How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: BAX

    Description: BCL2-associated X protein

    Entrez Gene ID: 581

    SwissProt Acc Number: Q07812

    RefSeq: NM_004324

    It was suspected to be CHD related:

    .."Gene expression analysis showed that the proapoptotic genes (ie, BAX, CASP1, FAS, FAS L, FOS,NFkB2, P53, PCNA) were significantly more expressed (P<0.001) in ACS plaques, whereas the antiapoptotic genes (ie, MDM2, TERT, XRCC1) were more transcribed (P<0.001) in stable angina plaques. "..

    From PMID: 15364800, in Journal Circulation. , 2004


    There were 49 potential papers with BAX and CHD.

    23592614 Beneficial effect of prolonged heme oxygenase 1 activation in a rat model of chronic heart failure.Disease models & mechanismsMore Details
    24267260 Quantitative and qualitative pleiotropic differences between Simvastatin single and Vytorin combination therapy in hypercholesterolemic subjects.AtherosclerosisMore Details
    23784108 MiRNA-146a regulates the maturation and differentiation of vascular smooth muscle cells by targeting NF-kappaB expression.Molecular medicine reportsMore Details
    23467745 Histamine H2 receptor activation exacerbates myocardial ischemia/reperfusion injury by disturbing mitochondrial and endothelial function.Basic research in cardiologyMore Details
    22704546 Continuous spinal cord stimulation reduced cardiac ischaemia/reperfusion injury in a rat model."Heart, lung & circulation"More Details
    22968213 Therapeutic effects of neuregulin-1 gene transduction in rats with myocardial infarction.Coronary artery diseaseMore Details
    22527939 Increased expression of calcium-sensing receptors in atherosclerosis confers hypersensitivity to acute myocardial infarction in rats.Molecular and cellular biochemistryMore Details
    21986482 "Caffeic acid phenethyl ester inhibits proliferation and migration, and induces apoptosis in platelet-derived growth factor-BB-stimulated human coronary smooth muscle cells."Journal of vascular researchMore Details
    23091611 Methylation of p15INK4b and expression of ANRIL on chromosome 9p21 are associated with coronary artery disease.PloS oneMore Details
    21825227 Angiotensin II impairs endothelial progenitor cell number and function in vitro and in vivo: implications for vascular regeneration.HypertensionMore Details
    20692056 Cardioprotective effect of dexrazoxane in a rat model of myocardial infarction: anti-apoptosis and promoting angiogenesis.International journal of cardiologyMore Details
    22128257 The Protective Effect of Epigallocatechin-3 Gallate on Ischemia/Reperfusion Injury in Isolated Rat Hearts: An ex vivo Approach.The Korean journal of physiology & pharmacology : official journal of the Korean More Details
    21693368 Protective effects of salvianolate on microvascular flow in a porcine model of myocardial ischaemia and reperfusion.Archives of cardiovascular diseasesMore Details
    20466442 "Autologous bone marrow cell implantation attenuates left ventricular remodeling and improves heart function in porcine myocardial infarction: an echocardiographic, six-month angiographic, and molecular-cellular study."International journal of cardiologyMore Details
    21654332 In vivo cardioprotection by pitavastatin from ischemic-reperfusion injury through suppression of IKK/NF-kappaB and upregulation of pAkt-e-NOS.Journal of cardiovascular pharmacologyMore Details
    21112198 The protective effect of peony extract on acute myocardial infarction in rats.Phytomedicine : international journal of phytotherapy and phytopharmacologyMore Details
    20450490 Hydrogen sulfide attenuates cardiac dysfunction in a rat model of heart failure: a mechanism through cardiac mitochondrial protection.Bioscience reportsMore Details
    20431057 Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits.Circulation researchMore Details
    20162343 Modulation of programmed forms of cell death by intracoronary levosimendan during regional myocardial ischemia in anesthetized pigs.Cardiovascular drugs and therapy / sponsored by the International Society ofMore Details
    19912162 "Cardioprotective effect of SMND-309, a novel derivate of salvianolic acid B on acute myocardial infarction in rats."Basic & clinical pharmacology & toxicologyMore Details
    20118406 "Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats."American journal of physiology. Heart and circulatory physiologyMore Details
    19680789 "Improvement of heart function in postinfarct heart failure swine models after hepatocyte growth factor gene transfer: comparison of low-, medium- and high-dose groups."Molecular biology reportsMore Details
    19948220 Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels.Pharmacological research : the official journal of the Italian PharmacologicalMore Details
    19419716 Induction of RISK by HMG-CoA reductase inhibition affords cardioprotection after myocardial infarction.AtherosclerosisMore Details
    19408120 Evaluation of human endothelial cells post stent deployment in a cardiovascular simulator in vitro.Annals of biomedical engineeringMore Details
    20026869 "Cardioprotective effects of benazepril, an angiotensin-converting enzyme inhibitor, in an ischaemia-reperfusion model of myocardial infarction in rats."Journal of the renin-angiotensin-aldosterone system : JRAASMore Details
    19207725 Effects of emulsified isoflurane on haemodynamics and cardiomyocyte apoptosis in rats with myocardial ischaemia.Clinical and experimental pharmacology & physiologyMore Details
    19162189 Donor pre-treatment with tacrolimus reduces transplant vasculopathy.Pharmacological research : the official journal of the Italian PharmacologicalMore Details
    18053090 Acidic pre-conditioning suppresses apoptosis and increases expression of Bcl-xL in coronary endothelial cells under simulated ischaemia.Journal of cellular and molecular medicineMore Details
    18389485 "Tanshinone IIB, a primary active constituent from Salvia miltiorrhiza, exerts neuroprotective effect via inhibition of neuronal apoptosis in vitro."Phytotherapy research : PTRMore Details
    18192848 Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat.Journal of hypertensionMore Details
    18355530 Granulocyte colony-stimulating factor prevents reperfusion injury after heart preservation.The Annals of thoracic surgeryMore Details
    18196499 Long-term effect of gene therapy for chronic ischemic myocardium using platelet-derived endothelial cell growth factor in dogs.The journal of gene medicineMore Details
    17374365 OxLDL-induced gene expression patterns in CASMC are mimicked in apoE-/- mice aortas.Biochemical and biophysical research communicationsMore Details
    16564529 Lymphocyte resistance to lysophosphatidylcholine mediated apoptosis in atherosclerosis.AtherosclerosisMore Details
    18092236 Cardioprotective role of cardiotrophin-1 gene transfer in a murine model of myocardial infarction."Growth factors (Chur, Switzerland)"More Details
    17106196 Erythropoietin enhances the angiogenic potency of autologous bone marrow stromal cells in a rat model of myocardial infarction.CardiologyMore Details
    17045939 Insulin-like growth factor-1 enhances the efficacy of myoblast transplantation with its multiple functions in the chronic myocardial infarction rat model.The Journal of heart and lung transplantation : the official publication of theMore Details
    16831207 Chlamydia (Chlamydophila) pneumoniae-induced cell death in human coronary artery endothelial cells is caspase-independent and accompanied by subcellular translocations of Bax and apoptosis-inducing factor.FEMS immunology and medical microbiologyMore Details
    17117137 Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats."Shock (Augusta, Ga.)"More Details
    15975372 Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction.The Annals of thoracic surgeryMore Details
    15374822 Gene therapy for chronic myocardial ischemia using platelet-derived endothelial cell growth factor in dogs.American journal of physiology. Heart and circulatory physiologyMore Details
    15364800 Different quantitative apoptotic traits in coronary atherosclerotic plaques from patients with stable angina pectoris and acute coronary syndromes.CirculationMore Details
    15454281 Vitamin C inhibits hypoxia-induced damage and apoptotic signaling pathways in cardiomyocytes and ischemic hearts.Free radical biology & medicineMore Details
    15020720 Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging.Physiological genomicsMore Details
    14996483 Increased apoptosis in remote non-infarcted myocardium in multivessel coronary disease.International journal of cardiologyMore Details
    15200985 Factors excercising an influence on recovery of hibernating myocardium after coronary artery bypass grafting.European journal of cardio-thoracic surgery : official journal of the EuropeanMore Details
    12969880 Vascular rarefaction in peripheral skeletal muscle after experimental heart failure.American journal of physiology. Heart and circulatory physiologyMore Details
    12907417 Balanced expression of mitochondrial apoptosis regulatory proteins correlates with long-term survival of cardiac allografts.American journal of physiology. Heart and circulatory physiologyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 50 unique genes interacted with BAX. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    BCL2A1 Two-hybrid10753914|10753914 CHD related
    Bak1 Affinity Capture-Western11850803 No
    VDAC1 Reconstituted Complex15637055|12767928 No
    OYE2 Phenotypic Enhancement17897954|17897954|17897954 No
    YWHAQ Affinity Capture-Western12426317|12426317 No
    SH3GLB1 Two-hybrid11161816|11259440 No
    BAX Two-hybrid11161816|21712378|21712378 CHD related
    SLC25A4 Affinity Capture-Western9748162|9748162 No
    MCL1 Two-hybrid10837489 No
    UBC Affinity Capture-Western18362350 No
    RNF144B Affinity Capture-Western20300062 No
    XRCC6 Affinity Capture-Western19247369|19177010|19118032|21042904 No
    PSMC3 Affinity Capture-Western20431057 No
    PSMC5 Affinity Capture-Western20431057 No
    HDAC6 Affinity Capture-Western21847364 No
    XRCC5 Affinity Capture-Western19177010 No
    XIAP Affinity Capture-Western21712378 CHD related
    TP53 Affinity Capture-Western21712378 CHD related
    HSPA4 Affinity Capture-Western15388581 No
    CYCS Co-localization15254227 No
    CASP3 Co-localization15254227 CHD related
    CASP7 Co-localization15254227 CHD related
    CASP8 Co-localization15254227 CHD related
    CASP9 Co-localization15254227 CHD related
    NOL3 in vivo15383280 No
    BID in vivo;yeast 2-hybrid15574335 CHD related
    BBC3 yeast 2-hybrid15574335 CHD related
    ERN1 in vitro;in vivo16645094 No
    PMAIP1 Affinity Capture-Western15705586|15705586 No
    BCL2 Affinity Capture-Western15231068|14980220|14980220|20865015|22262057 CHD related
    BCL2L1 Affinity Capture-Western9824152|12137781|21852238|21852238|22072718 CHD related
    BNIPL Two-hybrid12901880 No
    SNCA Reconstituted Complex11742726 No
    BCL2L10 Affinity Capture-Western11278245|11278245 No
    HSPD1 Affinity Capture-Western12070120 CHD related
    MOAP1 Affinity Capture-Western11060313|11060313 No
    BAK1 Affinity Capture-Western11571294|11571294 No
    BCL2L2 Affinity Capture-Western10381646 No
    MEPCE Affinity Capture-MS17643375 No
    TOMM40 Affinity Capture-Western17635912 No
    TOMM22 Affinity Capture-Western17635912 No
    UHRF2 Far Western21952639 No
    PARK7 Reconstituted Complex21852238 No
    BAD Affinity Capture-Western17274640 CHD related
    CLU Affinity Capture-Western19177010|19118032|16113678 No
    KCNA3 Reconstituted Complex20114030|18818304 No
    CRYAA Reconstituted Complex14752512|14752512 No
    CRYAB Reconstituted Complex14752512|14752512 No
    SFN in vivo11574543 No
    PPP1CA in vitro;in vivo17274640 No

    Involved FDA drugs

    There was no drug associated with BAX