How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CCR5

    Description: chemokine (C-C motif) receptor 5

    Entrez Gene ID: 1234

    SwissProt Acc Number: P51681

    RefSeq: NM_000579

    It was suspected to be CHD related:

    ..Overexpression of the CCR5 receptor should be considered as a factor that promotes the development of atherosclerosis in diabetic patients..

    From PMID: 16708639, in Journal Pol Merkur Lekarski , 2006


    References

    There were 25 potential papers with CCR5 and CHD.

    PMIDTitleJournalsDetails
    24118494 Increased pro-atherogenic monocyte-platelet crosstalk in monocyte subpopulations of patients with stable coronary artery disease.Journal of internal medicineMore Details
    23633271 "Efficacy of the CCR5 antagonist maraviroc in reducing early, ritonavir-induced atherogenesis and advanced plaque progression in mice."CirculationMore Details
    23312573 Association of the CCR5Delta32 polymorphism and its ligand RANTES-403G/A polymorphism with coronary artery disease: a meta-analysis.Thrombosis researchMore Details
    23498802 The significance for chronic rejection of cardiac allograft of regulated upon activation normal T-cell cytokine and its CCR5 receptor.Transplantation proceedingsMore Details
    24323316 The CCR5 chemokine receptor mediates vasoconstriction and stimulates intimal hyperplasia in human vessels in vitro.Cardiovascular researchMore Details
    22118500 Drug safety evaluation of maraviroc for the treatment of HIV infection.Expert opinion on drug safetyMore Details
    21816762 Autoimmunity against cardiac troponin I in ischaemia reperfusion injury.European journal of heart failureMore Details
    20182805 Effect of genetic variants of chemokine receptors on the development of myocardial infarction in Turkish population.Molecular biology reportsMore Details
    20978399 Mendelian randomization: potential use of genetics to enable causal inferences regarding HIV-associated biomarkers and outcomes.Current opinion in HIV and AIDSMore Details
    20628649 "Association of CCR2-CCR5 haplotypes and CCL3L1 copy number with Kawasaki Disease, coronary artery lesions, and IVIG responses in Japanese children."PloS oneMore Details
    18629619 The CCR5 (-2135C/T) polymorphism may be associated with the development of Kawasaki disease in Korean children.Journal of clinical immunologyMore Details
    18436884 Common CCR5-del32 frameshift mutation associated with serum levels of inflammatory markers and cardiovascular disease risk in the Bruneck population.Stroke; a journal of cerebral circulationMore Details
    17383752 Chemokine receptor 5 (CCR5) deletion polymorphism in North Indian patients with coronary artery disease.International journal of cardiologyMore Details
    16926016 Sequential patterns of chemokine- and chemokine receptor-synthesis following vessel wall injury in porcine coronary arteries.AtherosclerosisMore Details
    17521710 CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: impact of pre-inflammatory stimuli and renin-angiotensin system modulators.Thrombosis researchMore Details
    17015788 Cardiac troponin I but not cardiac troponin T induces severe autoimmune inflammation in the myocardium.CirculationMore Details
    17015796 The chemokine and chemokine receptor profile of infiltrating cells in the wall of arteries with cardiac allograft vasculopathy is indicative of a memory T-helper 1 response.CirculationMore Details
    16055130 Polymorphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of coronary heart disease among US women.AtherosclerosisMore Details
    16803997 Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population.Annals of the New York Academy of SciencesMore Details
    16424368 Interleukin 12 induces T-cell recruitment into the atherosclerotic plaque.Circulation researchMore Details
    15962231 Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease.The Journal of infectious diseasesMore Details
    15093715 Characterization of two populations of human coronary artery endothelial cells(1).The Journal of surgical researchMore Details
    15302103 Association of RANTES G-403A gene polymorphism with increased risk of coronary arteriosclerosis.European heart journalMore Details
    12695288 Elevated serum levels of the CXCR3 chemokine ITAC are associated with the development of transplant coronary artery disease.CirculationMore Details
    11504923 HIV envelope gp120 activates human arterial smooth muscle cells.Proceedings of the National Academy of Sciences of the United States of AmericaMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 41 unique genes interacted with CCR5. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    ARRB1 Reconstituted Complex12065593|12065593 No
    JAK2 Affinity Capture-Western11278738|11591716 CHD related
    STAT3 Affinity Capture-Western11350939|14674010 CHD related
    STAT5B Affinity Capture-Western11350939 No
    PIK3R2 Affinity Capture-Western11350939 No
    PSMA5 Two-hybrid11877445|11877445|11877445 No
    CCL4 in vitro;in vivo12427015,8663314 No
    TXK in vivo11859127 No
    CCL11 in vitro;in vivo11264152,10477718 CHD related
    PTK2B in vivo9446638 No
    CCR2 in vivo11350939 CHD related
    CCR5 in vitro;in vivo12065593,12176010 CHD related
    GNAI1 in vivo15251452 CHD related
    GNAO1 in vivo15251452 No
    GNAI2 in vivo15251452 No
    GNAI3 in vivo15251452 No
    JAK1 in vivo10037796 CHD related
    STAT1 in vivo14674010 CHD related
    GNAQ in vivo15251452 CHD related
    ADRBK1 in vivo10085131 CHD related
    PRAF2 in vivo;yeast 2-hybrid15757671 No
    ORM1 in vitro11336643 No
    LCK in vivo11591716 No
    CCL2 in vivo10477718 CHD related
    CCL7 in vitro10477718 CHD related
    CCL5 Affinity Capture-Western14637022|11449371|11116158 CHD related
    CXCR4 Reconstituted Complex12429730 CHD related
    CCL3 Reconstituted Complex11700073 CHD related
    PTK2 Affinity Capture-Western10384144 No
    CCL3L1 Reconstituted Complex11734558|11449371|11734558,11449371 CHD related
    AFP Affinity Capture-Western12176010 No
    CD4 Affinity Capture-Western10816381 CHD related
    ADRBK2 in vitro10085131 No
    CCL13 in vivo10477718 No
    CCL14 in vitro;in vivo11085751 No
    CCL16 in vivo11470772 No
    CCL8 in vivo9468473,10477718 No
    DNM2 in vivo10477567 No
    CCL3L3 in vitro;in vivo11734558,10364178 No
    STAT5A in vivo10037796 No
    ARL6IP5 in vivo15757671 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB04835Maraviroc"For treatment-experienced adult patients infected with only CCR5-tropic HIV-1 detectable, who have evidence of viral replication and HIV-1 strains resistant to multiple antiretroviral agents."J05AX09