Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)
Website using assistance : Leihong Wu (11019004@zju.edu.cn)
Coronary Heart Disease Research Platform
Description: CD28 molecule
Entrez Gene ID: 940
SwissProt Acc Number: P10747
RefSeq: NM_006139
It was suspected to be CHD related:
.."In DM patients, CD4+CD28(null)T-cells are expanded and are associated with poor glycaemic control"..
From PMID: 21217142, in Journal Eur Heart J , 2011There were 7 potential papers with CD28 and CHD.
PMID | Title | Journals | Details |
---|---|---|---|
22882906 | Persistent accumulation of interferon-gamma-producing CD8+CD56+ T cells in blood from patients with coronary artery disease. | Atherosclerosis | More Details |
22282196 | High levels of costimulatory receptors OX40 and 4-1BB characterize CD4+CD28null T cells in patients with acute coronary syndrome. | Circulation research | More Details |
18818214 | CD4+ CD28 null T cells in coronary artery disease: when helpers become killers. | Cardiovascular research | More Details |
18281862 | Behcet's disease. | Current opinion in rheumatology | More Details |
15864782 | Endothelial inducible costimulator ligand expression is increased during human cardiac allograft rejection and regulates endothelial cell-dependent allo-activation of CD8+ T cells in vitro. | European journal of immunology | More Details |
15621570 | CTLA4Ig prevents initiation but not evolution of anti-phospholipid syndrome in NZW/BXSB mice. | Autoimmunity | More Details |
15374847 | Blockade of the interaction between PD-1 and PD-L1 accelerates graft arterial disease in cardiac allografts. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.
There were totally 19 unique genes interacted with CD28. Show PPI network
Gene name | Interaction type | reference PMID | CHD relation |
---|---|---|---|
CD80 | Reconstituted Complex | 7545666|7545666 | CHD related |
GRAP2 | Affinity Capture-Western | 10820259|10820259|10820259 | No |
LRRC23 | Reconstituted Complex | 1847722 | No |
DUSP14 | Two-hybrid | 11123293|11123293|11123293 | No |
PIK3R2 | Affinity Capture-Western | 19190244|7509360,8080844 | No |
PIK3CA | Affinity Capture-Western | 9915850 | CHD related |
PLCG1 | in vivo | 8386518 | CHD related |
NSF | in vivo | 11680900 | No |
PIK3CG | in vivo | 9915850 | CHD related |
PTPRC | in vivo | 1355979 | CHD related |
LCK | in vitro | 10430626 | No |
IL12A | in vitro;in vivo | 7516408 | CHD related |
GRB2 | Reconstituted Complex | 9694876 | CHD related |
PIK3R1 | Protein-peptide | 8621607 | CHD related |
UBC | Affinity Capture-MS | 22505724 | No |
CD247 | in vivo | 8760790 | No |
CD4 | in vitro | 7539755 | CHD related |
ITK | in vitro;in vivo | 10586033,8992971,15144186 | No |
CD86 | in vivo | 11021528,7513726 | CHD related |
There was no drug associated with CD28