How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: CD36

    Description: CD36 molecule (thrombospondin receptor)

    Entrez Gene ID: 948

    SwissProt Acc Number: P16671

    RefSeq: NM_000072

    It was suspected to be CHD related:

    ..Patients with CD36 deficiency are associated with enhanced atherosclerotic cardiovascular diseases...

    From PMID: 22075538, in Journal J Atheroscler Thromb.? , 2012


    There were 40 potential papers with CD36 and CHD.

    23332800 Randomized placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt: effects on circulating eicosanoids and cardiovascular risk factors."Clinical nutrition (Edinburgh, Scotland)"More Details
    23856131 Is CD36 gene polymorphism in region encoding lipid-binding domain associated with early onset CAD?GeneMore Details
    23633271 "Efficacy of the CCR5 antagonist maraviroc in reducing early, ritonavir-induced atherogenesis and advanced plaque progression in mice."CirculationMore Details
    23739627 Monocyte gene expression and coronary artery disease.Current opinion in clinical nutrition and metabolic careMore Details
    22750995 Decreased TSP-1 following percutaneous coronary intervention is associated with major adverse cardiac events in ST-elevation myocardial infarction.Clinical hemorheology and microcirculationMore Details
    24049523 Association of CD36 gene polymorphisms with echo- and electrocardiographic parameters in patients with early onset coronary artery disease.Archives of medical science : AMSMore Details
    24282409 Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease.International journal of endocrinologyMore Details
    22128087 CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis.Physiological genomicsMore Details
    22113854 Polymorphism of the CD36 Gene and Cardiovascular Risk Factors in Patients with Coronary Artery Disease Manifested at a Young Age.Biochemical geneticsMore Details
    21828047 Reduced expression of adipose triglyceride lipase enhances tumor necrosis factor alpha-induced intercellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase C-dependent activation of nuclear factor-kappaB.The Journal of biological chemistryMore Details
    20935172 Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile.Human molecular geneticsMore Details
    21668445 Modulation of human monocyte CD36 by type 2 diabetes mellitus and other atherosclerotic risk factors.European journal of clinical investigationMore Details
    21308491 Heterogeneity of human monocytes: an optimized four-color flow cytometry protocol for analysis of monocyte subsets.Journal of cardiovascular translational researchMore Details
    21262584 "The macrophage Ox-LDL receptor, CD36 and its association with type II diabetes mellitus."Molecular genetics and metabolismMore Details
    21701167 Early impact of prescription Omega-3 fatty acids on platelet biomarkers in patients with coronary artery disease and hypertriglyceridemia.CardiologyMore Details
    20112301 Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats.Molecular nutrition & food researchMore Details
    19751271 "In vivo extravasated human monocytes have an altered expression of CD16, HLA-DR, CD86, CD36 and CX(3)CR1."Scandinavian journal of immunologyMore Details
    19776136 Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease.The American journal of clinical nutritionMore Details
    19503102 "The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats."Acta pharmacologica SinicaMore Details
    19032580 Phosphatidylethanol mediates its effects on the vascular endothelial growth factor via HDL receptor in endothelial cells."Alcoholism, clinical and experimental research"More Details
    18662803 "Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages."Biochimica et biophysica actaMore Details
    18067591 CD36 mRNA expression is increased in CD14+ monocytes of patients with coronary heart disease.Clinical and experimental pharmacology & physiologyMore Details
    18456003 4-hydroxynonenal contributes to macrophage foam cell formation through increased expression of class A scavenger receptor at the level of translation.Free radical biology & medicineMore Details
    18818414 Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16670819 Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients.Molecular and cellular biochemistryMore Details
    17312010 Robust immunohistochemical staining of several classes of proteins in tissues subjected to autolysis.The journal of histochemistry and cytochemistry : official journal of theMore Details
    17458880 Monocyte cholesterol homeostasis correlates with the presence of detergent resistant membrane microdomains.Cytometry. Part A : the journal of the International Society for AnalyticalMore Details
    17653516 High P-selectin expression and low CD36 occupancy on circulating platelets are strong predictors of restenosis after coronary stenting in patients with coronary artery disease.Heart and vesselsMore Details
    18035074 Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction.American heart journalMore Details
    17924847 CD36 polymorphism and its relationship with body mass index and coronary artery disease in a Korean population.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    16716120 Novel immunoblotting monoclonal antibodies against human and rat CD36/fat used to identify an isoform of CD36 in rat muscle.DNA and cell biologyMore Details
    16252156 Importance of blood cellular genomic profile in coronary heart disease.Journal of biomedical scienceMore Details
    16170677 "[HIV infection, antiretroviral therapy, and endothelium]."HerzMore Details
    15912310 Takotsubo-shaped cardiomyopathy with type I CD36 deficiency.Heart and vesselsMore Details
    15374879 "Circulating endothelial cells, von Willebrand factor, interleukin-6, and prognosis in patients with acute coronary syndromes."BloodMore Details
    16285995 3'UTR/T polymorphism of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is associated with modified anti-platelet activity of atorvastatin in hypercholesterolemic subjects.AtherosclerosisMore Details
    15681296 Allelic variants of the human scavenger receptor class B type 1 and paraoxonase 1 on coronary heart disease: genotype-phenotype correlations."Arteriosclerosis, thrombosis, and vascular biology"More Details
    15282206 A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians.Human molecular geneticsMore Details
    15488865 "Cytomegalovirus stimulated mRNA accumulation and cell surface expression of the oxidized LDL scavenger receptor, CD36."AtherosclerosisMore Details
    11135615 PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation.Nature medicineMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 18 unique genes interacted with CD36. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    HSD11B1 Reconstituted Complex9555943 No
    LDLR Reconstituted Complex9555943 CHD related
    VLDLR Reconstituted Complex9555943 No
    FYN Affinity Capture-Western1715582|7521304 No
    LYN Affinity Capture-Western1715582|1715582 No
    YES1 Affinity Capture-Western1715582|7521304 No
    MATK Affinity Capture-Western9171348 No
    ITGA2B Affinity Capture-Western11238109 CHD related
    ITGB3 Affinity Capture-Western11238109|11238109 CHD related
    ITGA6 Affinity Capture-Western11238109|11238109 No
    CD9 Affinity Capture-Western11238109|11238109 CHD related
    ITGB1 Affinity Capture-Western11238109|11238109 CHD related
    APP Reconstituted Complex21832049 No
    COL1A1 in vitro2468670 CHD related
    COL1A2 in vitro10772928 CHD related
    CAND1 Affinity Capture-MS21145461 No
    THBS1 in vivo10772961,10487979 CHD related
    SRC in vivo7521304 CHD related

    Involved FDA drugs

    There was no drug associated with CD36