Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)
Website using assistance : Leihong Wu (11019004@zju.edu.cn)
Coronary Heart Disease Research Platform
Description: CD36 molecule (thrombospondin receptor)
Entrez Gene ID: 948
SwissProt Acc Number: P16671
RefSeq: NM_000072
It was suspected to be CHD related:
..Patients with CD36 deficiency are associated with enhanced atherosclerotic cardiovascular diseases...
From PMID: 22075538, in Journal J Atheroscler Thromb.? , 2012There were 40 potential papers with CD36 and CHD.
| PMID | Title | Journals | Details |
|---|---|---|---|
| 23332800 | Randomized placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt: effects on circulating eicosanoids and cardiovascular risk factors. | "Clinical nutrition (Edinburgh, Scotland)" | More Details |
| 23856131 | Is CD36 gene polymorphism in region encoding lipid-binding domain associated with early onset CAD? | Gene | More Details |
| 23633271 | "Efficacy of the CCR5 antagonist maraviroc in reducing early, ritonavir-induced atherogenesis and advanced plaque progression in mice." | Circulation | More Details |
| 23739627 | Monocyte gene expression and coronary artery disease. | Current opinion in clinical nutrition and metabolic care | More Details |
| 22750995 | Decreased TSP-1 following percutaneous coronary intervention is associated with major adverse cardiac events in ST-elevation myocardial infarction. | Clinical hemorheology and microcirculation | More Details |
| 24049523 | Association of CD36 gene polymorphisms with echo- and electrocardiographic parameters in patients with early onset coronary artery disease. | Archives of medical science : AMS | More Details |
| 24282409 | Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease. | International journal of endocrinology | More Details |
| 22128087 | CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis. | Physiological genomics | More Details |
| 22113854 | Polymorphism of the CD36 Gene and Cardiovascular Risk Factors in Patients with Coronary Artery Disease Manifested at a Young Age. | Biochemical genetics | More Details |
| 21828047 | Reduced expression of adipose triglyceride lipase enhances tumor necrosis factor alpha-induced intercellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase C-dependent activation of nuclear factor-kappaB. | The Journal of biological chemistry | More Details |
| 20935172 | Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile. | Human molecular genetics | More Details |
| 21668445 | Modulation of human monocyte CD36 by type 2 diabetes mellitus and other atherosclerotic risk factors. | European journal of clinical investigation | More Details |
| 21308491 | Heterogeneity of human monocytes: an optimized four-color flow cytometry protocol for analysis of monocyte subsets. | Journal of cardiovascular translational research | More Details |
| 21262584 | "The macrophage Ox-LDL receptor, CD36 and its association with type II diabetes mellitus." | Molecular genetics and metabolism | More Details |
| 21701167 | Early impact of prescription Omega-3 fatty acids on platelet biomarkers in patients with coronary artery disease and hypertriglyceridemia. | Cardiology | More Details |
| 20112301 | Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats. | Molecular nutrition & food research | More Details |
| 19751271 | "In vivo extravasated human monocytes have an altered expression of CD16, HLA-DR, CD86, CD36 and CX(3)CR1." | Scandinavian journal of immunology | More Details |
| 19776136 | Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease. | The American journal of clinical nutrition | More Details |
| 19503102 | "The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats." | Acta pharmacologica Sinica | More Details |
| 19032580 | Phosphatidylethanol mediates its effects on the vascular endothelial growth factor via HDL receptor in endothelial cells. | "Alcoholism, clinical and experimental research" | More Details |
| 18662803 | "Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages." | Biochimica et biophysica acta | More Details |
| 18067591 | CD36 mRNA expression is increased in CD14+ monocytes of patients with coronary heart disease. | Clinical and experimental pharmacology & physiology | More Details |
| 18456003 | 4-hydroxynonenal contributes to macrophage foam cell formation through increased expression of class A scavenger receptor at the level of translation. | Free radical biology & medicine | More Details |
| 18818414 | Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 16670819 | Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients. | Molecular and cellular biochemistry | More Details |
| 17312010 | Robust immunohistochemical staining of several classes of proteins in tissues subjected to autolysis. | The journal of histochemistry and cytochemistry : official journal of the | More Details |
| 17458880 | Monocyte cholesterol homeostasis correlates with the presence of detergent resistant membrane microdomains. | Cytometry. Part A : the journal of the International Society for Analytical | More Details |
| 17653516 | High P-selectin expression and low CD36 occupancy on circulating platelets are strong predictors of restenosis after coronary stenting in patients with coronary artery disease. | Heart and vessels | More Details |
| 18035074 | Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction. | American heart journal | More Details |
| 17924847 | CD36 polymorphism and its relationship with body mass index and coronary artery disease in a Korean population. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 16716120 | Novel immunoblotting monoclonal antibodies against human and rat CD36/fat used to identify an isoform of CD36 in rat muscle. | DNA and cell biology | More Details |
| 16252156 | Importance of blood cellular genomic profile in coronary heart disease. | Journal of biomedical science | More Details |
| 16170677 | "[HIV infection, antiretroviral therapy, and endothelium]." | Herz | More Details |
| 15912310 | Takotsubo-shaped cardiomyopathy with type I CD36 deficiency. | Heart and vessels | More Details |
| 15374879 | "Circulating endothelial cells, von Willebrand factor, interleukin-6, and prognosis in patients with acute coronary syndromes." | Blood | More Details |
| 16285995 | 3'UTR/T polymorphism of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is associated with modified anti-platelet activity of atorvastatin in hypercholesterolemic subjects. | Atherosclerosis | More Details |
| 15681296 | Allelic variants of the human scavenger receptor class B type 1 and paraoxonase 1 on coronary heart disease: genotype-phenotype correlations. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 15282206 | A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. | Human molecular genetics | More Details |
| 15488865 | "Cytomegalovirus stimulated mRNA accumulation and cell surface expression of the oxidized LDL scavenger receptor, CD36." | Atherosclerosis | More Details |
| 11135615 | PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. | Nature medicine | More Details |
NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.
There were totally 18 unique genes interacted with CD36. Show PPI network
| Gene name | Interaction type | reference PMID | CHD relation |
|---|---|---|---|
| HSD11B1 | Reconstituted Complex | 9555943 | No |
| LDLR | Reconstituted Complex | 9555943 | CHD related |
| VLDLR | Reconstituted Complex | 9555943 | No |
| FYN | Affinity Capture-Western | 1715582|7521304 | No |
| LYN | Affinity Capture-Western | 1715582|1715582 | No |
| YES1 | Affinity Capture-Western | 1715582|7521304 | No |
| MATK | Affinity Capture-Western | 9171348 | No |
| ITGA2B | Affinity Capture-Western | 11238109 | CHD related |
| ITGB3 | Affinity Capture-Western | 11238109|11238109 | CHD related |
| ITGA6 | Affinity Capture-Western | 11238109|11238109 | No |
| CD9 | Affinity Capture-Western | 11238109|11238109 | CHD related |
| ITGB1 | Affinity Capture-Western | 11238109|11238109 | CHD related |
| APP | Reconstituted Complex | 21832049 | No |
| COL1A1 | in vitro | 2468670 | CHD related |
| COL1A2 | in vitro | 10772928 | CHD related |
| CAND1 | Affinity Capture-MS | 21145461 | No |
| THBS1 | in vivo | 10772961,10487979 | CHD related |
| SRC | in vivo | 7521304 | CHD related |
There was no drug associated with CD36