How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: CD14

    Description: CD14 molecule

    Entrez Gene ID: 929

    SwissProt Acc Number: P08571

    RefSeq: NM_000591

    It was suspected to be CHD related:

    .."These data provide insight into the pathogenetic role of the CD14 C-260T polymorphism in atherosclerosis as -260TT genotype may favour increased inflammation in atheroma promoting possible worsening atherosclerosis, at least in Central of Italy elderly population."..

    From PMID: 17098305, in Journal Int J Cardiol , 2007


    There were 54 potential papers with CD14 and CHD.

    24118494 Increased pro-atherogenic monocyte-platelet crosstalk in monocyte subpopulations of patients with stable coronary artery disease.Journal of internal medicineMore Details
    23761916 The connection between ruptured cerebral aneurysms and odontogenic bacteria."Journal of neurology, neurosurgery, and psychiatry"More Details
    23277403 The association between CD14 gene C-260T polymorphism and coronary heart disease risk: a meta-analysis.Molecular biology reportsMore Details
    23739627 Monocyte gene expression and coronary artery disease.Current opinion in clinical nutrition and metabolic careMore Details
    23240665 CD14++CD16+ monocytes in patients with acute ischaemic heart failure.European journal of clinical investigationMore Details
    24134608 The effect of statin therapy withdrawal on monocyte subsets.European journal of clinical investigationMore Details
    23452203 Evaluation of microparticles in whole blood by multicolour flow cytometry assay.Scandinavian journal of clinical and laboratory investigationMore Details
    23017356 Effects of omega-3 fatty acids on postprandial triglycerides and monocyte activation.AtherosclerosisMore Details
    22212813 The CD14++CD16+ monocyte subset and monocyte-platelet interactions in patients with ST-elevation myocardial infarction.Journal of thrombosis and haemostasis : JTHMore Details
    22056216 CRP and CD14 polymorphisms correlate with coronary plaque volume in patients with coronary artery disease--IVUS substudy of the ENCORE trials.AtherosclerosisMore Details
    23146639 "Association among oral health, apical periodontitis, CD14 polymorphisms, and coronary heart disease in middle-aged adults."Journal of endodonticsMore Details
    22613847 "The significant increase of FcgammaRIIIA (CD16), a sensitive marker, in patients with coronary heart disease."GeneMore Details
    23091596 Fractional flow reserve is not associated with inflammatory markers in patients with stable coronary artery disease.PloS oneMore Details
    23056467 Cause or effect of arteriogenesis: compositional alterations of microparticles from CAD patients undergoing external counterpulsation therapy.PloS oneMore Details
    22984364 A Multinomial Ordinal Probit Model with Singular Value Decomposition Method for a Multinomial Trait.Journal of probability and statisticsMore Details
    21286777 Genetic polymorphisms of TP53 and FAS promoter modulate the progression of coronary artery disease after coronary artery bypass grafting: a gender-specific view.Inflammation research : official journal of the European Histamine ResearchMore Details
    21052690 The 5352 A allele of the pro-inflammatory caspase-1 gene predicts late-acquired stent malapposition in STEMI patients treated with sirolimus stents.Heart and vesselsMore Details
    21308491 Heterogeneity of human monocytes: an optimized four-color flow cytometry protocol for analysis of monocyte subsets.Journal of cardiovascular translational researchMore Details
    20555430 Effects of raloxifene treatment on the phenotype of blood monocytes.Canadian journal of physiology and pharmacologyMore Details
    19829130 Role of the CD14 C(-260)T promoter polymorphism in determining the first clinical manifestation of coronary artery disease."Journal of cardiovascular medicine (Hagerstown, Md.)"More Details
    19795323 CD14 promoter polymorphism (- 159C-->t) is not associated with myocardial infarction or coronary artery disease in patients with assumed high genetic risk.The Thoracic and cardiovascular surgeonMore Details
    19286938 Myocardial oxygenation and functional recovery in infarct rat hearts transplanted with mesenchymal stem cells.American journal of physiology. Heart and circulatory physiologyMore Details
    19125317 Native LDL-cholesterol mediated monocyte adhesion molecule overexpression is blocked by simvastatin.Cardiovascular drugs and therapy / sponsored by the International Society ofMore Details
    19346955 CD14 C-260T gene polymorphism and ischemic heart disease susceptibility: a HuGE review and meta-analysis.Genetics in medicine : official journal of the American College of MedicalMore Details
    18157711 Association between inflammatory gene polymorphisms and coronary artery disease in an Indian population.Journal of thrombosis and thrombolysisMore Details
    19616779 The formation of monocyte-platelet aggregates is independent of on-treatment residual agonists'-inducible platelet reactivity.AtherosclerosisMore Details
    19528795 Endothelial progenitor cells in patients with coronary artery disease and left ventricular dysfunction.Coronary artery diseaseMore Details
    17963771 Myeloid lineage of high proliferative potential human smooth muscle outgrowth cells circulating in blood and vasculogenic smooth muscle-like cells in vivo.AtherosclerosisMore Details
    18578002 Circulating CD34+ cell subsets in patients with coronary endothelial dysfunction.Nature clinical practice. Cardiovascular medicineMore Details
    18321997 Heterogeneity of human macrophages in culture and in atherosclerotic plaques.The American journal of pathologyMore Details
    17458880 Monocyte cholesterol homeostasis correlates with the presence of detergent resistant membrane microdomains.Cytometry. Part A : the journal of the International Society for AnalyticalMore Details
    17098305 "CD14 C (-260)T polymorphism, atherosclerosis, elderly: role of cytokines and metallothioneins."International journal of cardiologyMore Details
    17056323 Influence of the CD14 C260T promoter polymorphism on C-reactive protein levels in patients with coronary artery disease.The American journal of cardiologyMore Details
    17130346 Stent-based local delivery of nuclear factor-kappaB decoy attenuates in-stent restenosis in hypercholesterolemic rabbits.CirculationMore Details
    16890863 Synergistic effect of Toll-like receptor 4 and CD14 polymorphisms on the total atherosclerosis burden in patients with peripheral arterial disease.Journal of vascular surgeryMore Details
    16253262 Characterization of smooth muscle-like cells in circulating human peripheral blood.AtherosclerosisMore Details
    16827927 Edge restenosis: impact of low dose irradiation on cell proliferation and ICAM-1 expression.BMC cardiovascular disordersMore Details
    16230497 Genetic inflammatory factors predict restenosis after percutaneous coronary interventions.CirculationMore Details
    15753227 p38 mitogen-activated protein kinase downregulates endothelial progenitor cells.CirculationMore Details
    15686783 CD14 C(-260)T promoter polymorphism and prevalence of acute coronary syndromes.International journal of cardiologyMore Details
    16297172 The immune responses to human and microbial heat shock proteins in periodontal disease with and without coronary heart disease.Clinical and experimental immunologyMore Details
    16043646 Mechanisms of cardiac depression caused by lipoteichoic acids from Staphylococcus aureus in isolated rat hearts.CirculationMore Details
    15777548 Interaction between the C-260T polymorphism of the CD14 gene and the plasma IL-6 concentration on the risk of myocardial infarction: the HIFMECH study.AtherosclerosisMore Details
    15310678 CD14 and toll-like receptor 4: a link between infection and acute coronary events?Heart (British Cardiac Society)More Details
    15116260 Pharmacogenetics of the CD14 endotoxin receptor polymorphism and progression of coronary atherosclerosis.Thrombosis and haemostasisMore Details
    14996480 Promoter polymorphism in the CD14 gene and concentration of soluble CD14 in patients with in-stent restenosis after elective coronary stenting.International journal of cardiologyMore Details
    15367917 "TLR4/Asp299Gly, CD14/C-260T, plasma levels of the soluble receptor CD14 and the risk of coronary heart disease: The PRIME Study."European journal of human genetics : EJHGMore Details
    15744549 The effect of temperature variation in vitro on platelet-leukocyte interactions and individual prothrombotic potential.Journal of thrombosis and thrombolysisMore Details
    15175649 CD14 promoter polymorphism -159C>T is associated with susceptibility to chronic Chlamydia pneumoniae infection in peripheral blood monocytes.Genes and immunityMore Details
    14517520 A polymorphism in the promoter of the CD14 gene (CD14/-159) is associated with the development of coronary artery lesions in patients with Kawasaki disease.The Journal of pediatricsMore Details
    14648231 The C(-260)>T gene polymorphism in the promoter of the CD14 monocyte receptor gene is not associated with acute myocardial infarction.Clinical and experimental medicineMore Details
    12140663 Lipopolysaccharide receptor CD14 polymorphism and risk of stroke in a South-German population.Journal of neurologyMore Details
    12434421 "Human atherosclerotic plaques express DC-SIGN, a novel protein found on dendritic cells and macrophages."The Journal of pathologyMore Details
    12082592 Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease.The pharmacogenomics journalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 8 unique genes interacted with CD14. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    LBP Reconstituted Complex12417309|7583357 CHD related
    TLR2 Affinity Capture-Western10395652 CHD related
    TLR3 in vitro;in vivo16473828 No
    CD55 in vitro11745332 No
    LTF Reconstituted Complex11083760 No
    ITGB2 in vitro11745332 CHD related
    LGALS3BP in vitro7583357 No
    TLR4 in vivo12196527 CHD related

    Involved FDA drugs

    There was no drug associated with CD14