How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: AQP1

    Description: aquaporin 1 (Colton blood group)

    Entrez Gene ID: 358

    SwissProt Acc Number: P29972

    RefSeq: NM_198098

    It was suspected to be CHD related:

    .."The water channel aquaporin-1 (AQP1) is present in the pulmonary microvascular endothelium, and a number of studies suggest the importance of AQP1 as a molecular determinant of pulmonary microvascular water transport."..

    From PMID: 21197617, in Journal Lung. , 2011


    There were 1 potential papers with AQP1 and CHD.

    21197617 Downregulation of aquaporin-1 in alveolar microvessels in lungs adapted to chronic heart failure.LungMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 9 unique genes interacted with AQP1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    MDFI Two-hybrid16189514|16189514 No
    EFEMP2 Two-hybrid16189514|16189514 No
    KCTD17 Two-hybrid16189514|16189514 No
    KRTAP4-12 Two-hybrid16189514|16189514 No
    TRIP6 Two-hybrid16189514|16189514 No
    CCDC85B Two-hybrid16189514|16189514 No
    AQP1 in vitro;in vivo7693713 CHD related
    EPHB2 in vivo;yeast 2-hybrid10839360 No
    PICK1 yeast 2-hybrid10839360 No

    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00819AcetazolamideFor adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucomaS01EC01