Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)
Website using assistance : Leihong Wu (11019004@zju.edu.cn)
Coronary Heart Disease Research Platform
Description: CD34 molecule
Entrez Gene ID: 947
SwissProt Acc Number: P28906
RefSeq: NM_001025109
It was supported literatures to be a novel CHD related gene:.."The endothelial regenerative response to injury induced by PCI,assessed by CD34+ KDR+ EPCs mobilized among progenitor cells, determines the risk of TLR and MACEs in stable coronary artery disease patients."..
From PMID: 22805118, in Journal J Thromb Haemost. , 2012There were 65 potential papers with CD34 and CHD.
| PMID | Title | Journals | Details |
|---|---|---|---|
| 23182004 | Reduced number and impaired function of circulating endothelial progenitor cells in patients with abdominal aortic aneurysm. | International journal of cardiology | More Details |
| 24044550 | Initial use of endothelial progenitor cells capturing stents in paediatric congenital heart disease. | Cardiology in the young | More Details |
| 23680469 | Increased levels of CD34+ cells are associated in patients with abdominal aortic aneurysms compared with patients with peripheral vascular disease. | The Journal of surgical research | More Details |
| 22517646 | "Remote ischemic preconditioning immediately before percutaneous coronary intervention does not impact myocardial necrosis, inflammatory response, and circulating endothelial progenitor cell counts: a single center randomized sham controlled trial." | Catheterization and cardiovascular interventions : official journal of the | More Details |
| 23523459 | The REMEDEE trial: a randomized comparison of a combination sirolimus-eluting endothelial progenitor cell capture stent with a paclitaxel-eluting stent. | JACC. Cardiovascular interventions | More Details |
| 22612275 | Endothelial progenitor cell capture stent: safety and effectiveness. | Journal of interventional cardiology | More Details |
| 23062532 | Role of circulating osteogenic progenitor cells in calcific aortic stenosis. | Journal of the American College of Cardiology | More Details |
| 21733913 | Capture of circulatory endothelial progenitor cells and accelerated re-endothelialization of a bio-engineered stent in human ex vivo shunt and rabbit denudation model. | European heart journal | More Details |
| 22306248 | Number of microparticles generated during acute myocardial infarction and stable angina correlates with platelet activation. | Archives of medical research | More Details |
| 21834062 | The Genous endothelial progenitor cell capture stent accelerates stent re-endothelialization but does not affect intimal hyperplasia in porcine coronary arteries. | Catheterization and cardiovascular interventions : official journal of the | More Details |
| 22855739 | Osteocalcin positive CD133+/CD34-/KDR+ progenitor cells as an independent marker for unstable atherosclerosis. | European heart journal | More Details |
| 21246370 | Circulating endothelial progenitor cells are reduced in SLE in the absence of coronary artery calcification. | Rheumatology international | More Details |
| 22415084 | "Expression of junctional adhesion molecule-C on the surface of platelets supports adhesion, but not differentiation, of human CD34 cells in vitro." | Cellular physiology and biochemistry : international journal of experimental | More Details |
| 23217199 | Myocardial dysfunction in patients with type 2 diabetes mellitus: role of endothelial progenitor cells and oxidative stress. | Cardiovascular diabetology | More Details |
| 20624659 | CD34+ cell mobilization and upregulation of myocardial cytokines in a rabbit model of myocardial ischemia. | International journal of cardiology | More Details |
| 21763653 | Final results of the HEALING IIB trial to evaluate a bio-engineered CD34 antibody coated stent (GenousStent) designed to promote vascular healing by capture of circulating endothelial progenitor cells in CAD patients. | Atherosclerosis | More Details |
| 21493893 | Malignant tumor formation after transplantation of short-term cultured bone marrow mesenchymal stem cells in experimental myocardial infarction and diabetic neuropathy. | Circulation research | More Details |
| 21197559 | Different clinical models of CD34 + cells mobilization in patients with cardiovascular disease. | Journal of thrombosis and thrombolysis | More Details |
| 20963594 | Effect of mini-tyrosyl-tRNA synthetase/mini-tryptophanyl-tRNA synthetase on ischemic angiogenesis in rats: proliferation and migration of endothelial cells. | Heart and vessels | More Details |
| 22089276 | Use of endothelial progenitor capture cell stent during percutaneous treatment of coronary bifurcations: a prospective angiographic registry. | Critical pathways in cardiology | More Details |
| 21962766 | [Coronary disease extension determines mobilization of endothelial progenitor cells and cytokines after a first myocardial infarction with ST elevation]. | Revista espanola de cardiologia | More Details |
| 21986631 | Coronary microcirculation remodeling in patients with idiopathic dilated cardiomyopathy. | Cardiology | More Details |
| 20543191 | Circulating endothelial progenitor cell levels and function in patients who experienced late coronary stent thrombosis. | European heart journal | More Details |
| 20448125 | Impact of primitive cells in intracoronary thrombi on lesion prognosis: temporal analysis of cellular constituents of thrombotic material obtained from patients with acute coronary syndrome. | Heart (British Cardiac Society) | More Details |
| 19926621 | Coronary intimal thickening in newborn babies and <or=1-year-old infants. | Angiology | More Details |
| 20080904 | Role of circulating endothelial progenitor cells in patients with rheumatoid arthritis with coronary calcification. | The Journal of rheumatology | More Details |
| 20935001 | Coronary endothelial dysfunction in humans is associated with coronary retention of osteogenic endothelial progenitor cells. | European heart journal | More Details |
| 20078384 | Evaluation of mobilized peripheral blood CD34(+) cells from patients with severe coronary artery disease as a source of endothelial progenitor cells. | Cytotherapy | More Details |
| 21072182 | Quantification of circulating endothelial progenitor cells using the modified ISHAGE protocol. | PloS one | More Details |
| 20565948 | Expression of a retinoic acid signature in circulating CD34 cells from coronary artery disease patients. | BMC genomics | More Details |
| 19739088 | An optimized flow cytometry protocol for analysis of angiogenic monocytes and endothelial progenitor cells in peripheral blood. | Cytometry. Part A : the journal of the International Society for Analytical | More Details |
| 19147447 | Cell therapy generates a favourable chemokine gradient for stem cell recruitment into the infarcted heart in rabbits. | European journal of heart failure | More Details |
| 19433985 | Myocardial homing and coronary endothelial function after autologous blood CD34+ progenitor cells intracoronary injection in the chronic phase of myocardial infarction. | Journal of cardiovascular pharmacology | More Details |
| 19482845 | Dissociation of phenotypic and functional endothelial progenitor cells in patients undergoing percutaneous coronary intervention. | Heart (British Cardiac Society) | More Details |
| 19528795 | Endothelial progenitor cells in patients with coronary artery disease and left ventricular dysfunction. | Coronary artery disease | More Details |
| 18977801 | Local vessel injury following percutaneous coronary intervention does not promote early mobilisation of endothelial progenitor cells in the absence of myocardial necrosis. | Heart (British Cardiac Society) | More Details |
| 18929243 | Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis. | Journal of the American College of Cardiology | More Details |
| 18273546 | Relationship of the percentage of circulating endothelial progenitor cell to the severity of coronary artery disease. | Heart and vessels | More Details |
| 17984121 | Effect of low doses of red wine and pure resveratrol on circulating endothelial progenitor cells. | Journal of biochemistry | More Details |
| 18578002 | Circulating CD34+ cell subsets in patients with coronary endothelial dysfunction. | Nature clinical practice. Cardiovascular medicine | More Details |
| 17676354 | "Differential increase of CD34, KDR/CD34, CD133/CD34 and CD117/CD34 positive cells in peripheral blood of patients with acute myocardial infarction." | Clinical research in cardiology : official journal of the German Cardiac Society | More Details |
| 17894361 | Role of progenitor endothelial cells in cardiovascular disease and upcoming therapies. | Catheterization and cardiovascular interventions : official journal of the | More Details |
| 17332488 | Circulating apoptotic progenitor cells: a novel biomarker in patients with acute coronary syndromes. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 16889848 | Transplantation of mesenchymal stem cells from human bone marrow improves damaged heart function in rats. | International journal of cardiology | More Details |
| 18061073 | Circulating progenitor cells can be reliably identified on the basis of aldehyde dehydrogenase activity. | Journal of the American College of Cardiology | More Details |
| 17924284 | Mobilization of haematopoietic and non-haematopoietic cells by granulocyte-colony stimulating factor and vascular endothelial growth factor gene therapy in patients with stable severe coronary artery disease. | Scandinavian cardiovascular journal : SCJ | More Details |
| 17404157 | Coronary collaterals remain recruitable after percutaneous intervention. | Circulation | More Details |
| 17255539 | Vascular dysfunction and reduced circulating endothelial progenitor cells in young healthy UK South Asian men. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 16891014 | Effects of GM-CSF on the stem cells mobilization and plasma C-reactive protein levels in patients with acute myocardial infarction. | International journal of cardiology | More Details |
| 17114286 | Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice. | Proceedings of the National Academy of Sciences of the United States of America | More Details |
| 16682302 | A novel drug-eluting stent coated with an integrin-binding cyclic Arg-Gly-Asp peptide inhibits neointimal hyperplasia by recruiting endothelial progenitor cells. | Journal of the American College of Cardiology | More Details |
| 16701171 | Low molecular weight fucan prevents transplant coronaropathy in rat cardiac allograft model. | Transplant immunology | More Details |
| 16807650 | Detection and quantification of mature circulating endothelial cells using flow cytometry and immunomagnetic beads: a methodological comparison. | Thrombosis and haemostasis | More Details |
| 16148285 | Circulating endothelial progenitor cells and cardiovascular outcomes. | The New England journal of medicine | More Details |
| 16185299 | Adenomatoid tumor of the adrenal gland: case report with immunohistochemical study. | Pathology international | More Details |
| 15896752 | Angiogenesis occurs within the intimal proliferation that characterizes transplant coronary artery vasculopathy. | The Journal of heart and lung transplantation : the official publication of the | More Details |
| 15374879 | "Circulating endothelial cells, von Willebrand factor, interleukin-6, and prognosis in patients with acute coronary syndromes." | Blood | More Details |
| 15621483 | Upregulation of endothelial adhesion molecules in hearts with congestive and ischemic cardiomyopathy: immunohistochemical evaluation of inflammatory endothelial cell activation. | European journal of cardio-thoracic surgery : official journal of the European | More Details |
| 16061116 | The mobilization of CD34 positive mononuclear cells after myocardial infarction is abolished by revascularization of the culprit vessel. | International journal of cardiology | More Details |
| 16039284 | Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease. | Atherosclerosis | More Details |
| 15891993 | Angiogenesis and lymphangiogenesis and expression of lymphangiogenic factors in the atherosclerotic intima of human coronary arteries. | Human pathology | More Details |
| 15093715 | Characterization of two populations of human coronary artery endothelial cells(1). | The Journal of surgical research | More Details |
| 15454379 | Intramyocardial CD34+ cell transplantation combined with off-pump coronary artery bypass grafting. | The heart surgery forum | More Details |
| 11549570 | Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis. | The American journal of pathology | More Details |
| 11442525 | "Association between plaque instability, angiogenesis and symptomatic carotid occlusive disease." | The British journal of surgery | More Details |
NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.
There were totally 5 unique genes interacted with CD34. Show PPI network
| Gene name | Interaction type | reference PMID | CHD relation |
|---|---|---|---|
| CRKL | Reconstituted Complex | 11389015|11389015 | No |
| ATF5 | Two-hybrid | 10373550 | No |
| CREM | Two-hybrid | 10373550 | CHD related |
| PRKCD | in vitro;in vivo | 1694174 | CHD related |
| CHST4 | in vitro | 10330415 | No |
There was no drug associated with CD34