How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: AVP

    Description: arginine vasopressin

    Entrez Gene ID: 551

    SwissProt Acc Number: P01185

    RefSeq: NM_000490

    It was suspected to be CHD related:

    ..Arginine vasopressin (AVP) has recently been demonstrated as an alternative in the treatment of severe refractory vasodilatation in coronary artery bypass grafting..

    From PMID: 11845867, in Journal Ann Thorac Surg , 2002


    References

    There were 12 potential papers with AVP and CHD.

    PMIDTitleJournalsDetails
    23298558 Copeptin and cardiovascular disease: a review of a novel neurohormone.International journal of cardiologyMore Details
    23591802 Transcatheter closure of abnormal vessels and arteriovenous fistulas with the Amplatzer vascular plug 4 in patients with congenital heart disease.Pediatric cardiologyMore Details
    24116686 Estimation of the tissue damage after MI through time-frequency analysis of the electromechanical signals.Journal of medical engineering & technologyMore Details
    23347332 "A novel echocardiographic method for the detection of subclinical atherosclerosis in newly diagnosed, untreated type 2 diabetes.""Echocardiography (Mount Kisco, N.Y.)"More Details
    22964653 Copeptin: a new marker in cardiology."Journal of cardiovascular medicine (Hagerstown, Md.)"More Details
    21854551 Effects of renal denervation on the NKCC2 cotransporter in the thick ascending limb of the loop of Henle in rats with congestive heart failure."Acta physiologica (Oxford, England)"More Details
    20970750 "Dobutamine-norepinephrine, but not vasopressin, restores the ventriculoarterial matching in experimental cardiogenic shock."Translational research : the journal of laboratory and clinical medicineMore Details
    20486958 The relation between the color M-mode propagation velocity of the descending aorta and coronary and carotid atherosclerosis and flow-mediated dilatation."Echocardiography (Mount Kisco, N.Y.)"More Details
    19664189 Vasopressin and ischaemic heart disease: more than coronary vasoconstriction?"Critical care (London, England)"More Details
    17635349 Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure."Acta physiologica (Oxford, England)"More Details
    17621455 "Arginine vasopressin during sinus rhythm: effects on haemodynamic variables, left anterior descending coronary artery cross sectional area and cardiac index, before and after inhibition of NO-synthase, in pigs."ResuscitationMore Details
    15680533 Effects of intravenous arginine vasopressin on epicardial coronary artery cross sectional area in a swine resuscitation model.ResuscitationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 9 unique genes interacted with AVP. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    CRYAB FRET17075130|16274233 No
    AVP Reconstituted Complex17075130 CHD related
    OXTR in vivo7921229 No
    TXNDC17 Biochemical Activity14607844|14607844 No
    MLL Biochemical Activity14607844 No
    ELAVL1 Affinity Capture-RNA19322201 No
    AVPR2 in vivo11857925 No
    AVPR1B in vivo7929452 No
    AVPR1A in vivo8106369 CHD related


    Involved FDA drugs

    There was no drug associated with AVP