How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: AR

    Description: androgen receptor

    Entrez Gene ID: 367

    SwissProt Acc Number: P10275

    RefSeq: NM_000044

    It was suspected to be CHD related:

    ..Shorter polyglutamine stretch in the androgen receptor correlates with more severe CAD and worse predisposing factors in postmenopausal women undergoing coronary angiography. ..

    From PMID: 21712734, in Journal Menopause , 2011


    References

    There were 89 potential papers with AR and CHD.

    PMIDTitleJournalsDetails
    24012967 Eriosema laurentii De Wild (Leguminosae) methanol extract has estrogenic properties and prevents menopausal symptoms in ovariectomized Wistar rats.Journal of ethnopharmacologyMore Details
    23764371 "Cardiovascular adenosine receptors: expression, actions and interactions."Pharmacology & therapeuticsMore Details
    23261005 Impact of beta(1)- and beta(2)-adrenergic receptor gene single nucleotide polymorphisms on heart rate response to metoprolol prior to coronary computed tomographic angiography.The American journal of cardiologyMore Details
    23487600 Repair of incompetent truncal valves: early and mid-term results.Interactive cardiovascular and thoracic surgeryMore Details
    23423270 Ten-year results of a randomized trial comparing tacrolimus versus cyclosporine a in combination with mycophenolate mofetil after heart transplantation.TransplantationMore Details
    22772435 Real-time intraoperative visualization of myocardial circulation using augmented reality temperature display.The international journal of cardiovascular imagingMore Details
    24142755 Aspirin resistance in patients with impaired renal functions.Kardiologia polskaMore Details
    24197810 Non-atherosclerotic multiple coronary artery aneurysms.BMJ case reportsMore Details
    23428667 A multimarker study of degenerative aortic valve disease: stenoinsufficiency shows more indices of bad prognosis.CardiologyMore Details
    23001834 Comparison between adenosine and isoflurane for assessing the coronary flow reserve in mouse models of left ventricular pressure and volume overload.American journal of physiology. Heart and circulatory physiologyMore Details
    22345059 Prognostic implications of tricuspid regurgitation in patients with severe aortic regurgitation: results from a cohort of 756 patients.Interactive cardiovascular and thoracic surgeryMore Details
    22709742 From pressure overload to volume overload: aortic regurgitation after transcatheter aortic valve implantation.American heart journalMore Details
    23123995 Augmented reality image guidance improves navigation for beating heart mitral valve repair."Innovations (Philadelphia, Pa.)"More Details
    21636287 Aspirin resistance in off-pump coronary artery bypass grafting.European journal of cardio-thoracic surgery : official journal of the EuropeanMore Details
    22104341 Efficacy of combined renal and mesenteric revascularization.Journal of vascular surgeryMore Details
    23319968 The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology.Archives of medical science : AMSMore Details
    22661511 Aldose reductase modulates cardiac glycogen synthase kinase-3beta phosphorylation during ischemia-reperfusion.American journal of physiology. Heart and circulatory physiologyMore Details
    22561563 [Prevalence of laboratory aspirin resistance in 431 old patients].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University.More Details
    22786488 Long term hormone therapy for perimenopausal and postmenopausal women.The Cochrane database of systematic reviewsMore Details
    22068192 Impact of health screening and education on knowledge of coronary heart disease risk factors.Journal of the American Pharmacists Association : JAPhAMore Details
    21267513 Autonomic contribution to endothelin-1 increase during laboratory anger-recall stress in patients with coronary artery disease."Molecular medicine (Cambridge, Mass.)"More Details
    21107691 Outcome of renal transplantation in patients with diabetic nephropathy -- a single-center experience.International urology and nephrologyMore Details
    21847356 A(2A) adenosine receptor-mediated increase in coronary flow in hyperlipidemic APOE-knockout mice.Journal of experimental pharmacologyMore Details
    21302014 Myocardial perfusion imaging analysis in patients with regurgitant valvular heart disease.Journal of nuclear cardiology : official publication of the American Society ofMore Details
    20692245 Insertion/insertion genotype of alpha(2B)-adrenergic receptor gene polymorphism is associated with silent myocardial ischemia in patients with type 2 diabetes mellitus.Clinical biochemistryMore Details
    20303607 Increased serum neopterin in patients with nonrheumatic aortic valve stenosis.International journal of cardiologyMore Details
    20368479 Tendency to angry rumination predicts stress-provoked endothelin-1 increase in patients with coronary artery disease.Psychosomatic medicineMore Details
    19016915 Comparison of laboratory detection methods of aspirin resistance in coronary artery disease patients.International journal of laboratory hematologyMore Details
    20829384 Repair of left coronary artery ostial isolation caused by aortic valve leaflet.Interactive cardiovascular and thoracic surgeryMore Details
    20502967 Central aortic valve coaptation area during diastole as seen by 64-multidetector computed tomography (MDCT).The international journal of cardiovascular imagingMore Details
    20688214 Viral endomyocardial infection is an independent predictor and potentially treatable risk factor for graft loss and coronary vasculopathy in pediatric cardiac transplant recipients.Journal of the American College of CardiologyMore Details
    20719736 Dynamic aortic pouch: a rare etiology of aortic regurgitation.The heart surgery forumMore Details
    19761933 The alpha-1D Is the predominant alpha-1-adrenergic receptor subtype in human epicardial coronary arteries.Journal of the American College of CardiologyMore Details
    19625469 Is the aortic valve pathology type different for early and late mortality in concomitant aortic valve replacement and coronary artery bypass surgery?Interactive cardiovascular and thoracic surgeryMore Details
    19587314 Therapeutic efficacy of a combination of a beta1-adrenoreceptor (AR) blocker and beta2-AR agonist in a rat model of postmyocardial infarction dilated heart failure exceeds that of a beta1-AR blocker plus angiotensin-converting enzyme inhibitor.The Journal of pharmacology and experimental therapeuticsMore Details
    19439376 Unknown ankylosing spondylitis with only cardiac involvement in patient with surgical indication: Call for patient and family members immunological screening.International journal of cardiologyMore Details
    19766452 Behcet's disease as a frequently unrecognized cause of aortic regurgitation: suggestive and misleading echocardiography findings.Journal of the American Society of Echocardiography : official publication of theMore Details
    19184536 Recent improvements in the development of A(2B) adenosine receptor agonists.Purinergic signallingMore Details
    19285617 Quilty effect correlates with biopsy-proven acute cellular rejection but does not predict transplanted heart coronary artery vasculopathy.The Journal of heart and lung transplantation : the official publication of theMore Details
    19196803 Androgen-androgen receptor system protects against angiotensin II-induced vascular remodeling.EndocrinologyMore Details
    19038389 Staccato reperfusion prevents reperfusion injury in patients undergoing coronary angioplasty: a 1-year follow-up pilot study.AtherosclerosisMore Details
    19628121 Effect of beta-blocker therapy on survival in patients with severe aortic regurgitation results from a cohort of 756 patients.Journal of the American College of CardiologyMore Details
    19101292 Very mild hypothermia during ischemia and reperfusion improves postinfarction ventricular remodeling.The Annals of thoracic surgeryMore Details
    19101291 Regional heterogeneity of myocardial reperfusion injury: effect of mild hypothermia.The Annals of thoracic surgeryMore Details
    19639282 Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiology.Handbook of experimental pharmacologyMore Details
    18801377 Mechanisms involved in testosterone-induced vasodilatation in pig prostatic small arteries.Life sciencesMore Details
    18809152 Is the aortic root dilated in obstructive sleep apnoea syndrome?Archives of cardiovascular diseasesMore Details
    18070946 Incidence of aortic valve regurgitation and outcome after percutaneous closure of atrial septal defects and patent foramen ovale.Heart (British Cardiac Society)More Details
    18443746 Recent improvements in the development of A(2B) adenosine receptor agonists.Purinergic signallingMore Details
    18655115 First percutaneous transcatheter aortic valve-in-valve implant with three year follow-up.Catheterization and cardiovascular interventions : official journal of theMore Details
    18353108 Beta1- and beta2-adrenoceptor polymorphisms and cardiovascular diseases.Fundamental & clinical pharmacologyMore Details
    18533043 Validation of a questionnaire measuring the regulation of autonomic function.BMC complementary and alternative medicineMore Details
    17112609 Ischemia and apoptosis in an animal model of permanent infarct-related artery occlusion.International journal of cardiologyMore Details
    17717207 Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo.Anesthesia and analgesiaMore Details
    17889196 Clinical implications of late mitral valve regurgitation appearance in the follow-up of heart transplantation.Transplantation proceedingsMore Details
    17456064 Assessment of mitral inflow during standardized Valsalva maneuver in stratification of diastolic function."Echocardiography (Mount Kisco, N.Y.)"More Details
    17016676 Differential role of PI3K/Akt pathway in the infarct size limitation and antiarrhythmic protection in the rat heart.Molecular and cellular biochemistryMore Details
    17277020 Aspirin before reperfusion blunts the infarct size limiting effect of atorvastatin.American journal of physiology. Heart and circulatory physiologyMore Details
    17568273 64-slice multidetector computed tomography (MDCT) for detection of aortic regurgitation and quantification of severity.Investigative radiologyMore Details
    17541557 "In patients chronically treated with metoprolol, the demand of inotropic catecholamine support after coronary artery bypass grafting is determined by the Arg389Gly-beta 1-adrenoceptor polymorphism."Naunyn-Schmiedeberg's archives of pharmacologyMore Details
    17697832 Accuracy of 64-slice computed tomography for the preoperative detection of coronary artery disease in patients with chronic aortic regurgitation.The American journal of cardiologyMore Details
    16702043 "Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism."PlateletsMore Details
    16697257 Ventricular septal defect closure in right coronary cusp prolapse and aortic regurgitation complicating VSD in the outlet septum: which treatment is most appropriate?"Heart, lung & circulation"More Details
    17133230 Early adiposity rebound: causes and consequences for obesity in children and adults.International journal of obesity (2005)More Details
    16864725 Causes of pure aortic regurgitation in patients having isolated aortic valve replacement at a single US tertiary hospital (1993 to 2005).CirculationMore Details
    16300799 Adenosine receptor-mediated coronary vascular protection in post-ischemic mouse heart.Life sciencesMore Details
    16569551 Common adrenergic receptor polymorphisms as novel risk factors for vasospastic angina.American heart journalMore Details
    16340184 Dipyridamole decreases protease-activated receptor and annexin-v binding on platelets of post stroke patients with aspirin nonresponsiveness."Cerebrovascular diseases (Basel, Switzerland)"More Details
    16498243 Sudden cardiac death in the young: a strategy for prevention by targeted evaluation.CardiologyMore Details
    16030061 "Infarct-related artery occlusion, tissue markers of ischaemia, and increased apoptosis in the peri-infarct viable myocardium."European heart journalMore Details
    16309399 Acute effect of cerivastatin on cardiac regional ischemia in a rat model mimicking off-pump coronary surgery.Journal of cardiac surgeryMore Details
    15935888 Impact of ELISA-detected anti-HLA antibodies on pediatric cardiac allograft outcome.Human immunologyMore Details
    16352247 Factors influencing the mean postoperative gradients across stentless porcine valves."Heart, lung & circulation"More Details
    16015456 Early antecedents of adult work stress: social-emotional competence and anger in adolescence.Journal of behavioral medicineMore Details
    15549618 Coronary artery dilatation and aortic outflow tract enlargement in children with unicommissural aortic valves.Pediatric cardiologyMore Details
    15890890 The CAG repeat polymorphism in the androgen receptor gene is associated with HDL-cholesterol but not with coronary atherosclerosis or myocardial infarction.Clinical chemistryMore Details
    15536156 Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease.The Journal of clinical endocrinology and metabolismMore Details
    16020950 Meta-analysis of trials comparing oral anticoagulation and aspirin versus dual antiplatelet therapy after coronary stenting. Clues for the management of patients with an indication for long-term anticoagulation undergoing coronary stenting.CardiologyMore Details
    15364841 Aortic valve repair using a differentiated surgical strategy.CirculationMore Details
    15548188 A technique for infusion of cardioplegic solution in coronary artery bypass with aortic regurgitation.Journal of cardiac surgeryMore Details
    14634049 Comparison of three different A1 adenosine receptor antagonists on infarct size and multiple cycle ischemic preconditioning in anesthetized dogs.The Journal of pharmacology and experimental therapeuticsMore Details
    15242731 Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization.Journal of molecular and cellular cardiologyMore Details
    14992681 Testosterone-induced coronary vasodilatation occurs via a non-genomic mechanism: evidence of a direct calcium antagonism action."Clinical science (London, England : 1979)"More Details
    12545296 [Brachytherapy after coronary interventions: current state and future perspectives].Zeitschrift fur KardiologieMore Details
    14974917 The androgen receptor gene CAG polymorphism is associated with the severity of coronary artery disease in men.Clinical endocrinologyMore Details
    12689858 A3 adenosine receptor agonist IB-MECA reduces myocardial ischemia-reperfusion injury in dogs.American journal of physiology. Heart and circulatory physiologyMore Details
    12244475 [CT angiography of the coronary arteries with a 16-row spiral tomograph. Effect of spatial resolution on image quality].Der RadiologeMore Details
    11406842 Notes on interval estimation of the attributable risk in cross-sectional sampling.Statistics in medicineMore Details
    11045426 Cardiac functional improvement by a human Bcl-2 transgene in a mouse model of ischemia/reperfusion injury.The journal of gene medicineMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 247 unique genes interacted with AR. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    GNB2L1 Two-hybrid12958311|12958311|12958311|12958311 No
    FLNA Two-hybrid12682292|12682292 No
    RAN Two-hybrid10400640 No
    NR2C2 Two-hybrid10611280 No
    NCOA3 Two-hybrid10965917|11747336|10965917|14966121 No
    RNF4 Two-hybrid9710597|10617653|9710597|11719514 No
    NCOA4 Two-hybrid9892017|8643607|11818501|8643607|8643607|11779876|11779876|12612084|15604093 No
    PAK6 Two-hybrid11278661|11773441|11773441|11278661|11278661 No
    RCHY1 Two-hybrid12200228|17721809|16914734 No
    PIAS2 Two-hybrid11117529|9920921 No
    HNF4A Co-localization12944908 No
    IL6ST Affinity Capture-Western15129430|15129430 CHD related
    SMAD3 Affinity Capture-Western11707452|11280774|11280774|11280774|12226080|12226080 CHD related
    CCNH Reconstituted Complex10734072|10734072 No
    CDK7 Affinity Capture-Western10734072|10734072|21157430|10734072 No
    AR Protein-peptide15525515|15525515|15062556|15256534|11504717|12682292|15062556,9111344,9417052,14966121,15305378 CHD related
    STAT3 Affinity Capture-Western11322786|11751884|11751884,12804609 CHD related
    XRCC5 Reconstituted Complex15640154|15640154 No
    XRCC6 Affinity Capture-Western15640154|15640154 No
    NCOA1 Two-hybrid15256534|12163482 No
    NCOR1 Two-hybrid15256534|14593076|12089345|12089345|12089345|16914745|15598662|16469706 No
    NCOR2 Two-hybrid12441355|12441355|12441355|14593076|11923464|12441355|15062576|22508987|17356171|11923464,15062576 No
    NCOA2 Two-hybrid14593076|12810069|14966121|12612084|15684378 No
    FOXO1 Affinity Capture-Western12482965|12482965|12482965|12482965 CHD related
    MAGEA11 Co-localization15684378|15684378|15684378|15684378|19828458 No
    TP53 Phenotypic Suppression11504717 CHD related
    TGFB1I1 Two-hybrid11856738|11856738|11856738|11779876|11779876 No
    GRIP1 Two-hybrid10607837|10607837 No
    PELP1 Affinity Capture-Western15466214 No
    TCF4 Affinity Capture-Western12799378|12799378|12799378 No
    SART3 Affinity Capture-Western15031286|15031286 No
    HDAC3 Reconstituted Complex12943985|16469706 CHD related
    HDAC4 Reconstituted Complex12943985|21242980|21242980 CHD related
    PSPC1 Affinity Capture-MS12810069 No
    NONO Affinity Capture-MS12810069|12810069|12810069|17452459|12810069 No
    EFCAB6 Affinity Capture-Western12612053 No
    HDAC1 Two-hybrid11994312|15640443|15835920 CHD related
    NSD1 Two-hybrid11509567 No
    TSG101 Two-hybrid10508170 No
    COX5B Two-hybrid11719263|11719263|11719263 No
    RAF1 Co-purification8349631|8349631 CHD related
    SVIL Two-hybrid11792840|11792840 No
    FHL2 Two-hybrid10654935 No
    PIAS4 Reconstituted Complex11439351 No
    NR0B1 Affinity Capture-Western11875111 No
    SRY Two-hybrid11585838|11585838 CHD related
    UBE2I Two-hybrid10383460|10383460 No
    CALR Reconstituted Complex8107809|8107809 No
    SPDEF Reconstituted Complex10625666 No
    ETV5 Reconstituted Complex8798622 No
    PIAS1 Two-hybrid11117529 No
    PIAS3 Two-hybrid11117529|11071847 No
    HMGB1 Reconstituted Complex9671457|9671457,11748221 CHD related
    HMGB2 Reconstituted Complex9671457 No
    GTF2F1 Reconstituted Complex9238003|9238003 No
    GTF2F2 Reconstituted Complex9238003|9238003 No
    TBP Reconstituted Complex9238003 No
    GTF2H1 Affinity Capture-Western10734072|10734072,11266437 No
    PMEPA1 Affinity Capture-Western18703514 No
    SMARCA4 Affinity Capture-Western14966121|19762545|18487222 No
    SMARCC1 Affinity Capture-Western14966121 No
    HSPB2 Affinity Capture-Western17974989 No
    MDM2 Affinity Capture-Western17974989|15640443|21157430|12145204 CHD related
    UBC Affinity Capture-Western17974989|15640443|12145204|20501646|19345326|20069563|19706771|12559985|21157430|20181722|22846800|23041672 No
    MDN1 Two-hybrid19762545 No
    NLRP10 Two-hybrid19762545 No
    SMARCA2 Two-hybrid19762545|18487222 No
    ZBTB16 Two-hybrid19762545 No
    MED24 Two-hybrid19762545 No
    DENND5A Two-hybrid19762545 No
    ZBTB1 Two-hybrid19762545 No
    MED12L Two-hybrid19762545 No
    SMARCD1 Two-hybrid19762545 No
    SPOP Two-hybrid19762545 No
    MLH3 Two-hybrid19762545 No
    KIFAP3 Two-hybrid19762545 No
    ZNF318 Affinity Capture-Western16469430 No
    SMARCE1 Reconstituted Complex18559499 No
    EP300 Affinity Capture-Western18487222|10779504 CHD related
    TGIF1 Reconstituted Complex11682623|11682623 No
    SFPQ Affinity Capture-Western17452459 No
    GADD45GIP1 Affinity Capture-Western17885209|17885209|17885209 No
    USP26 Affinity Capture-Western20501646 No
    RNF6 Reconstituted Complex19345326 No
    TH1L Affinity Capture-Western20069563|20069563 No
    STUB1 Affinity Capture-Western19706771|21157430|15107424|15107424|20661446|15107424 No
    REPS2 Two-hybrid15604093 No
    KIF1A Two-hybrid15604093|15604093 No
    ERCC3 Affinity Capture-Western21157430|21157430 No
    ERCC2 Reconstituted Complex21157430 No
    GTF2H2 Reconstituted Complex21157430 No
    ZBTB7A Affinity Capture-Western20812024|20812024 No
    E2F1 Affinity Capture-Western22508987 CHD related
    LCOR Two-hybrid21856747|21856747 No
    LATS2 Two-hybrid15131260 No
    COPS2 Two-hybrid17356171|17356171 No
    USP10 Affinity Capture-MS16368182 No
    TAF1 Affinity Capture-Western20181722 No
    ARID5A Two-hybrid15941852 No
    TCF20 Affinity Capture-Western21935435|21935435 No
    DCAF6 Two-hybrid15784617|15784617 No
    FKBP5 Affinity Capture-Western20661446 No
    FKBP4 Affinity Capture-Western20661446 No
    PPP5C Affinity Capture-Western20661446 No
    DNAJC7 Affinity Capture-Western20661446 No
    PPID Affinity Capture-Western20661446 No
    TAB2 Affinity Capture-Western16469706 No
    TBL1XR1 Affinity Capture-Western16469706 No
    SIN3A Affinity Capture-Western16469706 No
    SIN3B Affinity Capture-Western16469706 No
    MED14 in vivo12218053 No
    KDM1A in vitro;in vivo16079795 No
    CDK6 in vitro;in vivo15790678 No
    RUNX2 in vitro10521447 No
    CASP3 in vitro;in vivo9535906,8626669,9208847 CHD related
    IARS in vitro;yeast 2-hybrid10669760 No
    UBE3A in vitro;yeast 2-hybrid9891052 No
    CASP7 in vitro9535906 CHD related
    NRIP1 in vivo9368054 No
    PXN in vitro12941817 No
    PSMC3IP in vitro;in vivo;yeast 2-hybrid11739747 No
    KAT2B in vitro10779504 No
    RBAK in vitro;in vivo;yeast 2-hybrid14664718 No
    APOL2 in vitro;yeast 2-hybrid15107424 No
    JMJD1C in vitro;in vivo;yeast 2-hybrid17353003 No
    CTDSP2 in vitro;in vivo;yeast 2-hybrid16724108 No
    IFI16 in vitro;in vivo16494870 No
    ESR1 in vitro12389206 CHD related
    NR3C1 in vitro;yeast 2-hybrid9162033 CHD related
    SLC25A4 in vitro;in vivo;yeast 2-hybrid12039962 No
    IDE in vitro8051160 No
    NFKB1 in vitro;in vivo8798655 CHD related
    RELA in vitro;in vivo8798655 CHD related
    RANBP9 Two-hybrid12361945|12361945|12361945 No
    AKT1 Reconstituted Complex11404460|11404460|11404460,11156376,16210317 CHD related
    CALM1 Affinity Capture-Western14695896|14695896|14695896|14695896 No
    RAD9A Two-hybrid14966297 No
    NCOA6 Two-hybrid14645241 No
    CTNNB1 Reconstituted Complex11792709|11792709|12944908|12944908 CHD related
    DAXX Two-hybrid15572661|15572661|15572661 No
    SP1 Affinity Capture-Western15661808|17984071|10809237,9535906 No
    GSK3B Reconstituted Complex15178691|15178691 CHD related
    GSN Reconstituted Complex12941811 No
    SELENBP1 Affinity Capture-Western1540595 No
    HSPA1A Affinity Capture-Western1540595 CHD related
    HSP90AA1 Affinity Capture-Western1540595 CHD related
    UXT Two-hybrid11854421|11854421|11854421|21730289 No
    CAV1 Affinity Capture-Western11278309|11278309|11278309|11278309 CHD related
    JUN Affinity Capture-Western9211894 CHD related
    PRKDC Affinity Capture-MS15640154 No
    BAG1 Reconstituted Complex14517289|11278763|11278763,14517289 No
    CREBBP Two-hybrid15691881|9822653|9482849,9822653 No
    CCND1 Affinity Capture-Western15558026|15558026|10344732 CHD related
    FOXA1 Affinity Capture-Western12750453|12750453|12750453 No
    RNF14 Two-hybrid11673464|19345326|17082327|10085091 No
    DCC Affinity Capture-Western12864730|12864730|12864730 No
    SRC Affinity Capture-Western11032808|15466214 CHD related
    PTEN Reconstituted Complex15205473|15205473 CHD related
    RB1 Reconstituted Complex9813067|9675141|9675141|16964284 CHD related
    BRCA1 Reconstituted Complex11085509|11016951|11016951 CHD related
    ZMIZ1 Affinity Capture-Western14609956|14609956 No
    MAPK1 Reconstituted Complex10318905|9725910,10318905 CHD related
    EGFR Affinity Capture-Western15305378|15288768|12534934,15288768 CHD related
    GSK3A Affinity Capture-Western15361837 No
    KAT7 Affinity Capture-Western10930412|10930412|10930412 No
    NR2C1 Affinity Capture-Western12949936|12949936|12949936 No
    TDG Reconstituted Complex12874288 No
    KAT5 Biochemical Activity11994312|11994312|10364196|11591700|11591700|11994312,10364196 No
    CDK9 Affinity Capture-Western11266437|11266437 No
    YWHAQ Reconstituted Complex11266503 No
    PRMT1 Reconstituted Complex11050077 No
    NR0B2 Reconstituted Complex11735420|11735420|11735420 No
    POU2F1 Reconstituted Complex10480874 No
    POU2F2 Reconstituted Complex10480874 No
    DAP3 Reconstituted Complex10903152|10903152 No
    CEBPA Reconstituted Complex9817600 No
    CEBPB Reconstituted Complex9817600 No
    AES Two-hybrid11416139|11416139|11416139|11416139 No
    CDC37 Reconstituted Complex11085988|11085988 No
    TMF1 Reconstituted Complex10428808|12165860 No
    CCNE1 Affinity Capture-Western10953010 CHD related
    SMAD4 Affinity Capture-Western12226080|12226080|12226080 No
    PATZ1 Affinity Capture-Western11719514 No
    PA2G4 Reconstituted Complex12165860|12165860|9565586,15583694 No
    PRPF6 Affinity Capture-Western12039962|12039962 No
    TRIM24 Reconstituted Complex9115274|19909775|9115274 No
    MED1 Affinity Capture-Western12218053|12218053 No
    GAPDH Two-hybrid8872471|8872471 No
    CDC25B Reconstituted Complex12569365 No
    TRIM68 Affinity Capture-Western18451177 No
    WHSC1 Affinity Capture-Western19481544|19481544 No
    PHB Affinity Capture-Western16964284 No
    SIRT1 Affinity Capture-Western16923962|16923962|16923962|22318606 CHD related
    HDAC7 Affinity Capture-Western16860317 No
    RAD54L2 Affinity Capture-Western16212558|16212558|19692572|10961928 No
    ZMIZ2 Affinity Capture-Western16051670|16051670 No
    SREBF1 Affinity Capture-Western18245227|18245227 No
    RUVBL1 Affinity Capture-Western18087039 No
    KDM5B Affinity Capture-Western18048344 No
    ERG Affinity Capture-Western20478527 No
    KDM4A Affinity Capture-Western17555712 No
    KDM4D Affinity Capture-Western17555712 No
    RREB1 Affinity Capture-Western17550981 No
    SRCAP Affinity Capture-Western20432434 No
    TADA3 Reconstituted Complex20413580 No
    RNF40 Affinity Capture-Western22155569 No
    RNF20 Affinity Capture-Western22155569 No
    GTF2H3 Affinity Capture-Western21157430|21157430 No
    CHD8 Affinity Capture-Western20308527|20308527 No
    SETD7 Affinity Capture-Western21273441 No
    E2F4 Affinity Capture-Western22508987 No
    PSMC3 Affinity Capture-Western19325002 No
    ZNF451 Affinity Capture-Western18656483 No
    TNK2 Affinity Capture-Western17494760 No
    DDB2 Affinity Capture-Western22846800 No
    PAX6 Two-hybrid19790232|19790232|21935435 No
    WDR77 Reconstituted Complex12972618 No
    ZBTB32 Affinity Capture-Western20147518|20147518 No
    PARK7 Two-hybrid17510388|17510388 No
    SUMO1 in vitro;in vivo12177000 No
    RAC3 in vitro;in vivo11747336 No
    HIPK3 in vitro;in vivo;yeast 2-hybrid9725910 No
    MYBBP1A in vitro;yeast 2-hybrid11779876,10607837 No
    MYST2 in vitro;in vivo;yeast 2-hybrid10930412 No
    PNRC1 in vivo10428808 No
    NISCH in vitro;in vivo15028622 No
    PNRC2 in vitro;in vivo;yeast 2-hybrid10894149 No
    CASP1 in vitro9535906 CHD related
    RNASEL in vitro;in vivo16166078 No
    CDK1 in vitro;in vivo;yeast 2-hybrid12569365,9725910 CHD related
    ATF2 in vitro9920921 CHD related
    RUNX1 in vitro10521447 CHD related
    POU5F1 in vitro;in vivo11096094 No
    NR5A1 in vitro11518799 No
    GAK in vitro;in vivo;yeast 2-hybrid16161052 No
    WIPI1 in vitro15602573 No
    APPBP2 in vitro;in vivo;yeast 2-hybrid14729952 No
    DDC in vitro;in vivo;yeast 2-hybrid12864730 No
    TRIP4 in vitro;yeast 2-hybrid12390891 No
    SMAD1 in vivo17183365 CHD related
    CASP8 in vivo17170703 CHD related
    HIF1A in vivo17426252 CHD related
    NR3C2 yeast 2-hybrid12644298 CHD related
    CUL4B in vivo17392787 No
    AHR in vivo17392787 No
    CDC25A in vivo19013180 No
    KLK2 in vitro15542435 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00367LevonorgestrelFor the treatment of menopausal and postmenopausal disorders and alone or in combination with other hormones as an oral contraceptive.G03AC03;G03AD01
    approvedDB00421Spironolactone"Used primarily to treat low-renin hypertension, hypokalemia, and Conn's syndrome."C03DA01
    approvedDB00499FlutamideFor the management of locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostateL02BB01
    approvedDB00621OxandroloneUse to promote weight gain after weight loss following extensive surgery.A14AA08
    approvedDB00624Testosterone"To be used as hormone replacement or substitution of diminished or absent endogenous testosterone. Use in males: For management of congenital or acquired hypogonadism, hypogonadism associated with HIV infection, and male climacteric (andopause). Use in females: For palliative treatment of androgen-responsive, advanced, inoperable, metastatis (skeletal) carcinoma of the breast in women who are 1-5 years postmenopausal; testosterone esters may be used in combination with estrogens in the management of moderate to severe vasomotor symptoms associated with menopause in women who do not respond to adequately to estrogen therapy alone."G03BA02;G03BA03;G03EK01
    approvedDB00665Nilutamide"For use in combination with surgical castration for the treatment of metastatic prostate cancer involving distant lymph nodes, bone, or visceral organs (Stage D2)."L02BB02
    approvedDB00687FludrocortisoneFor partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.H02AA02
    illicit;approvedDB00858Drostanolone"For use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal."
    illicit;approvedDB00984Nandrolone phenpropionate"For the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the prophylaxis of hereditary angioedema."A14AB01;S01XA11
    approvedDB01128BicalutamideFor treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.L02BB03
    illicit;approvedDB01185Fluoxymesterone"In males, used as replacement therapy in conditions associated with symptoms of deficiency or absence of endogenous testosterone. In females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal."G03BA01
    approvedDB01395DrospirenoneFor the prevention of pregnancy in women who elect an oral contraceptive.
    approvedDB01406DanazolFor the treatment of endometriosis and fibrocystic breast disease (in patients unresponsive to simple measures). Also used for the prophylactic treatment of all types of hereditary angioedema in males and females.G03XA01
    approvedDB01420Testosterone PropionateTestosterone propionate is an anabolic steroid and a short ester form of testosterone that becomes active in the body. It is often used for muscle mass building.G03BA03
    illicit;experimentalDB01481Delta1-dihydrotestosterone
    illicit;experimentalDB01541Boldenone
    illicit;experimentalDB01564Calusterone"An anabolic steroid which can theoretically aid in restauration and buildup of certain tissues, especially muscle. It is similar to synthetic testosterone and is still in early investigation. It was also investigated for use as a treatment for metastatic breast cancer."
    experimentalDB02266Flufenamic AcidM01AG03
    illicit;experimentalDB02901DihydrotestosteroneA14AA01;G03BB02
    experimentalDB02932(2r)-N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)Sulfonyl]-2-Hydroxy-2-Methylpropanamide
    experimentalDB02998Methyltrienolone
    experimentalDB04709"(3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE"
    approvedDB04839CyproteroneFor the palliative treatment of patients with advanced prostatic carcinoma.G03HA01
    experimentalDB06870"17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE"
    experimentalDB07039(2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
    experimentalDB07286"2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE"
    experimentalDB07419(2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
    experimentalDB07421"4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile"
    experimentalDB07422(2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide
    experimentalDB07423(2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
    experimentalDB07454(R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
    experimentalDB07717"(5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE"
    experimentalDB07769S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
    experimentalDB08035"1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE"
    experimentalDB08087"4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE"
    experimentalDB08088"2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile"
    experimentalDB08089"6-[BIS(2,2,2-TRIFLUOROETHYL)AMINO]-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE"
    experimentalDB08461"3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL"
    illicit;approvedDB08804Nandrolone decanoate"For the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the prophylaxis of hereditary angioedema."S01XA11;A14AB01