lipids and type 2 diabetes mellitus with coronary heart disease in Chinese.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    15306190 "APOA5 gene polymorphism modulates levels of triglyceride, HDL cholesterol and FERHDL but is not a risk factor for coronary artery disease."AtherosclerosisMore Details
    15342688 "Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study."Journal of lipid researchMore Details
    15542401 A single nucleotide polymorphism -1131T>C in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and alters triglyceride metabolism in Chinese.Molecular genetics and metabolismMore Details
    15177130 Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease.AtherosclerosisMore Details
    14551155 Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia."Arteriosclerosis, thrombosis, and vascular biology"More Details
    14729863 "APOA5 gene variants, lipoprotein particle distribution, and progression of coronary heart disease: results from the LOCAT study."Journal of lipid researchMore Details
    12937897 The single nucleotide polymorphism -1131T>C in the apolipoprotein A5 (APOA5) gene is associated with elevated triglycerides in patients with hyperlipidemia."Journal of molecular medicine (Berlin, Germany)"More Details
    12951359 The APOA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore.Journal of lipid researchMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There was NO PPI interaction information about APOA5



    Involved FDA drugs

    There was no drug associated with APOA5