How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CAT

    Description: catalase

    Entrez Gene ID: 847

    SwissProt Acc Number: P04040

    RefSeq: NM_001752

    It was suspected to be CHD related:

    ..while the expression of catalase and eNOS was significantly decreased in HCAECs compared with controls..

    From PMID: 19721395, in Journal Med Sci Monit , 2009


    References

    There were 30 potential papers with CAT and CHD.

    PMIDTitleJournalsDetails
    23582780 Detection of hypofibrinolysis in stable coronary artery disease using the overall haemostatic potential assay.Thrombosis researchMore Details
    22772600 Predictors of complicated athero-thrombotic lesions in non-ST segment acute coronary syndrome."Journal of cardiovascular medicine (Hagerstown, Md.)"More Details
    23988394 Symptom burden and comorbidities impact the consistency of responses on patient reported functional outcomes.Archives of physical medicine and rehabilitationMore Details
    23923985 High conjugated linoleic acid enriched ghee (clarified butter) increases the antioxidant and antiatherogenic potency in female Wistar rats.Lipids in health and diseaseMore Details
    22951390 Cerebroprotective effect of Eclipta alba against global model of cerebral ischemia induced oxidative stress in rats.Phytomedicine : international journal of phytotherapy and phytopharmacologyMore Details
    22890915 "Association between polymorphisms of eNOS and GPx-1 genes, activity of free-radical processes and in-stent restenosis."Molecular and cellular biochemistryMore Details
    22189441 Roles of reactive oxygen species in methyl jasmonate and nitric oxide-induced tanshinone production in Salvia miltiorrhiza hairy roots.Plant cell reportsMore Details
    21996047 Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease."Nutrition (Burbank, Los Angeles County, Calif.)"More Details
    22690296 Antioxidant enzymes as potential targets in cardioprotection and treatment of cardiovascular diseases. Enzyme antioxidants: the next stage of pharmacological counterwork to the oxidative stress.Heart internationalMore Details
    23041084 "Association of three polymorphisms of scavenger receptor class BI gene (exon8, exon1, intron5) with coronary stenosis in a coronary Tunisian population."GeneMore Details
    22645453 "The relationship between coenzyme Q10, oxidative stress, and antioxidant enzymes activities and coronary artery disease."TheScientificWorldJournalMore Details
    22883224 Markers of hypercoagulability in CAD patients. Effects of single aspirin and clopidogrel treatment.Thrombosis journalMore Details
    20962664 Head-to-head comparison of early vessel healing by optical coherence tomography after implantation of different stents in the same patient."Journal of cardiovascular medicine (Hagerstown, Md.)"More Details
    21622683 Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice.Cardiovascular researchMore Details
    21904649 Von Willebrand factor and oxidative stress parameters in acute coronary syndromes.Oxidative medicine and cellular longevityMore Details
    19815167 Early and mid-term clinical outcomes with the CATANIA coronary stent system vs. bare metal stents in patients with coronary artery disease.Cardiovascular revascularization medicine : including molecular interventionsMore Details
    18821077 Efficacy of computer aided analysis in detection of significant coronary artery stenosis in cardiac using dual source computed tomography.The international journal of cardiovascular imagingMore Details
    18300746 The effect of glucose-insulin-potassium treatment on myocardial oxidative stress in patients with acute coronary syndromes undergoing percutaneous coronary intervention.Coronary artery diseaseMore Details
    17978864 Effects of tamoxifen on myocardial ischemia-reperfusion injury model in ovariectomized rats.Molecular and cellular biochemistryMore Details
    16904092 Oxidative injury and antioxidants in coronary artery bypass graft surgery: off-pump CABG significantly reduces oxidative stress.Clinica chimica acta; international journal of clinical chemistryMore Details
    16950378 The role of oxidative stress in postoperative delirium.General hospital psychiatryMore Details
    16283323 Dynamic multi-section CT imaging in acute myocardial infarction: preliminary animal experience.European radiologyMore Details
    16216277 Role of lupeol and lupeol linoleate on lipemic-oxidative stress in experimental hypercholesterolemia.Life sciencesMore Details
    16873555 Exercise training reverses downregulation of HSP70 and antioxidant enzymes in porcine skeletal muscle after chronic coronary artery occlusion."American journal of physiology. Regulatory, integrative and comparative"More Details
    15880795 Late distortion of the original Palmaz stent implanted in postoperative lesions associated with congenital heart disease.Catheterization and cardiovascular interventions : official journal of theMore Details
    15836781 Electroporation by nucleofector is the best nonviral transfection technique in human endothelial and smooth muscle cells.Genetic vaccines and therapyMore Details
    12601203 MR imaging of reperfused myocardial infarction: comparison of necrosis-specific and intravascular contrast agents in a cat model.RadiologyMore Details
    12751697 Activity of antioxidant enzymes in children from families at high risk of premature coronary heart disease.Scandinavian journal of clinical and laboratory investigationMore Details
    12193092 Involvement of endothelin-1 in acute ischaemic arrhythmias in cats and rats."Clinical science (London, England : 1979)"More Details
    10831712 Irreversibly damaged myocardium at MR imaging with a necrotic tissue-specific contrast agent in a cat model.RadiologyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 13 unique genes interacted with CAT. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    ABL2 Affinity Capture-Western12777400 No
    CAT Co-crystal Structure10666617|10656833,10666617,11134921 CHD related
    PEX5 Two-hybrid10567403 No
    APP Reconstituted Complex21832049 No
    HSD17B4 Co-fractionation22939629 No
    STIM1 Co-fractionation22939629 No
    MECP2 Co-fractionation22939629 No
    TLR10 yeast 2-hybrid16482509 No
    ABL1 Affinity Capture-Western12777400|12777400|12777400 No
    USP53 Affinity Capture-MS19615732 No
    UBC Affinity Capture-MS18781797|21139048|21890473|21906983 No
    SUMO4 Affinity Capture-MS16236267|16236267 CHD related
    PTPN11 in vitro15556604 CHD related


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB01213Fomepizole"Antizol is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis"V03AB34
    experimentalDB03014Heme