How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: APOE

    Description: apolipoprotein E

    Entrez Gene ID: 348

    SwissProt Acc Number: P02649

    RefSeq: NM_000041

    It was suspected to be CHD related:

    ..APOE -491 T allele may reduce the risk of atherosclerotic lesions among middle-aged women...

    From PMID: 22101914, in Journal Mol Cell Biochem. , 2012


    There were 229 potential papers with APOE and CHD.

    24082102 Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease.Proceedings of the National Academy of Sciences of the United States of AmericaMore Details
    24280342 Activation of paraoxonase 1 is associated with HDL remodeling ex vivo.Clinica chimica acta; international journal of clinical chemistryMore Details
    23677746 Nonmelanoma skin cancer is associated with reduced Alzheimer disease risk.NeurologyMore Details
    23382465 "Smoking, apolipoprotein E genotypes, and mortality (the Ludwigshafen RIsk and Cardiovascular Health study)."European heart journalMore Details
    23110590 Age-dependent interaction of apolipoprotein E gene with eastern birthplace in Finland affects severity of coronary atherosclerosis and risk of fatal myocardial infarction--Helsinki Sudden Death Study.Annals of medicineMore Details
    23592636 Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine.Physiological genomicsMore Details
    23672999 Apolipoprotein E in VLDL and LDL with apolipoprotein C-III is associated with a lower risk of coronary heart disease.Journal of the American Heart AssociationMore Details
    22544617 Cardiovascular risk in cognitively preserved elderlies is associated with glucose hypometabolism in the posterior cingulate cortex and precuneus regardless of brain atrophy and apolipoprotein gene variations."Age (Dordrecht, Netherlands)"More Details
    23652567 Effects of cholesteryl ester transfer protein inhibitors on human lipoprotein metabolism: why have they failed in lowering coronary heart disease risk?Current opinion in lipidologyMore Details
    23583468 "Different effects of PPARA, PPARG and ApoE SNPs on serum lipids in patients with coronary heart disease based on the presence of diabetes."GeneMore Details
    23096223 "High serum apolipoprotein E determines hypertriglyceridemic dyslipidemias, coronary disease and apoA-I dysfunctionality."LipidsMore Details
    23919842 "Association between APOE, SCARB1, PPARalpha polymorphisms and serum lipids in a population of Lithuanian adults."Lipids in health and diseaseMore Details
    23826174 Association between apolipoprotein E gene polymorphism and the risk of coronary artery disease in Chinese population: evidence from a meta-analysis of 40 studies.PloS oneMore Details
    22552896 Pathology supported genetic testing and treatment of cardiovascular disease in middle age for prevention of Alzheimer's disease.Metabolic brain diseaseMore Details
    22078485 Coronary risk correlates with cerebral amyloid deposition.Neurobiology of agingMore Details
    22277050 Investigation of polymorphic variants of PPARD and APOE genes in Turkish coronary heart disease patients.DNA and cell biologyMore Details
    22360411 Coronary artery wall imaging in mice using osmium tetroxide and micro-computed tomography (micro-CT).Journal of anatomyMore Details
    22442750 "ApoE isoforms, treatment of diabetes and the risk of coronary heart disease."World journal of diabetesMore Details
    22393217 A dynamic view of depressive symptoms and neurocognitive change among patients with coronary artery disease.Archives of general psychiatryMore Details
    22101914 APOE -491 T allele may reduce the risk of atherosclerotic lesions among middle-aged women.Molecular and cellular biochemistryMore Details
    22837136 Apolipoprotein E polymorphism is associated with both number of diseased vessels and extent of coronary artery disease in Czech patients with CAD."Biomedical papers of the Medical Faculty of the University Palacky, Olomouc,"More Details
    22632920 Apo E4 and lipoprotein-associated phospholipase A2 synergistically increase cardiovascular risk.AtherosclerosisMore Details
    22264578 The association of apolipoprotein E polymorphism and lipid levels in children with a family history of premature coronary artery disease.Journal of clinical lipidologyMore Details
    22071360 Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women.AtherosclerosisMore Details
    22540255 New roles of HDL in inflammation and hematopoiesis.Annual review of nutritionMore Details
    22301884 Antisense inhibition of apoB synthesis with mipomersen reduces plasma apoC-III and apoC-III-containing lipoproteins.Journal of lipid researchMore Details
    23050023 Association of genetic variants influencing lipid levels with coronary artery disease in Japanese individuals.PloS oneMore Details
    23173569 Identification of the HDL-ApoCIII to VLDL-ApoCIII ratio as a predictor of coronary artery disease in the general population: the Chin-Shan Community Cardiovascular Cohort (CCCC) study in Taiwan.Lipids in health and diseaseMore Details
    22520940 Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease.Cardiovascular diabetologyMore Details
    22111029 Premature coronary artery disease and familial hypercholesterolemia: need for early diagnosis and cascade screening in the Indian population.Cardiology research and practiceMore Details
    22359512 Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.PLoS geneticsMore Details
    21802082 The aminoterminal 1-185 domain of human apolipoprotein E suffices for the de novo biogenesis of apoE-containing HDL-like particles in apoA-I deficient mice.AtherosclerosisMore Details
    21889313 Chlamydia pneumoniae heat shock protein 60 is associated with apoptotic signaling pathway in human atheromatous plaques of coronary artery disease patients.Journal of cardiologyMore Details
    21855069 Impaired CXCR4 expression and cell engraftment of bone marrow-derived cells from aged atherogenic mice.AtherosclerosisMore Details
    21862702 "Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk."Journal of lipid researchMore Details
    21394030 Association of the serum apolipoprotein levels with the occurrence of coronary vasospasm.Coronary artery diseaseMore Details
    21611899 Correlation between Fc gamma R III a and aortic atherosclerotic plaque destabilization in ApoE knockout mice and intervention effects of effective components of chuanxiong rhizome and red peony root.Chinese journal of integrative medicineMore Details
    21596318 Emerging genomic applications in coronary artery disease.JACC. Cardiovascular interventionsMore Details
    20688498 Saturated fat intake and alcohol consumption modulate the association between the APOE polymorphism and risk of future coronary heart disease: a nested case-control study in the Spanish EPIC cohort.The Journal of nutritional biochemistryMore Details
    21228258 Use of genotype frequencies in medicated groups to investigate prescribing practice: APOE and statins as a proof of principle.Clinical chemistryMore Details
    21847356 A(2A) adenosine receptor-mediated increase in coronary flow in hyperlipidemic APOE-knockout mice.Journal of experimental pharmacologyMore Details
    21681990 Discovery of biomarker candidates for coronary artery disease from an APOE-knock out mouse model using iTRAQ-based multiplex quantitative proteomics.ProteomicsMore Details
    21716749 Relationship between ApoE gene polymorphism and coronary heart disease in Gaza Strip.Journal of cardiovascular disease researchMore Details
    20803190 Biomedical risk factors for decreased cognitive functioning in type 1 diabetes: an 18 year follow-up of the Diabetes Control and Complications Trial (DCCT) cohort.DiabetologiaMore Details
    20966394 S100A12 in vascular smooth muscle accelerates vascular calcification in apolipoprotein E-null mice by activating an osteogenic gene regulatory program."Arteriosclerosis, thrombosis, and vascular biology"More Details
    22042884 Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.Circulation. Cardiovascular geneticsMore Details
    21764664 Transcriptional fingerprint of human whole blood at the site of coronary occlusion in acute myocardial infarction.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on More Details
    20304614 "The influence of the S19W SNP of the APOA5 gene on triglyceride levels in southern Brazil: interactions with the APOE gene, sex and menopause status.""Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    21080234 Presence of apolipoprotein C-III attenuates apolipoprotein E-mediated cellular uptake of cholesterol-containing lipid particles by HepG2 cells.LipidsMore Details
    21252261 Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study.Journal of lipid researchMore Details
    21397230 Effects of ezetimibe on atherosclerosis in preclinical models.AtherosclerosisMore Details
    21292266 Electronegative low-density lipoprotein: origin and impact on health and disease.AtherosclerosisMore Details
    21841254 "Gender differences in tea, coffee, and cognitive decline in the elderly: the Cardiovascular Health Study."Journal of Alzheimer's disease : JADMore Details
    21254242 Effect of apolipoprotein E genotypes on incidence and development of coronary stenosis in Iranian patients with coronary artery disease.Journal of clinical laboratory analysisMore Details
    22028770 APOE genotype-function relationship: evidence of -491 A/T promoter polymorphism modifying transcription control but not type 2 diabetes risk.PloS oneMore Details
    21450082 Apolipoprotein E epsilon-4 polymorphism is associated with younger age at referral to a lipidology clinic and a poorer response to lipid-lowering therapy.Lipids in health and diseaseMore Details
    20498921 "APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men.""Molecular medicine (Cambridge, Mass.)"More Details
    20543710 Apolipoprotein E genotypes in pseudoexfoliation syndrome and pseudoexfoliation glaucoma.Journal of glaucomaMore Details
    20643407 Interactions between age and apoE genotype on fasting and postprandial triglycerides levels.AtherosclerosisMore Details
    20693183 Apolipoprotein E genotype and mortality in Southern European and Anglo-Celt patients with type 2 diabetes: the Fremantle Diabetes Study.European journal of endocrinology / European Federation of Endocrine SocietiesMore Details
    19091445 Coronary heart disease is associated with non-amnestic mild cognitive impairment.Neurobiology of agingMore Details
    20197419 A metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice.Physiological genomicsMore Details
    22460205 "Genetic variants at the APOE, lipoprotein lipase (LpL), cholesteryl ester transfer protein (CETP), and endothelial nitric oxide (eNOS) genes and coronary artery disease (CAD): CETP Taq1 B2B2 associates with lower risk of CAD in Asian Indians."Journal of community geneticsMore Details
    20739760 Apolipoprotein E gene polymorphism and total serum cholesterol level in Iranian population.Journal of postgraduate medicineMore Details
    20603483 Depressive symptoms and risk of dementia: the Framingham Heart Study.NeurologyMore Details
    20504763 Angiotensin-converting enzyme inhibition down-regulates the pro-atherogenic chemokine receptor 9 (CCR9)-chemokine ligand 25 (CCL25) axis.The Journal of biological chemistryMore Details
    20102908 Relation of change in apolipoprotein B/apolipoprotein A-I ratio to coronary plaque regression after Pravastatin treatment in patients with coronary artery disease.The American journal of cardiologyMore Details
    20032288 Cancer linked to Alzheimer disease but not vascular dementia.NeurologyMore Details
    20715976 Integrated role of two apoliprotein E polymorphisms on apolipoprotein B levels and coronary artery disease in a biethnic population.Metabolic syndrome and related disordersMore Details
    20452461 Role of amyloid beta in lipid homeostasis.Biochimica et biophysica actaMore Details
    19685167 Butyrylcholinesterase K variant and the APOE-epsilon 4 allele work in synergy to increase the risk of coronary artery disease especially in diabetic patients.Molecular biology reportsMore Details
    19907187 Human full-length osteoprotegerin induces the proliferation of rodent vascular smooth muscle cells both in vitro and in vivo.Journal of vascular researchMore Details
    20184726 Caspase-1 genetic variation is not associated with Alzheimer's disease risk.BMC medical geneticsMore Details
    19056704 Effects of rosuvastatin on electronegative LDL as characterized by capillary isotachophoresis: the ROSARY Study.Journal of lipid researchMore Details
    19583979 "Apolipoprotein E genotyping method by real time PCR, a fast and cost-effective alternative to the TaqMan and FRET assays."Journal of neuroscience methodsMore Details
    19713976 Impact of ACE and ApoE polymorphisms on myocardial perfusion: correlation with myocardial single photon emission computed tomographic imaging.Journal of human geneticsMore Details
    19733021 Apolipoprotein E (apoE) polymorphism: a risk factor for fatal coronary sclerosis?Forensic science internationalMore Details
    18378026 Role of apolipoproteins E and A-I: epistatic villains of triglyceride mediation in coronary heart disease.International journal of cardiologyMore Details
    19323972 Clopidogrel attenuates atheroma formation and induces a stable plaque phenotype in apolipoprotein E knockout mice.Microvascular researchMore Details
    19233360 Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype.AtherosclerosisMore Details
    19336475 Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.Human molecular geneticsMore Details
    19389852 Fetuin-A protects against atherosclerotic calcification in CKD.Journal of the American Society of Nephrology : JASNMore Details
    19252179 ApoE and ApoC-I polymorphisms: association of genotype with cardiovascular disease phenotype in African Americans.Journal of lipid researchMore Details
    19372458 Core2 1-6-N-glucosaminyltransferase-I deficiency protects injured arteries from neointima formation in ApoE-deficient mice."Arteriosclerosis, thrombosis, and vascular biology"More Details
    19155782 The environmental and genetic evidence for the association of hyperlipidemia and hypertension.Journal of hypertensionMore Details
    19722574 Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesion.Journal of agricultural and food chemistryMore Details
    19667307 "APOE genotype, lipids, and coronary heart disease risk: a prospective population study."Archives of internal medicineMore Details
    20031582 Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort.Circulation. Cardiovascular geneticsMore Details
    21637672 "Effects of APOE, APOB and LDLR variants on serum lipids and lack of association with xanthelasma in individuals from Southeastern Brazil."Genetics and molecular biologyMore Details
    19956623 Loss of PDZK1 causes coronary artery occlusion and myocardial infarction in Paigen diet-fed apolipoprotein E deficient mice.PloS oneMore Details
    19691831 "Gene polymorphisms in APOE, NOS3, and LIPC genes may be risk factors for cardiac adverse events after primary CABG."Journal of cardiothoracic surgeryMore Details
    19494537 "Apolipoprotein E, CI and B gene polymorphisms in a sample of patients with coronary heart disease in the Kuwaiti population.""Medical principles and practice : international journal of the Kuwait University,"More Details
    19948027 Plasma PLTP activity is inversely associated with HDL-C levels.Nutrition & metabolismMore Details
    18721571 The apolipoprotein E epsilon4 allele is not associated with cognitive dysfunction in cardiac surgery.The Annals of thoracic surgeryMore Details
    18603482 Influence of genetic factors in the modulation of postprandial lipemia.Atherosclerosis. SupplementsMore Details
    18855536 Pharmacogenetics of apolipoprotein E gene during lipid-lowering therapy: lipid levels and prevention of coronary heart disease.PharmacogenomicsMore Details
    21291761 "Association between apolipoprotein E polymorphism, lipids, and coronary artery disease in Tunisian type 2 diabetes."Journal of clinical lipidologyMore Details
    18725890 Differential modulation of diet-induced obesity and adipocyte functionality by human apolipoprotein E3 and E4 in mice.International journal of obesity (2005)More Details
    18067591 CD36 mRNA expression is increased in CD14+ monocytes of patients with coronary heart disease.Clinical and experimental pharmacology & physiologyMore Details
    17462871 Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease."Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    18342019 Influence of PDZK1 on lipoprotein metabolism and atherosclerosis.Biochimica et biophysica actaMore Details
    18054357 Inhibition of intestinal absorption of cholesterol by ezetimibe or bile acids by SC-435 alters lipoprotein metabolism and extends the lifespan of SR-BI/apoE double knockout mice.AtherosclerosisMore Details
    18374151 Sex-based differences in vascular repair with bone marrow cell therapy: relevance of regulatory and Th2-type cytokines.Transplantation proceedingsMore Details
    18179501 Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men.Journal of the American Geriatrics SocietyMore Details
    18398670 Synergistic effect between apolipoprotein E and apolipoprotein A1 gene polymorphisms in the risk for coronary artery disease.Molecular and cellular biochemistryMore Details
    18289451 Vascular factors and risk for neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study.International psychogeriatrics / IPAMore Details
    18611440 Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice.Pharmacological research : the official journal of the Italian PharmacologicalMore Details
    18289550 "Synergistic effects of the apolipoprotein E epsilon3/epsilon2/epsilon4, the cholesteryl ester transfer protein TaqIB, and the apolipoprotein C3 -482 C>T polymorphisms on their association with coronary artery disease."AtherosclerosisMore Details
    18704761 Molecular genetics of myocardial infarction.Genomic medicineMore Details
    17683517 The Mediterranean paradox for susceptibility factors in coronary heart disease extends to genetics.Annals of human geneticsMore Details
    17991756 Characterization of high density lipoprotein particles in familial apolipoprotein A-I deficiency.Journal of lipid researchMore Details
    17594534 Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts.Molecular biology reportsMore Details
    18388879 Effect of APOE genotype on lipid levels in patients with coronary heart disease during a 3-week inpatient rehabilitation program.Clinical pharmacology and therapeuticsMore Details
    18591462 Low HDL cholesterol is a risk factor for deficit and decline in memory in midlife: the Whitehall II study."Arteriosclerosis, thrombosis, and vascular biology"More Details
    18298348 Apolipoprotein E polymorphisms in Mexican patients with coronary artery disease.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    18163216 Apolipoprotein E gene is related to mortality only in normal weight individuals: the Rotterdam Study.European journal of epidemiologyMore Details
    18609102 Diagnostic performance of plasma high sensitive C-reactive protein in detecting three-vessel coronary artery disease: modification by apolipoprotein E genotype.Scandinavian journal of clinical and laboratory investigationMore Details
    17878422 Association of apolipoprotein E genotypes with lipid levels and coronary risk.JAMA : the journal of the American Medical AssociationMore Details
    17403027 The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk.Annals of human geneticsMore Details
    17889142 Effect of apolipoprotein E polymorphism on renal transplantation.Transplantation proceedingsMore Details
    17689519 The presence of apolipoprotein epsilon4 and epsilon2 alleles augments the risk of coronary artery disease in type 2 diabetic patients.Clinical biochemistryMore Details
    17984379 "Spontaneous atherothrombosis and medial degradation in Apoe-/-, Npc1-/- mice."CirculationMore Details
    17367769 "Association between plasma lipid parameters and APOC3 genotypes in Brazilian subjects: effect of gender, smoking and APOE genotypes."Clinica chimica acta; international journal of clinical chemistryMore Details
    17443358 Deposition of free cholesterol in the blood vessels of patients with coronary artery disease: a possible novel mechanism for atherogenesis.LipidsMore Details
    17478321 Mechanism by which alcohol and wine polyphenols affect coronary heart disease risk.Annals of epidemiologyMore Details
    17393220 Postprandial lipemia is modified by the presence of the APOB-516C/T polymorphism in a healthy Caucasian population.LipidsMore Details
    17332893 Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL.The Journal of clinical investigationMore Details
    17562993 Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study.Archives of ophthalmologyMore Details
    17559752 Effects of ezetimibe on lipids and lipoproteins in patients with hypercholesterolemia and different apolipoprotein E genotypes.Current medical research and opinionMore Details
    17217375 Robust association of the APOE epsilon4 allele with premature myocardial infarction especially in patients without hypercholesterolaemia: the Aachen study.European journal of clinical investigationMore Details
    17306734 Gene-environment interaction and its impact on coronary heart disease risk."Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    16678832 A genome scan for loci influencing levels and trends of lipoprotein lipid-related traits since childhood: The Bogalusa Heart Study.AtherosclerosisMore Details
    17982164 "Apolipoprotein E polymorphisms, dietary fat and fibre, and serum lipids: the EPIC Norfolk study."European heart journalMore Details
    17567623 Apolipoprotein E polymorphisms influence effect of pravastatin on survival after myocardial infarction in a Mediterranean population: the GISSI-Prevenzione study.European heart journalMore Details
    16806235 "Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice."AtherosclerosisMore Details
    17379005 Associations of apolipoprotein E polymorphism with low-density lipoprotein size and subfraction profiles in Arab patients with coronary heart disease.Metabolism: clinical and experimentalMore Details
    17848120 Apolipoprotein E polymorphism--a risk factor for metabolic syndrome.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    18020970 Hyperhomocysteinemia and high-density lipoprotein metabolism in cardiovascular disease.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    17852827 Improvement of myocardial blood flow by lipid-lowering therapy with pravastatin is modulated by apolipoprotein E genotype.Scandinavian journal of clinical and laboratory investigationMore Details
    17901562 Potentially reduced exposure cigarettes accelerate atherosclerosis: evidence for the role of nicotine.Cardiovascular toxicologyMore Details
    16606866 APOE alleles are not associated with calcific aortic stenosis.Heart (British Cardiac Society)More Details
    16621646 Structural and phylogenetic approaches to assess the significance of human Apolipoprotein E variation.Molecular genetics and metabolismMore Details
    16888319 Protective effect of apolipoprotein E2 on coronary artery disease in African Americans is mediated through lipoprotein cholesterol.Journal of lipid researchMore Details
    17092867 APOE distribution in world populations with new data from India and the UK.Annals of human biologyMore Details
    16682673 Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers.NeurologyMore Details
    16717174 Performance-based physical function and future dementia in older people.Archives of internal medicineMore Details
    16445917 Apolipoprotein E genotype and statins affect CRP levels through independent and different mechanisms: AGES-Reykjavik Study.AtherosclerosisMore Details
    16556855 Influence of HDL cholesterol on preclinical carotid atherosclerosis in familial hypercholesterolemia."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16459141 Combined effects of apoE-CI-CII cluster and LDL-R gene polymorphisms on chromosome 19 and coronary artery disease risk.International journal of hygiene and environmental healthMore Details
    16631444 Accumulation of apoE-enriched triglyceride-rich lipoproteins in patients with coronary artery disease.Metabolism: clinical and experimentalMore Details
    19804074 "The effects of apoA-I/C-III/A-IV, apoE and apoB polymorphisms on carotid artery intima-media thickness."Future cardiologyMore Details
    16154574 Modulating effects of cholesterol feeding and simvastatin treatment on platelet-activating factor acetylhydrolase activity and lysophosphatidylcholine concentration.AtherosclerosisMore Details
    16545358 Association between apolipoprotein E polymorphism and coronary artery disease in the Kermanshah population in Iran.Clinical biochemistryMore Details
    16269665 Macrophage apolipoprotein E reduces atherosclerosis and prevents premature death in apolipoprotein E and scavenger receptor-class BI double-knockout mice."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16254208 Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16461842 Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells.CirculationMore Details
    16322531 Increased apolipoprotein deposits in early atherosclerotic lesions distinguish symptomatic from asymptomatic patients."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16298355 "Improved prediction of early-onset coronary artery disease using APOE epsilon4, BChE-K, PPARgamma2 Pro12 and ENOS T-786C in a polygenic model."Clinical biochemistryMore Details
    17174184 Apolipoprotein E genotype and circulating interleukin-10 levels in patients with stable and unstable coronary artery disease.Journal of the American College of CardiologyMore Details
    17129981 Low-density lipoprotein (LDL) particle size in healthy prepubertal children: the STRIP study."Acta paediatrica (Oslo, Norway : 1992)"More Details
    16458317 Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice.AtherosclerosisMore Details
    16760224 "Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participants."American journal of epidemiologyMore Details
    16786033 "Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease."Molecular psychiatryMore Details
    16168296 Lipoprotein lipase gene polymorphisms and the risk of target vessel revascularization after percutaneous coronary intervention.Journal of the American College of CardiologyMore Details
    16118069 Apolipoprotein E polymorphism is not a predictor for repeated coronary artery bypass surgery.Scandinavian cardiovascular journal : SCJMore Details
    16194201 Modeling premature occurrence of acute coronary syndrome with atherogenic and thrombogenic risk factors and gene markers in extended families.Journal of thrombosis and haemostasis : JTHMore Details
    16015283 Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions.European journal of human genetics : EJHGMore Details
    15914296 Atherosclerotic lesions in the common coronary arteries of ApoE knockout mice.Cardiovascular pathology : the official journal of the Society for CardiovascularMore Details
    15967843 "Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice."CirculationMore Details
    15539621 "Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican.""Arteriosclerosis, thrombosis, and vascular biology"More Details
    15676165 Serum levels of interleukin-18 in patients with stable and unstable angina pectoris.International journal of cardiologyMore Details
    16043164 "Contemporaneous carrier-state of two or three ""proatherosclerotic"" variants of APOE, ICAM1, PPARA and PAI-1 genes differentiate CAD patients from healthy individuals."Clinica chimica acta; international journal of clinical chemistryMore Details
    15817610 Associations between apoE genotype and colon and rectal cancer.CarcinogenesisMore Details
    16039278 Increased hypercholesterolemia and atherosclerosis in mice lacking both ApoE and leptin receptor.AtherosclerosisMore Details
    15769459 Toll-like receptor 2 stimulation induces intimal hyperplasia and atherosclerotic lesion development.Cardiovascular researchMore Details
    15692099 Lymphocytes are not required for the rapid onset of coronary heart disease in scavenger receptor class B type I/apolipoprotein E double knockout mice."Arteriosclerosis, thrombosis, and vascular biology"More Details
    15657615 Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD.European journal of human genetics : EJHGMore Details
    15899673 Apolipoprotein E haplotyping by denaturing high-performance liquid chromatography.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    15319409 Methodological problems in genetic association studies of longevity--the apolipoprotein E gene as an example.International journal of epidemiologyMore Details
    15545514 Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice.CirculationMore Details
    15571629 The apolipoprotein E polymorphism and the cholesterol-raising effect of coffee.Lipids in health and diseaseMore Details
    15488872 No APOEepsilon4 effect on coronary heart disease risk in a cohort with low smoking prevalence: the Whitehall II study.AtherosclerosisMore Details
    15180698 Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans.Annals of human geneticsMore Details
    15057551 Effects of insulin sensitizers on plaque vulnerability associated with elevated lipid content in atheroma in ApoE-knockout mice.Acta diabetologicaMore Details
    15177121 Triglyceride-rich lipoproteins inhibit cholesterol efflux to apolipoprotein (apo) A1 from human macrophage foam cells.AtherosclerosisMore Details
    15177126 Alcohol consumption and inflammatory markers in older adults: the Cardiovascular Health Study.AtherosclerosisMore Details
    15370197 Apolipoprotein E polymorphism and stroke in a population from eastern Turkey.Journal of neurogeneticsMore Details
    12969990 Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3."Arteriosclerosis, thrombosis, and vascular biology"More Details
    14688198 Short telomeres protect from diet-induced atherosclerosis in apolipoprotein E-null mice.FASEB journal : official publication of the Federation of American Societies for More Details
    15070435 How to identify gene-environment interactions in a multifactorial disease: CHD as an example.The Proceedings of the Nutrition SocietyMore Details
    15571826 The apolipoprotein E polymorphism is associated with circulating C-reactive protein (the Ludwigshafen risk and cardiovascular health study).European heart journalMore Details
    15530894 Pharmacogenetics of HMG-CoA reductase inhibitors: exploring the potential for genotype-based individualization of coronary heart disease management.AtherosclerosisMore Details
    15466371 Apolipoprotein E gene polymorphisms and thrombosis and restenosis after coronary artery stenting.Journal of lipid researchMore Details
    15276511 Preliminary report on the interaction of apolipoprotein E polymorphism with aortic atherosclerosis and acute nephropathy after CABG.The Annals of thoracic surgeryMore Details
    15630634 "Apolipoprotein E and familial dysbetalipoproteinemia: clinical, biochemical, and genetic aspects."Seminars in vascular medicineMore Details
    15145987 Storage of human plasma samples leads to alterations in the lipoprotein distribution of apoC-III and apoE.Journal of lipid researchMore Details
    15183747 Apolipoprotein E gene polymorphism effects triglycerides but not CAD risk in Caucasian women younger than 65 years.Annales de genetiqueMore Details
    15543563 Five polymorphisms in gene candidates for cardiovascular disease in Afro-Brazilian individuals.Journal of clinical laboratory analysisMore Details
    15207428 Assessment of the health status in the Massa Lombarda cohort: a preliminary description of the program evaluating cardio-cerebro-vascular disease risk factors and quality of life in an elderly population.Archives of gerontology and geriatrics. SupplementMore Details
    12964943 "Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD."BMC medical geneticsMore Details
    14530190 Association between apolipoprotein E alleles and calcific valvular heart disease.CirculationMore Details
    12937897 The single nucleotide polymorphism -1131T>C in the apolipoprotein A5 (APOA5) gene is associated with elevated triglycerides in patients with hyperlipidemia."Journal of molecular medicine (Berlin, Germany)"More Details
    12923233 The influence of the apolipoprotein E gene promoter (-219G/ T) polymorphism on postprandial lipoprotein metabolism in young normolipemic males.Journal of lipid researchMore Details
    12711862 "Oxidized LDL autoantibodies are related to apolipoprotein E phenotype, independently of postprandial change in plasma triglycerides and LDL size, among patients with angiographically verified coronary artery disease and healthy controls."Journal of biomedical scienceMore Details
    12742802 Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study.Archives of internal medicineMore Details
    12774036 Independent effects of the -219 G>T and epsilon 2/ epsilon 3/ epsilon 4 polymorphisms in the apolipoprotein E gene on coronary artery disease: the Southampton Atherosclerosis Study.European journal of human genetics : EJHGMore Details
    12626663 "AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent."The Journal of pharmacology and experimental therapeuticsMore Details
    12835223 Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis.CirculationMore Details
    12810610 Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease.CirculationMore Details
    12573381 Large-scale evidence that the cardiotoxicity of smoking is not significantly modified by the apolipoprotein E epsilon2/epsilon3/epsilon4 genotype.LancetMore Details
    12475897 Pharmacological interference with intestinal bile acid transport reduces plasma cholesterol in LDL receptor/apoE deficiency.FASEB journal : official publication of the Federation of American Societies for More Details
    14694215 "Obesity modulates the association among APOE genotype, insulin, and glucose in men."Obesity researchMore Details
    12700893 The association of the R219K polymorphism in the ATP-binding cassette transporter 1 ( ABCA1) gene with coronary heart disease and hyperlipidaemia."Journal of molecular medicine (Berlin, Germany)"More Details
    12521230 TaqMan systems for genotyping of disease-related polymorphisms present in the gene encoding apolipoprotein E.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    12112572 Lipoprotein lipase and APOE/APOC-I/APOC-II gene cluster diversity in native Brazilian populations.American journal of human biology : the official journal of the Human BiologyMore Details
    12461692 The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe.European journal of human genetics : EJHGMore Details
    12023827 Gene-diet interaction and plasma lipid responses to dietary intervention.Biochemical Society transactionsMore Details
    11803456 Codon 311 (Cys --> Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer's and vascular dementias.Molecular psychiatryMore Details
    11230170 A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation.Genome researchMore Details
    11359359 Medical utility of apoe allele determination in assessing the need for antioxidant therapy.Medical hypothesesMore Details
    11463413 Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study.LancetMore Details
    11256794 Polymorphisms in the apolipoprotein E gene regulatory region in relation to coronary heart disease and their effect on plasma apolipoprotein E.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    11172484 Lipoprotein distribution of apolipoprotein C-III and its relationship to the presence in plasma of triglyceride-rich remnant lipoproteins.Metabolism: clinical and experimentalMore Details
    11726725 Apolipoprotein E phenotype regulates cholesterol absorption in healthy 13-month-old children--The STRIP Study.Pediatric researchMore Details
    11359065 "Population genetic analysis of the genes APOE, APOB(3'VNTR) and ACE in some black and Amerindian communities from Colombia."Human heredityMore Details
    11007687 "Effect of apolipoprotein E polymorphism on serum lipid, lipoproteins, and atherosclerosis in hemodialysis patients."American journal of kidney diseases : the official journal of the National KidneyMore Details
    10827377 "Acute myocardial infarction in young adults: prognostic role of angiotensin-converting enzyme, angiotensin II type I receptor, apolipoprotein E, endothelial constitutive nitric oxide synthase, and glycoprotein IIIa genetic polymorphisms at medium-term follow-up."American heart journalMore Details
    10861896 "Apo E genotype, diabetes, and peripheral arterial disease in older men: the Honolulu Asia-aging study."Genetic epidemiologyMore Details
    11096027 Cardiovascular infection by Chlamydia pneumoniae is not related to apolipoprotein E genotype.Clinical infectious diseases : an official publication of the Infectious DiseasesMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 55 unique genes interacted with APOE. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    LRP8 Reconstituted Complex12950167 CHD related
    PLTP Affinity Capture-Western12810820 CHD related
    LRP2 Reconstituted Complex7768901 No
    NEFM Reconstituted Complex8620924 No
    UBC Affinity Capture-Western11401504 No
    LRP1 Affinity Capture-Western2779654 CHD related
    Set Reconstituted Complex21289314 No
    GCDH Two-hybrid21163940 No
    PDCD4 Two-hybrid21163940|21163940 No
    APOE Two-hybrid21163940|9147408,7566652 CHD related
    C19orf52 Two-hybrid21163940 No
    CYP2C18 Two-hybrid21163940 No
    ELAVL1 Two-hybrid21163940 No
    FARSA Two-hybrid21163940 No
    FBXL12 Two-hybrid21163940 No
    IFIT5 Two-hybrid21163940 No
    LONP1 Two-hybrid21163940 No
    NOS3 Two-hybrid21163940 CHD related
    PRAM1 Two-hybrid21163940 No
    PRDX2 Two-hybrid21163940 CHD related
    RHEB Two-hybrid21163940 No
    ST13 Two-hybrid21163940|21163940 No
    ACTG1 Two-hybrid21163940 No
    ANKH Two-hybrid21163940 No
    EPN2 Two-hybrid21163940 No
    FOXG1 Two-hybrid21163940 No
    FXYD7 Two-hybrid21163940 No
    HTRA1 Two-hybrid21163940 No
    IQSEC1 Two-hybrid21163940 No
    MID1IP1 Two-hybrid21163940 No
    PCMT1 Two-hybrid21163940 No
    PLEKHA6 Two-hybrid21163940 No
    RPL4 Two-hybrid21163940 No
    TYRO3 Two-hybrid21163940 No
    ZNF558 Two-hybrid21163940 No
    CNTF in vitro9236223 CHD related
    ALB in vitro8063017 CHD related
    APP in vitro10559559 No
    A2M Affinity Capture-Western9831625|9831625|21163940 No
    MAPT Reconstituted Complex8620924 No
    CSNK2A1 Biochemical Activity15882073 CHD related
    CDC37 Two-hybrid21163940 No
    CYP2C8 Two-hybrid21163940 CHD related
    ECSIT Two-hybrid21163940 No
    IFIT3 Two-hybrid21163940 No
    LOXL4 Two-hybrid21163940 No
    MAST1 Two-hybrid21163940 No
    PSEN1 Two-hybrid21163940 No
    RNF32 Two-hybrid21163940 No
    CTSB in vivo12057992 CHD related
    MAP2 in vitro8624078 No
    PRNP in vivo15146195 No
    VLDLR in vivo12167620 No
    SCARB1 in vitro;in vivo12138091 CHD related
    LDLR in vitro;in vivo12036962 CHD related

    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00062Human Serum Albumin"For treatment of severe blood loss, hypervolemia, hypoproteinemia"
    approvedDB00064Serum albumin iodonatedFor determination of total blood and plasma volumes