How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CD38

    Description: CD38 molecule

    Entrez Gene ID: 952

    SwissProt Acc Number: P28907

    RefSeq: NM_001775

    It was suspected to be CHD related:

    ..CD38 signaling pathway mediates FasL-induced intracellular Ca(2+) release through nicotinic acid adenine dinucleotide phosphate (NAADP) in mouse coronary arterial myocytes (CAMs) and thereby produces vasoconstriction in coronary arteries...

    From PMID: 20200208, in Journal Am J Physiol Cell Physiol , 2010


    References

    There were 2 potential papers with CD38 and CHD.

    PMIDTitleJournalsDetails
    23163821 Transcription factor complex AP-1 mediates inflammation initiated by Chlamydia pneumoniae infection.Cellular microbiologyMore Details
    20200208 Lysosome-dependent Ca(2+) release response to Fas activation in coronary arterial myocytes through NAADP: evidence from CD38 gene knockouts.American journal of physiology. Cell physiologyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 9 unique genes interacted with CD38. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    FCGR3A FRET11895784 CHD related
    CD3E Affinity Capture-Western14523017|14523017 No
    CD247 Affinity Capture-Western14523017|14523017 No
    LCK Affinity Capture-Western14523017 No
    ZAP70 Co-fractionation14523017 No
    CD9 in vivo15941914 CHD related
    CBL FRET19635790|18974118|18974118 No
    PECAM1 in vitro9551996 CHD related
    CD4 in vitro7539755 CHD related


    Involved FDA drugs

    There was no drug associated with CD38