How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CCR1

    Description: chemokine (C-C motif) receptor 1

    Entrez Gene ID: 1230

    SwissProt Acc Number: P32246

    RefSeq: NM_001295

    It was suspected to be CHD related:

    .."Left ventricular developed pressure was 84.5+/-19.8 mmHg in Ccr1(-/-) mice compared to 49.0+/-19.7 mmHg in wild-type mice (P<0.01) and coronary flow reserve was improved in Ccr1(-/-) mice. In conclusion, functional impairment and structural remodelling after MI is reduced in the genetic absence of Ccr1 due to an abrogated early inflammatory recruitment of neutrophils and improved tissue healing, thus revealing a potential therapeutic target."..

    From PMID: 18088392, in Journal J Cell Mol Med. , 2008


    References

    There were 6 potential papers with CCR1 and CHD.

    PMIDTitleJournalsDetails
    23217153 Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes.BMC medical genomicsMore Details
    20378860 "Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium."Circulation researchMore Details
    18088392 Ccr1 deficiency reduces inflammatory remodelling and preserves left ventricular function after myocardial infarction.Journal of cellular and molecular medicineMore Details
    16806235 "Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice."AtherosclerosisMore Details
    17015788 Cardiac troponin I but not cardiac troponin T induces severe autoimmune inflammation in the myocardium.CirculationMore Details
    16456237 Altered chemokine receptor profile on circulating leukocytes in human heart failure.Cell biochemistry and biophysicsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 21 unique genes interacted with CCR1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    CCL7 Reconstituted Complex8530354|8530354,7545673 CHD related
    CCL3 in vitro;in vivo10660125,10202040,7545673 CHD related
    CCL4 in vitro7594543 No
    CCR1 in vivo10202040 CHD related
    PLP2 in vivo;yeast 2-hybrid15474493 No
    CREB3 in vivo;yeast 2-hybrid15001559 No
    JAK1 in vivo14674010 CHD related
    STAT1 in vivo14674010 CHD related
    STAT3 in vivo14674010 CHD related
    CCL26 in vivo15039444 No
    CCL2 in vitro8631787 CHD related
    CCL23 Reconstituted Complex9886417|9558365,10660125,9886417 No
    CCL5 Reconstituted Complex11449371|11116158 CHD related
    CCL3L1 Reconstituted Complex11449371|11449371 CHD related
    CCL14 in vitro;in vivo11085751 No
    CCL15 in vivo9346309 No
    CCL16 in vivo11470772,10910894 No
    CCL8 in vivo9115216 No
    GNA14 in vitro;in vivo8626727 No
    TPST1 in vitro17558413 No
    TPST2 in vitro17558413 No


    Involved FDA drugs

    There was no drug associated with CCR1