How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: CD34

    Description: CD34 molecule

    Entrez Gene ID: 947

    SwissProt Acc Number: P28906

    RefSeq: NM_001025109

    It was supported literatures to be a novel CHD related gene:

    .."The endothelial regenerative response to injury induced by PCI,assessed by CD34+ KDR+ EPCs mobilized among progenitor cells, determines the risk of TLR and MACEs in stable coronary artery disease patients."..

    From PMID: 22805118, in Journal J Thromb Haemost. , 2012


    There were 65 potential papers with CD34 and CHD.

    23182004 Reduced number and impaired function of circulating endothelial progenitor cells in patients with abdominal aortic aneurysm.International journal of cardiologyMore Details
    24044550 Initial use of endothelial progenitor cells capturing stents in paediatric congenital heart disease.Cardiology in the youngMore Details
    23680469 Increased levels of CD34+ cells are associated in patients with abdominal aortic aneurysms compared with patients with peripheral vascular disease.The Journal of surgical researchMore Details
    22517646 "Remote ischemic preconditioning immediately before percutaneous coronary intervention does not impact myocardial necrosis, inflammatory response, and circulating endothelial progenitor cell counts: a single center randomized sham controlled trial."Catheterization and cardiovascular interventions : official journal of theMore Details
    23523459 The REMEDEE trial: a randomized comparison of a combination sirolimus-eluting endothelial progenitor cell capture stent with a paclitaxel-eluting stent.JACC. Cardiovascular interventionsMore Details
    22612275 Endothelial progenitor cell capture stent: safety and effectiveness.Journal of interventional cardiologyMore Details
    23062532 Role of circulating osteogenic progenitor cells in calcific aortic stenosis.Journal of the American College of CardiologyMore Details
    21733913 Capture of circulatory endothelial progenitor cells and accelerated re-endothelialization of a bio-engineered stent in human ex vivo shunt and rabbit denudation model.European heart journalMore Details
    22306248 Number of microparticles generated during acute myocardial infarction and stable angina correlates with platelet activation.Archives of medical researchMore Details
    21834062 The Genous endothelial progenitor cell capture stent accelerates stent re-endothelialization but does not affect intimal hyperplasia in porcine coronary arteries.Catheterization and cardiovascular interventions : official journal of theMore Details
    22855739 Osteocalcin positive CD133+/CD34-/KDR+ progenitor cells as an independent marker for unstable atherosclerosis.European heart journalMore Details
    21246370 Circulating endothelial progenitor cells are reduced in SLE in the absence of coronary artery calcification.Rheumatology internationalMore Details
    22415084 "Expression of junctional adhesion molecule-C on the surface of platelets supports adhesion, but not differentiation, of human CD34 cells in vitro."Cellular physiology and biochemistry : international journal of experimentalMore Details
    23217199 Myocardial dysfunction in patients with type 2 diabetes mellitus: role of endothelial progenitor cells and oxidative stress.Cardiovascular diabetologyMore Details
    20624659 CD34+ cell mobilization and upregulation of myocardial cytokines in a rabbit model of myocardial ischemia.International journal of cardiologyMore Details
    21763653 Final results of the HEALING IIB trial to evaluate a bio-engineered CD34 antibody coated stent (GenousStent) designed to promote vascular healing by capture of circulating endothelial progenitor cells in CAD patients.AtherosclerosisMore Details
    21493893 Malignant tumor formation after transplantation of short-term cultured bone marrow mesenchymal stem cells in experimental myocardial infarction and diabetic neuropathy.Circulation researchMore Details
    21197559 Different clinical models of CD34 + cells mobilization in patients with cardiovascular disease.Journal of thrombosis and thrombolysisMore Details
    20963594 Effect of mini-tyrosyl-tRNA synthetase/mini-tryptophanyl-tRNA synthetase on ischemic angiogenesis in rats: proliferation and migration of endothelial cells.Heart and vesselsMore Details
    22089276 Use of endothelial progenitor capture cell stent during percutaneous treatment of coronary bifurcations: a prospective angiographic registry.Critical pathways in cardiologyMore Details
    21962766 [Coronary disease extension determines mobilization of endothelial progenitor cells and cytokines after a first myocardial infarction with ST elevation].Revista espanola de cardiologiaMore Details
    21986631 Coronary microcirculation remodeling in patients with idiopathic dilated cardiomyopathy.CardiologyMore Details
    20543191 Circulating endothelial progenitor cell levels and function in patients who experienced late coronary stent thrombosis.European heart journalMore Details
    20448125 Impact of primitive cells in intracoronary thrombi on lesion prognosis: temporal analysis of cellular constituents of thrombotic material obtained from patients with acute coronary syndrome.Heart (British Cardiac Society)More Details
    19926621 Coronary intimal thickening in newborn babies and <or=1-year-old infants.AngiologyMore Details
    20080904 Role of circulating endothelial progenitor cells in patients with rheumatoid arthritis with coronary calcification.The Journal of rheumatologyMore Details
    20935001 Coronary endothelial dysfunction in humans is associated with coronary retention of osteogenic endothelial progenitor cells.European heart journalMore Details
    20078384 Evaluation of mobilized peripheral blood CD34(+) cells from patients with severe coronary artery disease as a source of endothelial progenitor cells.CytotherapyMore Details
    21072182 Quantification of circulating endothelial progenitor cells using the modified ISHAGE protocol.PloS oneMore Details
    20565948 Expression of a retinoic acid signature in circulating CD34 cells from coronary artery disease patients.BMC genomicsMore Details
    19739088 An optimized flow cytometry protocol for analysis of angiogenic monocytes and endothelial progenitor cells in peripheral blood.Cytometry. Part A : the journal of the International Society for AnalyticalMore Details
    19147447 Cell therapy generates a favourable chemokine gradient for stem cell recruitment into the infarcted heart in rabbits.European journal of heart failureMore Details
    19433985 Myocardial homing and coronary endothelial function after autologous blood CD34+ progenitor cells intracoronary injection in the chronic phase of myocardial infarction.Journal of cardiovascular pharmacologyMore Details
    19482845 Dissociation of phenotypic and functional endothelial progenitor cells in patients undergoing percutaneous coronary intervention.Heart (British Cardiac Society)More Details
    19528795 Endothelial progenitor cells in patients with coronary artery disease and left ventricular dysfunction.Coronary artery diseaseMore Details
    18977801 Local vessel injury following percutaneous coronary intervention does not promote early mobilisation of endothelial progenitor cells in the absence of myocardial necrosis.Heart (British Cardiac Society)More Details
    18929243 Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis.Journal of the American College of CardiologyMore Details
    18273546 Relationship of the percentage of circulating endothelial progenitor cell to the severity of coronary artery disease.Heart and vesselsMore Details
    17984121 Effect of low doses of red wine and pure resveratrol on circulating endothelial progenitor cells.Journal of biochemistryMore Details
    18578002 Circulating CD34+ cell subsets in patients with coronary endothelial dysfunction.Nature clinical practice. Cardiovascular medicineMore Details
    17676354 "Differential increase of CD34, KDR/CD34, CD133/CD34 and CD117/CD34 positive cells in peripheral blood of patients with acute myocardial infarction."Clinical research in cardiology : official journal of the German Cardiac SocietyMore Details
    17894361 Role of progenitor endothelial cells in cardiovascular disease and upcoming therapies.Catheterization and cardiovascular interventions : official journal of theMore Details
    17332488 Circulating apoptotic progenitor cells: a novel biomarker in patients with acute coronary syndromes."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16889848 Transplantation of mesenchymal stem cells from human bone marrow improves damaged heart function in rats.International journal of cardiologyMore Details
    18061073 Circulating progenitor cells can be reliably identified on the basis of aldehyde dehydrogenase activity.Journal of the American College of CardiologyMore Details
    17924284 Mobilization of haematopoietic and non-haematopoietic cells by granulocyte-colony stimulating factor and vascular endothelial growth factor gene therapy in patients with stable severe coronary artery disease.Scandinavian cardiovascular journal : SCJMore Details
    17404157 Coronary collaterals remain recruitable after percutaneous intervention.CirculationMore Details
    17255539 Vascular dysfunction and reduced circulating endothelial progenitor cells in young healthy UK South Asian men."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16891014 Effects of GM-CSF on the stem cells mobilization and plasma C-reactive protein levels in patients with acute myocardial infarction.International journal of cardiologyMore Details
    17114286 Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice.Proceedings of the National Academy of Sciences of the United States of AmericaMore Details
    16682302 A novel drug-eluting stent coated with an integrin-binding cyclic Arg-Gly-Asp peptide inhibits neointimal hyperplasia by recruiting endothelial progenitor cells.Journal of the American College of CardiologyMore Details
    16701171 Low molecular weight fucan prevents transplant coronaropathy in rat cardiac allograft model.Transplant immunologyMore Details
    16807650 Detection and quantification of mature circulating endothelial cells using flow cytometry and immunomagnetic beads: a methodological comparison.Thrombosis and haemostasisMore Details
    16148285 Circulating endothelial progenitor cells and cardiovascular outcomes.The New England journal of medicineMore Details
    16185299 Adenomatoid tumor of the adrenal gland: case report with immunohistochemical study.Pathology internationalMore Details
    15896752 Angiogenesis occurs within the intimal proliferation that characterizes transplant coronary artery vasculopathy.The Journal of heart and lung transplantation : the official publication of theMore Details
    15374879 "Circulating endothelial cells, von Willebrand factor, interleukin-6, and prognosis in patients with acute coronary syndromes."BloodMore Details
    15621483 Upregulation of endothelial adhesion molecules in hearts with congestive and ischemic cardiomyopathy: immunohistochemical evaluation of inflammatory endothelial cell activation.European journal of cardio-thoracic surgery : official journal of the EuropeanMore Details
    16061116 The mobilization of CD34 positive mononuclear cells after myocardial infarction is abolished by revascularization of the culprit vessel.International journal of cardiologyMore Details
    16039284 Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease.AtherosclerosisMore Details
    15891993 Angiogenesis and lymphangiogenesis and expression of lymphangiogenic factors in the atherosclerotic intima of human coronary arteries.Human pathologyMore Details
    15093715 Characterization of two populations of human coronary artery endothelial cells(1).The Journal of surgical researchMore Details
    15454379 Intramyocardial CD34+ cell transplantation combined with off-pump coronary artery bypass grafting.The heart surgery forumMore Details
    11549570 Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis.The American journal of pathologyMore Details
    11442525 "Association between plaque instability, angiogenesis and symptomatic carotid occlusive disease."The British journal of surgeryMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 5 unique genes interacted with CD34. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    CRKL Reconstituted Complex11389015|11389015 No
    ATF5 Two-hybrid10373550 No
    CREM Two-hybrid10373550 CHD related
    PRKCD in vitro;in vivo1694174 CHD related
    CHST4 in vitro10330415 No

    Involved FDA drugs

    There was no drug associated with CD34