How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: C5

    Description: complement component 5

    Entrez Gene ID: 727

    SwissProt Acc Number: P01031

    RefSeq: NM_001735

    It was suspected to be CHD related:

    .."Recent trials evaluating the C5 complement inhibitor, pexelizumab, have shown that modulation of inflammation during ischemia/reperfusion in patients with acute myocardial infarction (MI) or undergoing coronary artery bypass graft (CABG) surgery may improve clinical outcomes."..

    From PMID: 16875911, in Journal Am Heart J , 2006


    References

    There were 10 potential papers with C5 and CHD.

    PMIDTitleJournalsDetails
    24107981 Revisiting comorbidities in gout: a cluster analysis.Annals of the rheumatic diseasesMore Details
    22984364 A Multinomial Ordinal Probit Model with Singular Value Decomposition Method for a Multinomial Trait.Journal of probability and statisticsMore Details
    20880552 Effects of C5 complement inhibitor pexelizumab on outcome in high-risk coronary artery bypass grafting: combined results from the PRIMO-CABG I and II trials.The Journal of thoracic and cardiovascular surgeryMore Details
    20125109 Autonomic dysreflexia and myocardial ischemia.Spinal cordMore Details
    19131645 Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex.Circulation researchMore Details
    18954626 "Pexelizumab in ischemic heart disease: a systematic review and meta-analysis on 15,196 patients."The Journal of thoracic and cardiovascular surgeryMore Details
    18329570 Prevalence in digital panoramic radiographs of carotid area calcification among Iraqi individuals with stroke-related disease."Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics"More Details
    16875911 Effect of pexelizumab on mortality in patients with acute myocardial infarction or undergoing coronary artery bypass surgery: a systematic overview.American heart journalMore Details
    15952913 Pexelizumab -- a C5 complement inhibitor for use in both acute myocardial infarction and cardiac surgery with cardiopulmonary bypass.Expert opinion on biological therapyMore Details
    12955216 [Volumetric MRI for evaluation of regional pattern and progressin of neocortical degeneration in Alzheimer's disease].Der RadiologeMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 9 unique genes interacted with C5. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    C6 Co-fractionation1387399|1387399 No
    C7 Reconstituted Complex1387399 CHD related
    C8B Reconstituted Complex3624872 CHD related
    C5 in vitro8175701,3624872 CHD related
    C5AR1 Reconstituted Complex9553099 CHD related
    CPB2 Biochemical Activity11939578 CHD related
    C3 Reconstituted Complex11367533 CHD related
    C2 in vitro12878586,8175701 No
    CPN1 in vitro11939578 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00028Intravenous Immunoglobulin"IVIg is used in the treatment of immunodeficiencies, as well as autoimmune and inflammatory disorders. These indications includes idiopathic thrombocytopenic purpura, Kawasaki disease, hypogammaglobulinemia, B cell chronic lymphocytic leukemia, bone marrow transplant complications, Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy (CIDP), multiple sclerosis, rheumatoid arthritis, myesthenia gravis, Wiskott–Aldrich syndrome and inflammatory skin diseases."J06BA02;J06BA01
    approvedDB01257EculizumabFor the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH) to reduce hemolysis.