How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: C3

    Description: complement component 3

    Entrez Gene ID: 718

    SwissProt Acc Number: P01024

    RefSeq: NM_000064

    It was suspected to be CHD related:

    .."Inflammatory markers such as C-reactive protein (CRP), leucocyte count and complement component 3 (C3) have been linked to CHD and to hyperlipidaemia and several other CHD risk factors."..

    From PMID: 15765889, in Journal Drugs. , 2004


    There were 59 potential papers with C3 and CHD.

    24240384 Alpha lipoic acid attenuates inflammatory response during extracorporeal circulation.Cardiovascular journal of AfricaMore Details
    23792422 Aging affects high-density lipoprotein composition and function.Biochimica et biophysica actaMore Details
    24107981 Revisiting comorbidities in gout: a cluster analysis.Annals of the rheumatic diseasesMore Details
    24020867 "Abdominal obesity with hypertriglyceridaemia, lipoprotein(a) and apolipoprotein A-I determine marked cardiometabolic risk."European journal of clinical investigationMore Details
    23677468 Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and C3(H2O)."Journal of immunology (Baltimore, Md. : 1950)"More Details
    23377670 Synergistic effect between lipoprotein lipase and apolipoprotein C3 genes in determining the severity of coronary artery disease.Journal of cardiovascular translational researchMore Details
    21840418 The HDL proteome in acute coronary syndromes shifts to an inflammatory profile.Biochimica et biophysica actaMore Details
    22466360 Short stature is an independent risk marker for mortality and incident coronary heart disease only in women: a structural relationship?Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiologyMore Details
    20926148 "Human plasma complement C3 is independently associated with coronary heart disease, but only in heavy smokers (the CODAM study)."International journal of cardiologyMore Details
    22968297 Clinical biomarkers of high-density lipoprotein dysfunction among middle-aged Turks.Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiologyMore Details
    22827323 Coronary artery dilation among patients with paediatric-onset systemic lupus erythematosus.Scandinavian journal of rheumatologyMore Details
    21419112 Complement C3 and cleavage products in cardiometabolic risk.Clinica chimica acta; international journal of clinical chemistryMore Details
    21893561 An analysis of the metabolic syndrome phenotype in systemic lupus erythematosus.LupusMore Details
    21245264 The atherogenic bacterium Porphyromonas gingivalis evades circulating phagocytes by adhering to erythrocytes.Infection and immunityMore Details
    22054125 Lack of association between apolipoprotein C3 gene polymorphisms and risk of coronary heart disease in a Han population in East China.Lipids in health and diseaseMore Details
    22460246 "Influence of genetic variants in the apolipoprotein A5 and C3 gene on lipids, lipoproteins, and its association with coronary artery disease in Indians."Journal of community geneticsMore Details
    19913840 "Serum complement C3: a determinant of cardiometabolic risk, additive to the metabolic syndrome, in middle-aged population."Metabolism: clinical and experimentalMore Details
    20110529 Noncalcified coronary plaque in systemic lupus erythematosus.The Journal of rheumatologyMore Details
    19701693 Genetic variants on apolipoprotein gene cluster influence triglycerides with a risk of coronary artery disease among Indians.Molecular biology reportsMore Details
    19900229 Serum apolipoprotein C-III in high-density lipoprotein: a key diabetogenic risk factor in Turks.Diabetic medicine : a journal of the British Diabetic AssociationMore Details
    19592465 "c-Jun DNAzymes inhibit myocardial inflammation, ROS generation, infarct size, and improve cardiac function after ischemia-reperfusion injury.""Arteriosclerosis, thrombosis, and vascular biology"More Details
    18823627 "Association of lipoprotein lipase D9N polymorphism with myocardial infarction in type 2 diabetes: the genetics, outcomes, and lipids in type 2 diabetes (GOLD) study."AtherosclerosisMore Details
    20216929 The mannose-binding lectin pathway is a significant contributor to reperfusion injury in the type 2 diabetic heart.Diabetes & vascular disease research : official journal of the InternationalMore Details
    18381373 Prognostic and therapeutic implications of dipyridamole stress cardiovascular magnetic resonance on the basis of the ischaemic cascade.Heart (British Cardiac Society)More Details
    19711212 Mannose-binding lectin as a risk factor for acute coronary syndromes.Annals of medicineMore Details
    19817643 Impaired anti-inflammatory function of apolipoprotein A-II concentrations predicts metabolic syndrome and diabetes at 4 years follow-up in elderly Turks.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    18467706 "Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons."The American journal of pathologyMore Details
    18573392 High-dose insulin therapy attenuates systemic inflammatory response in coronary artery bypass grafting patients.The Annals of thoracic surgeryMore Details
    18289550 "Synergistic effects of the apolipoprotein E epsilon3/epsilon2/epsilon4, the cholesteryl ester transfer protein TaqIB, and the apolipoprotein C3 -482 C>T polymorphisms on their association with coronary artery disease."AtherosclerosisMore Details
    18319219 Serum total and high-density lipoprotein phospholipid levels in a population-based study and relationship to risk of metabolic syndrome and coronary disease.AngiologyMore Details
    18268142 Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction.CirculationMore Details
    18329570 Prevalence in digital panoramic radiographs of carotid area calcification among Iraqi individuals with stroke-related disease."Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics"More Details
    17932899 The impact of chronically diseased coronary arteries and stenting on the corrected TIMI frame count in elective coronary angiography and percutaneous coronary intervention procedures.Catheterization and cardiovascular interventions : official journal of theMore Details
    17568238 Complement C3 and C4 in plasma and incidence of myocardial infarction and stroke: a population-based cohort study.European journal of cardiovascular prevention and rehabilitation : officialMore Details
    17511629 Postprandial inflammation and endothelial dysfuction.Biochemical Society transactionsMore Details
    17631062 Usefulness of the serum complement component C4 as a predictor of stroke in patients with known or suspected coronary artery disease referred for coronary angiography.The American journal of cardiologyMore Details
    17134686 Reduction of hyperacute rejection and protection of metabolism and function in hearts of human decay accelerating factor (hDAF)-expressing pigs.Cardiovascular researchMore Details
    17321106 "Hostility, anger, and depression predict increases in C3 over a 10-year period.""Brain, behavior, and immunity"More Details
    17398178 "Serum complement C3/C4 ratio, a novel marker for recurrent cardiovascular events."The American journal of cardiologyMore Details
    17208225 Neutrophil activation and arteritis induced by C. albicans water-soluble mannoprotein-beta-glucan complex (CAWS).Experimental and molecular pathologyMore Details
    17639571 The application of ultra-performance liquid chromatography/tandem mass spectrometry to the detection and quantitation of apolipoproteins in human serum.Rapid communications in mass spectrometry : RCMMore Details
    16874160 The third component of the complement (C3) is a marker of the risk of atherogenesis.European journal of cardiovascular prevention and rehabilitation : officialMore Details
    16714057 Serum gamma glutamyltransferase as a marker of metabolic syndrome and coronary disease likelihood in nondiabetic middle-aged and elderly adults.Preventive medicineMore Details
    16363249 Complement C3 and C-reactive protein levels in patients with stable coronary artery disease.Thrombosis and haemostasisMore Details
    15799759 Complement activation in acute coronary syndromes."APMIS : acta pathologica, microbiologica, et immunologica Scandinavica"More Details
    15910556 Upregulation of the immune system in primary hypercholesterolaemia: effect of atorvastatin therapy.Journal of internal medicineMore Details
    15709100 The prevalence of carotid artery calcification on the panoramic radiographs of patients with renal disease.Dento maxillo facial radiologyMore Details
    15487975 Cross-sectional study of complement C3 as a coronary risk factor among men and women."Clinical science (London, England : 1979)"More Details
    16360363 Inflammatory markers and serum lipids in idiopathic dilated cardiomyopathy.The American journal of cardiologyMore Details
    15303978 Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons.XenotransplantationMore Details
    15043507 Evidence for a complex risk profile in obese postmenopausal Turkish women with hypertriglyceridaemia and elevated apolipoprotein B."Clinical science (London, England : 1979)"More Details
    14660654 The apolipoprotein(a) component of lipoprotein(a) stimulates actin stress fiber formation and loss of cell-cell contact in cultured endothelial cells.The Journal of biological chemistryMore Details
    15530914 Association of high serum concentration of the third component of complement (C3) with pre-existing severe coronary artery disease and new vascular events in women.AtherosclerosisMore Details
    15547024 "Up regulation of C3, C4, and soluble intercellular adhesion molecule-1 co-expresses with high sensitivity C reactive protein in familial hypoalphalipoproteinaemia: further evidence of inflammatory activation."Heart (British Cardiac Society)More Details
    12736856 "[HIV-infection, HAART (highly-active antiretroviral therapy) and hyperlipidemia]."Deutsche medizinische Wochenschrift (1946)More Details
    12399879 [Long-term analysis of clinical disease activity and chronic organ damage in patients with systemic lupus erythematosus].Zeitschrift fur RheumatologieMore Details
    11916007 Eight novel mutations and functional impairments of the LDL receptor in familial hypercholesterolemia in the north of Japan.Journal of human geneticsMore Details
    11872951 Increased frequency of the C3*F allele and the Leiden mutation of coagulation factor V in patients with severe coronary heart disease who survived myocardial infarction.Experimental and clinical immunogeneticsMore Details
    10907114 "Triglycerides, apo C3 and Lp B:C3 and cardiovascular risk in type II diabetes."DiabetologiaMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 29 unique genes interacted with C3. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    CFP Reconstituted Complex11513971|3421908|11513971 No
    CFHR5 Reconstituted Complex11058592 No
    ITGAX Reconstituted Complex4062888 CHD related
    C5 Reconstituted Complex11367533 CHD related
    CFB Reconstituted Complex11367533 CHD related
    LRP1 in vivo10608878 CHD related
    CR1 in vitro;in vivo9988761,10382758 No
    CR2 in vitro;in vivo11684127,1830068 No
    C3 in vitro10622723 CHD related
    CFI Biochemical Activity8648130|9291131|1401896,9291131 CHD related
    CFH Reconstituted Complex9291131|11367533,9988761 CHD related
    CFHR3 Reconstituted Complex10622723 No
    CFHR4 Reconstituted Complex10622723|10622723 No
    CPN1 Biochemical Activity11939578|11939578 No
    UBC Affinity Capture-MS20639865 No
    RAD21 Affinity Capture-Western22145905 No
    CTSG in vitro1861080 No
    CD46 in vitro1717583 No
    ITGAM in vitro;in vivo4062888,11073102 CHD related
    GC in vitro2824652 No
    LAMA1 in vitro3488995 CHD related
    PAPPA in vitro6203109 CHD related
    ABL1 in vitro4062888 No
    MASP1 in vitro9719152 No
    C3AR1 in vitro11342658 No
    OLFM4 in vitro2824652 No
    C2 in vitro3546307 No
    GPR77 in vitro11773063 No
    VSIG4 in vitro16530040,17051150 No

    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00028Intravenous Immunoglobulin"IVIg is used in the treatment of immunodeficiencies, as well as autoimmune and inflammatory disorders. These indications includes idiopathic thrombocytopenic purpura, Kawasaki disease, hypogammaglobulinemia, B cell chronic lymphocytic leukemia, bone marrow transplant complications, Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy (CIDP), multiple sclerosis, rheumatoid arthritis, myesthenia gravis, Wiskott–Aldrich syndrome and inflammatory skin diseases."J06BA02;J06BA01