How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: CD151

    Description: CD151 molecule (Raph blood group)

    Entrez Gene ID: 977

    SwissProt Acc Number: P48509

    RefSeq: NM_001039490

    It was supported literatures to be a novel CHD related gene:

    .."Intramyocardial injection of rAAV-CD151 could enhance the myocardial express of CD151 protein, increase capillary and arteriole densities and improve blood perfusion in swine with myocardial infarction."..

    From PMID: 19927637, in Journal Zhonghua Xin Xue Guan Bing Za Zhi. , 2009


    There were 1 potential papers with CD151 and CHD.

    19079294 Assessment of myocardial blood perfusion improved by CD151 in a pig myocardial infarction model.Acta pharmacologica SinicaMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 9 unique genes interacted with CD151. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    CD46 Affinity Capture-Western10741407 No
    ITGA3 Reconstituted Complex10734060|14676841 CHD related
    PTGFRN Affinity Capture-Western11278880|11278880 No
    ITGB1 Affinity Capture-Western12175627|14676841 CHD related
    UBC Affinity Capture-Western18713730 No
    CD82 Affinity Capture-Western15492270 No
    ITGA6 in vivo10811835 No
    MMP7 in vitro;in vivo;yeast 2-hybrid16200075 CHD related
    RNF128 in vivo18713730 No

    Involved FDA drugs

    There was no drug associated with CD151