How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CCR8

    Description: chemokine (C-C motif) receptor 8

    Entrez Gene ID: 1237

    SwissProt Acc Number: P51685

    RefSeq: NM_005201

    It was supported literatures to be a novel CHD related gene:

    ..These results indicate that CCR8 is an endothelial receptor that may modulate endothelial function..

    From PMID: 11133740, in Journal Blood. , 2001


    References

    There were 0 potential papers with CCR8 and CHD.

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 7 unique genes interacted with CCR8. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    CCL1 in vitro;in vivo12967681,9211859 No
    CCL4 in vitro;in vivo9521068 No
    CCL16 in vitro;in vivo10910894 No
    CCL17 in vitro12832759,9521068 No
    CCR8 in vivo9521068 CHD related
    TPST1 in vitro17558413 No
    TPST2 in vitro17558413 No


    Involved FDA drugs

    There was no drug associated with CCR8