Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)
Website using assistance : Leihong Wu (11019004@zju.edu.cn)
Coronary Heart Disease Research Platform
Description: apolipoprotein E
Entrez Gene ID: 348
SwissProt Acc Number: P02649
RefSeq: NM_000041
It was suspected to be CHD related:
..APOE -491 T allele may reduce the risk of atherosclerotic lesions among middle-aged women...
From PMID: 22101914, in Journal Mol Cell Biochem. , 2012There were 229 potential papers with APOE and CHD.
| PMID | Title | Journals | Details |
|---|---|---|---|
| 24082102 | Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease. | Proceedings of the National Academy of Sciences of the United States of America | More Details |
| 24280342 | Activation of paraoxonase 1 is associated with HDL remodeling ex vivo. | Clinica chimica acta; international journal of clinical chemistry | More Details |
| 23677746 | Nonmelanoma skin cancer is associated with reduced Alzheimer disease risk. | Neurology | More Details |
| 23382465 | "Smoking, apolipoprotein E genotypes, and mortality (the Ludwigshafen RIsk and Cardiovascular Health study)." | European heart journal | More Details |
| 23110590 | Age-dependent interaction of apolipoprotein E gene with eastern birthplace in Finland affects severity of coronary atherosclerosis and risk of fatal myocardial infarction--Helsinki Sudden Death Study. | Annals of medicine | More Details |
| 23592636 | Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine. | Physiological genomics | More Details |
| 23672999 | Apolipoprotein E in VLDL and LDL with apolipoprotein C-III is associated with a lower risk of coronary heart disease. | Journal of the American Heart Association | More Details |
| 22544617 | Cardiovascular risk in cognitively preserved elderlies is associated with glucose hypometabolism in the posterior cingulate cortex and precuneus regardless of brain atrophy and apolipoprotein gene variations. | "Age (Dordrecht, Netherlands)" | More Details |
| 23652567 | Effects of cholesteryl ester transfer protein inhibitors on human lipoprotein metabolism: why have they failed in lowering coronary heart disease risk? | Current opinion in lipidology | More Details |
| 23583468 | "Different effects of PPARA, PPARG and ApoE SNPs on serum lipids in patients with coronary heart disease based on the presence of diabetes." | Gene | More Details |
| 23096223 | "High serum apolipoprotein E determines hypertriglyceridemic dyslipidemias, coronary disease and apoA-I dysfunctionality." | Lipids | More Details |
| 23919842 | "Association between APOE, SCARB1, PPARalpha polymorphisms and serum lipids in a population of Lithuanian adults." | Lipids in health and disease | More Details |
| 23826174 | Association between apolipoprotein E gene polymorphism and the risk of coronary artery disease in Chinese population: evidence from a meta-analysis of 40 studies. | PloS one | More Details |
| 22552896 | Pathology supported genetic testing and treatment of cardiovascular disease in middle age for prevention of Alzheimer's disease. | Metabolic brain disease | More Details |
| 22078485 | Coronary risk correlates with cerebral amyloid deposition. | Neurobiology of aging | More Details |
| 22277050 | Investigation of polymorphic variants of PPARD and APOE genes in Turkish coronary heart disease patients. | DNA and cell biology | More Details |
| 22360411 | Coronary artery wall imaging in mice using osmium tetroxide and micro-computed tomography (micro-CT). | Journal of anatomy | More Details |
| 22442750 | "ApoE isoforms, treatment of diabetes and the risk of coronary heart disease." | World journal of diabetes | More Details |
| 22393217 | A dynamic view of depressive symptoms and neurocognitive change among patients with coronary artery disease. | Archives of general psychiatry | More Details |
| 22101914 | APOE -491 T allele may reduce the risk of atherosclerotic lesions among middle-aged women. | Molecular and cellular biochemistry | More Details |
| 22837136 | Apolipoprotein E polymorphism is associated with both number of diseased vessels and extent of coronary artery disease in Czech patients with CAD. | "Biomedical papers of the Medical Faculty of the University Palacky, Olomouc," | More Details |
| 22632920 | Apo E4 and lipoprotein-associated phospholipase A2 synergistically increase cardiovascular risk. | Atherosclerosis | More Details |
| 22264578 | The association of apolipoprotein E polymorphism and lipid levels in children with a family history of premature coronary artery disease. | Journal of clinical lipidology | More Details |
| 22071360 | Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women. | Atherosclerosis | More Details |
| 22540255 | New roles of HDL in inflammation and hematopoiesis. | Annual review of nutrition | More Details |
| 22301884 | Antisense inhibition of apoB synthesis with mipomersen reduces plasma apoC-III and apoC-III-containing lipoproteins. | Journal of lipid research | More Details |
| 23050023 | Association of genetic variants influencing lipid levels with coronary artery disease in Japanese individuals. | PloS one | More Details |
| 23173569 | Identification of the HDL-ApoCIII to VLDL-ApoCIII ratio as a predictor of coronary artery disease in the general population: the Chin-Shan Community Cardiovascular Cohort (CCCC) study in Taiwan. | Lipids in health and disease | More Details |
| 22520940 | Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease. | Cardiovascular diabetology | More Details |
| 22111029 | Premature coronary artery disease and familial hypercholesterolemia: need for early diagnosis and cascade screening in the Indian population. | Cardiology research and practice | More Details |
| 22359512 | Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. | PLoS genetics | More Details |
| 21802082 | The aminoterminal 1-185 domain of human apolipoprotein E suffices for the de novo biogenesis of apoE-containing HDL-like particles in apoA-I deficient mice. | Atherosclerosis | More Details |
| 21889313 | Chlamydia pneumoniae heat shock protein 60 is associated with apoptotic signaling pathway in human atheromatous plaques of coronary artery disease patients. | Journal of cardiology | More Details |
| 21855069 | Impaired CXCR4 expression and cell engraftment of bone marrow-derived cells from aged atherogenic mice. | Atherosclerosis | More Details |
| 21862702 | "Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk." | Journal of lipid research | More Details |
| 21394030 | Association of the serum apolipoprotein levels with the occurrence of coronary vasospasm. | Coronary artery disease | More Details |
| 21611899 | Correlation between Fc gamma R III a and aortic atherosclerotic plaque destabilization in ApoE knockout mice and intervention effects of effective components of chuanxiong rhizome and red peony root. | Chinese journal of integrative medicine | More Details |
| 21596318 | Emerging genomic applications in coronary artery disease. | JACC. Cardiovascular interventions | More Details |
| 20688498 | Saturated fat intake and alcohol consumption modulate the association between the APOE polymorphism and risk of future coronary heart disease: a nested case-control study in the Spanish EPIC cohort. | The Journal of nutritional biochemistry | More Details |
| 21228258 | Use of genotype frequencies in medicated groups to investigate prescribing practice: APOE and statins as a proof of principle. | Clinical chemistry | More Details |
| 21847356 | A(2A) adenosine receptor-mediated increase in coronary flow in hyperlipidemic APOE-knockout mice. | Journal of experimental pharmacology | More Details |
| 21681990 | Discovery of biomarker candidates for coronary artery disease from an APOE-knock out mouse model using iTRAQ-based multiplex quantitative proteomics. | Proteomics | More Details |
| 21716749 | Relationship between ApoE gene polymorphism and coronary heart disease in Gaza Strip. | Journal of cardiovascular disease research | More Details |
| 20803190 | Biomedical risk factors for decreased cognitive functioning in type 1 diabetes: an 18 year follow-up of the Diabetes Control and Complications Trial (DCCT) cohort. | Diabetologia | More Details |
| 20966394 | S100A12 in vascular smooth muscle accelerates vascular calcification in apolipoprotein E-null mice by activating an osteogenic gene regulatory program. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 22042884 | Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study. | Circulation. Cardiovascular genetics | More Details |
| 21764664 | Transcriptional fingerprint of human whole blood at the site of coronary occlusion in acute myocardial infarction. | EuroIntervention : journal of EuroPCR in collaboration with the Working Group on | More Details |
| 20304614 | "The influence of the S19W SNP of the APOA5 gene on triglyceride levels in southern Brazil: interactions with the APOE gene, sex and menopause status." | "Nutrition, metabolism, and cardiovascular diseases : NMCD" | More Details |
| 21080234 | Presence of apolipoprotein C-III attenuates apolipoprotein E-mediated cellular uptake of cholesterol-containing lipid particles by HepG2 cells. | Lipids | More Details |
| 21252261 | Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study. | Journal of lipid research | More Details |
| 21397230 | Effects of ezetimibe on atherosclerosis in preclinical models. | Atherosclerosis | More Details |
| 21292266 | Electronegative low-density lipoprotein: origin and impact on health and disease. | Atherosclerosis | More Details |
| 21841254 | "Gender differences in tea, coffee, and cognitive decline in the elderly: the Cardiovascular Health Study." | Journal of Alzheimer's disease : JAD | More Details |
| 21254242 | Effect of apolipoprotein E genotypes on incidence and development of coronary stenosis in Iranian patients with coronary artery disease. | Journal of clinical laboratory analysis | More Details |
| 22028770 | APOE genotype-function relationship: evidence of -491 A/T promoter polymorphism modifying transcription control but not type 2 diabetes risk. | PloS one | More Details |
| 21450082 | Apolipoprotein E epsilon-4 polymorphism is associated with younger age at referral to a lipidology clinic and a poorer response to lipid-lowering therapy. | Lipids in health and disease | More Details |
| 20498921 | "APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men." | "Molecular medicine (Cambridge, Mass.)" | More Details |
| 20543710 | Apolipoprotein E genotypes in pseudoexfoliation syndrome and pseudoexfoliation glaucoma. | Journal of glaucoma | More Details |
| 20643407 | Interactions between age and apoE genotype on fasting and postprandial triglycerides levels. | Atherosclerosis | More Details |
| 20693183 | Apolipoprotein E genotype and mortality in Southern European and Anglo-Celt patients with type 2 diabetes: the Fremantle Diabetes Study. | European journal of endocrinology / European Federation of Endocrine Societies | More Details |
| 19091445 | Coronary heart disease is associated with non-amnestic mild cognitive impairment. | Neurobiology of aging | More Details |
| 20197419 | A metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice. | Physiological genomics | More Details |
| 22460205 | "Genetic variants at the APOE, lipoprotein lipase (LpL), cholesteryl ester transfer protein (CETP), and endothelial nitric oxide (eNOS) genes and coronary artery disease (CAD): CETP Taq1 B2B2 associates with lower risk of CAD in Asian Indians." | Journal of community genetics | More Details |
| 20739760 | Apolipoprotein E gene polymorphism and total serum cholesterol level in Iranian population. | Journal of postgraduate medicine | More Details |
| 20603483 | Depressive symptoms and risk of dementia: the Framingham Heart Study. | Neurology | More Details |
| 20504763 | Angiotensin-converting enzyme inhibition down-regulates the pro-atherogenic chemokine receptor 9 (CCR9)-chemokine ligand 25 (CCL25) axis. | The Journal of biological chemistry | More Details |
| 20102908 | Relation of change in apolipoprotein B/apolipoprotein A-I ratio to coronary plaque regression after Pravastatin treatment in patients with coronary artery disease. | The American journal of cardiology | More Details |
| 20032288 | Cancer linked to Alzheimer disease but not vascular dementia. | Neurology | More Details |
| 20715976 | Integrated role of two apoliprotein E polymorphisms on apolipoprotein B levels and coronary artery disease in a biethnic population. | Metabolic syndrome and related disorders | More Details |
| 20452461 | Role of amyloid beta in lipid homeostasis. | Biochimica et biophysica acta | More Details |
| 19685167 | Butyrylcholinesterase K variant and the APOE-epsilon 4 allele work in synergy to increase the risk of coronary artery disease especially in diabetic patients. | Molecular biology reports | More Details |
| 19907187 | Human full-length osteoprotegerin induces the proliferation of rodent vascular smooth muscle cells both in vitro and in vivo. | Journal of vascular research | More Details |
| 20184726 | Caspase-1 genetic variation is not associated with Alzheimer's disease risk. | BMC medical genetics | More Details |
| 19056704 | Effects of rosuvastatin on electronegative LDL as characterized by capillary isotachophoresis: the ROSARY Study. | Journal of lipid research | More Details |
| 19583979 | "Apolipoprotein E genotyping method by real time PCR, a fast and cost-effective alternative to the TaqMan and FRET assays." | Journal of neuroscience methods | More Details |
| 19713976 | Impact of ACE and ApoE polymorphisms on myocardial perfusion: correlation with myocardial single photon emission computed tomographic imaging. | Journal of human genetics | More Details |
| 19733021 | Apolipoprotein E (apoE) polymorphism: a risk factor for fatal coronary sclerosis? | Forensic science international | More Details |
| 18378026 | Role of apolipoproteins E and A-I: epistatic villains of triglyceride mediation in coronary heart disease. | International journal of cardiology | More Details |
| 19323972 | Clopidogrel attenuates atheroma formation and induces a stable plaque phenotype in apolipoprotein E knockout mice. | Microvascular research | More Details |
| 19233360 | Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype. | Atherosclerosis | More Details |
| 19336475 | Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. | Human molecular genetics | More Details |
| 19389852 | Fetuin-A protects against atherosclerotic calcification in CKD. | Journal of the American Society of Nephrology : JASN | More Details |
| 19252179 | ApoE and ApoC-I polymorphisms: association of genotype with cardiovascular disease phenotype in African Americans. | Journal of lipid research | More Details |
| 19372458 | Core2 1-6-N-glucosaminyltransferase-I deficiency protects injured arteries from neointima formation in ApoE-deficient mice. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 19155782 | The environmental and genetic evidence for the association of hyperlipidemia and hypertension. | Journal of hypertension | More Details |
| 19722574 | Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesion. | Journal of agricultural and food chemistry | More Details |
| 19667307 | "APOE genotype, lipids, and coronary heart disease risk: a prospective population study." | Archives of internal medicine | More Details |
| 20031582 | Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort. | Circulation. Cardiovascular genetics | More Details |
| 21637672 | "Effects of APOE, APOB and LDLR variants on serum lipids and lack of association with xanthelasma in individuals from Southeastern Brazil." | Genetics and molecular biology | More Details |
| 19956623 | Loss of PDZK1 causes coronary artery occlusion and myocardial infarction in Paigen diet-fed apolipoprotein E deficient mice. | PloS one | More Details |
| 19691831 | "Gene polymorphisms in APOE, NOS3, and LIPC genes may be risk factors for cardiac adverse events after primary CABG." | Journal of cardiothoracic surgery | More Details |
| 19494537 | "Apolipoprotein E, CI and B gene polymorphisms in a sample of patients with coronary heart disease in the Kuwaiti population." | "Medical principles and practice : international journal of the Kuwait University," | More Details |
| 19948027 | Plasma PLTP activity is inversely associated with HDL-C levels. | Nutrition & metabolism | More Details |
| 18721571 | The apolipoprotein E epsilon4 allele is not associated with cognitive dysfunction in cardiac surgery. | The Annals of thoracic surgery | More Details |
| 18603482 | Influence of genetic factors in the modulation of postprandial lipemia. | Atherosclerosis. Supplements | More Details |
| 18855536 | Pharmacogenetics of apolipoprotein E gene during lipid-lowering therapy: lipid levels and prevention of coronary heart disease. | Pharmacogenomics | More Details |
| 21291761 | "Association between apolipoprotein E polymorphism, lipids, and coronary artery disease in Tunisian type 2 diabetes." | Journal of clinical lipidology | More Details |
| 18725890 | Differential modulation of diet-induced obesity and adipocyte functionality by human apolipoprotein E3 and E4 in mice. | International journal of obesity (2005) | More Details |
| 18067591 | CD36 mRNA expression is increased in CD14+ monocytes of patients with coronary heart disease. | Clinical and experimental pharmacology & physiology | More Details |
| 17462871 | Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease. | "Nutrition, metabolism, and cardiovascular diseases : NMCD" | More Details |
| 18342019 | Influence of PDZK1 on lipoprotein metabolism and atherosclerosis. | Biochimica et biophysica acta | More Details |
| 18054357 | Inhibition of intestinal absorption of cholesterol by ezetimibe or bile acids by SC-435 alters lipoprotein metabolism and extends the lifespan of SR-BI/apoE double knockout mice. | Atherosclerosis | More Details |
| 18374151 | Sex-based differences in vascular repair with bone marrow cell therapy: relevance of regulatory and Th2-type cytokines. | Transplantation proceedings | More Details |
| 18179501 | Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men. | Journal of the American Geriatrics Society | More Details |
| 18398670 | Synergistic effect between apolipoprotein E and apolipoprotein A1 gene polymorphisms in the risk for coronary artery disease. | Molecular and cellular biochemistry | More Details |
| 18289451 | Vascular factors and risk for neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study. | International psychogeriatrics / IPA | More Details |
| 18611440 | Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice. | Pharmacological research : the official journal of the Italian Pharmacological | More Details |
| 18289550 | "Synergistic effects of the apolipoprotein E epsilon3/epsilon2/epsilon4, the cholesteryl ester transfer protein TaqIB, and the apolipoprotein C3 -482 C>T polymorphisms on their association with coronary artery disease." | Atherosclerosis | More Details |
| 18704761 | Molecular genetics of myocardial infarction. | Genomic medicine | More Details |
| 17683517 | The Mediterranean paradox for susceptibility factors in coronary heart disease extends to genetics. | Annals of human genetics | More Details |
| 17991756 | Characterization of high density lipoprotein particles in familial apolipoprotein A-I deficiency. | Journal of lipid research | More Details |
| 17594534 | Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts. | Molecular biology reports | More Details |
| 18388879 | Effect of APOE genotype on lipid levels in patients with coronary heart disease during a 3-week inpatient rehabilitation program. | Clinical pharmacology and therapeutics | More Details |
| 18591462 | Low HDL cholesterol is a risk factor for deficit and decline in memory in midlife: the Whitehall II study. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 18298348 | Apolipoprotein E polymorphisms in Mexican patients with coronary artery disease. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 18163216 | Apolipoprotein E gene is related to mortality only in normal weight individuals: the Rotterdam Study. | European journal of epidemiology | More Details |
| 18609102 | Diagnostic performance of plasma high sensitive C-reactive protein in detecting three-vessel coronary artery disease: modification by apolipoprotein E genotype. | Scandinavian journal of clinical and laboratory investigation | More Details |
| 17878422 | Association of apolipoprotein E genotypes with lipid levels and coronary risk. | JAMA : the journal of the American Medical Association | More Details |
| 17403027 | The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk. | Annals of human genetics | More Details |
| 17889142 | Effect of apolipoprotein E polymorphism on renal transplantation. | Transplantation proceedings | More Details |
| 17689519 | The presence of apolipoprotein epsilon4 and epsilon2 alleles augments the risk of coronary artery disease in type 2 diabetic patients. | Clinical biochemistry | More Details |
| 17984379 | "Spontaneous atherothrombosis and medial degradation in Apoe-/-, Npc1-/- mice." | Circulation | More Details |
| 17367769 | "Association between plasma lipid parameters and APOC3 genotypes in Brazilian subjects: effect of gender, smoking and APOE genotypes." | Clinica chimica acta; international journal of clinical chemistry | More Details |
| 17443358 | Deposition of free cholesterol in the blood vessels of patients with coronary artery disease: a possible novel mechanism for atherogenesis. | Lipids | More Details |
| 17478321 | Mechanism by which alcohol and wine polyphenols affect coronary heart disease risk. | Annals of epidemiology | More Details |
| 17393220 | Postprandial lipemia is modified by the presence of the APOB-516C/T polymorphism in a healthy Caucasian population. | Lipids | More Details |
| 17332893 | Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL. | The Journal of clinical investigation | More Details |
| 17562993 | Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study. | Archives of ophthalmology | More Details |
| 17559752 | Effects of ezetimibe on lipids and lipoproteins in patients with hypercholesterolemia and different apolipoprotein E genotypes. | Current medical research and opinion | More Details |
| 17217375 | Robust association of the APOE epsilon4 allele with premature myocardial infarction especially in patients without hypercholesterolaemia: the Aachen study. | European journal of clinical investigation | More Details |
| 17306734 | Gene-environment interaction and its impact on coronary heart disease risk. | "Nutrition, metabolism, and cardiovascular diseases : NMCD" | More Details |
| 16678832 | A genome scan for loci influencing levels and trends of lipoprotein lipid-related traits since childhood: The Bogalusa Heart Study. | Atherosclerosis | More Details |
| 17982164 | "Apolipoprotein E polymorphisms, dietary fat and fibre, and serum lipids: the EPIC Norfolk study." | European heart journal | More Details |
| 17567623 | Apolipoprotein E polymorphisms influence effect of pravastatin on survival after myocardial infarction in a Mediterranean population: the GISSI-Prevenzione study. | European heart journal | More Details |
| 16806235 | "Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice." | Atherosclerosis | More Details |
| 17379005 | Associations of apolipoprotein E polymorphism with low-density lipoprotein size and subfraction profiles in Arab patients with coronary heart disease. | Metabolism: clinical and experimental | More Details |
| 17848120 | Apolipoprotein E polymorphism--a risk factor for metabolic syndrome. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 18020970 | Hyperhomocysteinemia and high-density lipoprotein metabolism in cardiovascular disease. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 17852827 | Improvement of myocardial blood flow by lipid-lowering therapy with pravastatin is modulated by apolipoprotein E genotype. | Scandinavian journal of clinical and laboratory investigation | More Details |
| 17901562 | Potentially reduced exposure cigarettes accelerate atherosclerosis: evidence for the role of nicotine. | Cardiovascular toxicology | More Details |
| 16606866 | APOE alleles are not associated with calcific aortic stenosis. | Heart (British Cardiac Society) | More Details |
| 16621646 | Structural and phylogenetic approaches to assess the significance of human Apolipoprotein E variation. | Molecular genetics and metabolism | More Details |
| 16888319 | Protective effect of apolipoprotein E2 on coronary artery disease in African Americans is mediated through lipoprotein cholesterol. | Journal of lipid research | More Details |
| 17092867 | APOE distribution in world populations with new data from India and the UK. | Annals of human biology | More Details |
| 16682673 | Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers. | Neurology | More Details |
| 16717174 | Performance-based physical function and future dementia in older people. | Archives of internal medicine | More Details |
| 16445917 | Apolipoprotein E genotype and statins affect CRP levels through independent and different mechanisms: AGES-Reykjavik Study. | Atherosclerosis | More Details |
| 16556855 | Influence of HDL cholesterol on preclinical carotid atherosclerosis in familial hypercholesterolemia. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 16459141 | Combined effects of apoE-CI-CII cluster and LDL-R gene polymorphisms on chromosome 19 and coronary artery disease risk. | International journal of hygiene and environmental health | More Details |
| 16631444 | Accumulation of apoE-enriched triglyceride-rich lipoproteins in patients with coronary artery disease. | Metabolism: clinical and experimental | More Details |
| 19804074 | "The effects of apoA-I/C-III/A-IV, apoE and apoB polymorphisms on carotid artery intima-media thickness." | Future cardiology | More Details |
| 16154574 | Modulating effects of cholesterol feeding and simvastatin treatment on platelet-activating factor acetylhydrolase activity and lysophosphatidylcholine concentration. | Atherosclerosis | More Details |
| 16545358 | Association between apolipoprotein E polymorphism and coronary artery disease in the Kermanshah population in Iran. | Clinical biochemistry | More Details |
| 16269665 | Macrophage apolipoprotein E reduces atherosclerosis and prevents premature death in apolipoprotein E and scavenger receptor-class BI double-knockout mice. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 16254208 | Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 16461842 | Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells. | Circulation | More Details |
| 16322531 | Increased apolipoprotein deposits in early atherosclerotic lesions distinguish symptomatic from asymptomatic patients. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 16298355 | "Improved prediction of early-onset coronary artery disease using APOE epsilon4, BChE-K, PPARgamma2 Pro12 and ENOS T-786C in a polygenic model." | Clinical biochemistry | More Details |
| 17174184 | Apolipoprotein E genotype and circulating interleukin-10 levels in patients with stable and unstable coronary artery disease. | Journal of the American College of Cardiology | More Details |
| 17129981 | Low-density lipoprotein (LDL) particle size in healthy prepubertal children: the STRIP study. | "Acta paediatrica (Oslo, Norway : 1992)" | More Details |
| 16458317 | Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice. | Atherosclerosis | More Details |
| 16760224 | "Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participants." | American journal of epidemiology | More Details |
| 16786033 | "Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease." | Molecular psychiatry | More Details |
| 16168296 | Lipoprotein lipase gene polymorphisms and the risk of target vessel revascularization after percutaneous coronary intervention. | Journal of the American College of Cardiology | More Details |
| 16118069 | Apolipoprotein E polymorphism is not a predictor for repeated coronary artery bypass surgery. | Scandinavian cardiovascular journal : SCJ | More Details |
| 16194201 | Modeling premature occurrence of acute coronary syndrome with atherogenic and thrombogenic risk factors and gene markers in extended families. | Journal of thrombosis and haemostasis : JTH | More Details |
| 16015283 | Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions. | European journal of human genetics : EJHG | More Details |
| 15914296 | Atherosclerotic lesions in the common coronary arteries of ApoE knockout mice. | Cardiovascular pathology : the official journal of the Society for Cardiovascular | More Details |
| 15967843 | "Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice." | Circulation | More Details |
| 15539621 | "Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican." | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 15676165 | Serum levels of interleukin-18 in patients with stable and unstable angina pectoris. | International journal of cardiology | More Details |
| 16043164 | "Contemporaneous carrier-state of two or three ""proatherosclerotic"" variants of APOE, ICAM1, PPARA and PAI-1 genes differentiate CAD patients from healthy individuals." | Clinica chimica acta; international journal of clinical chemistry | More Details |
| 15817610 | Associations between apoE genotype and colon and rectal cancer. | Carcinogenesis | More Details |
| 16039278 | Increased hypercholesterolemia and atherosclerosis in mice lacking both ApoE and leptin receptor. | Atherosclerosis | More Details |
| 15769459 | Toll-like receptor 2 stimulation induces intimal hyperplasia and atherosclerotic lesion development. | Cardiovascular research | More Details |
| 15692099 | Lymphocytes are not required for the rapid onset of coronary heart disease in scavenger receptor class B type I/apolipoprotein E double knockout mice. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 15657615 | Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD. | European journal of human genetics : EJHG | More Details |
| 15899673 | Apolipoprotein E haplotyping by denaturing high-performance liquid chromatography. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 15319409 | Methodological problems in genetic association studies of longevity--the apolipoprotein E gene as an example. | International journal of epidemiology | More Details |
| 15545514 | Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice. | Circulation | More Details |
| 15571629 | The apolipoprotein E polymorphism and the cholesterol-raising effect of coffee. | Lipids in health and disease | More Details |
| 15488872 | No APOEepsilon4 effect on coronary heart disease risk in a cohort with low smoking prevalence: the Whitehall II study. | Atherosclerosis | More Details |
| 15180698 | Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans. | Annals of human genetics | More Details |
| 15057551 | Effects of insulin sensitizers on plaque vulnerability associated with elevated lipid content in atheroma in ApoE-knockout mice. | Acta diabetologica | More Details |
| 15177121 | Triglyceride-rich lipoproteins inhibit cholesterol efflux to apolipoprotein (apo) A1 from human macrophage foam cells. | Atherosclerosis | More Details |
| 15177126 | Alcohol consumption and inflammatory markers in older adults: the Cardiovascular Health Study. | Atherosclerosis | More Details |
| 15370197 | Apolipoprotein E polymorphism and stroke in a population from eastern Turkey. | Journal of neurogenetics | More Details |
| 12969990 | Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 14688198 | Short telomeres protect from diet-induced atherosclerosis in apolipoprotein E-null mice. | FASEB journal : official publication of the Federation of American Societies for | More Details |
| 15070435 | How to identify gene-environment interactions in a multifactorial disease: CHD as an example. | The Proceedings of the Nutrition Society | More Details |
| 15571826 | The apolipoprotein E polymorphism is associated with circulating C-reactive protein (the Ludwigshafen risk and cardiovascular health study). | European heart journal | More Details |
| 15530894 | Pharmacogenetics of HMG-CoA reductase inhibitors: exploring the potential for genotype-based individualization of coronary heart disease management. | Atherosclerosis | More Details |
| 15466371 | Apolipoprotein E gene polymorphisms and thrombosis and restenosis after coronary artery stenting. | Journal of lipid research | More Details |
| 15276511 | Preliminary report on the interaction of apolipoprotein E polymorphism with aortic atherosclerosis and acute nephropathy after CABG. | The Annals of thoracic surgery | More Details |
| 15630634 | "Apolipoprotein E and familial dysbetalipoproteinemia: clinical, biochemical, and genetic aspects." | Seminars in vascular medicine | More Details |
| 15145987 | Storage of human plasma samples leads to alterations in the lipoprotein distribution of apoC-III and apoE. | Journal of lipid research | More Details |
| 15183747 | Apolipoprotein E gene polymorphism effects triglycerides but not CAD risk in Caucasian women younger than 65 years. | Annales de genetique | More Details |
| 15543563 | Five polymorphisms in gene candidates for cardiovascular disease in Afro-Brazilian individuals. | Journal of clinical laboratory analysis | More Details |
| 15207428 | Assessment of the health status in the Massa Lombarda cohort: a preliminary description of the program evaluating cardio-cerebro-vascular disease risk factors and quality of life in an elderly population. | Archives of gerontology and geriatrics. Supplement | More Details |
| 12964943 | "Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD." | BMC medical genetics | More Details |
| 14530190 | Association between apolipoprotein E alleles and calcific valvular heart disease. | Circulation | More Details |
| 12937897 | The single nucleotide polymorphism -1131T>C in the apolipoprotein A5 (APOA5) gene is associated with elevated triglycerides in patients with hyperlipidemia. | "Journal of molecular medicine (Berlin, Germany)" | More Details |
| 12923233 | The influence of the apolipoprotein E gene promoter (-219G/ T) polymorphism on postprandial lipoprotein metabolism in young normolipemic males. | Journal of lipid research | More Details |
| 12711862 | "Oxidized LDL autoantibodies are related to apolipoprotein E phenotype, independently of postprandial change in plasma triglycerides and LDL size, among patients with angiographically verified coronary artery disease and healthy controls." | Journal of biomedical science | More Details |
| 12742802 | Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study. | Archives of internal medicine | More Details |
| 12774036 | Independent effects of the -219 G>T and epsilon 2/ epsilon 3/ epsilon 4 polymorphisms in the apolipoprotein E gene on coronary artery disease: the Southampton Atherosclerosis Study. | European journal of human genetics : EJHG | More Details |
| 12626663 | "AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent." | The Journal of pharmacology and experimental therapeutics | More Details |
| 12835223 | Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis. | Circulation | More Details |
| 12810610 | Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease. | Circulation | More Details |
| 12573381 | Large-scale evidence that the cardiotoxicity of smoking is not significantly modified by the apolipoprotein E epsilon2/epsilon3/epsilon4 genotype. | Lancet | More Details |
| 12475897 | Pharmacological interference with intestinal bile acid transport reduces plasma cholesterol in LDL receptor/apoE deficiency. | FASEB journal : official publication of the Federation of American Societies for | More Details |
| 14694215 | "Obesity modulates the association among APOE genotype, insulin, and glucose in men." | Obesity research | More Details |
| 12700893 | The association of the R219K polymorphism in the ATP-binding cassette transporter 1 ( ABCA1) gene with coronary heart disease and hyperlipidaemia. | "Journal of molecular medicine (Berlin, Germany)" | More Details |
| 12521230 | TaqMan systems for genotyping of disease-related polymorphisms present in the gene encoding apolipoprotein E. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 12112572 | Lipoprotein lipase and APOE/APOC-I/APOC-II gene cluster diversity in native Brazilian populations. | American journal of human biology : the official journal of the Human Biology | More Details |
| 12461692 | The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe. | European journal of human genetics : EJHG | More Details |
| 12023827 | Gene-diet interaction and plasma lipid responses to dietary intervention. | Biochemical Society transactions | More Details |
| 11803456 | Codon 311 (Cys --> Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer's and vascular dementias. | Molecular psychiatry | More Details |
| 11230170 | A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation. | Genome research | More Details |
| 11359359 | Medical utility of apoe allele determination in assessing the need for antioxidant therapy. | Medical hypotheses | More Details |
| 11463413 | Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study. | Lancet | More Details |
| 11256794 | Polymorphisms in the apolipoprotein E gene regulatory region in relation to coronary heart disease and their effect on plasma apolipoprotein E. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 11172484 | Lipoprotein distribution of apolipoprotein C-III and its relationship to the presence in plasma of triglyceride-rich remnant lipoproteins. | Metabolism: clinical and experimental | More Details |
| 11726725 | Apolipoprotein E phenotype regulates cholesterol absorption in healthy 13-month-old children--The STRIP Study. | Pediatric research | More Details |
| 11359065 | "Population genetic analysis of the genes APOE, APOB(3'VNTR) and ACE in some black and Amerindian communities from Colombia." | Human heredity | More Details |
| 11007687 | "Effect of apolipoprotein E polymorphism on serum lipid, lipoproteins, and atherosclerosis in hemodialysis patients." | American journal of kidney diseases : the official journal of the National Kidney | More Details |
| 10827377 | "Acute myocardial infarction in young adults: prognostic role of angiotensin-converting enzyme, angiotensin II type I receptor, apolipoprotein E, endothelial constitutive nitric oxide synthase, and glycoprotein IIIa genetic polymorphisms at medium-term follow-up." | American heart journal | More Details |
| 10861896 | "Apo E genotype, diabetes, and peripheral arterial disease in older men: the Honolulu Asia-aging study." | Genetic epidemiology | More Details |
| 11096027 | Cardiovascular infection by Chlamydia pneumoniae is not related to apolipoprotein E genotype. | Clinical infectious diseases : an official publication of the Infectious Diseases | More Details |
NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.
There were totally 55 unique genes interacted with APOE. Show PPI network
| Gene name | Interaction type | reference PMID | CHD relation |
|---|---|---|---|
| LRP8 | Reconstituted Complex | 12950167 | CHD related |
| PLTP | Affinity Capture-Western | 12810820 | CHD related |
| LRP2 | Reconstituted Complex | 7768901 | No |
| NEFM | Reconstituted Complex | 8620924 | No |
| UBC | Affinity Capture-Western | 11401504 | No |
| LRP1 | Affinity Capture-Western | 2779654 | CHD related |
| Set | Reconstituted Complex | 21289314 | No |
| GCDH | Two-hybrid | 21163940 | No |
| PDCD4 | Two-hybrid | 21163940|21163940 | No |
| APOE | Two-hybrid | 21163940|9147408,7566652 | CHD related |
| C19orf52 | Two-hybrid | 21163940 | No |
| CYP2C18 | Two-hybrid | 21163940 | No |
| ELAVL1 | Two-hybrid | 21163940 | No |
| FARSA | Two-hybrid | 21163940 | No |
| FBXL12 | Two-hybrid | 21163940 | No |
| IFIT5 | Two-hybrid | 21163940 | No |
| LONP1 | Two-hybrid | 21163940 | No |
| NOS3 | Two-hybrid | 21163940 | CHD related |
| PRAM1 | Two-hybrid | 21163940 | No |
| PRDX2 | Two-hybrid | 21163940 | CHD related |
| RHEB | Two-hybrid | 21163940 | No |
| ST13 | Two-hybrid | 21163940|21163940 | No |
| ACTG1 | Two-hybrid | 21163940 | No |
| ANKH | Two-hybrid | 21163940 | No |
| EPN2 | Two-hybrid | 21163940 | No |
| FOXG1 | Two-hybrid | 21163940 | No |
| FXYD7 | Two-hybrid | 21163940 | No |
| HTRA1 | Two-hybrid | 21163940 | No |
| IQSEC1 | Two-hybrid | 21163940 | No |
| MID1IP1 | Two-hybrid | 21163940 | No |
| PCMT1 | Two-hybrid | 21163940 | No |
| PLEKHA6 | Two-hybrid | 21163940 | No |
| RPL4 | Two-hybrid | 21163940 | No |
| TYRO3 | Two-hybrid | 21163940 | No |
| ZNF558 | Two-hybrid | 21163940 | No |
| CNTF | in vitro | 9236223 | CHD related |
| ALB | in vitro | 8063017 | CHD related |
| APP | in vitro | 10559559 | No |
| A2M | Affinity Capture-Western | 9831625|9831625|21163940 | No |
| MAPT | Reconstituted Complex | 8620924 | No |
| CSNK2A1 | Biochemical Activity | 15882073 | CHD related |
| CDC37 | Two-hybrid | 21163940 | No |
| CYP2C8 | Two-hybrid | 21163940 | CHD related |
| ECSIT | Two-hybrid | 21163940 | No |
| IFIT3 | Two-hybrid | 21163940 | No |
| LOXL4 | Two-hybrid | 21163940 | No |
| MAST1 | Two-hybrid | 21163940 | No |
| PSEN1 | Two-hybrid | 21163940 | No |
| RNF32 | Two-hybrid | 21163940 | No |
| CTSB | in vivo | 12057992 | CHD related |
| MAP2 | in vitro | 8624078 | No |
| PRNP | in vivo | 15146195 | No |
| VLDLR | in vivo | 12167620 | No |
| SCARB1 | in vitro;in vivo | 12138091 | CHD related |
| LDLR | in vitro;in vivo | 12036962 | CHD related |
| Status | DrubBank ID | Name | Indication | ATC Code |
|---|---|---|---|---|
| approved | DB00062 | Human Serum Albumin | "For treatment of severe blood loss, hypervolemia, hypoproteinemia" | |
| approved | DB00064 | Serum albumin iodonated | For determination of total blood and plasma volumes |