How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CCL2

    Description: chemokine (C-C motif) ligand 2

    Entrez Gene ID: 6347

    SwissProt Acc Number: P13500

    RefSeq: NM_002982

    It was suspected to be CHD related:

    .."There were significant positive associations between serum PON3 and β-2-microglobulin, CCL2 and high-sensitivity C-reactive protein in CAD patients, but not in PAD. "..

    From PMID: 22153698, in Journal Atherosclerosis.? , 2012


    References

    There were 16 potential papers with CCL2 and CHD.

    PMIDTitleJournalsDetails
    23925450 Treatment with the CC chemokine-binding protein Evasin-4 improves post-infarction myocardial injury and survival in mice.Thrombosis and haemostasisMore Details
    23921151 Cadmium modulates adipocyte functions in metallothionein-null mice.Toxicology and applied pharmacologyMore Details
    23375685 Expression pattern in human macrophages dependent on 9p21.3 coronary artery disease risk locus.AtherosclerosisMore Details
    22153698 Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease.AtherosclerosisMore Details
    21764664 Transcriptional fingerprint of human whole blood at the site of coronary occlusion in acute myocardial infarction.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on More Details
    20702809 High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo."Arteriosclerosis, thrombosis, and vascular biology"More Details
    20431065 "Chemokine ligand 2 genetic variants, serum monocyte chemoattractant protein-1 levels, and the risk of coronary artery disease.""Arteriosclerosis, thrombosis, and vascular biology"More Details
    20181074 CCR2 and coronary artery disease: a woscops substudy.BMC research notesMore Details
    19332042 A monocyte chemoattractant protein-1 gene polymorphism is not associated with coronary artery disease in a Han Chinese population.Clinica chimica acta; international journal of clinical chemistryMore Details
    18617279 "Differential expression of cytokines, chemokines and chemokine receptors in patients with coronary artery disease."International journal of cardiologyMore Details
    19421322 Atorvastatin reduces plasma levels of chemokine (CXCL10) in patients with Crohn's disease.PloS oneMore Details
    18276914 Site-specific atherogenic gene expression correlates with subsequent variable lesion development in coronary and peripheral vasculature."Arteriosclerosis, thrombosis, and vascular biology"More Details
    18267955 MCP-1 induces cardioprotection against ischaemia/reperfusion injury: role of reactive oxygen species.Cardiovascular researchMore Details
    18230355 Association between the -2518G/A polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene and myocardial infarction in Tunisian patients.Clinica chimica acta; international journal of clinical chemistryMore Details
    17698927 Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease.Physiological genomicsMore Details
    16926016 Sequential patterns of chemokine- and chemokine receptor-synthesis following vessel wall injury in porcine coronary arteries.AtherosclerosisMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 21 unique genes interacted with CCL2. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    DARC Reconstituted Complex13679391|13679391,17416748 No
    CCL2 Reconstituted Complex7651403|8639605,8989326,7651403 CHD related
    CDC6 Affinity Capture-Western21383955 No
    ORC2 Affinity Capture-Western21383955 No
    ORC4 Affinity Capture-Western21383955 No
    MCM2 Affinity Capture-Western21383955 No
    MCM3 Affinity Capture-Western21383955 No
    MCM7 Affinity Capture-Western21383955 No
    CDC45 Affinity Capture-Western21383955 No
    PCNA Affinity Capture-Western21383955 CHD related
    CCR3 Reconstituted Complex8642344 CHD related
    CCL5 Phenotypic Enhancement11350939 CHD related
    VCAN Reconstituted Complex11083865 CHD related
    MMP1 in vitro;in vivo12149192,9558113 CHD related
    MMP8 in vitro;in vivo12149192,9558113 CHD related
    MMP3 in vitro;in vivo12149192,9558113 CHD related
    CCR10 in vitro;in vivo9364936,10706668 No
    CCR1 in vitro8631787 CHD related
    CCR2 in vitro;in vivo10529171,9287323 CHD related
    CCR5 in vivo10477718 CHD related
    CCRL1 in vitro10734104 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB01055Mimosine
    approvedDB01406DanazolFor the treatment of endometriosis and fibrocystic breast disease (in patients unresponsive to simple measures). Also used for the prophylactic treatment of all types of hereditary angioedema in males and females.G03XA01