How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: BCL2A1

    Description: BCL2-related protein A1

    Entrez Gene ID: 597

    SwissProt Acc Number: Q16548

    RefSeq: NM_001114735

    It was supported literatures to be a novel CHD related gene:

    ..Treatment with cytokine-like doses of rhBCL2 or rhBCL2A1 protein or BH4-domain peptides reduces apoptosis and tissue injury following I/R by a TLR2-MyD88-dependent mechanism...

    From PMID: 20161703, in Journal PLoS One. , 2010


    References

    There were 1 potential papers with BCL2A1 and CHD.

    PMIDTitleJournalsDetails
    20161703 Extracellular BCL2 proteins are danger-associated molecular patterns that reduce tissue damage in murine models of ischemia-reperfusion injury.PloS oneMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 17 unique genes interacted with BCL2A1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    BAD Two-hybrid11483855|15694340 CHD related
    BMF Protein-peptide15694340 No
    PMAIP1 Protein-peptide15694340 No
    BIK Protein-peptide15694340 No
    HRK Protein-peptide15694340 No
    APP Reconstituted Complex21832049 No
    GRB2 in vitro;in vivo9670936 CHD related
    BAK1 in vivo;yeast 2-hybrid10381646 No
    BCL2L11 in vitro16697956 No
    BAX Two-hybrid10753914|10753914 CHD related
    BOK Two-hybrid9356461|9356461 No
    Bcl2l11 Protein-peptide15694340|10198631 No
    BID Affinity Capture-Western11929871|11929871,16697956 CHD related
    HAT1 Co-crystal Structure22615379 No
    HDAC4 Negative Genetic22318606 CHD related
    NR4A1 in vivo18835031 CHD related
    BBC3 in vitro15694340 CHD related


    Involved FDA drugs

    There was no drug associated with BCL2A1