How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CCR2

    Description: chemokine (C-C motif) receptor 2

    Entrez Gene ID: 729230

    SwissProt Acc Number: P41597

    RefSeq: NM_001123041

    It was suspected to be CHD related:

    ..The MCP-1/chemokine receptor 2 (CCR2) signaling pathway plays a critical role in the pathogenesis of graft vasculopathy...

    From PMID: 15284091, in Journal Arterioscler Thromb Vasc Biol , 2004


    References

    There were 29 potential papers with CCR2 and CHD.

    PMIDTitleJournalsDetails
    23240665 CD14++CD16+ monocytes in patients with acute ischaemic heart failure.European journal of clinical investigationMore Details
    22891282 "Microbial carriage state of peripheral blood dendritic cells (DCs) in chronic periodontitis influences DC differentiation, atherogenic potential.""Journal of immunology (Baltimore, Md. : 1950)"More Details
    22752804 Impact of MCP-1 and CCR-2 gene polymorphisms on coronary artery disease susceptibility.Molecular biology reportsMore Details
    22212813 The CD14++CD16+ monocyte subset and monocyte-platelet interactions in patients with ST-elevation myocardial infarction.Journal of thrombosis and haemostasis : JTHMore Details
    23074996 Important role of CCR2 in a murine model of coronary vasculitis.BMC immunologyMore Details
    21816762 Autoimmunity against cardiac troponin I in ischaemia reperfusion injury.European journal of heart failureMore Details
    21983520 Therapeutic siRNA silencing in inflammatory monocytes in mice.Nature biotechnologyMore Details
    21868018 Genetic variants of the monocyte chemoattractant protein-1 gene and its receptor CCR2 and risk of coronary artery disease: a meta-analysis.AtherosclerosisMore Details
    21247529 Effect of CC chemokine receptor 2 CCR2 blockade on serum C-reactive protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte chemoattractant protein-1 promoter region.The American journal of cardiologyMore Details
    21242297 Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis.The Journal of experimental medicineMore Details
    21308491 Heterogeneity of human monocytes: an optimized four-color flow cytometry protocol for analysis of monocyte subsets.Journal of cardiovascular translational researchMore Details
    20702809 High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo."Arteriosclerosis, thrombosis, and vascular biology"More Details
    20182805 Effect of genetic variants of chemokine receptors on the development of myocardial infarction in Turkish population.Molecular biology reportsMore Details
    20181074 CCR2 and coronary artery disease: a woscops substudy.BMC research notesMore Details
    20836883 Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation.Thrombosis journalMore Details
    19036374 Acetaldehyde stimulates monocyte adhesion in a P-selectin- and TNFalpha-dependent manner.AtherosclerosisMore Details
    18617279 "Differential expression of cytokines, chemokines and chemokine receptors in patients with coronary artery disease."International journal of cardiologyMore Details
    19506371 Single nucleotide polymorphisms in monocyte chemoattractant protein-1 and its receptor act synergistically to increase the risk of carotid atherosclerosis."Cerebrovascular diseases (Basel, Switzerland)"More Details
    17383752 Chemokine receptor 5 (CCR5) deletion polymorphism in North Indian patients with coronary artery disease.International journal of cardiologyMore Details
    16926016 Sequential patterns of chemokine- and chemokine receptor-synthesis following vessel wall injury in porcine coronary arteries.AtherosclerosisMore Details
    17482150 Association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease.Clinica chimica acta; international journal of clinical chemistryMore Details
    17329566 Chemokine regulation of atherosclerosis.Journal of leukocyte biologyMore Details
    16806235 "Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice."AtherosclerosisMore Details
    17015788 Cardiac troponin I but not cardiac troponin T induces severe autoimmune inflammation in the myocardium.CirculationMore Details
    16055130 Polymorphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of coronary heart disease among US women.AtherosclerosisMore Details
    16306213 "Induction of MCP1, CCR2, and iNOS expression in THP-1 macrophages by serum of children late after Kawasaki disease."Pediatric researchMore Details
    15284091 Antimonocyte chemoattractant protein-1 gene therapy attenuates graft vasculopathy."Arteriosclerosis, thrombosis, and vascular biology"More Details
    14592942 Novel anti-inflammatory actions of amlodipine in a rat model of arteriosclerosis induced by long-term inhibition of nitric oxide synthesis.American journal of physiology. Heart and circulatory physiologyMore Details
    12719858 Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age."Journal of molecular medicine (Berlin, Germany)"More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 10 unique genes interacted with CCR2. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    CCL11 in vivo11264152 CHD related
    CCL2 in vitro;in vivo10529171,9287323 CHD related
    CCL7 in vitro8530354 CHD related
    CCR5 in vivo11350939 CHD related
    CCL13 in vivo12149192,9195948 No
    CCL16 in vivo11470772 No
    CCL8 in vivo9115216,12149192 No
    TPST1 in vitro17558413 No
    TPST2 in vitro17558413 No
    JAK2 in vitro;in vivo9670957 CHD related


    Involved FDA drugs

    There was no drug associated with CCR2